Resting state functional connectivity and treatment response in late-life depression
Identifieur interne : 006B59 ( Main/Merge ); précédent : 006B58; suivant : 006B60Resting state functional connectivity and treatment response in late-life depression
Auteurs : Carmen Andreescu [États-Unis] ; Dana L. Tudorascu [États-Unis] ; Meryl A. Butters [États-Unis] ; Erica Tamburo [États-Unis] ; Meenal Patel [États-Unis] ; Julie Price [États-Unis] ; Jordan F. Karp [États-Unis] ; Charles F. Iii Reynolds [États-Unis] ; Howard Aizenstein [États-Unis]Source :
- Psychiatry research. Neuroimaging [ 0925-4927 ] ; 2013.
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Abstract
Indices of functional connectivity in the default mode network (DMN) are promising neural markers of treatment response in late-life depression. We examined the differences in DMN functional connectivity between treatment-responsive and treatment-resistant depressed older adults. Forty-seven depressed older adults underwent MRI scanning pre- and post-pharmacotherapy. Forty-six never depressed older adults underwent MR scanning as comparison subjects. Treatment response was defined as achieving a Hamilton Depression Rating Scale of 10 or less post-treatment. We analyzed resting state functional connectivity using the posterior cingulate cortex as the seed region-of-interest. The resulting correlation maps were employed to investigate between-group differences. Additionally we examined the association between white matter hyperintensity burden and functional connectivity results. Comparison of pre- and post-treatment scans of depressed participants revealed greater post-treatment functional connectivity in the frontal precentral gyrus. Relative to treatment-responsive participants, treatment-resistant participants had increased functional connectivity in the left striatum. When adjusting for white matter hyperintensity burden, the observed differences lost significance for the PCC-prefrontal functional connectivity, but not for the PCC-striatum functional connectivity. The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity.
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Tudorascu</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Internal Medicine, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Biostatistics Department, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Butters, Meryl A" sort="Butters, Meryl A" uniqKey="Butters M" first="Meryl A." last="Butters">Meryl A. Butters</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Tamburo, Erica" sort="Tamburo, Erica" uniqKey="Tamburo E" first="Erica" last="Tamburo">Erica Tamburo</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Meenal" sort="Patel, Meenal" uniqKey="Patel M" first="Meenal" last="Patel">Meenal Patel</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Bioengineering Department, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Radiology, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Karp, Jordan F" sort="Karp, Jordan F" uniqKey="Karp J" first="Jordan F." last="Karp">Jordan F. Karp</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Reynolds, Charles F Iii" sort="Reynolds, Charles F Iii" uniqKey="Reynolds C" first="Charles F. Iii" last="Reynolds">Charles F. Iii Reynolds</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, University of Pittsburgh School of Medicine</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Bioengineering Department, University of Pittsburgh</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j" type="main">Psychiatry research. Neuroimaging</title><title level="j" type="abbreviated">Psychiatr. res., neuroimaging</title><idno type="ISSN">0925-4927</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Psychiatry research. Neuroimaging</title><title level="j" type="abbreviated">Psychiatr. res., neuroimaging</title><idno type="ISSN">0925-4927</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Default mode network</term><term>Elderly</term><term>Functional connectivity</term><term>Geriatric depression</term><term>Hyperintensity</term><term>Nuclear magnetic resonance imaging</term><term>Rest</term><term>Treatment</term><term>White matter</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Repos</term><term>Traitement</term><term>Imagerie RMN</term><term>Substance blanche</term><term>Hyperintensité</term><term>Personne âgée</term><term>Connectivité fonctionnelle</term><term>Dépression gériatrique</term><term>Réseau du mode par défaut</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Indices of functional connectivity in the default mode network (DMN) are promising neural markers of treatment response in late-life depression. We examined the differences in DMN functional connectivity between treatment-responsive and treatment-resistant depressed older adults. Forty-seven depressed older adults underwent MRI scanning pre- and post-pharmacotherapy. Forty-six never depressed older adults underwent MR scanning as comparison subjects. Treatment response was defined as achieving a Hamilton Depression Rating Scale of 10 or less post-treatment. We analyzed resting state functional connectivity using the posterior cingulate cortex as the seed region-of-interest. The resulting correlation maps were employed to investigate between-group differences. Additionally we examined the association between white matter hyperintensity burden and functional connectivity results. Comparison of pre- and post-treatment scans of depressed participants revealed greater post-treatment functional connectivity in the frontal precentral gyrus. Relative to treatment-responsive participants, treatment-resistant participants had increased functional connectivity in the left striatum. When adjusting for white matter hyperintensity burden, the observed differences lost significance for the PCC-prefrontal functional connectivity, but not for the PCC-striatum functional connectivity. The post-treatment "frontalization" of the DMN connectivity suggests a normalizing effect of antidepressant treatment. Moreover, our study confirms the central role of white matter lesions in disrupting brain functional connectivity.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Andreescu, Carmen" sort="Andreescu, Carmen" uniqKey="Andreescu C" first="Carmen" last="Andreescu">Carmen Andreescu</name></noRegion><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name><name sortKey="Aizenstein, Howard" sort="Aizenstein, Howard" uniqKey="Aizenstein H" first="Howard" last="Aizenstein">Howard Aizenstein</name><name sortKey="Butters, Meryl A" sort="Butters, Meryl A" uniqKey="Butters M" first="Meryl A." last="Butters">Meryl A. Butters</name><name sortKey="Karp, Jordan F" sort="Karp, Jordan F" uniqKey="Karp J" first="Jordan F." last="Karp">Jordan F. Karp</name><name sortKey="Patel, Meenal" sort="Patel, Meenal" uniqKey="Patel M" first="Meenal" last="Patel">Meenal Patel</name><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><name sortKey="Reynolds, Charles F Iii" sort="Reynolds, Charles F Iii" uniqKey="Reynolds C" first="Charles F. Iii" last="Reynolds">Charles F. Iii Reynolds</name><name sortKey="Tamburo, Erica" sort="Tamburo, Erica" uniqKey="Tamburo E" first="Erica" last="Tamburo">Erica Tamburo</name><name sortKey="Tudorascu, Dana L" sort="Tudorascu, Dana L" uniqKey="Tudorascu D" first="Dana L." last="Tudorascu">Dana L. Tudorascu</name><name sortKey="Tudorascu, Dana L" sort="Tudorascu, Dana L" uniqKey="Tudorascu D" first="Dana L." last="Tudorascu">Dana L. 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