Comparative Genomics and Evolutionary Modularity of Prokaryotes.
Identifieur interne : 000587 ( PubMed/Corpus ); précédent : 000586; suivant : 000588Comparative Genomics and Evolutionary Modularity of Prokaryotes.
Auteurs : Cedoljub Bundalovic-Torma ; John ParkinsonSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- genetics : Bacteria.
- Biological Evolution, Genomics, High-Throughput Screening Assays.
Abstract
The soaring number of high-quality genomic sequences has ushered in the era of post-genomic research where our understanding of organisms has dramatically shifted towards defining the function of genes within their larger biological contexts. As a result, novel high-throughput experimental technologies are being increasingly employed to uncover physical and functional associations of genes and proteins in complex biological processes. Through the construction and analysis of physical, genetic and metabolic networks generated for the model organisms, such as Escherichia coli, organizational principles of the genome have been deduced, such as modularity, which has important implications toward understanding prokaryotic evolution and adaptation to novel lifestyles.
DOI: 10.1007/978-3-319-23603-2_4
PubMed: 26621462
Links to Exploration step
pubmed:26621462Le document en format XML
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As a result, novel high-throughput experimental technologies are being increasingly employed to uncover physical and functional associations of genes and proteins in complex biological processes. Through the construction and analysis of physical, genetic and metabolic networks generated for the model organisms, such as Escherichia coli, organizational principles of the genome have been deduced, such as modularity, which has important implications toward understanding prokaryotic evolution and adaptation to novel lifestyles.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26621462</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>01</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0065-2598</ISSN><JournalIssue CitedMedium="Print"><Volume>883</Volume><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Advances in experimental medicine and biology</Title><ISOAbbreviation>Adv. Exp. Med. Biol.</ISOAbbreviation></Journal><ArticleTitle>Comparative Genomics and Evolutionary Modularity of Prokaryotes.</ArticleTitle><Pagination><MedlinePgn>77-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/978-3-319-23603-2_4</ELocationID><Abstract><AbstractText>The soaring number of high-quality genomic sequences has ushered in the era of post-genomic research where our understanding of organisms has dramatically shifted towards defining the function of genes within their larger biological contexts. As a result, novel high-throughput experimental technologies are being increasingly employed to uncover physical and functional associations of genes and proteins in complex biological processes. Through the construction and analysis of physical, genetic and metabolic networks generated for the model organisms, such as Escherichia coli, organizational principles of the genome have been deduced, such as modularity, which has important implications toward understanding prokaryotic evolution and adaptation to novel lifestyles.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bundalovic-Torma</LastName><ForeName>Cedoljub</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Structure and Function, The Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St. Rm 21-9830, Toronto, ON, Canada, M5G 0A4. ceda.bundalovic-torma@sickkids.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parkinson</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Structure and Function, The Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St. Rm 20-9709, Toronto, ON, Canada, M5G 0A4. jparkin@sickkids.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Adv Exp Med Biol</MedlineTA><NlmUniqueID>0121103</NlmUniqueID><ISSNLinking>0065-2598</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="Y">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023281" MajorTopicYN="N">Genomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057166" MajorTopicYN="N">High-Throughput Screening Assays</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Comparative genomics</Keyword><Keyword MajorTopicYN="N">Genomic-context</Keyword><Keyword MajorTopicYN="N">High-throughput interaction screening</Keyword><Keyword MajorTopicYN="N">Modularity</Keyword><Keyword MajorTopicYN="N">Network biology</Keyword><Keyword MajorTopicYN="N">Prokaryotic evolution</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26621462</ArticleId><ArticleId IdType="doi">10.1007/978-3-319-23603-2_4</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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