The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.
Identifieur interne : 000105 ( PubMed/Corpus ); précédent : 000104; suivant : 000106The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.
Auteurs : Ziv Gan-Or ; Jacques Y. Montplaisir ; Jay P. Ross ; Judes Poirier ; Simon C. Warby ; Isabelle Arnulf ; Stephanie Strong ; Yves Dauvilliers ; Claire S. Leblond ; Michele T M. Hu ; Birgit Högl ; Ambra Stefani ; Christelle Charley Monaca ; Valérie Cochen De Cock ; Michel Boivin ; Luigi Ferini-Strambi ; Giuseppe Plazzi ; Elena Antelmi ; Peter Young ; Anna Heidbreder ; Thomas R. Barber ; Samuel G. Evetts ; Michal Rolinski ; Patrick A. Dion ; Alex Desautels ; Jean-François Gagnon ; Nicolas Dupré ; Ronald B. Postuma ; Guy A. RouleauSource :
- Neurobiology of aging [ 1558-1497 ] ; 2017.
Abstract
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
DOI: 10.1016/j.neurobiolaging.2016.10.002
PubMed: 27814994
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.</title><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address: ziv.gan-or@mail.mcgill.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y" last="Montplaisir">Jacques Y. Montplaisir</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ross, Jay P" sort="Ross, Jay P" uniqKey="Ross J" first="Jay P" last="Ross">Jay P. Ross</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Poirier, Judes" sort="Poirier, Judes" uniqKey="Poirier J" first="Judes" last="Poirier">Judes Poirier</name><affiliation><nlm:affiliation>Department of Psychiatry, McGill University, Montréal, Quebec, Canada; Douglas Mental Health University Institute, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Warby, Simon C" sort="Warby, Simon C" uniqKey="Warby S" first="Simon C" last="Warby">Simon C. Warby</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name><affiliation><nlm:affiliation>Sleep Disorders Unit, Pitié Salpêtrière Hospital, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière and Sorbonne Universities, UPMC Paris 6 univ, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Strong, Stephanie" sort="Strong, Stephanie" uniqKey="Strong S" first="Stephanie" last="Strong">Stephanie Strong</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation><nlm:affiliation>Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology Hôpital-Gui-de Chauliac, CHU Montpellier, INSERM U1061, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leblond, Claire S" sort="Leblond, Claire S" uniqKey="Leblond C" first="Claire S" last="Leblond">Claire S. Leblond</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Michele T M" sort="Hu, Michele T M" uniqKey="Hu M" first="Michele T M" last="Hu">Michele T M. Hu</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name><affiliation><nlm:affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Stefani, Ambra" sort="Stefani, Ambra" uniqKey="Stefani A" first="Ambra" last="Stefani">Ambra Stefani</name><affiliation><nlm:affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Monaca, Christelle Charley" sort="Monaca, Christelle Charley" uniqKey="Monaca C" first="Christelle Charley" last="Monaca">Christelle Charley Monaca</name><affiliation><nlm:affiliation>Department of Clinical Neurophysiology and Sleep Center, University Lille North of France, CHU Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Cock, Valerie Cochen" sort="De Cock, Valerie Cochen" uniqKey="De Cock V" first="Valérie Cochen" last="De Cock">Valérie Cochen De Cock</name><affiliation><nlm:affiliation>Sleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France; EuroMov, University of Montpellier, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boivin, Michel" sort="Boivin, Michel" uniqKey="Boivin M" first="Michel" last="Boivin">Michel Boivin</name><affiliation><nlm:affiliation>GRIP, École de psychologie, Université Laval, Québec city, Quebec, Canada; Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name><affiliation><nlm:affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy; IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Antelmi, Elena" sort="Antelmi, Elena" uniqKey="Antelmi E" first="Elena" last="Antelmi">Elena Antelmi</name><affiliation><nlm:affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Peter" sort="Young, Peter" uniqKey="Young P" first="Peter" last="Young">Peter Young</name><affiliation><nlm:affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heidbreder, Anna" sort="Heidbreder, Anna" uniqKey="Heidbreder A" first="Anna" last="Heidbreder">Anna Heidbreder</name><affiliation><nlm:affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barber, Thomas R" sort="Barber, Thomas R" uniqKey="Barber T" first="Thomas R" last="Barber">Thomas R. Barber</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Evetts, Samuel G" sort="Evetts, Samuel G" uniqKey="Evetts S" first="Samuel G" last="Evetts">Samuel G. Evetts</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rolinski, Michal" sort="Rolinski, Michal" uniqKey="Rolinski M" first="Michal" last="Rolinski">Michal Rolinski</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A" last="Dion">Patrick A. Dion</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Neurosciences, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Département de psychologie, Université du Québec à Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dupre, Nicolas" sort="Dupre, Nicolas" uniqKey="Dupre N" first="Nicolas" last="Dupré">Nicolas Dupré</name><affiliation><nlm:affiliation>Faculté de Médecine, Université Laval, CHU de Québec (Enfant-Jésus), Québec, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada; Department of Neurology, Montreal General Hospital, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27814994</idno><idno type="pmid">27814994</idno><idno type="doi">10.1016/j.neurobiolaging.2016.10.002</idno><idno type="wicri:Area/PubMed/Corpus">000105</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000105</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.</title><author><name sortKey="Gan Or, Ziv" sort="Gan Or, Ziv" uniqKey="Gan Or Z" first="Ziv" last="Gan-Or">Ziv Gan-Or</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address: ziv.gan-or@mail.mcgill.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Montplaisir, Jacques Y" sort="Montplaisir, Jacques Y" uniqKey="Montplaisir J" first="Jacques Y" last="Montplaisir">Jacques Y. Montplaisir</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Ross, Jay P" sort="Ross, Jay P" uniqKey="Ross J" first="Jay P" last="Ross">Jay P. Ross</name><affiliation><nlm:affiliation>Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Poirier, Judes" sort="Poirier, Judes" uniqKey="Poirier J" first="Judes" last="Poirier">Judes Poirier</name><affiliation><nlm:affiliation>Department of Psychiatry, McGill University, Montréal, Quebec, Canada; Douglas Mental Health University Institute, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Warby, Simon C" sort="Warby, Simon C" uniqKey="Warby S" first="Simon C" last="Warby">Simon C. Warby</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name><affiliation><nlm:affiliation>Sleep Disorders Unit, Pitié Salpêtrière Hospital, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière and Sorbonne Universities, UPMC Paris 6 univ, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Strong, Stephanie" sort="Strong, Stephanie" uniqKey="Strong S" first="Stephanie" last="Strong">Stephanie Strong</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dauvilliers, Yves" sort="Dauvilliers, Yves" uniqKey="Dauvilliers Y" first="Yves" last="Dauvilliers">Yves Dauvilliers</name><affiliation><nlm:affiliation>Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology Hôpital-Gui-de Chauliac, CHU Montpellier, INSERM U1061, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leblond, Claire S" sort="Leblond, Claire S" uniqKey="Leblond C" first="Claire S" last="Leblond">Claire S. Leblond</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Michele T M" sort="Hu, Michele T M" uniqKey="Hu M" first="Michele T M" last="Hu">Michele T M. Hu</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name><affiliation><nlm:affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Stefani, Ambra" sort="Stefani, Ambra" uniqKey="Stefani A" first="Ambra" last="Stefani">Ambra Stefani</name><affiliation><nlm:affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Monaca, Christelle Charley" sort="Monaca, Christelle Charley" uniqKey="Monaca C" first="Christelle Charley" last="Monaca">Christelle Charley Monaca</name><affiliation><nlm:affiliation>Department of Clinical Neurophysiology and Sleep Center, University Lille North of France, CHU Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Cock, Valerie Cochen" sort="De Cock, Valerie Cochen" uniqKey="De Cock V" first="Valérie Cochen" last="De Cock">Valérie Cochen De Cock</name><affiliation><nlm:affiliation>Sleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France; EuroMov, University of Montpellier, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boivin, Michel" sort="Boivin, Michel" uniqKey="Boivin M" first="Michel" last="Boivin">Michel Boivin</name><affiliation><nlm:affiliation>GRIP, École de psychologie, Université Laval, Québec city, Quebec, Canada; Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Ferini Strambi, Luigi" sort="Ferini Strambi, Luigi" uniqKey="Ferini Strambi L" first="Luigi" last="Ferini-Strambi">Luigi Ferini-Strambi</name><affiliation><nlm:affiliation>Department of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name><affiliation><nlm:affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy; IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Antelmi, Elena" sort="Antelmi, Elena" uniqKey="Antelmi E" first="Elena" last="Antelmi">Elena Antelmi</name><affiliation><nlm:affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Peter" sort="Young, Peter" uniqKey="Young P" first="Peter" last="Young">Peter Young</name><affiliation><nlm:affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Heidbreder, Anna" sort="Heidbreder, Anna" uniqKey="Heidbreder A" first="Anna" last="Heidbreder">Anna Heidbreder</name><affiliation><nlm:affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Barber, Thomas R" sort="Barber, Thomas R" uniqKey="Barber T" first="Thomas R" last="Barber">Thomas R. Barber</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Evetts, Samuel G" sort="Evetts, Samuel G" uniqKey="Evetts S" first="Samuel G" last="Evetts">Samuel G. Evetts</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rolinski, Michal" sort="Rolinski, Michal" uniqKey="Rolinski M" first="Michal" last="Rolinski">Michal Rolinski</name><affiliation><nlm:affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A" last="Dion">Patrick A. Dion</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Neurosciences, Université de Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation><nlm:affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Département de psychologie, Université du Québec à Montréal, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dupre, Nicolas" sort="Dupre, Nicolas" uniqKey="Dupre N" first="Nicolas" last="Dupré">Nicolas Dupré</name><affiliation><nlm:affiliation>Faculté de Médecine, Université Laval, CHU de Québec (Enfant-Jésus), Québec, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B" last="Postuma">Ronald B. Postuma</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada; Department of Neurology, Montreal General Hospital, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27814994</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>05</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-1497</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Neurobiology of aging</Title><ISOAbbreviation>Neurobiol. Aging</ISOAbbreviation></Journal><ArticleTitle>The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.