Finding our way through phenotypes.
Identifieur interne : 000586 ( PubMed/Corpus ); précédent : 000585; suivant : 000587Finding our way through phenotypes.
Auteurs : Andrew R. Deans ; Suzanna E. Lewis ; Eva Huala ; Salvatore S. Anzaldo ; Michael Ashburner ; James P. Balhoff ; David C. Blackburn ; Judith A. Blake ; J Gordon Burleigh ; Bruno Chanet ; Laurel D. Cooper ; Mélanie Courtot ; Sándor Csösz ; Hong Cui ; Wasila Dahdul ; Sandip Das ; T Alexander Dececchi ; Agnes Dettai ; Rui Diogo ; Robert E. Druzinsky ; Michel Dumontier ; Nico M. Franz ; Frank Friedrich ; George V. Gkoutos ; Melissa Haendel ; Luke J. Harmon ; Terry F. Hayamizu ; Yongqun He ; Heather M. Hines ; Nizar Ibrahim ; Laura M. Jackson ; Pankaj Jaiswal ; Christina James-Zorn ; Sebastian Köhler ; Guillaume Lecointre ; Hilmar Lapp ; Carolyn J. Lawrence ; Nicolas Le Novère ; John G. Lundberg ; James Macklin ; Austin R. Mast ; Peter E. Midford ; István Mik ; Christopher J. Mungall ; Anika Oellrich ; David Osumi-Sutherland ; Helen Parkinson ; Martín J. Ramírez ; Stefan Richter ; Peter N. Robinson ; Alan Ruttenberg ; Katja S. Schulz ; Erik Segerdell ; Katja C. Seltmann ; Michael J. Sharkey ; Aaron D. Smith ; Barry Smith ; Chelsea D. Specht ; R Burke Squires ; Robert W. Thacker ; Anne Thessen ; Jose Fernandez-Triana ; Mauno Vihinen ; Peter D. Vize ; Lars Vogt ; Christine E. Wall ; Ramona L. Walls ; Monte Westerfeld ; Robert A. Wharton ; Christian S. Wirkner ; James B. Woolley ; Matthew J. Yoder ; Aaron M. Zorn ; Paula MabeeSource :
- PLoS biology [ 1545-7885 ] ; 2015.
English descriptors
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Abstract
Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.
DOI: 10.1371/journal.pbio.1002033
PubMed: 25562316
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pubmed:25562316Le document en format XML
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Lewis</name><affiliation><nlm:affiliation>Genome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Huala, Eva" sort="Huala, Eva" uniqKey="Huala E" first="Eva" last="Huala">Eva Huala</name><affiliation><nlm:affiliation>Department of Plant Biology, Carnegie Institution for Science, Stanford, California, United States of America; Phoenix Bioinformatics, Palo Alto, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Anzaldo, Salvatore S" sort="Anzaldo, Salvatore S" uniqKey="Anzaldo S" first="Salvatore S" last="Anzaldo">Salvatore S. Anzaldo</name><affiliation><nlm:affiliation>School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Ashburner, Michael" sort="Ashburner, Michael" uniqKey="Ashburner M" first="Michael" last="Ashburner">Michael Ashburner</name><affiliation><nlm:affiliation>Department of Genetics, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Balhoff, James P" sort="Balhoff, James P" uniqKey="Balhoff J" first="James P" last="Balhoff">James P. Balhoff</name><affiliation><nlm:affiliation>National Evolutionary Synthesis Center, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Blackburn, David C" sort="Blackburn, David C" uniqKey="Blackburn D" first="David C" last="Blackburn">David C. Blackburn</name><affiliation><nlm:affiliation>Department of Vertebrate Zoology and Anthropology, California Academy of Sciences, San Francisco, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Blake, Judith A" sort="Blake, Judith A" uniqKey="Blake J" first="Judith A" last="Blake">Judith A. Blake</name><affiliation><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Burleigh, J Gordon" sort="Burleigh, J Gordon" uniqKey="Burleigh J" first="J Gordon" last="Burleigh">J Gordon Burleigh</name><affiliation><nlm:affiliation>Department of Biology, University of Florida, Gainesville, Florida, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chanet, Bruno" sort="Chanet, Bruno" uniqKey="Chanet B" first="Bruno" last="Chanet">Bruno Chanet</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Laurel D" sort="Cooper, Laurel D" uniqKey="Cooper L" first="Laurel D" last="Cooper">Laurel D. Cooper</name><affiliation><nlm:affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Courtot, Melanie" sort="Courtot, Melanie" uniqKey="Courtot M" first="Mélanie" last="Courtot">Mélanie Courtot</name><affiliation><nlm:affiliation>Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Csosz, Sandor" sort="Csosz, Sandor" uniqKey="Csosz S" first="Sándor" last="Csösz">Sándor Csösz</name><affiliation><nlm:affiliation>MTA-ELTE-MTM, Ecology Research Group, Pázmány Péter sétány 1C, Budapest, Hungary.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Hong" sort="Cui, Hong" uniqKey="Cui H" first="Hong" last="Cui">Hong Cui</name><affiliation><nlm:affiliation>School of Information Resources and Library Science, University of Arizona, Tucson, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dahdul, Wasila" sort="Dahdul, Wasila" uniqKey="Dahdul W" first="Wasila" last="Dahdul">Wasila Dahdul</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Das, Sandip" sort="Das, Sandip" uniqKey="Das S" first="Sandip" last="Das">Sandip Das</name><affiliation><nlm:affiliation>Department of Botany, University of Delhi, Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Dececchi, T Alexander" sort="Dececchi, T Alexander" uniqKey="Dececchi T" first="T Alexander" last="Dececchi">T Alexander Dececchi</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dettai, Agnes" sort="Dettai, Agnes" uniqKey="Dettai A" first="Agnes" last="Dettai">Agnes Dettai</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Diogo, Rui" sort="Diogo, Rui" uniqKey="Diogo R" first="Rui" last="Diogo">Rui Diogo</name><affiliation><nlm:affiliation>Department of Anatomy, Howard University College of Medicine, Washington D.C., United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Druzinsky, Robert E" sort="Druzinsky, Robert E" uniqKey="Druzinsky R" first="Robert E" last="Druzinsky">Robert E. Druzinsky</name><affiliation><nlm:affiliation>Department of Oral Biology, College of Dentistry, University of Illinois, Chicago, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dumontier, Michel" sort="Dumontier, Michel" uniqKey="Dumontier M" first="Michel" last="Dumontier">Michel Dumontier</name><affiliation><nlm:affiliation>Stanford Center for Biomedical Informatics Research, Stanford, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Franz, Nico M" sort="Franz, Nico M" uniqKey="Franz N" first="Nico M" last="Franz">Nico M. Franz</name><affiliation><nlm:affiliation>School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Friedrich, Frank" sort="Friedrich, Frank" uniqKey="Friedrich F" first="Frank" last="Friedrich">Frank Friedrich</name><affiliation><nlm:affiliation>Biocenter Grindel and Zoological Museum, Hamburg University, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gkoutos, George V" sort="Gkoutos, George V" uniqKey="Gkoutos G" first="George V" last="Gkoutos">George V. Gkoutos</name><affiliation><nlm:affiliation>Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Haendel, Melissa" sort="Haendel, Melissa" uniqKey="Haendel M" first="Melissa" last="Haendel">Melissa Haendel</name><affiliation><nlm:affiliation>Department of Medical Informatics & Epidemiology, Oregon Health & Science University, Portland, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Harmon, Luke J" sort="Harmon, Luke J" uniqKey="Harmon L" first="Luke J" last="Harmon">Luke J. Harmon</name><affiliation><nlm:affiliation>Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hayamizu, Terry F" sort="Hayamizu, Terry F" uniqKey="Hayamizu T" first="Terry F" last="Hayamizu">Terry F. Hayamizu</name><affiliation><nlm:affiliation>Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="He, Yongqun" sort="He, Yongqun" uniqKey="He Y" first="Yongqun" last="He">Yongqun He</name><affiliation><nlm:affiliation>Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hines, Heather M" sort="Hines, Heather M" uniqKey="Hines H" first="Heather M" last="Hines">Heather M. Hines</name><affiliation><nlm:affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Ibrahim, Nizar" sort="Ibrahim, Nizar" uniqKey="Ibrahim N" first="Nizar" last="Ibrahim">Nizar Ibrahim</name><affiliation><nlm:affiliation>Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Laura M" sort="Jackson, Laura M" uniqKey="Jackson L" first="Laura M" last="Jackson">Laura M. Jackson</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Jaiswal, Pankaj" sort="Jaiswal, Pankaj" uniqKey="Jaiswal P" first="Pankaj" last="Jaiswal">Pankaj Jaiswal</name><affiliation><nlm:affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="James Zorn, Christina" sort="James Zorn, Christina" uniqKey="James Zorn C" first="Christina" last="James-Zorn">Christina James-Zorn</name><affiliation><nlm:affiliation>Cincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Kohler, Sebastian" sort="Kohler, Sebastian" uniqKey="Kohler S" first="Sebastian" last="Köhler">Sebastian Köhler</name><affiliation><nlm:affiliation>Institute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lecointre, Guillaume" sort="Lecointre, Guillaume" uniqKey="Lecointre G" first="Guillaume" last="Lecointre">Guillaume Lecointre</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lapp, Hilmar" sort="Lapp, Hilmar" uniqKey="Lapp H" first="Hilmar" last="Lapp">Hilmar Lapp</name><affiliation><nlm:affiliation>National Evolutionary Synthesis Center, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Lawrence, Carolyn J" sort="Lawrence, Carolyn J" uniqKey="Lawrence C" first="Carolyn J" last="Lawrence">Carolyn J. Lawrence</name><affiliation><nlm:affiliation>Department of Genetics, Development and Cell Biology and Department of Agronomy, Iowa State University, Ames, Iowa, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Le Novere, Nicolas" sort="Le Novere, Nicolas" uniqKey="Le Novere N" first="Nicolas" last="Le Novère">Nicolas Le Novère</name><affiliation><nlm:affiliation>Signalling ISP, Babraham Institute, Babraham, Cambridgeshire, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lundberg, John G" sort="Lundberg, John G" uniqKey="Lundberg J" first="John G" last="Lundberg">John G. Lundberg</name><affiliation><nlm:affiliation>Department of Ichthyology, The Academy of Natural Sciences, Philadelphia, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Macklin, James" sort="Macklin, James" uniqKey="Macklin J" first="James" last="Macklin">James Macklin</name><affiliation><nlm:affiliation>Eastern Cereal and Oilseed Research Centre, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mast, Austin R" sort="Mast, Austin R" uniqKey="Mast A" first="Austin R" last="Mast">Austin R. Mast</name><affiliation><nlm:affiliation>Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Midford, Peter E" sort="Midford, Peter E" uniqKey="Midford P" first="Peter E" last="Midford">Peter E. Midford</name><affiliation><nlm:affiliation>Richmond, Virginia, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mik, Istvan" sort="Mik, Istvan" uniqKey="Mik I" first="István" last="Mik">István Mik</name><affiliation><nlm:affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mungall, Christopher J" sort="Mungall, Christopher J" uniqKey="Mungall C" first="Christopher J" last="Mungall">Christopher J. Mungall</name><affiliation><nlm:affiliation>Genome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Oellrich, Anika" sort="Oellrich, Anika" uniqKey="Oellrich A" first="Anika" last="Oellrich">Anika Oellrich</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Osumi Sutherland, David" sort="Osumi Sutherland, David" uniqKey="Osumi Sutherland D" first="David" last="Osumi-Sutherland">David Osumi-Sutherland</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Parkinson, Helen" sort="Parkinson, Helen" uniqKey="Parkinson H" first="Helen" last="Parkinson">Helen Parkinson</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez, Martin J" sort="Ramirez, Martin J" uniqKey="Ramirez M" first="Martín J" last="Ramírez">Martín J. Ramírez</name><affiliation><nlm:affiliation>Division of Arachnology, Museo Argentino de Ciencias Naturales - CONICET, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Richter, Stefan" sort="Richter, Stefan" uniqKey="Richter S" first="Stefan" last="Richter">Stefan Richter</name><affiliation><nlm:affiliation>Allgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Peter N" sort="Robinson, Peter N" uniqKey="Robinson P" first="Peter N" last="Robinson">Peter N. Robinson</name><affiliation><nlm:affiliation>Institut für Medizinische Genetik und Humangenetik Charité - Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ruttenberg, Alan" sort="Ruttenberg, Alan" uniqKey="Ruttenberg A" first="Alan" last="Ruttenberg">Alan Ruttenberg</name><affiliation><nlm:affiliation>School of Dental Medicine, University at Buffalo, Buffalo, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schulz, Katja S" sort="Schulz, Katja S" uniqKey="Schulz K" first="Katja S" last="Schulz">Katja S. Schulz</name><affiliation><nlm:affiliation>Smithsonian Institution, National Museum of Natural History, Washington, D.C., United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Segerdell, Erik" sort="Segerdell, Erik" uniqKey="Segerdell E" first="Erik" last="Segerdell">Erik Segerdell</name><affiliation><nlm:affiliation>Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Seltmann, Katja C" sort="Seltmann, Katja C" uniqKey="Seltmann K" first="Katja C" last="Seltmann">Katja C. Seltmann</name><affiliation><nlm:affiliation>Division of Invertebrate Zoology, American Museum of Natural History, New York, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sharkey, Michael J" sort="Sharkey, Michael J" uniqKey="Sharkey M" first="Michael J" last="Sharkey">Michael J. Sharkey</name><affiliation><nlm:affiliation>Department of Entomology, University of Kentucky, Lexington, Kentucky, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Aaron D" sort="Smith, Aaron D" uniqKey="Smith A" first="Aaron D" last="Smith">Aaron D. Smith</name><affiliation><nlm:affiliation>Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Barry" sort="Smith, Barry" uniqKey="Smith B" first="Barry" last="Smith">Barry Smith</name><affiliation><nlm:affiliation>Department of Philosophy, University at Buffalo, Buffalo, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Specht, Chelsea D" sort="Specht, Chelsea D" uniqKey="Specht C" first="Chelsea D" last="Specht">Chelsea D. Specht</name><affiliation><nlm:affiliation>Department of Plant and Microbial Biology, Integrative Biology, and the University and Jepson Herbaria, University of California, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Squires, R Burke" sort="Squires, R Burke" uniqKey="Squires R" first="R Burke" last="Squires">R Burke Squires</name><affiliation><nlm:affiliation>Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thacker, Robert W" sort="Thacker, Robert W" uniqKey="Thacker R" first="Robert W" last="Thacker">Robert