Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue.
Identifieur interne : 001A85 ( PubMed/Curation ); précédent : 001A84; suivant : 001A86Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue.
Auteurs : T. Yamada [Canada] ; P L Mcgeer ; E G McgeerSource :
- Neuroscience letters [ 0304-3940 ] ; 1992.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (pathology), Brain (pathology), Cell Nucleus (ultrastructure), Female, Glial Fibrillary Acidic Protein (analysis), Humans, Huntington Disease (pathology), Male, Middle Aged, Neurofilament Proteins (analysis), Neuroglia (pathology), Neuroglia (ultrastructure), Parkinson Disease (pathology), Reference Values, Staining and Labeling, Supranuclear Palsy, Progressive (pathology), tau Proteins (analysis).
- MESH :
- chemical , analysis : Glial Fibrillary Acidic Protein, Neurofilament Proteins, tau Proteins.
- pathology : Alzheimer Disease, Brain, Huntington Disease, Neuroglia, Parkinson Disease, Supranuclear Palsy, Progressive.
- ultrastructure : Cell Nucleus, Neuroglia.
- Aged, Female, Humans, Male, Middle Aged, Reference Values, Staining and Labeling.
Abstract
Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy (PSP). They were positive by Bielschowsky's and Bodian's silver staining as well as by immunostaining with Tau-2, Alz-50, anti-GFAP and anti-paired helical filament antibodies, but not with anti-ubiquitin antibody. They were predominantly localized in the striatum, thalamus and frontal cortex but were not seen in white matter and were not plentiful in areas of heavy neuronal degeneration. Electron microscopy clearly showed the nuclear pairing and localized the Tau protein to bundles suggestive of microtubules in the cytoplasm and proximal processes. Such glial cells were rarely seen in cases of other neurodegenerative diseases or neurologically normal controls. These data suggest that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss.
PubMed: 1371861
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Yamada</name><affiliation wicri:level="1"><nlm:affiliation>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver</wicri:regionArea></affiliation></author><author><name sortKey="Mcgeer, P L" sort="Mcgeer, P L" uniqKey="Mcgeer P" first="P L" last="Mcgeer">P L Mcgeer</name></author><author><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E G" last="Mcgeer">E G Mcgeer</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="ISSN">0304-3940</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (pathology)</term><term>Brain (pathology)</term><term>Cell Nucleus (ultrastructure)</term><term>Female</term><term>Glial Fibrillary Acidic Protein (analysis)</term><term>Humans</term><term>Huntington Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Neurofilament Proteins (analysis)</term><term>Neuroglia (pathology)</term><term>Neuroglia (ultrastructure)</term><term>Parkinson Disease (pathology)</term><term>Reference Values</term><term>Staining and Labeling</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>tau Proteins (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Glial Fibrillary Acidic Protein</term><term>Neurofilament Proteins</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Huntington Disease</term><term>Neuroglia</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Cell Nucleus</term><term>Neuroglia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Staining and Labeling</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy (PSP). They were positive by Bielschowsky's and Bodian's silver staining as well as by immunostaining with Tau-2, Alz-50, anti-GFAP and anti-paired helical filament antibodies, but not with anti-ubiquitin antibody. They were predominantly localized in the striatum, thalamus and frontal cortex but were not seen in white matter and were not plentiful in areas of heavy neuronal degeneration. Electron microscopy clearly showed the nuclear pairing and localized the Tau protein to bundles suggestive of microtubules in the cytoplasm and proximal processes. Such glial cells were rarely seen in cases of other neurodegenerative diseases or neurologically normal controls. These data suggest that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1371861</PMID><DateCreated><Year>1992</Year><Month>04</Month><Day>03</Day></DateCreated><DateCompleted><Year>1992</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3940</ISSN><JournalIssue CitedMedium="Print"><Volume>135</Volume><Issue>1</Issue><PubDate><Year>1992</Year><Month>Jan</Month><Day>20</Day></PubDate></JournalIssue><Title>Neuroscience letters</Title><ISOAbbreviation>Neurosci. Lett.</ISOAbbreviation></Journal><ArticleTitle>Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue.</ArticleTitle><Pagination><MedlinePgn>99-102</MedlinePgn></Pagination><Abstract><AbstractText>Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy (PSP). They were positive by Bielschowsky's and Bodian's silver staining as well as by immunostaining with Tau-2, Alz-50, anti-GFAP and anti-paired helical filament antibodies, but not with anti-ubiquitin antibody. They were predominantly localized in the striatum, thalamus and frontal cortex but were not seen in white matter and were not plentiful in areas of heavy neuronal degeneration. Electron microscopy clearly showed the nuclear pairing and localized the Tau protein to bundles suggestive of microtubules in the cytoplasm and proximal processes. Such glial cells were rarely seen in cases of other neurodegenerative diseases or neurologically normal controls. 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