Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
Identifieur interne : 000106 ( PubMed/Corpus ); précédent : 000105; suivant : 000107Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.
Auteurs : Lisa Wang ; Michael G. Heckman ; Jan O. Aasly ; Grazia Annesi ; Maria Bozi ; Sun Ju Chung ; Carl Clarke ; David Crosiers ; Gertrud Eckstein ; Gaetan Garraux ; Georgios M. Hadjigeorgiou ; Nobu Hattori ; Beom Jeon ; Yun J. Kim ; Masato Kubo ; Suzanne Lesage ; Juei Jueng Lin ; Timothy Lynch ; Peter Lichtner ; George D. Mellick ; Vincent Mok ; Karin E. Morrison ; Aldo Quattrone ; Wataru Satake ; Peter A. Silburn ; Leonidas Stefanis ; Joanne D. Stockton ; Eng King Tan ; Tatsushi Toda ; Alexis Brice ; Christine Van Broeckhoven ; Ryan J. Uitti ; Karin Wirdefeldt ; Zbigniew Wszolek ; Georgia Xiromerisiou ; Demetrius M. Maraganore ; Thomas Gasser ; Rejko Krüger ; Matthew J. Farrer ; Owen A. Ross ; Manu SharmaSource :
- Neurobiology of aging [ 1558-1497 ] ; 2017.
Abstract
A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.
DOI: 10.1016/j.neurobiolaging.2016.09.022
PubMed: 27814993
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.</title><author><name sortKey="Wang, Lisa" sort="Wang, Lisa" uniqKey="Wang L" first="Lisa" last="Wang">Lisa Wang</name><affiliation><nlm:affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G" last="Heckman">Michael G. Heckman</name><affiliation><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O" last="Aasly">Jan O. Aasly</name><affiliation><nlm:affiliation>Department of Neurology, St Olavs Hospital and NTNU, Trondheim, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><nlm:affiliation>Neurology Department, Psychiatry Athens Hospital, Athens, Greece; 2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation><nlm:affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Clarke, Carl" sort="Clarke, Carl" uniqKey="Clarke C" first="Carl" last="Clarke">Carl Clarke</name><affiliation><nlm:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Crosiers, David" sort="Crosiers, David" uniqKey="Crosiers D" first="David" last="Crosiers">David Crosiers</name><affiliation><nlm:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Department of Neurology, University Hospital Antwerp, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Eckstein, Gertrud" sort="Eckstein, Gertrud" uniqKey="Eckstein G" first="Gertrud" last="Eckstein">Gertrud Eckstein</name><affiliation><nlm:affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name><affiliation><nlm:affiliation>Department of Neurology, Cyclotron Research Centre, University of Liège, Liège, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M" last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Hattori, Nobu" sort="Hattori, Nobu" uniqKey="Hattori N" first="Nobu" last="Hattori">Nobu Hattori</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Beom" sort="Jeon, Beom" uniqKey="Jeon B" first="Beom" last="Jeon">Beom Jeon</name><affiliation><nlm:affiliation>Institute Department of Neurology, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yun J" sort="Kim, Yun J" uniqKey="Kim Y" first="Yun J" last="Kim">Yun J. Kim</name><affiliation><nlm:affiliation>ILSONG Institute of Life Science, Hallym University, Hallym Institute of Translational Genomics and Bioinformatics, Department of Neurology, Hallym University Sacred Heart Hospital, Gangwon, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kubo, Masato" sort="Kubo, Masato" uniqKey="Kubo M" first="Masato" last="Kubo">Masato Kubo</name><affiliation><nlm:affiliation>Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei Jueng" last="Lin">Juei Jueng Lin</name><affiliation><nlm:affiliation>Department of Neurology, Chushang Show-Chwan Hospital, Nantou, Taiwan; Department of Neurology, Chung-Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><nlm:affiliation>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute, University College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name><affiliation><nlm:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mok, Vincent" sort="Mok, Vincent" uniqKey="Mok V" first="Vincent" last="Mok">Vincent Mok</name><affiliation><nlm:affiliation>Therese Pei Fong Chow Research Center for Prevention of Dementia, Faculty of Medicine, The Chinese University of Hong Kong, Department of Medicine & Therapeutics, Clinical Neurology Research Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Karin E" sort="Morrison, Karin E" uniqKey="Morrison K" first="Karin E" last="Morrison">Karin E. Morrison</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Southampton, Southampton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy; Department of Medical Sciences, Institute of Neurology, University Magna Graecia, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name><affiliation><nlm:affiliation>University of Queensland Centre for Clinical Research, Herston, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><nlm:affiliation>2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece; Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of Academy of Athens, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Stockton, Joanne D" sort="Stockton, Joanne D" uniqKey="Stockton J" first="Joanne D" last="Stockton">Joanne D. Stockton</name><affiliation><nlm:affiliation>Neurosciences Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation><nlm:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore; Programme in Neuroscience and Behavior Disorders, Duke-NUS Graduate Medical School, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation><nlm:affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><nlm:affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M" last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><nlm:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><nlm:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany; Clinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg City, Luxembourg; Centre Hospitalier de Luxembourg (CHL), Luxembourg City, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation><nlm:affiliation>Djavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A" last="Ross">Owen A. Ross</name><affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany. Electronic address: manu.sharma@uni-tuebingen.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27814993</idno><idno type="pmid">27814993</idno><idno type="doi">10.1016/j.neurobiolaging.2016.09.022</idno><idno type="wicri:Area/PubMed/Corpus">000106</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000106</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.