Depression, Antidepressants, and Bone Health in Older Adults: A Systematic Review
Identifieur interne : 005984 ( Main/Merge ); précédent : 005983; suivant : 005985Depression, Antidepressants, and Bone Health in Older Adults: A Systematic Review
Auteurs : Marie Anne Gebara [États-Unis] ; Marcie L. O. Shea [États-Unis] ; Kim L. Lipsey [États-Unis] ; Steven L. Teitelbaum [États-Unis] ; Roberto Civitelli [États-Unis] ; Daniel J. Müller [États-Unis, Canada] ; Charles F. Iii Reynolds [États-Unis] ; Benoit H. Mulsant [États-Unis, Canada] ; Eric J. Lenze [États-Unis]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2014.
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- topic : Personne âgée, Gérontologie.
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Abstract
OBJECTIVES: To examine the association between depression, antidepressant use, and bone health in older adults and the implications for treatment. DESIGN: Systematic review. SETTING: All studies that measured depression or antidepressant exposure and bone mineral density (BMD). PARTICIPANTS: Adults aged 60 and older. MEASUREMENTS: Age, site of BMD measurement using dual-energy X-ray absorptiometry (DXA), measure of depression or depressive symptoms, association between BMD changes, and depression or antidepressant use. RESULTS: Nineteen observational studies met the final inclusion criteria; no experimental studies were found. Several cross-sectional and longitudinal studies found that depression or depressive symptoms were associated with a decrease in BMD. Few studies and only two longitudinal studies addressed the association between serotonin reuptake inhibitor (SRI) antidepressant use and a decrease in BMD and they had conflicting results. CONCLUSION: Depression and depressive symptoms are associated with low bone mass and accelerated bone loss in older adults; putative mechanisms underlying this relationship are discussed. There is insufficient evidence that SRI antidepressants adversely affect bone health. Thus, a change in current recommendations for the use of antidepressants in older adults is not justified at the present time. Given the high public health significance of this question, more studies are required to determine whether (and in whom) antidepressants may be deleterious for bone health.
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Iii Reynolds</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychiatry, School of Medicine and Graduate School of Public Health, University of Pittsburgh</s1><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Psychiatry Behavioral and Community Health Sciences, School of Medicine and Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H." last="Mulsant">Benoit H. 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O." last="Shea">Marcie L. O. Shea</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, School of Medicine, Washington University</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Psychiatry, School of Medicine, Washington University</wicri:noRegion></affiliation></author><author><name sortKey="Lipsey, Kim L" sort="Lipsey, Kim L" uniqKey="Lipsey K" first="Kim L." last="Lipsey">Kim L. Lipsey</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Bernard Becker Medical Library, School of Medicine, Washington University</s1><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Bernard Becker Medical Library, School of Medicine, Washington University</wicri:noRegion></affiliation></author><author><name sortKey="Teitelbaum, Steven L" sort="Teitelbaum, Steven L" uniqKey="Teitelbaum S" first="Steven L." last="Teitelbaum">Steven L. Teitelbaum</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Pathology, School of Medicine, Washington University</s1><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Pathology, School of Medicine, Washington University</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Internal Medicine, School of Medicine, Washington University</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Civitelli, Roberto" sort="Civitelli, Roberto" uniqKey="Civitelli R" first="Roberto" last="Civitelli">Roberto Civitelli</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Internal Medicine, School of Medicine, Washington University</s1><s2>St. Louis, Missouri</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Muller, Daniel J" sort="Muller, Daniel J" uniqKey="Muller D" first="Daniel J." last="Müller">Daniel J. Müller</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Addiction and Mental Health</s1><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Centre for Addiction and Mental Health</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Toronto</s1><s3>CAN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Pharmacology and Toxicology, University of Toronto</s1><s2>Toronto, Ontario</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Reynolds, Charles F Iii" sort="Reynolds, Charles F Iii" uniqKey="Reynolds C" first="Charles F. Iii" last="Reynolds">Charles F. Iii Reynolds</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Psychiatry, School of Medicine and Graduate School of Public Health, University of Pittsburgh</s1><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Psychiatry Behavioral and Community Health Sciences, School of Medicine and Graduate School of Public Health, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H." last="Mulsant">Benoit H. Mulsant</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Addiction and Mental Health</s1><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Centre for Addiction and Mental Health</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Toronto</s1><s3>CAN</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lenze, Eric J" sort="Lenze, Eric J" uniqKey="Lenze E" first="Eric J." last="Lenze">Eric J. Lenze</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychiatry, School of Medicine, Washington University</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Psychiatry, School of Medicine, Washington University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of the American Geriatrics Society</title><title level="j" type="abbreviated">J. Am. Geriatr. Soc.</title><idno type="ISSN">0002-8614</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the American Geriatrics Society</title><title level="j" type="abbreviated">J. Am. Geriatr. Soc.</title><idno type="ISSN">0002-8614</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antidepressant agent</term><term>Bone</term><term>Depression</term><term>Diseases of the osteoarticular system</term><term>Elderly</term><term>Geriatrics</term><term>Gerontology</term><term>Health</term><term>Psychotropic</term><term>Systematic review</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term><term>Antidépresseur</term><term>Pathologie du système ostéoarticulaire</term><term>Os</term><term>Santé</term><term>Personne âgée</term><term>Revue systématique</term><term>Gériatrie</term><term>Gérontologie</term><term>Psychotrope</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term><term>Gérontologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVES: To examine the association between depression, antidepressant use, and bone health in older adults and the implications for treatment. DESIGN: Systematic review. SETTING: All studies that measured depression or antidepressant exposure and bone mineral density (BMD). PARTICIPANTS: Adults aged 60 and older. MEASUREMENTS: Age, site of BMD measurement using dual-energy X-ray absorptiometry (DXA), measure of depression or depressive symptoms, association between BMD changes, and depression or antidepressant use. RESULTS: Nineteen observational studies met the final inclusion criteria; no experimental studies were found. Several cross-sectional and longitudinal studies found that depression or depressive symptoms were associated with a decrease in BMD. Few studies and only two longitudinal studies addressed the association between serotonin reuptake inhibitor (SRI) antidepressant use and a decrease in BMD and they had conflicting results. CONCLUSION: Depression and depressive symptoms are associated with low bone mass and accelerated bone loss in older adults; putative mechanisms underlying this relationship are discussed. There is insufficient evidence that SRI antidepressants adversely affect bone health. Thus, a change in current recommendations for the use of antidepressants in older adults is not justified at the present time. Given the high public health significance of this question, more studies are required to determine whether (and in whom) antidepressants may be deleterious for bone health.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Missouri (État)</li><li>Ontario</li><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li><li>Toronto</li></settlement><orgName><li>Université de Pittsburgh</li><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Gebara, Marie Anne" sort="Gebara, Marie Anne" uniqKey="Gebara M" first="Marie Anne" last="Gebara">Marie Anne Gebara</name></noRegion><name sortKey="Civitelli, Roberto" sort="Civitelli, Roberto" uniqKey="Civitelli R" first="Roberto" last="Civitelli">Roberto Civitelli</name><name sortKey="Lenze, Eric J" sort="Lenze, Eric J" uniqKey="Lenze E" first="Eric J." last="Lenze">Eric J. Lenze</name><name sortKey="Lipsey, Kim L" sort="Lipsey, Kim L" uniqKey="Lipsey K" first="Kim L." last="Lipsey">Kim L. Lipsey</name><name sortKey="Muller, Daniel J" sort="Muller, Daniel J" uniqKey="Muller D" first="Daniel J." last="Müller">Daniel J. Müller</name><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H." last="Mulsant">Benoit H. Mulsant</name><name sortKey="Reynolds, Charles F Iii" sort="Reynolds, Charles F Iii" uniqKey="Reynolds C" first="Charles F. Iii" last="Reynolds">Charles F. Iii Reynolds</name><name sortKey="Reynolds, Charles F Iii" sort="Reynolds, Charles F Iii" uniqKey="Reynolds C" first="Charles F. Iii" last="Reynolds">Charles F. Iii Reynolds</name><name sortKey="Shea, Marcie L O" sort="Shea, Marcie L O" uniqKey="Shea M" first="Marcie L. O." last="Shea">Marcie L. O. Shea</name><name sortKey="Teitelbaum, Steven L" sort="Teitelbaum, Steven L" uniqKey="Teitelbaum S" first="Steven L." last="Teitelbaum">Steven L. Teitelbaum</name><name sortKey="Teitelbaum, Steven L" sort="Teitelbaum, Steven L" uniqKey="Teitelbaum S" first="Steven L." last="Teitelbaum">Steven L. Teitelbaum</name></country><country name="Canada"><region name="Ontario"><name sortKey="Muller, Daniel J" sort="Muller, Daniel J" uniqKey="Muller D" first="Daniel J." last="Müller">Daniel J. Müller</name></region><name sortKey="Muller, Daniel J" sort="Muller, Daniel J" uniqKey="Muller D" first="Daniel J." last="Müller">Daniel J. Müller</name><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H." last="Mulsant">Benoit H. Mulsant</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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