Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?
Identifieur interne : 000701 ( Istex/Corpus ); précédent : 000700; suivant : 000702Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?
Auteurs : Fida Bacha ; Rola Saad ; Neslihan Gungor ; Silva A. ArslanianSource :
- Pediatric Diabetes [ 1399-543X ] ; 2005-06.
English descriptors
- KwdEn :
- Adiponectin, Adiponectin levels, Arslanian, Bacha, Black children, Body composition, Fasting, Fasting adiponectin levels, Higher insulin secretion, Hyperinsulinemia, Insulin, Insulin secretion, Insulin sensitivity, Lower adiponectin levels, Lower insulin sensitivity, Pediatric, Pediatric diabetes, Prepubertal, Prepubertal children, Racial differences, Saad, Similar body composition, White children, White peers.
- Teeft :
- Adiponectin, Adiponectin levels, Arslanian, Bacha, Black children, Body composition, Fasting, Fasting adiponectin levels, Higher insulin secretion, Hyperinsulinemia, Insulin, Insulin secretion, Insulin sensitivity, Lower adiponectin levels, Lower insulin sensitivity, Pediatric, Pediatric diabetes, Prepubertal, Prepubertal children, Racial differences, Saad, Similar body composition, White children, White peers.
Abstract
Abstract: Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin
sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.
Url:
DOI: 10.1111/j.1399-543X.2005.00108.x
Links to Exploration step
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<front><div type="abstract">Abstract: Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin
sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.</div>
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Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin
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<titleGroup><title type="main" sort="PEDIATRIC DIABETES">Pediatric Diabetes</title>
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<titleGroup><title type="tocHeading1">Brief Report</title>
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<correspondenceTo>
*Fida Bacha, MD
Division of Endocrinology
Children's Hospital of Pittsburgh
3705 Fifth Avenue, DeSoto Street
Pittsburgh, PA 15213
USA
Tel: +1 412 692 8225;
fax: +1 412 692 5834;
e‐mail: <email>fida.bacha@chp.edu</email>
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<contentMeta><unparsedEditorialHistory>Submitted 20 October 2004. Accepted for publication 8 February 2005</unparsedEditorialHistory>
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<titleGroup><title type="main">Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African‐American children?</title>
<title type="shortAuthors"><b>Bacha et al.</b>
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<title type="short"><b>Adiponectin, insulin sensitivity, and secretion in children</b>
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Bacha F, Saad R, Gungor N, Arslanian SA. Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African-American children?
--><p><b>Abstract: </b>
Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin
sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.</p>
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<abstract>Abstract: Adiponectin is an adipocytokine with antidiabetogenic properties. The present study investigated: (i) the effect of race on adiponectin levels and (ii) the relationship of adiponectin levels in children to insulin sensitivity and secretion. Fasting adiponectin levels were determined in 22 healthy prepubertal black compared with 22 white children of similar body composition. We previously reported these black children to have lower insulin sensitivity and higher first‐phase insulin secretion than their white peers. Fasting adiponectin levels were lower in black children (9.9 ± 1.0 µg/mL vs. 15.7 ± 1.1 µg/mL, p < 0.001). Adiponectin correlated positively with insulin
sensitivity (r = 0.29, p = 0.06) and negatively with first‐phase insulin levels (r = −0.47, p = 0.001). In a multiple regression analysis, 48% of the variance in first‐phase insulin secretion was explained by the independent effects of race (p = 0.017), adiponectin (p = 0.03), and percentage of body fat (p < 0.001). Adiponectin did not contribute significantly to the variance in insulin sensitivity. In summary, black children have approximately 35% lower adiponectin levels than their white peers. Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored.</abstract>
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