</title><author><name sortKey="Wang, Lisa" sort="Wang, Lisa" uniqKey="Wang L" first="Lisa" last="Wang">Lisa Wang</name><affiliation><nlm:affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G" last="Heckman">Michael G. Heckman</name><affiliation><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O" last="Aasly">Jan O. Aasly</name><affiliation><nlm:affiliation>Department of Neurology, St Olavs Hospital and NTNU, Trondheim, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><nlm:affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><nlm:affiliation>Neurology Department, Psychiatry Athens Hospital, Athens, Greece; 2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation><nlm:affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Clarke, Carl" sort="Clarke, Carl" uniqKey="Clarke C" first="Carl" last="Clarke">Carl Clarke</name><affiliation><nlm:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Crosiers, David" sort="Crosiers, David" uniqKey="Crosiers D" first="David" last="Crosiers">David Crosiers</name><affiliation><nlm:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Department of Neurology, University Hospital Antwerp, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Eckstein, Gertrud" sort="Eckstein, Gertrud" uniqKey="Eckstein G" first="Gertrud" last="Eckstein">Gertrud Eckstein</name><affiliation><nlm:affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name><affiliation><nlm:affiliation>Department of Neurology, Cyclotron Research Centre, University of Liège, Liège, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M" last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><nlm:affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Hattori, Nobu" sort="Hattori, Nobu" uniqKey="Hattori N" first="Nobu" last="Hattori">Nobu Hattori</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Beom" sort="Jeon, Beom" uniqKey="Jeon B" first="Beom" last="Jeon">Beom Jeon</name><affiliation><nlm:affiliation>Institute Department of Neurology, Seoul National University Hospital, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yun J" sort="Kim, Yun J" uniqKey="Kim Y" first="Yun J" last="Kim">Yun J. Kim</name><affiliation><nlm:affiliation>ILSONG Institute of Life Science, Hallym University, Hallym Institute of Translational Genomics and Bioinformatics, Department of Neurology, Hallym University Sacred Heart Hospital, Gangwon, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kubo, Masato" sort="Kubo, Masato" uniqKey="Kubo M" first="Masato" last="Kubo">Masato Kubo</name><affiliation><nlm:affiliation>Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Juei Jueng" sort="Lin, Juei Jueng" uniqKey="Lin J" first="Juei Jueng" last="Lin">Juei Jueng Lin</name><affiliation><nlm:affiliation>Department of Neurology, Chushang Show-Chwan Hospital, Nantou, Taiwan; Department of Neurology, Chung-Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><nlm:affiliation>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute, University College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name><affiliation><nlm:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mok, Vincent" sort="Mok, Vincent" uniqKey="Mok V" first="Vincent" last="Mok">Vincent Mok</name><affiliation><nlm:affiliation>Therese Pei Fong Chow Research Center for Prevention of Dementia, Faculty of Medicine, The Chinese University of Hong Kong, Department of Medicine & Therapeutics, Clinical Neurology Research Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Karin E" sort="Morrison, Karin E" uniqKey="Morrison K" first="Karin E" last="Morrison">Karin E. Morrison</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Southampton, Southampton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><nlm:affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy; Department of Medical Sciences, Institute of Neurology, University Magna Graecia, Catanzaro, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Satake, Wataru" sort="Satake, Wataru" uniqKey="Satake W" first="Wataru" last="Satake">Wataru Satake</name><affiliation><nlm:affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A" last="Silburn">Peter A. Silburn</name><affiliation><nlm:affiliation>University of Queensland Centre for Clinical Research, Herston, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><nlm:affiliation>2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece; Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of Academy of Athens, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Stockton, Joanne D" sort="Stockton, Joanne D" uniqKey="Stockton J" first="Joanne D" last="Stockton">Joanne D. Stockton</name><affiliation><nlm:affiliation>Neurosciences Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng King" last="Tan">Eng King Tan</name><affiliation><nlm:affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore; Programme in Neuroscience and Behavior Disorders, Duke-NUS Graduate Medical School, Durham, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Toda, Tatsushi" sort="Toda, Tatsushi" uniqKey="Toda T" first="Tatsushi" last="Toda">Tatsushi Toda</name><affiliation><nlm:affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><nlm:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J" last="Uitti">Ryan J. Uitti</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew" sort="Wszolek, Zbigniew" uniqKey="Wszolek Z" first="Zbigniew" last="Wszolek">Zbigniew Wszolek</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><nlm:affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M" last="Maraganore">Demetrius M. Maraganore</name><affiliation><nlm:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><nlm:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><nlm:affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany; Clinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg City, Luxembourg; Centre Hospitalier de Luxembourg (CHL), Luxembourg City, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J" last="Farrer">Matthew J. Farrer</name><affiliation><nlm:affiliation>Djavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A" last="Ross">Owen A. Ross</name><affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><nlm:affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany. Electronic address: manu.sharma@uni-tuebingen.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27814993</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>05</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Neurobiology of aging</Title><ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation></Journal><ArticleTitle>Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.