Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.
Identifieur interne : 000991 ( PubMed/Corpus ); précédent : 000990; suivant : 000992Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.
Auteurs : S. Rios Romenets ; Y. Dauvilliers ; V. Cochen De Cock ; B. Carlander ; S. Bayard ; C. Galatas ; C. Wolfson ; R B PostumaSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Blood-Brain Barrier (physiopathology), Domperidone (adverse effects), Domperidone (therapeutic use), Dopamine Antagonists (adverse effects), Dopamine Antagonists (therapeutic use), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Prevalence, Restless Legs Syndrome (complications), Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (physiopathology), Treatment Outcome.
- MESH :
- chemical , adverse effects : Domperidone, Dopamine Antagonists.
- complications : Parkinson Disease, Restless Legs Syndrome.
- drug therapy : Parkinson Disease, Restless Legs Syndrome.
- physiopathology : Blood-Brain Barrier, Parkinson Disease, Restless Legs Syndrome.
- chemical , therapeutic use : Domperidone, Dopamine Antagonists.
- Aged, Female, Humans, Male, Middle Aged, Prevalence, Treatment Outcome.
Abstract
Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the blood-brain barrier, is commonly used in Parkinson's disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone.
DOI: 10.1016/j.parkreldis.2012.07.019
PubMed: 22922159
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pubmed:22922159Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.</title><author><name sortKey="Rios Romenets, S" sort="Rios Romenets, S" uniqKey="Rios Romenets S" first="S" last="Rios Romenets">S. Rios Romenets</name><affiliation><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave., Montreal L 7-312, Quebec H3G1A4, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dauvilliers, Y" sort="Dauvilliers, Y" uniqKey="Dauvilliers Y" first="Y" last="Dauvilliers">Y. Dauvilliers</name></author><author><name sortKey="Cochen De Cock, V" sort="Cochen De Cock, V" uniqKey="Cochen De Cock V" first="V" last="Cochen De Cock">V. Cochen De Cock</name></author><author><name sortKey="Carlander, B" sort="Carlander, B" uniqKey="Carlander B" first="B" last="Carlander">B. Carlander</name></author><author><name sortKey="Bayard, S" sort="Bayard, S" uniqKey="Bayard S" first="S" last="Bayard">S. Bayard</name></author><author><name sortKey="Galatas, C" sort="Galatas, C" uniqKey="Galatas C" first="C" last="Galatas">C. Galatas</name></author><author><name sortKey="Wolfson, C" sort="Wolfson, C" uniqKey="Wolfson C" first="C" last="Wolfson">C. Wolfson</name></author><author><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:22922159</idno><idno type="pmid">22922159</idno><idno type="doi">10.1016/j.parkreldis.2012.07.019</idno><idno type="wicri:Area/PubMed/Corpus">000991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.</title><author><name sortKey="Rios Romenets, S" sort="Rios Romenets, S" uniqKey="Rios Romenets S" first="S" last="Rios Romenets">S. Rios Romenets</name><affiliation><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave., Montreal L 7-312, Quebec H3G1A4, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dauvilliers, Y" sort="Dauvilliers, Y" uniqKey="Dauvilliers Y" first="Y" last="Dauvilliers">Y. Dauvilliers</name></author><author><name sortKey="Cochen De Cock, V" sort="Cochen De Cock, V" uniqKey="Cochen De Cock V" first="V" last="Cochen De Cock">V. Cochen De Cock</name></author><author><name sortKey="Carlander, B" sort="Carlander, B" uniqKey="Carlander B" first="B" last="Carlander">B. Carlander</name></author><author><name sortKey="Bayard, S" sort="Bayard, S" uniqKey="Bayard S" first="S" last="Bayard">S. Bayard</name></author><author><name sortKey="Galatas, C" sort="Galatas, C" uniqKey="Galatas C" first="C" last="Galatas">C. Galatas</name></author><author><name sortKey="Wolfson, C" sort="Wolfson, C" uniqKey="Wolfson C" first="C" last="Wolfson">C. Wolfson</name></author><author><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood-Brain Barrier (physiopathology)</term><term>Domperidone (adverse effects)</term><term>Domperidone (therapeutic use)</term><term>Dopamine Antagonists (adverse effects)</term><term>Dopamine Antagonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Prevalence</term><term>Restless Legs Syndrome (complications)</term><term>Restless Legs Syndrome (drug therapy)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Domperidone</term><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blood-Brain Barrier</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Domperidone</term><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the blood-brain barrier, is commonly used in Parkinson's disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22922159</PMID><DateCreated><Year>2012</Year><Month>12</Month><Day>25</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>92-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2012.07.019</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(12)00310-0</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the blood-brain barrier, is commonly used in Parkinson's disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">From two Parkinson's disease cohorts, we assessed restless legs prevalence according to standard criteria, in patients taking vs. not taking domperidone. Regression analysis was performed, adjusting for age, sex, disease duration, UPDRS, dopaminergic medications and other medications.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">One hundred eighty four patients were assessed, of whom 46 (25%) had restless legs. Thirteen out of twenty seven (48%) patients on domperidone had restless legs compared to 33/157 (21%) without (p = 0.010). Other medications were not associated with restless legs.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This unexpected finding suggests that dopaminergic neurons outside of the blood-brain barrier may be important in restless legs syndrome pathophysiology.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rios Romenets</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave., Montreal L 7-312, Quebec H3G1A4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dauvilliers</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Cochen De Cock</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Carlander</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Bayard</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Galatas</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Wolfson</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>R B</ForeName><Initials>RB</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018492">Dopamine Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>5587267Z69</RegistryNumber><NameOfSubstance UI="D004294">Domperidone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001812" MajorTopicYN="N">Blood-Brain Barrier</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004294" MajorTopicYN="N">Domperidone</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018492" MajorTopicYN="N">Dopamine Antagonists</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012148" MajorTopicYN="N">Restless Legs Syndrome</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>05</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>06</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>07</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22922159</ArticleId><ArticleId IdType="pii">S1353-8020(12)00310-0</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2012.07.019</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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