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Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?

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Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?

Auteurs : Fida Bacha [États-Unis] ; Rola Saad [États-Unis] ; Neslihan Gungor [États-Unis] ; Silva A. Arslanian [États-Unis]

Source :

Pediatric Diabetes [ 1399-543X ] ; 2005-06.

RBID : ISTEX:1E2C1015173736ED53DDD33E75765C2BBEEBF21C

English descriptors

Abstract

Abstract: Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin  sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.

Url:

https://api.istex.fr/document/1E2C1015173736ED53DDD33E75765C2BBEEBF21C/fulltext/pdf

DOI: 10.1111/j.1399-543X.2005.00108.x

Affiliations:

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Le document en format XML

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<front><div type="abstract">Abstract:  Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin  sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.</div>
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Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?

Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri