Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Identifieur interne : 000064 ( PubMed/Corpus ); précédent : 000063; suivant : 000065Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.
Auteurs : K. Brockmann ; C. Schulte ; N. Schneiderhan-Marra ; A. Apel ; C. Pont-Sunyer ; D. Vilas ; J. Ruiz-Martinez ; M. Langkamp ; J-C Corvol ; F. Cormier ; T. Knorpp ; T O Joos ; A. Bernard ; T. Gasser ; C. Marras ; B. Schüle ; J O Aasly ; T. Foroud ; J F Marti-Masso ; A. Brice ; E. Tolosa ; D. Berg ; W. MaetzlerSource :
- European journal of neurology [ 1468-1331 ] ; 2017.
Abstract
The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.
DOI: 10.1111/ene.13223
PubMed: 28102045
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<author><name sortKey="Brockmann, K" sort="Brockmann, K" uniqKey="Brockmann K" first="K" last="Brockmann">K. Brockmann</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
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<author><name sortKey="Schulte, C" sort="Schulte, C" uniqKey="Schulte C" first="C" last="Schulte">C. Schulte</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Schneiderhan Marra, N" sort="Schneiderhan Marra, N" uniqKey="Schneiderhan Marra N" first="N" last="Schneiderhan-Marra">N. Schneiderhan-Marra</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Apel, A" sort="Apel, A" uniqKey="Apel A" first="A" last="Apel">A. Apel</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pont Sunyer, C" sort="Pont Sunyer, C" uniqKey="Pont Sunyer C" first="C" last="Pont-Sunyer">C. Pont-Sunyer</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
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<author><name sortKey="Vilas, D" sort="Vilas, D" uniqKey="Vilas D" first="D" last="Vilas">D. Vilas</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ruiz Martinez, J" sort="Ruiz Martinez, J" uniqKey="Ruiz Martinez J" first="J" last="Ruiz-Martinez">J. Ruiz-Martinez</name>
<affiliation><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langkamp, M" sort="Langkamp, M" uniqKey="Langkamp M" first="M" last="Langkamp">M. Langkamp</name>
<affiliation><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation>
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<author><name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J-C" last="Corvol">J-C Corvol</name>
<affiliation><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
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<author><name sortKey="Cormier, F" sort="Cormier, F" uniqKey="Cormier F" first="F" last="Cormier">F. Cormier</name>
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<author><name sortKey="Knorpp, T" sort="Knorpp, T" uniqKey="Knorpp T" first="T" last="Knorpp">T. Knorpp</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
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<author><name sortKey="Joos, T O" sort="Joos, T O" uniqKey="Joos T" first="T O" last="Joos">T O Joos</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Bernard, A" sort="Bernard, A" uniqKey="Bernard A" first="A" last="Bernard">A. Bernard</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. Marras</name>
<affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schule, B" sort="Schule, B" uniqKey="Schule B" first="B" last="Schüle">B. Schüle</name>
<affiliation><nlm:affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</nlm:affiliation>
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<author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J O" last="Aasly">J O Aasly</name>
<affiliation><nlm:affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name>
<affiliation><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name>
<affiliation><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<affiliation><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Berg, D" sort="Berg, D" uniqKey="Berg D" first="D" last="Berg">D. Berg</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Maetzler, W" sort="Maetzler, W" uniqKey="Maetzler W" first="W" last="Maetzler">W. Maetzler</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.</title>
<author><name sortKey="Brockmann, K" sort="Brockmann, K" uniqKey="Brockmann K" first="K" last="Brockmann">K. Brockmann</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schulte, C" sort="Schulte, C" uniqKey="Schulte C" first="C" last="Schulte">C. Schulte</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schneiderhan Marra, N" sort="Schneiderhan Marra, N" uniqKey="Schneiderhan Marra N" first="N" last="Schneiderhan-Marra">N. Schneiderhan-Marra</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Apel, A" sort="Apel, A" uniqKey="Apel A" first="A" last="Apel">A. Apel</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pont Sunyer, C" sort="Pont Sunyer, C" uniqKey="Pont Sunyer C" first="C" last="Pont-Sunyer">C. Pont-Sunyer</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vilas, D" sort="Vilas, D" uniqKey="Vilas D" first="D" last="Vilas">D. Vilas</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ruiz Martinez, J" sort="Ruiz Martinez, J" uniqKey="Ruiz Martinez J" first="J" last="Ruiz-Martinez">J. Ruiz-Martinez</name>
<affiliation><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langkamp, M" sort="Langkamp, M" uniqKey="Langkamp M" first="M" last="Langkamp">M. Langkamp</name>
<affiliation><nlm:affiliation>Mediagnost GmbH, Reutlingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J-C" last="Corvol">J-C Corvol</name>
<affiliation><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cormier, F" sort="Cormier, F" uniqKey="Cormier F" first="F" last="Cormier">F. Cormier</name>
<affiliation><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Knorpp, T" sort="Knorpp, T" uniqKey="Knorpp T" first="T" last="Knorpp">T. Knorpp</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Joos, T O" sort="Joos, T O" uniqKey="Joos T" first="T O" last="Joos">T O Joos</name>
<affiliation><nlm:affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bernard, A" sort="Bernard, A" uniqKey="Bernard A" first="A" last="Bernard">A. Bernard</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marras, C" sort="Marras, C" uniqKey="Marras C" first="C" last="Marras">C. Marras</name>
<affiliation><nlm:affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schule, B" sort="Schule, B" uniqKey="Schule B" first="B" last="Schüle">B. Schüle</name>
<affiliation><nlm:affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J O" last="Aasly">J O Aasly</name>
<affiliation><nlm:affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name>
<affiliation><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Marti Masso, J F" sort="Marti Masso, J F" uniqKey="Marti Masso J" first="J F" last="Marti-Masso">J F Marti-Masso</name>
<affiliation><nlm:affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A" last="Brice">A. Brice</name>
<affiliation><nlm:affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E" last="Tolosa">E. Tolosa</name>
<affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Berg, D" sort="Berg, D" uniqKey="Berg D" first="D" last="Berg">D. Berg</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Maetzler, W" sort="Maetzler, W" uniqKey="Maetzler W" first="W" last="Maetzler">W. Maetzler</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of neurology</title>
<idno type="eISSN">1468-1331</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
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<front><div type="abstract" xml:lang="en">The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28102045</PMID>
<DateCreated><Year>2017</Year>
<Month>01</Month>
<Day>19</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>01</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1468-1331</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>2</Issue>
<PubDate><Year>2017</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>European journal of neurology</Title>
<ISOAbbreviation>Eur. J. Neurol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>427-e6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/ene.13223</ELocationID>
<Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The presentation of Parkinson's disease patients with mutations in the LRRK2 gene (PDLRRK2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">An extensive battery of peripheral inflammatory markers was measured in human serum in a multicentre cohort of 142 PDLRRK2 patients from the MJFF LRRK2 Consortium, stratified by three different subtypes as recently proposed for idiopathic Parkinson's disease: diffuse/malignant, intermediate and mainly pure motor.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients classified as diffuse/malignant presented with the highest levels of the pro-inflammatory proteins interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1) and macrophage inflammatory protein 1-β (MIP-1-β) paralleled by high levels of the neurotrophic protein brain-derived neurotrophic factor (BDNF). It was also possible to distinguish the clinical subtypes based on their inflammatory profile by using discriminant and area under the receiver operating characteristic curve analysis.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Inflammation seems to be associated with the presence of a specific clinical subtype in PDLRRK2 that is characterized by a broad and more severely affected spectrum of motor and non-motor symptoms. The pro-inflammatory metabolites IL-8, MCP-1 and MIP-1-β as well as BDNF are interesting candidates to be included in biomarker panels that aim to differentiate subtypes in PDLRRK2 and predict progression.</AbstractText>
<CopyrightInformation>© 2017 EAN.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brockmann</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schulte</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schneiderhan-Marra</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Apel</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pont-Sunyer</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vilas</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ruiz-Martinez</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langkamp</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Mediagnost GmbH, Reutlingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Corvol</LastName>
<ForeName>J-C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cormier</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Knorpp</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Joos</LastName>
<ForeName>T O</ForeName>
<Initials>TO</Initials>
<AffiliationInfo><Affiliation>Natural and Medical Sciences Institute at the University of Tübingen (NMI), Reutlingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bernard</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gasser</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marras</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schüle</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Parkinson Institute and Clinical Center, Sunnyvale, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aasly</LastName>
<ForeName>J O</ForeName>
<Initials>JO</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, St Olavs Hospital, Trondheim, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Foroud</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Medical and Molecular Genetics, Indiana University, Bloomington, IN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marti-Masso</LastName>
<ForeName>J F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario Donostia, Biodonostia Institut, San Sebastián, Guipuzcoa, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brice</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Département de Génétique et Cytogénétique, Hôpital de la Pitié Salpêtrière, Sorbonne Universités, INSERM, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tolosa</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berg</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maetzler</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Eur J Neurol</MedlineTA>
<NlmUniqueID>9506311</NlmUniqueID>
<ISSNLinking>1351-5101</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LRRK2</Keyword>
<Keyword MajorTopicYN="N">Parkinson</Keyword>
<Keyword MajorTopicYN="N">inflammation</Keyword>
<Keyword MajorTopicYN="N">phenotype</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>09</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>11</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>1</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>1</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>1</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28102045</ArticleId>
<ArticleId IdType="doi">10.1111/ene.13223</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
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