W. Thacker</name><affiliation><nlm:affiliation>Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thessen, Anne" sort="Thessen, Anne" uniqKey="Thessen A" first="Anne" last="Thessen">Anne Thessen</name><affiliation><nlm:affiliation>The Data Detektiv, 1412 Stearns Hill Road, Waltham, Massachusetts, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Triana, Jose" sort="Fernandez Triana, Jose" uniqKey="Fernandez Triana J" first="Jose" last="Fernandez-Triana">Jose Fernandez-Triana</name><affiliation><nlm:affiliation>Canadian National Collection of Insects, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vihinen, Mauno" sort="Vihinen, Mauno" uniqKey="Vihinen M" first="Mauno" last="Vihinen">Mauno Vihinen</name><affiliation><nlm:affiliation>Department of Experimental Medical Science, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Vize, Peter D" sort="Vize, Peter D" uniqKey="Vize P" first="Peter D" last="Vize">Peter D. Vize</name><affiliation><nlm:affiliation>Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vogt, Lars" sort="Vogt, Lars" uniqKey="Vogt L" first="Lars" last="Vogt">Lars Vogt</name><affiliation><nlm:affiliation>Universität Bonn, Institut für Evolutionsbiologie und Ökologie, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wall, Christine E" sort="Wall, Christine E" uniqKey="Wall C" first="Christine E" last="Wall">Christine E. Wall</name><affiliation><nlm:affiliation>Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Walls, Ramona L" sort="Walls, Ramona L" uniqKey="Walls R" first="Ramona L" last="Walls">Ramona L. Walls</name><affiliation><nlm:affiliation>iPlant Collaborative University of Arizona, Thomas J. Keating Bioresearch Building, Tucson, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Westerfeld, Monte" sort="Westerfeld, Monte" uniqKey="Westerfeld M" first="Monte" last="Westerfeld">Monte Westerfeld</name><affiliation><nlm:affiliation>Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wharton, Robert A" sort="Wharton, Robert A" uniqKey="Wharton R" first="Robert A" last="Wharton">Robert A. Wharton</name><affiliation><nlm:affiliation>Department of Entomology, Texas A & M University, College, Station, Texas, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wirkner, Christian S" sort="Wirkner, Christian S" uniqKey="Wirkner C" first="Christian S" last="Wirkner">Christian S. Wirkner</name><affiliation><nlm:affiliation>Allgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Woolley, James B" sort="Woolley, James B" uniqKey="Woolley J" first="James B" last="Woolley">James B. Woolley</name><affiliation><nlm:affiliation>Department of Entomology, Texas A & M University, College, Station, Texas, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Yoder, Matthew J" sort="Yoder, Matthew J" uniqKey="Yoder M" first="Matthew J" last="Yoder">Matthew J. Yoder</name><affiliation><nlm:affiliation>Illinois Natural History Survey, University of Illinois, Champaign, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Zorn, Aaron M" sort="Zorn, Aaron M" uniqKey="Zorn A" first="Aaron M" last="Zorn">Aaron M. Zorn</name><affiliation><nlm:affiliation>Cincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mabee, Paula" sort="Mabee, Paula" uniqKey="Mabee P" first="Paula" last="Mabee">Paula Mabee</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25562316</idno><idno type="pmid">25562316</idno><idno type="doi">10.1371/journal.pbio.1002033</idno><idno type="wicri:Area/PubMed/Corpus">000586</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Finding our way through phenotypes.</title><author><name sortKey="Deans, Andrew R" sort="Deans, Andrew R" uniqKey="Deans A" first="Andrew R" last="Deans">Andrew R. Deans</name><affiliation><nlm:affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Lewis, Suzanna E" sort="Lewis, Suzanna E" uniqKey="Lewis S" first="Suzanna E" last="Lewis">Suzanna E. Lewis</name><affiliation><nlm:affiliation>Genome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Huala, Eva" sort="Huala, Eva" uniqKey="Huala E" first="Eva" last="Huala">Eva Huala</name><affiliation><nlm:affiliation>Department of Plant Biology, Carnegie Institution for Science, Stanford, California, United States of America; Phoenix Bioinformatics, Palo Alto, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Anzaldo, Salvatore S" sort="Anzaldo, Salvatore S" uniqKey="Anzaldo S" first="Salvatore S" last="Anzaldo">Salvatore S. Anzaldo</name><affiliation><nlm:affiliation>School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Ashburner, Michael" sort="Ashburner, Michael" uniqKey="Ashburner M" first="Michael" last="Ashburner">Michael Ashburner</name><affiliation><nlm:affiliation>Department of Genetics, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Balhoff, James P" sort="Balhoff, James P" uniqKey="Balhoff J" first="James P" last="Balhoff">James P. Balhoff</name><affiliation><nlm:affiliation>National Evolutionary Synthesis