PittsburghV1, Main, Merge, bibRecord, 008437

Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study

Identifieur interne : 008437 ( Main/Merge ); précédent : 008436; suivant : 008438

Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study

Auteurs : Samay Jain [États-Unis] ; Thanh G. Ton [États-Unis] ; Subashan Perera [États-Unis] ; Yan Zheng [États-Unis] ; Phyllis K. Stein [États-Unis] ; Evan Thacker [États-Unis] ; Elsa S. Strotmeyer [États-Unis] ; Anne B. Newman [États-Unis] ; Will T. Longstreth Jr. [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2012-07.

RBID : ISTEX:3A3042CA6C76989505295128E6BE247A302211B0

Descripteurs français

Wicri :
- topic : Maladie cardio-vasculaire, Neurologie, Santé publique.

English descriptors

Abstract

Changes in cardiovascular physiology in Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, and carotid stenosis with the risk of PD diagnosis in the Cardiovascular Health Study, a community‐based cohort of older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24‐hour Holter monitoring), and any carotid stenosis (≥1%) by ultrasound were modeled as primary predictors of incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least 1 of the following: self‐report, antiparkinsonian medication use, and ICD‐9. If unadjusted models were significant, they were adjusted or stratified by age, sex, and smoking status, and those in which predictors were still significant (P ≤ .05) were also adjusted for race, diabetes, total cholesterol, low‐density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke, and C‐reactive protein. Of 5888 participants, 154 incident PD cases were identified over 14 years of follow‐up. After adjusting models with all covariates, those with any ECG abnormality (odds ratio [OR], 1.45; 95% CI, 1.02–2.07; P = .04) or any carotid stenosis (OR, 2.40; 95% CI, 1.40–4.09; P = .001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential premotor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset. © 2012 Movement Disorder Society

Url:

https://api.istex.fr/document/3A3042CA6C76989505295128E6BE247A302211B0/fulltext/pdf

DOI: 10.1002/mds.24979

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000D87
to stream Istex, to step Curation: 000D87
to stream Istex, to step Checkpoint: 001918

