Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.
Identifieur interne : 000624 ( PubMed/Curation ); précédent : 000623; suivant : 000625Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.
Auteurs : Janelle Drouin-Ouellet [Canada] ; Isabelle St-Amour [Canada] ; Martine Saint-Pierre [Canada] ; Jérôme Lamontagne-Proulx [Canada] ; Jasna Kriz [Canada] ; Roger A. Barker [Canada] ; Francesca Cicchetti [Canada]Source :
- The international journal of neuropsychopharmacology [ 1469-5111 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Animals, Antiparkinson Agents (pharmacology), B-Lymphocytes (metabolism), Brain (drug effects), Brain (immunology), Brain (metabolism), Case-Control Studies, Dexamethasone (pharmacology), Disease Models, Animal, Female, Green Fluorescent Proteins (genetics), Green Fluorescent Proteins (metabolism), Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Microglia (drug effects), Microglia (metabolism), Middle Aged, Monocytes (metabolism), Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson Disease (immunology), Parkinson Disease (metabolism), Time Factors, Toll-Like Receptor 2 (metabolism), Toll-Like Receptor 4 (metabolism), Toll-Like Receptors (blood), Toll-Like Receptors (immunology), Toll-Like Receptors (metabolism), Up-Regulation, alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
- MESH :
- chemical , blood : Toll-Like Receptors.
- chemical , genetics : Green Fluorescent Proteins, alpha-Synuclein.
- chemical , immunology : Toll-Like Receptors.
- chemical , metabolism : Green Fluorescent Proteins, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptors, alpha-Synuclein.
- chemical , pharmacology : Antiparkinson Agents, Dexamethasone.
- blood : Parkinson Disease.
- drug effects : Brain, Microglia.
- drug therapy : Parkinson Disease.
- genetics : Parkinson Disease.
- immunology : Brain, Parkinson Disease.
- metabolism : B-Lymphocytes, Brain, Microglia, Monocytes, Parkinson Disease.
- Aged, Aged, 80 and over, Animals, Case-Control Studies, Disease Models, Animal, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Time Factors, Up-Regulation.
Abstract
Accumulating evidence supports a role for the immune system in the pathogenesis of Parkinson's disease. Importantly, recent preclinical studies are now suggesting a specific contribution of inflammation to the α-synuclein-induced pathology seen in this condition.
DOI: 10.1093/ijnp/pyu103
PubMed: 25522431
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pubmed:25522431Le document en format XML
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<author><name sortKey="Drouin Ouellet, Janelle" sort="Drouin Ouellet, Janelle" uniqKey="Drouin Ouellet J" first="Janelle" last="Drouin-Ouellet">Janelle Drouin-Ouellet</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti). jd628@cam.ac.uk francesca.cicchetti@crchudequebec.ulaval.ca.</nlm:affiliation>
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<author><name sortKey="Lamontagne Proulx, Jerome" sort="Lamontagne Proulx, Jerome" uniqKey="Lamontagne Proulx J" first="Jérôme" last="Lamontagne-Proulx">Jérôme Lamontagne-Proulx</name>
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<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Antiparkinson Agents (pharmacology)</term>
<term>B-Lymphocytes (metabolism)</term>
<term>Brain (drug effects)</term>
<term>Brain (immunology)</term>
<term>Brain (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Accumulating evidence supports a role for the immune system in the pathogenesis of Parkinson's disease. Importantly, recent preclinical studies are now suggesting a specific contribution of inflammation to the α-synuclein-induced pathology seen in this condition.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25522431</PMID>
<DateCreated><Year>2015</Year>
<Month>04</Month>
<Day>07</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>01</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1469-5111</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Dec</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>The international journal of neuropsychopharmacology</Title>
<ISOAbbreviation>Int. J. Neuropsychopharmacol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson's disease.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/ijnp/pyu103</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">pyu103</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Accumulating evidence supports a role for the immune system in the pathogenesis of Parkinson's disease. Importantly, recent preclinical studies are now suggesting a specific contribution of inflammation to the α-synuclein-induced pathology seen in this condition.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used flow cytometry and western blots to detect toll-like receptor 2 and 4 expression in blood and brain samples of Parkinson's disease patients and mice overexpressing human α-synuclein. To further assess the effects of α-synuclein overexpression on the innate immune system, we performed a longitudinal study using Thy1.2-α-synuclein mice that expressed a bicistronic DNA construct (reporter genes luciferase and green fluorescent protein) under the transcriptional control of the murine toll-like receptor 2 promoter.