Center, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Blackburn, David C" sort="Blackburn, David C" uniqKey="Blackburn D" first="David C" last="Blackburn">David C. Blackburn</name><affiliation><nlm:affiliation>Department of Vertebrate Zoology and Anthropology, California Academy of Sciences, San Francisco, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Blake, Judith A" sort="Blake, Judith A" uniqKey="Blake J" first="Judith A" last="Blake">Judith A. Blake</name><affiliation><nlm:affiliation>The Jackson Laboratory, Bar Harbor, Maine, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Burleigh, J Gordon" sort="Burleigh, J Gordon" uniqKey="Burleigh J" first="J Gordon" last="Burleigh">J Gordon Burleigh</name><affiliation><nlm:affiliation>Department of Biology, University of Florida, Gainesville, Florida, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chanet, Bruno" sort="Chanet, Bruno" uniqKey="Chanet B" first="Bruno" last="Chanet">Bruno Chanet</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Laurel D" sort="Cooper, Laurel D" uniqKey="Cooper L" first="Laurel D" last="Cooper">Laurel D. Cooper</name><affiliation><nlm:affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Courtot, Melanie" sort="Courtot, Melanie" uniqKey="Courtot M" first="Mélanie" last="Courtot">Mélanie Courtot</name><affiliation><nlm:affiliation>Molecular Biology and Biochemistry Department, Simon Fraser University, Burnaby, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Csosz, Sandor" sort="Csosz, Sandor" uniqKey="Csosz S" first="Sándor" last="Csösz">Sándor Csösz</name><affiliation><nlm:affiliation>MTA-ELTE-MTM, Ecology Research Group, Pázmány Péter sétány 1C, Budapest, Hungary.</nlm:affiliation></affiliation></author><author><name sortKey="Cui, Hong" sort="Cui, Hong" uniqKey="Cui H" first="Hong" last="Cui">Hong Cui</name><affiliation><nlm:affiliation>School of Information Resources and Library Science, University of Arizona, Tucson, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dahdul, Wasila" sort="Dahdul, Wasila" uniqKey="Dahdul W" first="Wasila" last="Dahdul">Wasila Dahdul</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Das, Sandip" sort="Das, Sandip" uniqKey="Das S" first="Sandip" last="Das">Sandip Das</name><affiliation><nlm:affiliation>Department of Botany, University of Delhi, Delhi, India.</nlm:affiliation></affiliation></author><author><name sortKey="Dececchi, T Alexander" sort="Dececchi, T Alexander" uniqKey="Dececchi T" first="T Alexander" last="Dececchi">T Alexander Dececchi</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dettai, Agnes" sort="Dettai, Agnes" uniqKey="Dettai A" first="Agnes" last="Dettai">Agnes Dettai</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Diogo, Rui" sort="Diogo, Rui" uniqKey="Diogo R" first="Rui" last="Diogo">Rui Diogo</name><affiliation><nlm:affiliation>Department of Anatomy, Howard University College of Medicine, Washington D.C., United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Druzinsky, Robert E" sort="Druzinsky, Robert E" uniqKey="Druzinsky R" first="Robert E" last="Druzinsky">Robert E. Druzinsky</name><affiliation><nlm:affiliation>Department of Oral Biology, College of Dentistry, University of Illinois, Chicago, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Dumontier, Michel" sort="Dumontier, Michel" uniqKey="Dumontier M" first="Michel" last="Dumontier">Michel Dumontier</name><affiliation><nlm:affiliation>Stanford Center for Biomedical Informatics Research, Stanford, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Franz, Nico M" sort="Franz, Nico M" uniqKey="Franz N" first="Nico M" last="Franz">Nico M. Franz</name><affiliation><nlm:affiliation>School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Friedrich, Frank" sort="Friedrich, Frank" uniqKey="Friedrich F" first="Frank" last="Friedrich">Frank Friedrich</name><affiliation><nlm:affiliation>Biocenter Grindel and Zoological Museum, Hamburg University, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gkoutos, George V" sort="Gkoutos, George V" uniqKey="Gkoutos G" first="George V" last="Gkoutos">George V. Gkoutos</name><affiliation><nlm:affiliation>Department of Computer Science, Aberystwyth University, Aberystwyth, Ceredigion, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Haendel, Melissa" sort="Haendel, Melissa" uniqKey="Haendel M" first="Melissa" last="Haendel">Melissa Haendel</name><affiliation><nlm:affiliation>Department of Medical Informatics & Epidemiology, Oregon Health & Science University, Portland, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Harmon, Luke J" sort="Harmon, Luke J" uniqKey="Harmon L" first="Luke J" last="Harmon">Luke J. Harmon</name><affiliation><nlm:affiliation>Department of Biological Sciences, University of Idaho, Moscow, Idaho, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hayamizu, Terry F" sort="Hayamizu, Terry F" uniqKey="Hayamizu T" first="Terry F" last="Hayamizu">Terry