</ArticleTitle><Pagination><MedlinePgn>217.e1-217.e4</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0197-4580(16)30236-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2016.09.022</ELocationID><Abstract><AbstractText>A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heckman</LastName><ForeName>Michael G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aasly</LastName><ForeName>Jan O</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Department of Neurology, St Olavs Hospital and NTNU, Trondheim, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Annesi</LastName><ForeName>Grazia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozi</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neurology Department, Psychiatry Athens Hospital, Athens, Greece; 2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Sun Ju</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>Carl</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crosiers</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Department of Neurology, University Hospital Antwerp, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eckstein</LastName><ForeName>Gertrud</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garraux</LastName><ForeName>Gaetan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, Cyclotron Research Centre, University of Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hadjigeorgiou</LastName><ForeName>Georgios M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hattori</LastName><ForeName>Nobu</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Beom</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute Department of Neurology, Seoul National University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yun J</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>ILSONG Institute of Life Science, Hallym University, Hallym Institute of Translational Genomics and Bioinformatics, Department of Neurology, Hallym University Sacred Heart Hospital, Gangwon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubo</LastName><ForeName>Masato</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesage</LastName><ForeName>Suzanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Juei Jueng</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Chushang Show-Chwan Hospital, Nantou, Taiwan; Department of Neurology, Chung-Shan Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lynch</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute, University College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lichtner</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Helmholtz Zentrum München, German Research Centre for Environmental Health (Gmbh), Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mellick</LastName><ForeName>George D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mok</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Therese Pei Fong Chow Research Center for Prevention of Dementia, Faculty of Medicine, The Chinese University of Hong Kong, Department of Medicine & Therapeutics, Clinical Neurology Research Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Karin E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Southampton, Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quattrone</LastName><ForeName>Aldo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy; Department of Medical Sciences, Institute of Neurology, University Magna Graecia, Catanzaro, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Satake</LastName><ForeName>Wataru</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silburn</LastName><ForeName>Peter A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>University of Queensland Centre for Clinical Research, Herston, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefanis</LastName><ForeName>Leonidas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>2nd Neurology Clinic, University of Athens, Attikon Hospital, Athens, Greece; Divisions of Basic Neurosciences and Cell Biology, Biomedical Research Foundation of Academy of Athens, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stockton</LastName><ForeName>Joanne D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Neurosciences Department, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Eng King</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore; Programme in Neuroscience and Behavior Disorders, Duke-NUS Graduate Medical School, Durham, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toda</LastName><ForeName>Tatsushi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brice</LastName><ForeName>Alexis</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INSERM U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Broeckhoven</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitti</LastName><ForeName>Ryan J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wirdefeldt</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wszolek</LastName><ForeName>Zbigniew</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiromerisiou</LastName><ForeName>Georgia</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neurology, Faculty of Medicine, University of Thessaly and Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maraganore</LastName><ForeName>Demetrius M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasser</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krüger</LastName><ForeName>Rejko</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany; Clinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg City, Luxembourg; Centre Hospitalier de Luxembourg (CHL), Luxembourg City, Luxembourg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farrer</LastName><ForeName>Matthew J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Djavad Mowafhagian Centre for Brain, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Owen A</ForeName><Initials>OA</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Manu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tuebingen, Tuebingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Science Research, University of Tuebingen, Tuebingen, Germany. Electronic address: manu.sharma@uni-tuebingen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>GEOPD Consortium</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P50 NS072187</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS078086</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Aging</MedlineTA><NlmUniqueID>8100437</NlmUniqueID><ISSNLinking>0197-4580</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Am J Neurodegener Dis. 2013 Nov 29;2(4):287-99</RefSource><PMID Version="1">24319646</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31</RefSource><PMID Version="1">24510904</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2014 Jan;35(1):266.e5-14</RefSource><PMID Version="1">23962496</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurol. 2013 Aug;9(8):445-54</RefSource><PMID Version="1">23857047</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2011 May;69(5):778-92</RefSource><PMID Version="1">21391235</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2009 Apr 15;18(R1):R48-59</RefSource><PMID Version="1">19297401</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2011 Feb 19;377(9766):641-9</RefSource><PMID Version="1">21292315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2013 Feb 6;77(3):425-39</RefSource><PMID Version="1">23395371</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Genetic epidemiology</Keyword><Keyword MajorTopicYN="N">LRRK2</Keyword><Keyword MajorTopicYN="N">PARK16</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>01</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27814993</ArticleId><ArticleId IdType="pii">S0197-4580(16)30236-6</ArticleId><ArticleId IdType="doi">10.1016/j.neurobiolaging.2016.09.022</ArticleId><ArticleId IdType="pmc">PMC5154911</ArticleId><ArticleId IdType="mid">NIHMS821728</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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