PittsburghV1, Ncbi, Merge, bibRecord, 003986

Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

Identifieur interne : 003986 ( Ncbi/Merge ); précédent : 003985; suivant : 003987

Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

Auteurs : Oscar L. Lopez [États-Unis] ; William E. Klunk [États-Unis] ; Chester Mathis [États-Unis] ; Rhaven L. Coleman [États-Unis] ; Julie Price [États-Unis] ; James T. Becker [États-Unis] ; Howard J. Aizenstein [États-Unis] ; Beth Snitz [États-Unis] ; Ann Cohen [États-Unis] ; Milos Ikonomovic [États-Unis] ; Eric Mcdade [États-Unis] ; Steven T. Dekosky [États-Unis] ; Lisa Weissfeld [États-Unis] ; Lewis H. Kuller [États-Unis]

Source :

Neurology [ 1526-632X ] ; 2014.

RBID : pubmed:25305156

Descripteurs français

KwdFr :
- Amyloïde (métabolisme), Dysfonctionnement cognitif (diagnostic), Démence (), Démence (diagnostic), Démence (traitement médicamenteux), Dérivés de l'aniline, Encéphale (), Encéphale (imagerie diagnostique), Encéphale (métabolisme), Extraits de plantes (usage thérapeutique), Femelle, Ginkgo biloba, Humains, Maladies des petits vaisseaux cérébraux (physiopathologie), Maladies neurodégénératives (physiopathologie), Mâle, Méthode en double aveugle, Phytothérapie (), Sujet âgé de 80 ans ou plus, Thiazoles, Tomographie par émission de positons, Valeur prédictive des tests, Études longitudinales, Évaluation gériatrique, Évolution de la maladie.
MESH :
- diagnostic : Dysfonctionnement cognitif, Démence.
- imagerie diagnostique : Encéphale.
- métabolisme : Amyloïde, Encéphale.
- physiopathologie : Maladies des petits vaisseaux cérébraux, Maladies neurodégénératives.
- traitement médicamenteux : Démence.
- usage thérapeutique : Extraits de plantes.
- Démence, Dérivés de l'aniline, Encéphale, Femelle, Ginkgo biloba, Humains, Mâle, Méthode en double aveugle, Phytothérapie, Sujet âgé de 80 ans ou plus, Thiazoles, Tomographie par émission de positons, Valeur prédictive des tests, Études longitudinales, Évaluation gériatrique, Évolution de la maladie.

English descriptors

KwdEn :
- Aged, 80 and over, Amyloid (metabolism), Aniline Compounds, Brain (diagnostic imaging), Brain (drug effects), Brain (metabolism), Cerebral Small Vessel Diseases (physiopathology), Cognitive Dysfunction (diagnosis), Dementia (complications), Dementia (diagnosis), Dementia (drug therapy), Disease Progression, Double-Blind Method, Female, Geriatric Assessment, Ginkgo biloba, Humans, Longitudinal Studies, Male, Neurodegenerative Diseases (physiopathology), Phytotherapy (methods), Plant Extracts (therapeutic use), Positron-Emission Tomography, Predictive Value of Tests, Thiazoles.
MESH :
- chemical , metabolism : Amyloid.
- complications : Dementia.
- diagnosis : Cognitive Dysfunction, Dementia.
- diagnostic imaging : Brain.
- drug effects : Brain.
- drug therapy : Dementia.
- metabolism : Brain.
- methods : Phytotherapy.
- physiopathology : Cerebral Small Vessel Diseases, Neurodegenerative Diseases.
- chemical , therapeutic use : Plant Extracts.
- Aged, 80 and over, Aniline Compounds, Disease Progression, Double-Blind Method, Female, Geriatric Assessment, Ginkgo biloba, Humans, Longitudinal Studies, Male, Positron-Emission Tomography, Predictive Value of Tests, Thiazoles.

Abstract

To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later.