F. Hayamizu</name><affiliation><nlm:affiliation>Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, Maine, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="He, Yongqun" sort="He, Yongqun" uniqKey="He Y" first="Yongqun" last="He">Yongqun He</name><affiliation><nlm:affiliation>Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hines, Heather M" sort="Hines, Heather M" uniqKey="Hines H" first="Heather M" last="Hines">Heather M. Hines</name><affiliation><nlm:affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Ibrahim, Nizar" sort="Ibrahim, Nizar" uniqKey="Ibrahim N" first="Nizar" last="Ibrahim">Nizar Ibrahim</name><affiliation><nlm:affiliation>Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Laura M" sort="Jackson, Laura M" uniqKey="Jackson L" first="Laura M" last="Jackson">Laura M. Jackson</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Jaiswal, Pankaj" sort="Jaiswal, Pankaj" uniqKey="Jaiswal P" first="Pankaj" last="Jaiswal">Pankaj Jaiswal</name><affiliation><nlm:affiliation>Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="James Zorn, Christina" sort="James Zorn, Christina" uniqKey="James Zorn C" first="Christina" last="James-Zorn">Christina James-Zorn</name><affiliation><nlm:affiliation>Cincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Kohler, Sebastian" sort="Kohler, Sebastian" uniqKey="Kohler S" first="Sebastian" last="Köhler">Sebastian Köhler</name><affiliation><nlm:affiliation>Institute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lecointre, Guillaume" sort="Lecointre, Guillaume" uniqKey="Lecointre G" first="Guillaume" last="Lecointre">Guillaume Lecointre</name><affiliation><nlm:affiliation>Muséum national d'Histoire naturelle, Département Systématique et Evolution, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lapp, Hilmar" sort="Lapp, Hilmar" uniqKey="Lapp H" first="Hilmar" last="Lapp">Hilmar Lapp</name><affiliation><nlm:affiliation>National Evolutionary Synthesis Center, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Lawrence, Carolyn J" sort="Lawrence, Carolyn J" uniqKey="Lawrence C" first="Carolyn J" last="Lawrence">Carolyn J. Lawrence</name><affiliation><nlm:affiliation>Department of Genetics, Development and Cell Biology and Department of Agronomy, Iowa State University, Ames, Iowa, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Le Novere, Nicolas" sort="Le Novere, Nicolas" uniqKey="Le Novere N" first="Nicolas" last="Le Novère">Nicolas Le Novère</name><affiliation><nlm:affiliation>Signalling ISP, Babraham Institute, Babraham, Cambridgeshire, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lundberg, John G" sort="Lundberg, John G" uniqKey="Lundberg J" first="John G" last="Lundberg">John G. Lundberg</name><affiliation><nlm:affiliation>Department of Ichthyology, The Academy of Natural Sciences, Philadelphia, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Macklin, James" sort="Macklin, James" uniqKey="Macklin J" first="James" last="Macklin">James Macklin</name><affiliation><nlm:affiliation>Eastern Cereal and Oilseed Research Centre, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Mast, Austin R" sort="Mast, Austin R" uniqKey="Mast A" first="Austin R" last="Mast">Austin R. Mast</name><affiliation><nlm:affiliation>Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Midford, Peter E" sort="Midford, Peter E" uniqKey="Midford P" first="Peter E" last="Midford">Peter E. Midford</name><affiliation><nlm:affiliation>Richmond, Virginia, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mik, Istvan" sort="Mik, Istvan" uniqKey="Mik I" first="István" last="Mik">István Mik</name><affiliation><nlm:affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mungall, Christopher J" sort="Mungall, Christopher J" uniqKey="Mungall C" first="Christopher J" last="Mungall">Christopher J. Mungall</name><affiliation><nlm:affiliation>Genome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Oellrich, Anika" sort="Oellrich, Anika" uniqKey="Oellrich A" first="Anika" last="Oellrich">Anika Oellrich</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Osumi Sutherland, David" sort="Osumi Sutherland, David" uniqKey="Osumi Sutherland D" first="David" last="Osumi-Sutherland">David Osumi-Sutherland</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Parkinson, Helen" sort="Parkinson, Helen" uniqKey="Parkinson H" first="Helen" last="Parkinson">Helen Parkinson</name><affiliation><nlm:affiliation>European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez, Martin J" sort="Ramirez, Martin J" uniqKey="Ramirez M" first="Martín J" last="Ramírez">Martín J. Ramírez</name><affiliation><nlm:affiliation>Division of Arachnology, Museo Argentino de Ciencias Naturales - CONICET, Buenos Aires, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Richter, Stefan" sort="Richter, Stefan" uniqKey="Richter S" first="Stefan" last="Richter">Stefan Richter</name><affiliation><nlm:affiliation>Allgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Robinson, Peter