Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Identifieur interne : 004166 ( Main/Merge ); précédent : 004165; suivant : 004167Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Auteurs : Oscar L. Lopez [États-Unis] ; William E. Klunk [États-Unis] ; Chester Mathis [États-Unis] ; Rhaven L. Coleman [États-Unis] ; Julie Price [États-Unis] ; James T. Becker [États-Unis] ; Howard J. Aizenstein [États-Unis] ; Beth Snitz [États-Unis] ; Ann Cohen [États-Unis] ; Milos Ikonomovic [États-Unis] ; Eric Mcdade [États-Unis] ; Steven T. Dekosky [États-Unis] ; Lisa Weissfeld [États-Unis] ; Lewis H. Kuller [États-Unis]Source :
- Neurology [ 1526-632X ] ; 2014.
Descripteurs français
- KwdFr :
- Amyloïde (métabolisme), Dysfonctionnement cognitif (diagnostic), Démence (), Démence (diagnostic), Démence (traitement médicamenteux), Dérivés de l'aniline, Encéphale (), Encéphale (imagerie diagnostique), Encéphale (métabolisme), Extraits de plantes (usage thérapeutique), Femelle, Ginkgo biloba, Humains, Maladies des petits vaisseaux cérébraux (physiopathologie), Maladies neurodégénératives (physiopathologie), Mâle, Méthode en double aveugle, Phytothérapie (), Sujet âgé de 80 ans ou plus, Thiazoles, Tomographie par émission de positons, Valeur prédictive des tests, Études longitudinales, Évaluation gériatrique, Évolution de la maladie.
- MESH :
- diagnostic : Dysfonctionnement cognitif, Démence.
- imagerie diagnostique : Encéphale.
- métabolisme : Amyloïde, Encéphale.
- physiopathologie : Maladies des petits vaisseaux cérébraux, Maladies neurodégénératives.
- traitement médicamenteux : Démence.
- usage thérapeutique : Extraits de plantes.
- Démence, Dérivés de l'aniline, Encéphale, Femelle, Ginkgo biloba, Humains, Mâle, Méthode en double aveugle, Phytothérapie, Sujet âgé de 80 ans ou plus, Thiazoles, Tomographie par émission de positons, Valeur prédictive des tests, Études longitudinales, Évaluation gériatrique, Évolution de la maladie.
English descriptors
- KwdEn :
- Aged, 80 and over, Amyloid (metabolism), Aniline Compounds, Brain (diagnostic imaging), Brain (drug effects), Brain (metabolism), Cerebral Small Vessel Diseases (physiopathology), Cognitive Dysfunction (diagnosis), Dementia (complications), Dementia (diagnosis), Dementia (drug therapy), Disease Progression, Double-Blind Method, Female, Geriatric Assessment, Ginkgo biloba, Humans, Longitudinal Studies, Male, Neurodegenerative Diseases (physiopathology), Phytotherapy (methods), Plant Extracts (therapeutic use), Positron-Emission Tomography, Predictive Value of Tests, Thiazoles.
- MESH :
- chemical , metabolism : Amyloid.
- complications : Dementia.
- diagnosis : Cognitive Dysfunction, Dementia.
- diagnostic imaging : Brain.
- drug effects : Brain.
- drug therapy : Dementia.
- metabolism : Brain.
- methods : Phytotherapy.
- physiopathology : Cerebral Small Vessel Diseases, Neurodegenerative Diseases.
- chemical , therapeutic use : Plant Extracts.
- Aged, 80 and over, Aniline Compounds, Disease Progression, Double-Blind Method, Female, Geriatric Assessment, Ginkgo biloba, Humans, Longitudinal Studies, Male, Positron-Emission Tomography, Predictive Value of Tests, Thiazoles.
Abstract
To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later.
