PittsburghV1, Main, Merge, bibRecord, 002178

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

Identifieur interne : 002178 ( Main/Merge ); précédent : 002177; suivant : 002179

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

Auteurs : Kira G. Hartman [États-Unis] ; James D. Bortner [États-Unis] ; Gary W. Falk [États-Unis] ; Gregory G. Ginsberg [États-Unis] ; Nirag Jhala [États-Unis] ; Jian Yu [États-Unis] ; Martín G. Martín [États-Unis] ; Anil K. Rustgi [États-Unis] ; John P. Lynch [États-Unis]

Source :

Experimental biology and medicine (Maywood, N.J.) [ 1535-3702 ] ; 2014.

RBID : PMC:4156523

Descripteurs français

KwdFr :
- Humains, Inflammation (), Inflammation (anatomopathologie), Inflammation (métabolisme), Ingénierie tissulaire (), Ingénierie tissulaire (instrumentation), Maladies gastro-intestinales (), Maladies gastro-intestinales (anatomopathologie), Maladies gastro-intestinales (métabolisme), Modèles biologiques, Techniques de culture de tissus (), Techniques de culture de tissus (instrumentation).
MESH :
- anatomopathologie : Inflammation, Maladies gastro-intestinales.
- métabolisme : Inflammation, Maladies gastro-intestinales.
- instrumentation : Humains, Inflammation, Ingénierie tissulaire, Maladies gastro-intestinales, Modèles biologiques, Techniques de culture de tissus.

English descriptors

KwdEn :
- Gastrointestinal Diseases (metabolism), Gastrointestinal Diseases (pathology), Gastrointestinal Diseases (therapy), Humans, Inflammation (metabolism), Inflammation (pathology), Inflammation (therapy), Models, Biological, Tissue Culture Techniques (instrumentation), Tissue Culture Techniques (methods), Tissue Engineering (instrumentation), Tissue Engineering (methods).
MESH :
- instrumentation : Tissue Culture Techniques, Tissue Engineering.
- metabolism : Gastrointestinal Diseases, Inflammation.
- methods : Tissue Culture Techniques, Tissue Engineering.
- pathology : Gastrointestinal Diseases, Inflammation.
- therapy : Gastrointestinal Diseases, Inflammation.
- Humans, Models, Biological.

Abstract

Gastrointestinal (GI) illnesses are a significant health burden for the US population, with 40 million office visits each year for gastrointestinal complaints and nearly 250,000 deaths. Acute and chronic inflammation are a common element of many GI diseases. Inflammatory processes may be initiated by a chemical injury (acid reflux in the esophagus), an infectious agent (Helicobacter pylori infection in the stomach), autoimmune processes (graft versus host disease after bone marrow transplantation), or idiopathic (as in the case of inflammatory bowel diseases). Inflammation in these settings can contribute to acute complaints (pain, bleeding, obstruction, diarrhea) as well as chronic sequelae including strictures and cancer. Research into the pathophysiology of these conditions has been limited by the availability of primary human tissues or appropriate animal models that attempt to physiologically model the human disease. With the many recent advances in tissue engineering and primary human cell culture systems, it is conceivable that these approaches can be adapted to develop novel human ex vivo systems that incorporate many human cell types to recapitulate in vivo growth and differentiation in inflammatory microphysiological environments. Such an advance in technology would improve our understanding of human disease progression and enhance our ability to test for disease prevention strategies and novel therapeutics. We will review current models for the inflammatory and immunological aspects of Barrett’s esophagus, acute graft versus host disease, and inflammatory bowel disease and explore recent advances in culture methodologies that make these novel microphysiological research systems possible.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156523

DOI: 10.1177/1535370214529388
PubMed: 24781339
PubMed Central: 4156523

Links to Exploration step

PMC:4156523

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems</title>
<author><name sortKey="Hartman, Kira G" sort="Hartman, Kira G" uniqKey="Hartman K" first="Kira G." last="Hartman">Kira G. Hartman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bortner, James D" sort="Bortner, James D" uniqKey="Bortner J" first="James D." last="Bortner">James D. Bortner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falk, Gary W" sort="Falk, Gary W" uniqKey="Falk G" first="Gary W." last="Falk">Gary W. Falk</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ginsberg, Gregory G" sort="Ginsberg, Gregory G" uniqKey="Ginsberg G" first="Gregory G." last="Ginsberg">Gregory G. Ginsberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jhala, Nirag" sort="Jhala, Nirag" uniqKey="Jhala N" first="Nirag" last="Jhala">Nirag Jhala</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Departments of Pathology, and Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pathology, and Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Martin G" sort="Martin, Martin G" uniqKey="Martin M" first="Martín G." last="Martín">Martín G. Martín</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children’s Hospital and the David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, 90095 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children’s Hospital and the David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rustgi, Anil K" sort="Rustgi, Anil K" uniqKey="Rustgi A" first="Anil K." last="Rustgi">Anil K. Rustgi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lynch, John P" sort="Lynch, John P" uniqKey="Lynch J" first="John P." last="Lynch">John P. Lynch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24781339</idno>
<idno type="pmc">4156523</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156523</idno>
<idno type="RBID">PMC:4156523</idno>
<idno type="doi">10.1177/1535370214529388</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001009</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001009</idno>
<idno type="wicri:Area/Pmc/Curation">000F84</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F84</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000C67</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C67</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001C08</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C08</idno>
<idno type="wicri:Area/PubMed/Curation">001C00</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C00</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C00</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C00</idno>
<idno type="wicri:Area/Ncbi/Merge">001D66</idno>
<idno type="wicri:Area/Ncbi/Curation">001D66</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001D66</idno>
<idno type="wicri:doubleKey">1535-3702:2014:Hartman K:modeling:human:gastrointestinal</idno>
<idno type="wicri:Area/Main/Merge">002178</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems</title>
<author><name sortKey="Hartman, Kira G" sort="Hartman, Kira G" uniqKey="Hartman K" first="Kira G." last="Hartman">Kira G. Hartman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bortner, James D" sort="Bortner, James D" uniqKey="Bortner J" first="James D." last="Bortner">James D. Bortner</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falk, Gary W" sort="Falk, Gary W" uniqKey="Falk G" first="Gary W." last="Falk">Gary W. Falk</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ginsberg, Gregory G" sort="Ginsberg, Gregory G" uniqKey="Ginsberg G" first="Gregory G." last="Ginsberg">Gregory G. Ginsberg</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jhala, Nirag" sort="Jhala, Nirag" uniqKey="Jhala N" first="Nirag" last="Jhala">Nirag Jhala</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Departments of Pathology, and Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pathology, and Radiation Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Martin G" sort="Martin, Martin G" uniqKey="Martin M" first="Martín G." last="Martín">Martín G. Martín</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children’s Hospital and the David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, 90095 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Division of Gastroenterology and Nutrition, Mattel Children’s Hospital and the David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rustgi, Anil K" sort="Rustgi, Anil K" uniqKey="Rustgi A" first="Anil K." last="Rustgi">Anil K. Rustgi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lynch, John P" sort="Lynch, John P" uniqKey="Lynch J" first="John P." last="Lynch">John P. Lynch</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Experimental biology and medicine (Maywood, N.J.)</title>
<idno type="ISSN">1535-3702</idno>
<idno type="eISSN">1535-3699</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gastrointestinal Diseases (metabolism)</term>
<term>Gastrointestinal Diseases (pathology)</term>
<term>Gastrointestinal Diseases (therapy)</term>
<term>Humans</term>
<term>Inflammation (metabolism)</term>
<term>Inflammation (pathology)</term>
<term>Inflammation (therapy)</term>
<term>Models, Biological</term>
<term>Tissue Culture Techniques (instrumentation)</term>
<term>Tissue Culture Techniques (methods)</term>
<term>Tissue Engineering (instrumentation)</term>
<term>Tissue Engineering (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Inflammation ()</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (métabolisme)</term>
<term>Ingénierie tissulaire ()</term>
<term>Ingénierie tissulaire (instrumentation)</term>
<term>Maladies gastro-intestinales ()</term>
<term>Maladies gastro-intestinales (anatomopathologie)</term>
<term>Maladies gastro-intestinales (métabolisme)</term>
<term>Modèles biologiques</term>
<term>Techniques de culture de tissus ()</term>
<term>Techniques de culture de tissus (instrumentation)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Inflammation</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Tissue Culture Techniques</term>
<term>Tissue Engineering</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tissue Culture Techniques</term>
<term>Tissue Engineering</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Inflammation</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Models, Biological</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Humains</term>
<term>Inflammation</term>
<term>Ingénierie tissulaire</term>
<term>Maladies gastro-intestinales</term>
<term>Modèles biologiques</term>
<term>Techniques de culture de tissus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Gastrointestinal (GI) illnesses are a significant health burden for the US population, with 40 million office visits each year for gastrointestinal complaints and nearly 250,000 deaths. Acute and chronic inflammation are a common element of many GI diseases. Inflammatory processes may be initiated by a chemical injury (acid reflux in the esophagus), an infectious agent (<italic>Helicobacter pylori</italic>
 infection in the stomach), autoimmune processes (graft versus host disease after bone marrow transplantation), or idiopathic (as in the case of inflammatory bowel diseases). Inflammation in these settings can contribute to acute complaints (pain, bleeding, obstruction, diarrhea) as well as chronic sequelae including strictures and cancer. Research into the pathophysiology of these conditions has been limited by the availability of primary human tissues or appropriate animal models that attempt to physiologically model the human disease. With the many recent advances in tissue engineering and primary human cell culture systems, it is conceivable that these approaches can be adapted to develop novel human <italic>ex vivo</italic>
 systems that incorporate many human cell types to recapitulate <italic>in vivo</italic>
 growth and differentiation in inflammatory microphysiological environments. Such an advance in technology would improve our understanding of human disease progression and enhance our ability to test for disease prevention strategies and novel therapeutics. We will review current models for the inflammatory and immunological aspects of Barrett’s esophagus, acute graft versus host disease, and inflammatory bowel disease and explore recent advances in culture methodologies that make these novel microphysiological research systems possible.</p>
</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002178 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002178 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     PMC:4156523
   |texte=   Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:24781339" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

Modeling human gastrointestinal inflammatory diseases using microphysiological culture systems

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.