Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Identifieur interne : 000064 ( PubMed/Curation ); précédent : 000063; suivant : 000065Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Auteurs : K. Brockmann [Allemagne] ; C. Schulte [Allemagne] ; N. Schneiderhan-Marra [Allemagne] ; A. Apel [Allemagne] ; C. Pont-Sunyer [Espagne] ; D. Vilas [Espagne] ; J. Ruiz-Martinez [Espagne] ; M. Langkamp [Allemagne] ; J-C Corvol [France] ; F. Cormier [France] ; T. Knorpp [Allemagne] ; T O Joos [Allemagne] ; A. Bernard [Allemagne] ; T. Gasser [Allemagne] ; C. Marras [Canada] ; B. Schüle [États-Unis] ; J O Aasly [Norvège] ; T. Foroud [États-Unis] ; J F Marti-Masso [Espagne] ; A. Brice [France] ; E. Tolosa [Espagne] ; D. Berg [Allemagne] ; W. Maetzler [Allemagne]Source :
- European journal of neurology [ 1468-1331 ] ; 2017.
Abstract
The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.
DOI: 10.1111/ene.13223
PubMed: 28102045
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Bernard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. 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Foroud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. 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Brockmann</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schulte, C" sort="Schulte, C" uniqKey="Schulte C" first="C" last="Schulte">C. Schulte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Schneiderhan Marra, N" sort="Schneiderhan Marra, N" uniqKey="Schneiderhan Marra N" first="N" last="Schneiderhan-Marra">N. Schneiderhan-Marra</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Apel, A" sort="Apel, A" uniqKey="Apel A" first="A" last="Apel">A. Apel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Pont Sunyer, C" sort="Pont Sunyer, C" uniqKey="Pont Sunyer C" first="C" last="Pont-Sunyer">C. Pont-Sunyer</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Vilas, D" sort="Vilas, D" uniqKey="Vilas D" first="D" last="Vilas">D. Vilas</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Ruiz Martinez, J" sort="Ruiz Martinez, J" uniqKey="Ruiz Martinez J" first="J" last="Ruiz-Martinez">J. Ruiz-Martinez</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Langkamp, M" sort="Langkamp, M" uniqKey="Langkamp M" first="M" last="Langkamp">M. Langkamp</name><affiliation wicri:level="1"><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mediagnost GmbH, Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J-C" last="Corvol">J-C Corvol</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Cormier, F" sort="Cormier, F" uniqKey="Cormier F" first="F" last="Cormier">F. Cormier</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Knorpp, T" sort="Knorpp, T" uniqKey="Knorpp T" first="T" last="Knorpp">T. Knorpp</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Joos, T O" sort="Joos, T O" uniqKey="Joos T" first="T O" last="Joos">T O Joos</name><affiliation wicri:level="1"><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen</wicri:regionArea></affiliation></author><author><name sortKey="Bernard, A" sort="Bernard, A" uniqKey="Bernard A" first="A" last="Bernard">A. Bernard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. Marras</name><affiliation wicri:level="1"><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON</wicri:regionArea></affiliation></author><author><name sortKey="Schule, B" sort="Schule, B" uniqKey="Schule B" first="B" last="Schüle">B. Schüle</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson Institute and Clinical Center, Sunnyvale, CA</wicri:regionArea></affiliation></author><author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J O" last="Aasly">J O Aasly</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olavs Hospital, Trondheim</wicri:regionArea></affiliation></author><author><name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN</wicri:regionArea></affiliation></author><author><name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa</wicri:regionArea></affiliation></author><author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name><affiliation wicri:level="1"><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Berg, D" sort="Berg, D" uniqKey="Berg D" first="D" last="Berg">D. Berg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Maetzler, W" sort="Maetzler, W" uniqKey="Maetzler W" first="W" last="Maetzler">W. Maetzler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea></affiliation></author></analytic><series><title level="j">European journal of neurology</title><idno type="eISSN">1468-1331</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28102045</PMID><DateCreated><Year>2017</Year><Month>01</Month><Day>19</Day></DateCreated><DateRevised><Year>2017</Year><Month>01</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1468-1331</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>European journal of neurology</Title><ISOAbbreviation>Eur. J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>427-e6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ene.13223</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An extensive battery of peripheral inflammatory markers was measured in human serum in a multicentre cohort of 142 PDLRRK2 patients from the MJFF LRRK2 Consortium, stratified by three different subtypes as recently proposed for idiopathic Parkinson's disease: diffuse/malignant, intermediate and mainly pure motor.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients classified as diffuse/malignant presented with the highest levels of the pro-inflammatory proteins interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1) and macrophage inflammatory protein 1-β (MIP-1-β) paralleled by high levels of the neurotrophic protein brain-derived neurotrophic factor (BDNF). It was also possible to distinguish the clinical subtypes based on their inflammatory profile by using discriminant and area under the receiver operating characteristic curve analysis.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Inflammation seems to be associated with the presence of a specific clinical subtype in PDLRRK2 that is characterized by a broad and more severely affected spectrum of motor and non-motor symptoms. The pro-inflammatory metabolites IL-8, MCP-1 and MIP-1-β as well as BDNF are interesting candidates to be included in biomarker panels that aim to differentiate subtypes in PDLRRK2 and predict progression.</AbstractText><CopyrightInformation>© 2017 EAN.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brockmann</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulte</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneiderhan-Marra</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Apel</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pont-Sunyer</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vilas</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Martinez</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langkamp</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Mediagnost GmbH, Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corvol</LastName><ForeName>J-C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cormier</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knorpp</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joos</LastName><ForeName>T O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernard</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasser</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schüle</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aasly</LastName><ForeName>J O</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foroud</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marti-Masso</LastName><ForeName>J F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tolosa</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berg</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maetzler</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Neurol</MedlineTA><NlmUniqueID>9506311</NlmUniqueID><ISSNLinking>1351-5101</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LRRK2</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">inflammation</Keyword><Keyword MajorTopicYN="N">phenotype</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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