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Here, we report increases in toll-like receptors 2 and 4 expression in circulating monocytes and of toll-like receptor 4 in B cells and in the caudate/putamen of Parkinson's disease patients. Monthly bioluminescence imaging of Thy1.2-α-synuclein mice showed increasing toll-like receptor 2 expression from 10 months of age, although no change in toll-like receptor 2 and 4 expression was observed in the blood and brain of these mice at 12 months of age. Dexamethasone treatment starting at 5 months of age for 1 month significantly decreased the microglial response in the brain of these mice and promoted functional recovery as observed using a wheel-running activity test.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results show that toll-like receptors 2 and 4 are modulated in the blood and brain of Parkinson's disease patients and that overexpression of α-synuclein leads to a progressive microglial response, the inhibition of which has a beneficial impact on some motor phenotypes of an animal model of α-synucleinopathy.</AbstractText>
<CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of CINP.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Drouin-Ouellet</LastName>
<ForeName>Janelle</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti). jd628@cam.ac.uk francesca.cicchetti@crchudequebec.ulaval.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>St-Amour</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Saint-Pierre</LastName>
<ForeName>Martine</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lamontagne-Proulx</LastName>
<ForeName>Jérôme</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kriz</LastName>
<ForeName>Jasna</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barker</LastName>
<ForeName>Roger A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cicchetti</LastName>
<ForeName>Francesca</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom (Drs Drouin-Ouellet and Barker); Centre de recherche du CHU de Québec, Québec, QC, Canada (Dr St-Amour, Ms Saint-Pierre, Mr Lamontagne-Proulx, and Dr Cicchetti); Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada (Dr Kriz); and Département de psychiatrie et neurosciences, Université Laval, Québec, QC, Canada (Drs Kriz and Cicchetti). jd628@cam.ac.uk francesca.cicchetti@crchudequebec.ulaval.ca.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>12</Month>
<Day>07</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Int J Neuropsychopharmacol</MedlineTA>
<NlmUniqueID>9815893</NlmUniqueID>
<ISSNLinking>1461-1457</ISSNLinking>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2005 Dec;11(8):493-8</RefSource>
<PMID Version="1">16154792</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 1995 Dec 29;202(1-2):17-20</RefSource>
<PMID Version="1">8787820</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4</RefSource>
<PMID Version="1">1564476</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6632-7</RefSource>
<PMID Version="1">21467220</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2010 Jul 1;185(1):615-23</RefSource>
<PMID Version="1">20511551</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2009 Dec 1;183(11):7461-70</RefSource>
<PMID Version="1">19917698</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2008 Dec;67(12):1149-58</RefSource>
<PMID Version="1">19018246</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2001 Feb 1;113(1):146-52</RefSource>
<PMID Version="1">11137586</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet Neurol. 2011 Dec;10(12):1108-18</RefSource>
<PMID Version="1">22094131</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2009 Sep 23;29(38):11982-92</RefSource>
<PMID Version="1">19776284</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br J Pharmacol. 1999 Mar;126(6):1307-14</RefSource>
<PMID Version="1">10217523</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunology. 2009 Sep;128(1):58-68</RefSource>
<PMID Version="1">19689736</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurosci Res. 2002 Jun 1;68(5):568-78</RefSource>
<PMID Version="1">12111846</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2004 May;10 Suppl 1:S3-7</RefSource>
<PMID Version="1">15109580</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Br Med J (Clin Res Ed). 1986 Jan 4;292(6512):21-3</RefSource>
<PMID Version="1">3080050</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2007 Dec;12(4):377-90</RefSource>
<PMID Version="1">18198424</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain. 2009 Apr;132(Pt 4):940-54</RefSource>
<PMID Version="1">19153151</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Cell Dev Biol. 2006;22:409-37</RefSource>
<PMID Version="1">16822173</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2011 Sep;70(9):788-98</RefSource>
<PMID Version="1">21865887</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Synapse. 2007 Dec;61(12):991-1001</RefSource>
<PMID Version="1">17879265</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Pathol. 2011 Aug;179(2):954-63</RefSource>
<PMID Version="1">21801874</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Geriatr Gerontol Int. 2012 Jan;12(1):102-7</RefSource>
<PMID Version="1">21929737</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Front Immunol. 2013 Feb 04;4:23</RefSource>
<PMID Version="1">23382732</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2011 Nov;232(1):66-75</RefSource>
<PMID Version="1">21864527</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Behav Immun. 2012 Aug;26(6):880-5</RefSource>
<PMID Version="1">22401992</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2003 Oct 31;302(5646):841</RefSource>
<PMID Version="1">14593171</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Biol Chem. 2010 Apr 23;285(17):12543-50</RefSource>
<PMID Version="1">20200155</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Mar;28(3):392-5</RefSource>
<PMID Version="1">23401086</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Scand J Immunol. 1994 Nov;40(5):509-14</RefSource>
<PMID Version="1">7526441</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Acta Neurol Scand. 2009 May;119(5):332-7</RefSource>
<PMID Version="1">18976327</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Sci STKE. 2003 Feb 25;2003(171):re3</RefSource>
<PMID Version="1">12606705</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2007 Nov 15;22(15):2196-203</RefSource>
<PMID Version="1">17853477</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroimmunol. 2012 Nov 15;252(1-2):95-9</RefSource>
<PMID Version="1">22910543</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Immunol. 2007 Jun 1;178(11):6710-4</RefSource>
<PMID Version="1">17513715</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurotherapeutics. 2012 Apr;9(2):297-314</RefSource>
<PMID Version="1">22350713</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Trends Pharmacol Sci. 2012 Oct;33(10):542-51</RefSource>
<PMID Version="1">22944460</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Immunopharmacol Immunotoxicol. 2008;30(4):729-40</RefSource>
<PMID Version="1">18686098</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurochem Res. 2013 Jun;38(6):1252-9</RefSource>
<PMID Version="1">23525968</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Stroke. 1979 Jan-Feb;10(1):68-71</RefSource>
<PMID Version="1">432902</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>FASEB J. 2005 Apr;19(6):533-42</RefSource>
<PMID Version="1">15791003</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Brain Behav Immun. 2011 Aug;25(6):1143-52</RefSource>
<PMID Version="1">21376805</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(8):e71634</RefSource>
<PMID Version="1">24058406</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurology. 1988 Aug;38(8):1285-91</RefSource>
<PMID Version="1">3399080</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Aug 28;388(6645):839-40</RefSource>
<PMID Version="1">9278044</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9</RefSource>
<PMID Version="1">15451224</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Feb;57(2):168-75</RefSource>
<PMID Version="1">15668962</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Mol Med. 2014;46:e91</RefSource>
<PMID Version="1">24743837</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroinflammation. 2005 Jun 03;2:14</RefSource>
<PMID Version="1">15935098</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Hematol. 2004 Aug;32(8):748-55</RefSource>
<PMID Version="1">15308326</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genes Chromosomes Cancer. 2008 Jan;47(1):56-63</RefSource>
<PMID Version="1">17943974</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2009 May;30(5):759-68</RefSource>
<PMID Version="1">17905482</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neuroinflammation. 2011;8:137</RefSource>
<PMID Version="1">21989292</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1998 Oct 8;339(15):1044-53</RefSource>
<PMID Version="1">9761807</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur J Immunol. 1993 Dec;23(12):3126-35</RefSource>
<PMID Version="1">7504990</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2002 Apr;81(1):150-7</RefSource>
<PMID Version="1">12067227</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Nat Commun. 2013;4:1562</RefSource>
<PMID Version="1">23463005</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2008 Nov;29(11):1690-701</RefSource>
<PMID Version="1">17537546</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2012 Oct;237(2):318-34</RefSource>
<PMID Version="1">22750327</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Science. 2014 May 2;344(6183):519-23</RefSource>
<PMID Version="1">24786080</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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