DOI: 10.1212/WNL.0000000000000977
PubMed: 25305156

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001107
to stream PubMed, to step Curation: 001101
to stream PubMed, to step Checkpoint: 001101

Links to Exploration step

pubmed:25305156

Le document en format XML

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<author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville. lopezol@upmc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
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<author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
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<author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
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<region type="state">Pennsylvanie</region>
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<author><name sortKey="Coleman, Rhaven L" sort="Coleman, Rhaven L" uniqKey="Coleman R" first="Rhaven L" last="Coleman">Rhaven L. Coleman</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
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<region type="state">Pennsylvanie</region>
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</affiliation>
</author>
<author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J" last="Aizenstein">Howard J. Aizenstein</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikonomovic, Milos" sort="Ikonomovic, Milos" uniqKey="Ikonomovic M" first="Milos" last="Ikonomovic">Milos Ikonomovic</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.</title>
<author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="1"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville. lopezol@upmc.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Klunk, William E" sort="Klunk, William E" uniqKey="Klunk W" first="William E" last="Klunk">William E. Klunk</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mathis, Chester" sort="Mathis, Chester" uniqKey="Mathis C" first="Chester" last="Mathis">Chester Mathis</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coleman, Rhaven L" sort="Coleman, Rhaven L" uniqKey="Coleman R" first="Rhaven L" last="Coleman">Rhaven L. Coleman</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, Julie" sort="Price, Julie" uniqKey="Price J" first="Julie" last="Price">Julie Price</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aizenstein, Howard J" sort="Aizenstein, Howard J" uniqKey="Aizenstein H" first="Howard J" last="Aizenstein">Howard J. Aizenstein</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snitz, Beth" sort="Snitz, Beth" uniqKey="Snitz B" first="Beth" last="Snitz">Beth Snitz</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cohen, Ann" sort="Cohen, Ann" uniqKey="Cohen A" first="Ann" last="Cohen">Ann Cohen</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikonomovic, Milos" sort="Ikonomovic, Milos" uniqKey="Ikonomovic M" first="Milos" last="Ikonomovic">Milos Ikonomovic</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdade, Eric" sort="Mcdade, Eric" uniqKey="Mcdade E" first="Eric" last="Mcdade">Eric Mcdade</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dekosky, Steven T" sort="Dekosky, Steven T" uniqKey="Dekosky S" first="Steven T" last="Dekosky">Steven T. Dekosky</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weissfeld, Lisa" sort="Weissfeld, Lisa" uniqKey="Weissfeld L" first="Lisa" last="Weissfeld">Lisa Weissfeld</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H" last="Kuller">Lewis H. Kuller</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</nlm:affiliation>
<orgName type="university">Université de Pittsburgh</orgName>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
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<term>Aniline Compounds</term>
<term>Brain (diagnostic imaging)</term>
<term>Brain (drug effects)</term>
<term>Brain (metabolism)</term>
<term>Cerebral Small Vessel Diseases (physiopathology)</term>
<term>Cognitive Dysfunction (diagnosis)</term>
<term>Dementia (complications)</term>
<term>Dementia (diagnosis)</term>
<term>Dementia (drug therapy)</term>
<term>Disease Progression</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Ginkgo biloba</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Neurodegenerative Diseases (physiopathology)</term>
<term>Phytotherapy (methods)</term>
<term>Plant Extracts (therapeutic use)</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Amyloïde (métabolisme)</term>
<term>Dysfonctionnement cognitif (diagnostic)</term>
<term>Démence ()</term>
<term>Démence (diagnostic)</term>
<term>Démence (traitement médicamenteux)</term>
<term>Dérivés de l'aniline</term>
<term>Encéphale ()</term>
<term>Encéphale (imagerie diagnostique)</term>
<term>Encéphale (métabolisme)</term>
<term>Extraits de plantes (usage thérapeutique)</term>
<term>Femelle</term>
<term>Ginkgo biloba</term>
<term>Humains</term>
<term>Maladies des petits vaisseaux cérébraux (physiopathologie)</term>
<term>Maladies neurodégénératives (physiopathologie)</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Phytothérapie ()</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Thiazoles</term>