N" sort="Robinson, Peter N" uniqKey="Robinson P" first="Peter N" last="Robinson">Peter N. Robinson</name><affiliation><nlm:affiliation>Institut für Medizinische Genetik und Humangenetik Charité - Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ruttenberg, Alan" sort="Ruttenberg, Alan" uniqKey="Ruttenberg A" first="Alan" last="Ruttenberg">Alan Ruttenberg</name><affiliation><nlm:affiliation>School of Dental Medicine, University at Buffalo, Buffalo, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schulz, Katja S" sort="Schulz, Katja S" uniqKey="Schulz K" first="Katja S" last="Schulz">Katja S. Schulz</name><affiliation><nlm:affiliation>Smithsonian Institution, National Museum of Natural History, Washington, D.C., United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Segerdell, Erik" sort="Segerdell, Erik" uniqKey="Segerdell E" first="Erik" last="Segerdell">Erik Segerdell</name><affiliation><nlm:affiliation>Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Seltmann, Katja C" sort="Seltmann, Katja C" uniqKey="Seltmann K" first="Katja C" last="Seltmann">Katja C. Seltmann</name><affiliation><nlm:affiliation>Division of Invertebrate Zoology, American Museum of Natural History, New York, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Sharkey, Michael J" sort="Sharkey, Michael J" uniqKey="Sharkey M" first="Michael J" last="Sharkey">Michael J. Sharkey</name><affiliation><nlm:affiliation>Department of Entomology, University of Kentucky, Lexington, Kentucky, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Aaron D" sort="Smith, Aaron D" uniqKey="Smith A" first="Aaron D" last="Smith">Aaron D. Smith</name><affiliation><nlm:affiliation>Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Barry" sort="Smith, Barry" uniqKey="Smith B" first="Barry" last="Smith">Barry Smith</name><affiliation><nlm:affiliation>Department of Philosophy, University at Buffalo, Buffalo, New York, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Specht, Chelsea D" sort="Specht, Chelsea D" uniqKey="Specht C" first="Chelsea D" last="Specht">Chelsea D. Specht</name><affiliation><nlm:affiliation>Department of Plant and Microbial Biology, Integrative Biology, and the University and Jepson Herbaria, University of California, Berkeley, California, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Squires, R Burke" sort="Squires, R Burke" uniqKey="Squires R" first="R Burke" last="Squires">R Burke Squires</name><affiliation><nlm:affiliation>Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thacker, Robert W" sort="Thacker, Robert W" uniqKey="Thacker R" first="Robert W" last="Thacker">Robert W. Thacker</name><affiliation><nlm:affiliation>Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Thessen, Anne" sort="Thessen, Anne" uniqKey="Thessen A" first="Anne" last="Thessen">Anne Thessen</name><affiliation><nlm:affiliation>The Data Detektiv, 1412 Stearns Hill Road, Waltham, Massachusetts, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Triana, Jose" sort="Fernandez Triana, Jose" uniqKey="Fernandez Triana J" first="Jose" last="Fernandez-Triana">Jose Fernandez-Triana</name><affiliation><nlm:affiliation>Canadian National Collection of Insects, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vihinen, Mauno" sort="Vihinen, Mauno" uniqKey="Vihinen M" first="Mauno" last="Vihinen">Mauno Vihinen</name><affiliation><nlm:affiliation>Department of Experimental Medical Science, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Vize, Peter D" sort="Vize, Peter D" uniqKey="Vize P" first="Peter D" last="Vize">Peter D. Vize</name><affiliation><nlm:affiliation>Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Vogt, Lars" sort="Vogt, Lars" uniqKey="Vogt L" first="Lars" last="Vogt">Lars Vogt</name><affiliation><nlm:affiliation>Universität Bonn, Institut für Evolutionsbiologie und Ökologie, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wall, Christine E" sort="Wall, Christine E" uniqKey="Wall C" first="Christine E" last="Wall">Christine E. Wall</name><affiliation><nlm:affiliation>Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Walls, Ramona L" sort="Walls, Ramona L" uniqKey="Walls R" first="Ramona L" last="Walls">Ramona L. Walls</name><affiliation><nlm:affiliation>iPlant Collaborative University of Arizona, Thomas J. Keating Bioresearch Building, Tucson, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Westerfeld, Monte" sort="Westerfeld, Monte" uniqKey="Westerfeld M" first="Monte" last="Westerfeld">Monte Westerfeld</name><affiliation><nlm:affiliation>Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wharton, Robert A" sort="Wharton, Robert A" uniqKey="Wharton R" first="Robert A" last="Wharton">Robert A. Wharton</name><affiliation><nlm:affiliation>Department of Entomology, Texas A & M University, College, Station, Texas, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Wirkner, Christian S" sort="Wirkner, Christian S" uniqKey="Wirkner C" first="Christian S" last="Wirkner">Christian