The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.
Identifieur interne : 001733 ( PubMed/Checkpoint ); précédent : 001732; suivant : 001734The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.
Auteurs : E I Miklyaeva [Canada] ; N C Woodward ; E G Nikiforov ; G J Tompkins ; F. Klassen ; M E Ioffe ; I Q WhishawSource :
- Behavioural brain research [ 0166-4328 ] ; 1997.
English descriptors
- KwdEn :
- MESH :
- chemical , deficiency : Dopamine.
- physiology : Adaptation, Physiological, Dopamine, Motor Skills, Movement, Posture.
- physiopathology : Parkinson Disease, Secondary.
- chemical , toxicity : Oxidopamine.
- Animals, Biomechanical Phenomena, Female, Forelimb, Rats.
Abstract
Rats with unilateral dopamine (DA) depletions (hemiParkinson analogue rats) produced by intracerebral 6-hydroxydopamine injection are impaired in using the contralateral (bad) limbs for postural adjustments. This article examines whether the bad limbs are impaired in applying the forces required to initiate postural adjustments that anticipate and accompany voluntary movements. The rats were trained to reach for food using their good paw while standing on small platforms, each of which measured force changes produced by an individual limb. In one condition the force platforms were aligned to support the limb placement of normal rats and in the second they were aligned to permit the DA-depleted rats to use a compensatory reaching stance. It was found that the bad limbs of the DA-depleted rats produced normal supporting reactions but did not initiate adjustments in posture. Postural adjustments were initiated with the good limbs and preceded rather than accompanied the reaching movements. When constrained to use the posture of normal rats, the DA-deplete rats could not reach successfully, but when allowed to adjust their stance to increase reliance on the good limbs, reaching performance improved. Measures of ground reaction forces confirm that DA-depleted rats can support posture but cannot initiate postural adjustments with their impaired limbs.
PubMed: 9404623
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:9404623Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.</title><author><name sortKey="Miklyaeva, E I" sort="Miklyaeva, E I" uniqKey="Miklyaeva E" first="E I" last="Miklyaeva">E I Miklyaeva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, University of Lethbridge, Alberta, Canada. Mikliaeva@Hg.uleth.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, N C" sort="Woodward, N C" uniqKey="Woodward N" first="N C" last="Woodward">N C Woodward</name></author><author><name sortKey="Nikiforov, E G" sort="Nikiforov, E G" uniqKey="Nikiforov E" first="E G" last="Nikiforov">E G Nikiforov</name></author><author><name sortKey="Tompkins, G J" sort="Tompkins, G J" uniqKey="Tompkins G" first="G J" last="Tompkins">G J Tompkins</name></author><author><name sortKey="Klassen, F" sort="Klassen, F" uniqKey="Klassen F" first="F" last="Klassen">F. Klassen</name></author><author><name sortKey="Ioffe, M E" sort="Ioffe, M E" uniqKey="Ioffe M" first="M E" last="Ioffe">M E Ioffe</name></author><author><name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9404623</idno><idno type="pmid">9404623</idno><idno type="wicri:Area/PubMed/Corpus">001805</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001805</idno><idno type="wicri:Area/PubMed/Curation">001805</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001805</idno><idno type="wicri:Area/PubMed/Checkpoint">001805</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001805</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.</title><author><name sortKey="Miklyaeva, E I" sort="Miklyaeva, E I" uniqKey="Miklyaeva E" first="E I" last="Miklyaeva">E I Miklyaeva</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, University of Lethbridge, Alberta, Canada. Mikliaeva@Hg.uleth.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, University of Lethbridge, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Woodward, N C" sort="Woodward, N C" uniqKey="Woodward N" first="N C" last="Woodward">N C Woodward</name></author><author><name sortKey="Nikiforov, E G" sort="Nikiforov, E G" uniqKey="Nikiforov E" first="E G" last="Nikiforov">E G Nikiforov</name></author><author><name sortKey="Tompkins, G J" sort="Tompkins, G J" uniqKey="Tompkins G" first="G J" last="Tompkins">G J Tompkins</name></author><author><name sortKey="Klassen, F" sort="Klassen, F" uniqKey="Klassen F" first="F" last="Klassen">F. Klassen</name></author><author><name sortKey="Ioffe, M E" sort="Ioffe, M E" uniqKey="Ioffe M" first="M E" last="Ioffe">M E Ioffe</name></author><author><name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name></author></analytic><series><title level="j">Behavioural brain research</title><idno type="ISSN">0166-4328</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Dopamine (deficiency)</term><term>Dopamine (physiology)</term><term>Female</term><term>Forelimb</term><term>Motor Skills (physiology)</term><term>Movement (physiology)</term><term>Oxidopamine (toxicity)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Posture (physiology)</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Dopamine</term><term>Motor Skills</term><term>Movement</term><term>Posture</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biomechanical Phenomena</term><term>Female</term><term>Forelimb</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rats with unilateral dopamine (DA) depletions (hemiParkinson analogue rats) produced by intracerebral 6-hydroxydopamine injection are impaired in using the contralateral (bad) limbs for postural adjustments. This article examines whether the bad limbs are impaired in applying the forces required to initiate postural adjustments that anticipate and accompany