</ArticleTitle><Pagination><MedlinePgn>218.e13-218.e15</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0197-4580(16)30242-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurobiolaging.2016.10.002</ELocationID><Abstract><AbstractText>The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gan-Or</LastName><ForeName>Ziv</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address: ziv.gan-or@mail.mcgill.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montplaisir</LastName><ForeName>Jacques Y</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Jay P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poirier</LastName><ForeName>Judes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, McGill University, Montréal, Quebec, Canada; Douglas Mental Health University Institute, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Warby</LastName><ForeName>Simon C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Psychiatry, Université de Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnulf</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Sleep Disorders Unit, Pitié Salpêtrière Hospital, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière and Sorbonne Universities, UPMC Paris 6 univ, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strong</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dauvilliers</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Sleep Unit, National Reference Network for Narcolepsy, Department of Neurology Hôpital-Gui-de Chauliac, CHU Montpellier, INSERM U1061, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leblond</LastName><ForeName>Claire S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Michele T M</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Högl</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefani</LastName><ForeName>Ambra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monaca</LastName><ForeName>Christelle Charley</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurophysiology and Sleep Center, University Lille North of France, CHU Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Cock</LastName><ForeName>Valérie Cochen</ForeName><Initials>VC</Initials><AffiliationInfo><Affiliation>Sleep and Neurology Unit, Beau Soleil Clinic, Montpellier, France; EuroMov, University of Montpellier, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boivin</LastName><ForeName>Michel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>GRIP, École de psychologie, Université Laval, Québec city, Quebec, Canada; Institute of Genetic, Neurobiological and Social Foundations of Child Development, Tomsk State University, Tomsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferini-Strambi</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences, Università Vita-Salute San Raffaele, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plazzi</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy; IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antelmi</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heidbreder</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Sleep Medicine and Neuromuscular Disorders, University of Muenster, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barber</LastName><ForeName>Thomas R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evetts</LastName><ForeName>Samuel G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rolinski</LastName><ForeName>Michal</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dion</LastName><ForeName>Patrick A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desautels</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Department of Neurosciences, Université de Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gagnon</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montréal, Quebec, Canada; Département de psychologie, Université du Québec à Montréal, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dupré</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Faculté de Médecine, Université Laval, CHU de Québec (Enfant-Jésus), Québec, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>Ronald B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada; Department of Neurology, Montreal General Hospital, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouleau</LastName><ForeName>Guy A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurobiol Aging</MedlineTA><NlmUniqueID>8100437</NlmUniqueID><ISSNLinking>0197-4580</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">APOE</Keyword><Keyword MajorTopicYN="N">Dementia with Lewy bodies</Keyword><Keyword MajorTopicYN="N">Genetics</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">REM sleep behavior disorder</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27814994</ArticleId><ArticleId IdType="pii">S0197-4580(16)30242-1</ArticleId><ArticleId IdType="doi">10.1016/j.neurobiolaging.2016.10.002</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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