<term>Tomographie par émission de positons</term>
<term>Valeur prédictive des tests</term>
<term>Études longitudinales</term>
<term>Évaluation gériatrique</term>
<term>Évolution de la maladie</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid</term>
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<term>Maladies neurodégénératives</term>
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<term>Neurodegenerative Diseases</term>
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<term>Disease Progression</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Geriatric Assessment</term>
<term>Ginkgo biloba</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Thiazoles</term>
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<term>Femelle</term>
<term>Ginkgo biloba</term>
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<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Phytothérapie</term>
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<term>Tomographie par émission de positons</term>
<term>Valeur prédictive des tests</term>
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<front><div type="abstract" xml:lang="en">To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25305156</PMID>
<DateCreated><Year>2014</Year>
<Month>11</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>03</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>83</Volume>
<Issue>20</Issue>
<PubDate><Year>2014</Year>
<Month>Nov</Month>
<Day>11</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.</ArticleTitle>
<Pagination><MedlinePgn>1804-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000000977</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Subjects had a brain structural MRI scan and a PET scan with (11)C-labeled Pittsburgh compound B (PiB) in 2009, and were evaluated clinically in 2011.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">At baseline evaluation, of the 183 participants (146 cognitively normal [CN]); 37 mild cognitive impairment [MCI]), 139 (76%) were PiB+, had small hippocampal volume (<25th percentile), or had high white matter lesion (WML) volume (>75th percentile). Two years later, 111 (61%) were classified as CN, 51 (28%) as MCI, and 21 (11%) as dementia. At baseline, 51% of the CN participants and 67.5% of the MCI cases were PiB+. Thirty percent of the CN and 51% of the MCI cases had small hippocampi, and 24% of the CN and 40.5% of the MCI cases had abnormal WMLs. Of the 21 participants who progressed to dementia, 20 (95%) had at least one imaging abnormality. Only 3 (14%) were only PiB+, 1 (5%) had only small hippocampi, 1 (5%) had only WMLs, 1 (5%) was biomarker negative, and the other 16 had various pairs of imaging abnormalities. Continuous variables of PiB retention, left and right hippocampal volume, and WML volume were independent predictors of dementia in a logistic regression analysis controlling for age, sex, education level, and Mini-Mental State Examination scores.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The prevalence of β-amyloid deposition, neurodegeneration (i.e., hippocampal atrophy), and small vessel disease (WMLs) is high in CN older individuals and in MCI. A combination of 2 or 3 of these factors is a powerful predictor of short-term incidence of dementia.</AbstractText>
<CopyrightInformation>© 2014 American Academy of Neurology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lopez</LastName>
<ForeName>Oscar L</ForeName>
<Initials>OL</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville. lopezol@upmc.edu.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klunk</LastName>
<ForeName>William E</ForeName>
<Initials>WE</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mathis</LastName>
<ForeName>Chester</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coleman</LastName>
<ForeName>Rhaven L</ForeName>
<Initials>RL</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>Julie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Becker</LastName>
<ForeName>James T</ForeName>
<Initials>JT</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aizenstein</LastName>
<ForeName>Howard J</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Snitz</LastName>
<ForeName>Beth</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cohen</LastName>
<ForeName>Ann</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ikonomovic</LastName>
<ForeName>Milos</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McDade</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeKosky</LastName>
<ForeName>Steven T</ForeName>
<Initials>ST</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weissfeld</LastName>
<ForeName>Lisa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kuller</LastName>
<ForeName>Lewis H</ForeName>
<Initials>LH</Initials>
<AffiliationInfo><Affiliation>From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.</Affiliation>
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   |texte=   Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
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Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

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