DOI: 10.1212/WNL.0000000000000977
PubMed: 25305156
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pubmed:25305156Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.</title><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="1"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville. lopezol@upmc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Coleman, Rhaven L" sort="Coleman, Rhaven L" uniqKey="Coleman R" first="Rhaven L" last="Coleman">Rhaven L. Coleman</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J" last="Aizenstein">Howard J. Aizenstein</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ikonomovic, Milos" sort="Ikonomovic, Milos" uniqKey="Ikonomovic M" first="Milos" last="Ikonomovic">Milos Ikonomovic</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25305156</idno><idno type="pmid">25305156</idno><idno type="doi">10.1212/WNL.0000000000000977</idno><idno type="wicri:Area/PubMed/Corpus">001107</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001107</idno><idno type="wicri:Area/PubMed/Curation">001101</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001101</idno><idno type="wicri:Area/PubMed/Checkpoint">001101</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001101</idno><idno type="wicri:Area/Ncbi/Merge">003986</idno><idno type="wicri:Area/Ncbi/Curation">003986</idno><idno type="wicri:Area/Ncbi/Checkpoint">003986</idno><idno type="wicri:Area/Main/Merge">004166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.</title><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="1"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville. lopezol@upmc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Coleman, Rhaven L" sort="Coleman, Rhaven L" uniqKey="Coleman R" first="Rhaven L" last="Coleman">Rhaven L. Coleman</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J" last="Aizenstein">Howard J. Aizenstein</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ikonomovic, Milos" sort="Ikonomovic, Milos" uniqKey="Ikonomovic M" first="Milos" last="Ikonomovic">Milos Ikonomovic</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name><affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation><orgName type="university">Université de Pittsburgh</orgName><country>États-Unis</country><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged, 80 and over</term><term>Amyloid (metabolism)</term><term>Aniline Compounds</term><term>Brain (diagnostic imaging)</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Cerebral Small Vessel Diseases (physiopathology)</term><term>Cognitive Dysfunction (diagnosis)</term><term>Dementia (complications)</term><term>Dementia (diagnosis)</term><term>Dementia (drug therapy)</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Geriatric Assessment</term><term>Ginkgo biloba</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Phytotherapy (methods)</term><term>Plant Extracts (therapeutic use)</term><term>Positron-Emission Tomography</term><term>Predictive Value of Tests</term><term>Thiazoles</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amyloïde (métabolisme)</term><term>Dysfonctionnement cognitif (diagnostic)</term><term>Démence ()</term><term>Démence (diagnostic)</term><term>Démence (traitement médicamenteux)</term><term>Dérivés de l'aniline</term><term>Encéphale ()</term><term>Encéphale (imagerie diagnostique)</term><term>Encéphale (métabolisme)</term><term>Extraits de plantes (usage thérapeutique)</term><term>Femelle</term><term>Ginkgo biloba</term><term>Humains</term><term>Maladies des petits vaisseaux cérébraux (physiopathologie)</term><term>Maladies neurodégénératives (physiopathologie)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Phytothérapie ()</term><term>Sujet âgé de 80 ans ou plus</term><term>Thiazoles</term><term>Tomographie par émission de positons</term><term>Valeur prédictive des tests</term><term>Études longitudinales</term><term>Évaluation gériatrique</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognitive Dysfunction</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Dysfonctionnement cognitif</term><term>Démence</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Phytotherapy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Amyloïde</term><term>Encéphale</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladies des petits vaisseaux cérébraux</term><term>Maladies neurodégénératives</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Small Vessel Diseases</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Démence</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Extraits de plantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged, 80 and over</term><term>Aniline Compounds</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Geriatric Assessment</term><term>Ginkgo biloba</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Positron-Emission Tomography</term><term>Predictive Value of Tests</term><term>Thiazoles</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Démence</term><term>Dérivés de l'aniline</term><term>Encéphale</term><term>Femelle</term><term>Ginkgo biloba</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Phytothérapie</term><term>Sujet âgé de 80 ans ou plus</term><term>Thiazoles</term><term>Tomographie par émission de positons</term><term>Valeur prédictive des tests</term><term>Études longitudinales</term><term>Évaluation gériatrique</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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