Links to Exploration step

ISTEX:3A3042CA6C76989505295128E6BE247A302211B0

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study</title>
<author><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name>
</author>
<author><name sortKey="Ton, Thanh G" sort="Ton, Thanh G" uniqKey="Ton T" first="Thanh G." last="Ton">Thanh G. Ton</name>
</author>
<author><name sortKey="Perera, Subashan" sort="Perera, Subashan" uniqKey="Perera S" first="Subashan" last="Perera">Subashan Perera</name>
</author>
<author><name sortKey="Zheng, Yan" sort="Zheng, Yan" uniqKey="Zheng Y" first="Yan" last="Zheng">Yan Zheng</name>
</author>
<author><name sortKey="Stein, Phyllis K" sort="Stein, Phyllis K" uniqKey="Stein P" first="Phyllis K." last="Stein">Phyllis K. Stein</name>
</author>
<author><name sortKey="Thacker, Evan" sort="Thacker, Evan" uniqKey="Thacker E" first="Evan" last="Thacker">Evan Thacker</name>
</author>
<author><name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
</author>
<author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
</author>
<author><name sortKey="Longstreth Jr, Will T" sort="Longstreth Jr, Will T" uniqKey="Longstreth Jr W" first="Will T." last="Longstreth Jr.">Will T. Longstreth Jr.</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:3A3042CA6C76989505295128E6BE247A302211B0</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1002/mds.24979</idno>
<idno type="url">https://api.istex.fr/document/3A3042CA6C76989505295128E6BE247A302211B0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000D87</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D87</idno>
<idno type="wicri:Area/Istex/Curation">000D87</idno>
<idno type="wicri:Area/Istex/Checkpoint">001918</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001918</idno>
<idno type="wicri:doubleKey">0885-3185:2012:Jain S:cardiovascular:physiology:in</idno>
<idno type="wicri:Area/Main/Merge">008437</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study<ref type="note" target="#fn4"></ref>
<ref type="note" target="#fn3"></ref>
</title>
<author><name sortKey="Jain, Samay" sort="Jain, Samay" uniqKey="Jain S" first="Samay" last="Jain">Samay Jain</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh School of Medicine, Department of Neurology, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Correspondence address: Dr. Assistant Professor of Neurology, Clinical Director, Movement Disorders Division, Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Ave., Suite 811, Kaufmann Medical Building, Pittsburgh, PA 15213‐3232</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ton, Thanh G" sort="Ton, Thanh G" uniqKey="Ton T" first="Thanh G." last="Ton">Thanh G. Ton</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington School of Medicine, Department of Neurology, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perera, Subashan" sort="Perera, Subashan" uniqKey="Perera S" first="Subashan" last="Perera">Subashan Perera</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh School of Medicin,e Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zheng, Yan" sort="Zheng, Yan" uniqKey="Zheng Y" first="Yan" last="Zheng">Yan Zheng</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh School of Medicin,e Department of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Phyllis K" sort="Stein, Phyllis K" uniqKey="Stein P" first="Phyllis K." last="Stein">Phyllis K. Stein</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Washington University School of Medicine, Heart Rate Variability Laboratory, St. Louis, Missouri</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Thacker, Evan" sort="Thacker, Evan" uniqKey="Thacker E" first="Evan" last="Thacker">Evan Thacker</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington School of Public Health, Department of Epidemiology, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Graduate School of Public Health, Department of Epidemiology, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Longstreth Jr, Will T" sort="Longstreth Jr, Will T" uniqKey="Longstreth Jr W" first="Will T." last="Longstreth Jr.">Will T. Longstreth Jr.</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington School of Medicine, Department of Neurology, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Movement Disorders</title>
<title level="j" type="alt">MOVEMENT DISORDERS</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><biblScope unit="vol">27</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="988">988</biblScope>
<biblScope unit="page" to="995">995</biblScope>
<biblScope unit="page-count">8</biblScope>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-07">2012-07</date>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abnormality</term>
<term>African american</term>
<term>African american cohort</term>
<term>Antiparkinsonian medication</term>
<term>Antiparkinsonian medications</term>
<term>Baseline</term>
<term>Baseline assessment</term>
<term>Body mass index</term>
<term>Cardiovascular</term>
<term>Cardiovascular changes</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular health study</term>
<term>Cardiovascular physiology</term>
<term>Carotid</term>
<term>Carotid stenosis</term>
<term>Case ascertainment</term>
<term>Cerebrovascular disease</term>
<term>Charlson</term>
<term>Charlson scale</term>
<term>Clinical trials</term>
<term>Coffee drinking</term>
<term>Cohort</term>
<term>Comorbidity</term>
<term>Comorbidity charlson score</term>
<term>Data analysis</term>
<term>Data source</term>
<term>Data sources</term>
<term>Diabetes care</term>
<term>Diastolic blood pressure</term>
<term>Education level</term>
<term>Exploratory study</term>
<term>Heart rate variability</term>
<term>Heart rate variability measures</term>
<term>High concentrations</term>
<term>Homocysteine</term>
<term>Interaction term</term>
<term>Intima media</term>
<term>Medication</term>
<term>Motor signs</term>
<term>Movement disorders</term>
<term>Neurology</term>
<term>Nonmotor features</term>
<term>Odds ratio</term>
<term>Original cohort</term>
<term>Orthostasis</term>
<term>Other studies</term>
<term>Parasympathetic function</term>
<term>Parkinson disease</term>
<term>Participant</term>
<term>Physical activity</term>
<term>Pittsburgh school</term>
<term>Potential tool</term>
<term>Predictor</term>
<term>Premotor</term>
<term>Premotor disease</term>
<term>Premotor period</term>
<term>Primary predictor</term>
<term>Primary predictors</term>
<term>Public health</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Samay jain</term>
<term>Sensitivity analyses</term>
<term>Sensitivity analysis</term>
<term>Smoking status</term>
<term>Stenosis</term>
<term>Study year</term>
<term>Survival patterns</term>
<term>Systolic blood pressure</term>
<term>Telephone interviews</term>
<term>Total cholesterol</term>
<term>Unadjusted model</term>
<term>Variability</term>
<term>Vascular parkinsonism</term>
<term>Washington school</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term>
<term>African american</term>
<term>African american cohort</term>
<term>Antiparkinsonian medication</term>
<term>Antiparkinsonian medications</term>
<term>Baseline</term>
<term>Baseline assessment</term>
<term>Body mass index</term>
<term>Cardiovascular</term>
<term>Cardiovascular changes</term>
<term>Cardiovascular disease</term>
<term>Cardiovascular health study</term>
<term>Cardiovascular physiology</term>
<term>Carotid</term>
<term>Carotid stenosis</term>
<term>Case ascertainment</term>
<term>Cerebrovascular disease</term>
<term>Charlson</term>
<term>Charlson scale</term>
<term>Clinical trials</term>
<term>Coffee drinking</term>
<term>Cohort</term>
<term>Comorbidity</term>
<term>Comorbidity charlson score</term>
<term>Data analysis</term>
<term>Data source</term>
<term>Data sources</term>
<term>Diabetes care</term>
<term>Diastolic blood pressure</term>
<term>Education level</term>
<term>Exploratory study</term>
<term>Heart rate variability</term>
<term>Heart rate variability measures</term>
<term>High concentrations</term>
<term>Homocysteine</term>
<term>Interaction term</term>
<term>Intima media</term>
<term>Medication</term>
<term>Motor signs</term>
<term>Movement disorders</term>
<term>Neurology</term>
<term>Nonmotor features</term>
<term>Odds ratio</term>
<term>Original cohort</term>
<term>Orthostasis</term>
<term>Other studies</term>
<term>Parasympathetic function</term>
<term>Parkinson disease</term>
<term>Participant</term>
<term>Physical activity</term>
<term>Pittsburgh school</term>
<term>Potential tool</term>
<term>Predictor</term>
<term>Premotor</term>
<term>Premotor disease</term>
<term>Premotor period</term>
<term>Primary predictor</term>
<term>Primary predictors</term>
<term>Public health</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Samay jain</term>
<term>Sensitivity analyses</term>
<term>Sensitivity analysis</term>
<term>Smoking status</term>
<term>Stenosis</term>
<term>Study year</term>
<term>Survival patterns</term>
<term>Systolic blood pressure</term>
<term>Telephone interviews</term>
<term>Total cholesterol</term>
<term>Unadjusted model</term>
<term>Variability</term>
<term>Vascular parkinsonism</term>
<term>Washington school</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term>
<term>Neurologie</term>
<term>Santé publique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Changes in cardiovascular physiology in Parkinson's disease (PD) are common and may occur prior to diagnostic parkinsonian motor signs. We investigated associations of electrocardiographic (ECG) abnormalities, orthostasis, heart rate variability, and carotid stenosis with the risk of PD diagnosis in the Cardiovascular Health Study, a community‐based cohort of older adults. ECG abnormality, orthostasis (symptomatic or asymptomatic), heart rate variability (24‐hour Holter monitoring), and any carotid stenosis (≥1%) by ultrasound were modeled as primary predictors of incident PD diagnosis using multivariable logistic regression. Incident PD cases were identified by at least 1 of the following: self‐report, antiparkinsonian medication use, and ICD‐9. If unadjusted models were significant, they were adjusted or stratified by age, sex, and smoking status, and those in which predictors were still significant (P ≤ .05) were also adjusted for race, diabetes, total cholesterol, low‐density lipoprotein, blood pressure, body mass index, physical activity, education level, stroke, and C‐reactive protein. Of 5888 participants, 154 incident PD cases were identified over 14 years of follow‐up. After adjusting models with all covariates, those with any ECG abnormality (odds ratio [OR], 1.45; 95% CI, 1.02–2.07; P = .04) or any carotid stenosis (OR, 2.40; 95% CI, 1.40–4.09; P = .001) at baseline had a higher risk of incident PD diagnosis. Orthostasis and heart rate variability were not significant predictors. This exploratory study suggests that carotid stenosis and ECG abnormalities occur prior to motor signs in PD, thus serving as potential premotor features or risk factors for PD diagnosis. Replication is needed in a population with more thorough ascertainment of PD onset. © 2012 Movement Disorder Society</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008437 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 008437 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     ISTEX:3A3042CA6C76989505295128E6BE247A302211B0
   |texte=   Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study
}}

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur Pittsburgh

Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study

Cardiovascular physiology in premotor Parkinson's disease: A neuroepidemiologic study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri