Depression, Antidepressants, and Bone Health in Older Adults: A Systematic Review
Identifieur interne : 004012 ( PascalFrancis/Curation ); précédent : 004011; suivant : 004013Depression, Antidepressants, and Bone Health in Older Adults: A Systematic Review
Auteurs : Marie Anne Gebara [États-Unis] ; Marcie L. O. Shea [États-Unis] ; Kim L. Lipsey [États-Unis] ; Steven L. Teitelbaum [États-Unis] ; Roberto Civitelli [États-Unis] ; Daniel J. Müller [États-Unis, Canada] ; Charles F. Iii Reynolds [États-Unis] ; Benoit H. Mulsant [États-Unis, Canada] ; Eric J. Lenze [États-Unis]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée, Gérontologie.
English descriptors
- KwdEn :
Abstract
OBJECTIVES: To examine the association between depression, antidepressant use, and bone health in older adults and the implications for treatment. DESIGN: Systematic review. SETTING: All studies that measured depression or antidepressant exposure and bone mineral density (BMD). PARTICIPANTS: Adults aged 60 and older. MEASUREMENTS: Age, site of BMD measurement using dual-energy X-ray absorptiometry (DXA), measure of depression or depressive symptoms, association between BMD changes, and depression or antidepressant use. RESULTS: Nineteen observational studies met the final inclusion criteria; no experimental studies were found. Several cross-sectional and longitudinal studies found that depression or depressive symptoms were associated with a decrease in BMD. Few studies and only two longitudinal studies addressed the association between serotonin reuptake inhibitor (SRI) antidepressant use and a decrease in BMD and they had conflicting results. CONCLUSION: Depression and depressive symptoms are associated with low bone mass and accelerated bone loss in older adults; putative mechanisms underlying this relationship are discussed. There is insufficient evidence that SRI antidepressants adversely affect bone health. Thus, a change in current recommendations for the use of antidepressants in older adults is not justified at the present time. Given the high public health significance of this question, more studies are required to determine whether (and in whom) antidepressants may be deleterious for bone health.
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<front><div type="abstract" xml:lang="en">OBJECTIVES: To examine the association between depression, antidepressant use, and bone health in older adults and the implications for treatment. DESIGN: Systematic review. SETTING: All studies that measured depression or antidepressant exposure and bone mineral density (BMD). PARTICIPANTS: Adults aged 60 and older. MEASUREMENTS: Age, site of BMD measurement using dual-energy X-ray absorptiometry (DXA), measure of depression or depressive symptoms, association between BMD changes, and depression or antidepressant use. RESULTS: Nineteen observational studies met the final inclusion criteria; no experimental studies were found. Several cross-sectional and longitudinal studies found that depression or depressive symptoms were associated with a decrease in BMD. Few studies and only two longitudinal studies addressed the association between serotonin reuptake inhibitor (SRI) antidepressant use and a decrease in BMD and they had conflicting results. CONCLUSION: Depression and depressive symptoms are associated with low bone mass and accelerated bone loss in older adults; putative mechanisms underlying this relationship are discussed. There is insufficient evidence that SRI antidepressants adversely affect bone health. Thus, a change in current recommendations for the use of antidepressants in older adults is not justified at the present time. Given the high public health significance of this question, more studies are required to determine whether (and in whom) antidepressants may be deleterious for bone health.</div>
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<fC03 i1="02" i2="X" l="SPA"><s0>Antidepresor</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système ostéoarticulaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Os</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Bone</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hueso</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Santé</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Health</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Salud</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Personne âgée</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Elderly</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Anciano</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Revue systématique</s0>
<s2>FM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Systematic review</s0>
<s2>FM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Revisión sistemática</s0>
<s2>FM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Gériatrie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Geriatrics</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Geriatría</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Gérontologie</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Gerontology</s0>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Gerontología</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Psychotrope</s0>
<s2>FX</s2>
<s5>25</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Psychotropic</s0>
<s2>FX</s2>
<s5>25</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Psicotropo</s0>
<s2>FX</s2>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Trouble de l'humeur</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système ostéoarticulaire</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Osteoarticular system</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema osteoarticular</s0>
<s5>38</s5>
</fC07>
<fN21><s1>272</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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