A review of methods used to study cognitive deficits in Parkinson's disease.
Identifieur interne : 000990 ( PubMed/Corpus ); précédent : 000989; suivant : 000991A review of methods used to study cognitive deficits in Parkinson's disease.
Auteurs : Abdul Qayyum Rana ; Mohamed Sufian Masroor ; Atif Saeed KhanSource :
- Neurological research [ 1743-1328 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- diagnosis : Cognition Disorders, Learning Disorders.
- etiology : Cognition Disorders, Learning Disorders.
- Animals, Computer Simulation, Disease Models, Animal, Humans, Learning, Neuroimaging, Neuropsychological Tests.
Abstract
In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.
DOI: 10.1179/1743132812Y.0000000118
PubMed: 23317792
Links to Exploration step
pubmed:23317792Le document en format XML
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<author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name>
<affiliation><nlm:affiliation>Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto, ON, Canada. ranaaq@yahoo.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Masroor, Mohamed Sufian" sort="Masroor, Mohamed Sufian" uniqKey="Masroor M" first="Mohamed Sufian" last="Masroor">Mohamed Sufian Masroor</name>
</author>
<author><name sortKey="Khan, Atif Saeed" sort="Khan, Atif Saeed" uniqKey="Khan A" first="Atif Saeed" last="Khan">Atif Saeed Khan</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A review of methods used to study cognitive deficits in Parkinson's disease.</title>
<author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name>
<affiliation><nlm:affiliation>Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto, ON, Canada. ranaaq@yahoo.com</nlm:affiliation>
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</author>
<author><name sortKey="Masroor, Mohamed Sufian" sort="Masroor, Mohamed Sufian" uniqKey="Masroor M" first="Mohamed Sufian" last="Masroor">Mohamed Sufian Masroor</name>
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<author><name sortKey="Khan, Atif Saeed" sort="Khan, Atif Saeed" uniqKey="Khan A" first="Atif Saeed" last="Khan">Atif Saeed Khan</name>
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<series><title level="j">Neurological research</title>
<idno type="eISSN">1743-1328</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>Computer Simulation</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Learning</term>
<term>Learning Disorders (diagnosis)</term>
<term>Learning Disorders (etiology)</term>
<term>Neuroimaging</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
<term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
<term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Computer Simulation</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Learning</term>
<term>Neuroimaging</term>
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<front><div type="abstract" xml:lang="en">In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.</div>
</front>
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<DateCreated><Year>2013</Year>
<Month>01</Month>
<Day>15</Day>
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<DateCompleted><Year>2013</Year>
<Month>06</Month>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1743-1328</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>35</Volume>
<Issue>1</Issue>
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<Month>Jan</Month>
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<Title>Neurological research</Title>
<ISOAbbreviation>Neurol. Res.</ISOAbbreviation>
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<ArticleTitle>A review of methods used to study cognitive deficits in Parkinson's disease.</ArticleTitle>
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<ELocationID EIdType="doi" ValidYN="Y">10.1179/1743132812Y.0000000118</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In addition to the classic motor symptoms of Parkinson's disease (PD), some patients suffer from a variety of non-motor symptoms. Cognitive deficits such as impairments to learning and memory have been noted in PD and pose a clinical concern. However, during early stages of the disease these deficits may be subtle and difficult to diagnose. To date, various methodologies have been used to identify and diagnose these impairments in PD; imaging studies, animal models, and computer simulated learning paradigms being the most popular. This review discusses the advantages and disadvantages of each method in studying cognitive deficits associated with PD.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Imaging studies, including PET and magnetic resonance imaging scans, are useful when studying neural correlates of cognitive tasks. In contrast, toxin-induced and transgenic animal models are well suited for modelling physiological and behavioural conditions observed in humans. Computer simulated learning paradigms are used to analyze cognitive functioning when one engages in a cognitive task.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Based on the level of impairment being studied (i.e. neurobiological, behavioural, cognitive basis, or a combination thereof), the use of these methodologies, individually or in conjunction, is imperative when establishing a complete model of PD and its effect on cognition.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rana</LastName>
<ForeName>Abdul Qayyum</ForeName>
<Initials>AQ</Initials>
<AffiliationInfo><Affiliation>Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto, ON, Canada. ranaaq@yahoo.com</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Masroor</LastName>
<ForeName>Mohamed Sufian</ForeName>
<Initials>MS</Initials>
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<Author ValidYN="Y"><LastName>Khan</LastName>
<ForeName>Atif Saeed</ForeName>
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<MeshHeading><DescriptorName UI="D059906" MajorTopicYN="N">Neuroimaging</DescriptorName>
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<MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
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