S. Wirkner</name><affiliation><nlm:affiliation>Allgemeine & Spezielle Zoologie, Institut für Biowissenschaften, Universität Rostock, Universitätsplatz 2, Rostock, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Woolley, James B" sort="Woolley, James B" uniqKey="Woolley J" first="James B" last="Woolley">James B. Woolley</name><affiliation><nlm:affiliation>Department of Entomology, Texas A & M University, College, Station, Texas, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Yoder, Matthew J" sort="Yoder, Matthew J" uniqKey="Yoder M" first="Matthew J" last="Yoder">Matthew J. Yoder</name><affiliation><nlm:affiliation>Illinois Natural History Survey, University of Illinois, Champaign, Illinois, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Zorn, Aaron M" sort="Zorn, Aaron M" uniqKey="Zorn A" first="Aaron M" last="Zorn">Aaron M. Zorn</name><affiliation><nlm:affiliation>Cincinnati Children's Hospital, Division of Developmental Biology, Cincinnati, Ohio, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Mabee, Paula" sort="Mabee, Paula" uniqKey="Mabee P" first="Paula" last="Mabee">Paula Mabee</name><affiliation><nlm:affiliation>Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PLoS biology</title><idno type="eISSN">1545-7885</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Computational Biology</term><term>Data Curation</term><term>Databases, Factual (standards)</term><term>Gene-Environment Interaction</term><term>Genetic Association Studies</term><term>Genomics</term><term>Humans</term><term>Phenotype</term><term>Reference Standards</term><term>Reproducibility of Results</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Computational Biology</term><term>Data Curation</term><term>Gene-Environment Interaction</term><term>Genetic Association Studies</term><term>Genomics</term><term>Humans</term><term>Phenotype</term><term>Reference Standards</term><term>Reproducibility of Results</term><term>Terminology as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25562316</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>07</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>29</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1545-7885</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>PLoS biology</Title><ISOAbbreviation>PLoS Biol.</ISOAbbreviation></Journal><ArticleTitle>Finding our way through phenotypes.</ArticleTitle><Pagination><MedlinePgn>e1002033</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pbio.1002033</ELocationID><Abstract><AbstractText>Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deans</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lewis</LastName><ForeName>Suzanna E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Genome Division, Lawrence Berkeley National Lab, Berkeley, California, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huala</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Plant Biology, Carnegie Institution for Science, Stanford, California, United States of America; Phoenix Bioinformatics, Palo Alto, California, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anzaldo</LastName><ForeName>Salvatore S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashburner</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balhoff</LastName><ForeName>James P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>National Evolutionary Synthesis Center, Durham, North Carolina, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blackburn</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Vertebrate Zoology and Anthropology, California Academy of Sciences, San Francisco, California, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blake</LastName><ForeName>Judith A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>The Jackson Laboratory, Bar Harbor, Maine, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burleigh</LastName><ForeName>J Gordon</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Florida, Gainesville, Florida, United States of America.</Affiliation></AffiliationInfo></Author><Author 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South Dakota, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BBS/E/B/000C0419</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P30 CA034196</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P41 HD064556</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>01</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS 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UI="D009626" MajorTopicYN="N">Terminology as Topic</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4285398</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25562316</ArticleId><ArticleId IdType="doi">10.1371/journal.pbio.1002033</ArticleId><ArticleId IdType="pii">PBIOLOGY-D-14-02271</ArticleId><ArticleId IdType="pmc">PMC4285398</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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