voluntary movements. The rats were trained to reach for food using their good paw while standing on small platforms, each of which measured force changes produced by an individual limb. In one condition the force platforms were aligned to support the limb placement of normal rats and in the second they were aligned to permit the DA-depleted rats to use a compensatory reaching stance. It was found that the bad limbs of the DA-depleted rats produced normal supporting reactions but did not initiate adjustments in posture. Postural adjustments were initiated with the good limbs and preceded rather than accompanied the reaching movements. When constrained to use the posture of normal rats, the DA-deplete rats could not reach successfully, but when allowed to adjust their stance to increase reliance on the good limbs, reaching performance improved. Measures of ground reaction forces confirm that DA-depleted rats can support posture but cannot initiate postural adjustments with their impaired limbs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9404623</PMID><DateCreated><Year>1998</Year><Month>01</Month><Day>14</Day></DateCreated><DateCompleted><Year>1998</Year><Month>01</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0166-4328</ISSN><JournalIssue CitedMedium="Print"><Volume>88</Volume><Issue>2</Issue><PubDate><Year>1997</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Behavioural brain research</Title><ISOAbbreviation>Behav. Brain Res.</ISOAbbreviation></Journal><ArticleTitle>The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.</ArticleTitle><Pagination><MedlinePgn>143-52</MedlinePgn></Pagination><Abstract><AbstractText>Rats with unilateral dopamine (DA) depletions (hemiParkinson analogue rats) produced by intracerebral 6-hydroxydopamine injection are impaired in using the contralateral (bad) limbs for postural adjustments. This article examines whether the bad limbs are impaired in applying the forces required to initiate postural adjustments that anticipate and accompany voluntary movements. The rats were trained to reach for food using their good paw while standing on small platforms, each of which measured force changes produced by an individual limb. In one condition the force platforms were aligned to support the limb placement of normal rats and in the second they were aligned to permit the DA-depleted rats to use a compensatory reaching stance. It was found that the bad limbs of the DA-depleted rats produced normal supporting reactions but did not initiate adjustments in posture. Postural adjustments were initiated with the good limbs and preceded rather than accompanied the reaching movements. When constrained to use the posture of normal rats, the DA-deplete rats could not reach successfully, but when allowed to adjust their stance to increase reliance on the good limbs, reaching performance improved. Measures of ground reaction forces confirm that DA-depleted rats can support posture but cannot initiate postural adjustments with their impaired limbs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miklyaeva</LastName><ForeName>E I</ForeName><Initials>EI</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Lethbridge, Alberta, Canada. Mikliaeva@Hg.uleth.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woodward</LastName><ForeName>N C</ForeName><Initials>NC</Initials></Author><Author ValidYN="Y"><LastName>Nikiforov</LastName><ForeName>E G</ForeName><Initials>EG</Initials></Author><Author ValidYN="Y"><LastName>Tompkins</LastName><ForeName>G J</ForeName><Initials>GJ</Initials></Author><Author ValidYN="Y"><LastName>Klassen</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ioffe</LastName><ForeName>M E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Whishaw</LastName><ForeName>I Q</ForeName><Initials>IQ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Behav Brain Res</MedlineTA><NlmUniqueID>8004872</NlmUniqueID><ISSNLinking>0166-4328</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001696" MajorTopicYN="N">Biomechanical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005552" MajorTopicYN="N">Forelimb</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009048" MajorTopicYN="N">Motor Skills</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016627" MajorTopicYN="N">Oxidopamine</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>12</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>12</Month><Day>24</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>12</Month><Day>24</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9404623</ArticleId><ArticleId IdType="pii">S0166432897000430</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Ioffe, M E" sort="Ioffe, M E" uniqKey="Ioffe M" first="M E" last="Ioffe">M E Ioffe</name><name sortKey="Klassen, F" sort="Klassen, F" uniqKey="Klassen F" first="F" last="Klassen">F. Klassen</name><name sortKey="Nikiforov, E G" sort="Nikiforov, E G" uniqKey="Nikiforov E" first="E G" last="Nikiforov">E G Nikiforov</name><name sortKey="Tompkins, G J" sort="Tompkins, G J" uniqKey="Tompkins G" first="G J" last="Tompkins">G J Tompkins</name><name sortKey="Whishaw, I Q" sort="Whishaw, I Q" uniqKey="Whishaw I" first="I Q" last="Whishaw">I Q Whishaw</name><name sortKey="Woodward, N C" sort="Woodward, N C" uniqKey="Woodward N" first="N C" last="Woodward">N C Woodward</name></noCountry><country name="Canada"><noRegion><name sortKey="Miklyaeva, E I" sort="Miklyaeva, E I" uniqKey="Miklyaeva E" first="E I" last="Miklyaeva">E I Miklyaeva</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001733 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001733 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:9404623
|texte= The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:9404623" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |