Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.
Identifieur interne : 000F55 ( PubMed/Checkpoint ); précédent : 000F54; suivant : 000F56Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.
Auteurs : A H Rajput [Canada] ; H H Sitte ; A. Rajput ; M E Fenton ; C. Pifl ; O. HornykiewiczSource :
- Neurology [ 1526-632X ] ; 2008.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Chemistry (physiology), Dopamine (metabolism), Female, Globus Pallidus (chemistry), Globus Pallidus (metabolism), Globus Pallidus (pathology), Humans, Male, Middle Aged, Motor Skills Disorders (classification), Motor Skills Disorders (metabolism), Motor Skills Disorders (pathology), Parkinson Disease (classification), Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- chemical , metabolism : Dopamine.
- chemistry : Globus Pallidus.
- classification : Motor Skills Disorders, Parkinson Disease.
- metabolism : Globus Pallidus, Motor Skills Disorders, Parkinson Disease.
- pathology : Globus Pallidus, Motor Skills Disorders, Parkinson Disease.
- physiology : Brain Chemistry.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.
DOI: 10.1212/01.wnl.0000285082.18969.3a
PubMed: 18172064
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:18172064Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.</title><author><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A H" last="Rajput">A H Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Canada. ali.rajput@saskatoonhealthregion.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region</wicri:regionArea><wicri:noRegion>University of Saskatchewan/Saskatoon Health Region</wicri:noRegion></affiliation></author><author><name sortKey="Sitte, H H" sort="Sitte, H H" uniqKey="Sitte H" first="H H" last="Sitte">H H Sitte</name></author><author><name sortKey="Rajput, A" sort="Rajput, A" uniqKey="Rajput A" first="A" last="Rajput">A. Rajput</name></author><author><name sortKey="Fenton, M E" sort="Fenton, M E" uniqKey="Fenton M" first="M E" last="Fenton">M E Fenton</name></author><author><name sortKey="Pifl, C" sort="Pifl, C" uniqKey="Pifl C" first="C" last="Pifl">C. Pifl</name></author><author><name sortKey="Hornykiewicz, O" sort="Hornykiewicz, O" uniqKey="Hornykiewicz O" first="O" last="Hornykiewicz">O. Hornykiewicz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18172064</idno><idno type="pmid">18172064</idno><idno type="doi">10.1212/01.wnl.0000285082.18969.3a</idno><idno type="wicri:Area/PubMed/Corpus">000F88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F88</idno><idno type="wicri:Area/PubMed/Curation">000F88</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F88</idno><idno type="wicri:Area/PubMed/Checkpoint">000F88</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.</title><author><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A H" last="Rajput">A H Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Canada. ali.rajput@saskatoonhealthregion.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region</wicri:regionArea><wicri:noRegion>University of Saskatchewan/Saskatoon Health Region</wicri:noRegion></affiliation></author><author><name sortKey="Sitte, H H" sort="Sitte, H H" uniqKey="Sitte H" first="H H" last="Sitte">H H Sitte</name></author><author><name sortKey="Rajput, A" sort="Rajput, A" uniqKey="Rajput A" first="A" last="Rajput">A. Rajput</name></author><author><name sortKey="Fenton, M E" sort="Fenton, M E" uniqKey="Fenton M" first="M E" last="Fenton">M E Fenton</name></author><author><name sortKey="Pifl, C" sort="Pifl, C" uniqKey="Pifl C" first="C" last="Pifl">C. Pifl</name></author><author><name sortKey="Hornykiewicz, O" sort="Hornykiewicz, O" uniqKey="Hornykiewicz O" first="O" last="Hornykiewicz">O. Hornykiewicz</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Chemistry (physiology)</term><term>Dopamine (metabolism)</term><term>Female</term><term>Globus Pallidus (chemistry)</term><term>Globus Pallidus (metabolism)</term><term>Globus Pallidus (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills Disorders (classification)</term><term>Motor Skills Disorders (metabolism)</term><term>Motor Skills Disorders (pathology)</term><term>Parkinson Disease (classification)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Motor Skills Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Globus Pallidus</term><term>Motor Skills Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Globus Pallidus</term><term>Motor Skills Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Chemistry</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18172064</PMID><DateCreated><Year>2008</Year><Month>04</Month><Day>16</Day></DateCreated><DateCompleted><Year>2008</Year><Month>05</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>70</Volume><Issue>16 Pt 2</Issue><PubDate><Year>2008</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.</ArticleTitle><Pagination><MedlinePgn>1403-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/01.wnl.0000285082.18969.3a</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Globus pallidus and striatum dopamine (DA) levels were measured with high performance liquid chromatography in eight autopsy confirmed PD and five control frozen brains.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">DA levels in the external globus pallidus (GPe) of normal brains were nearly six times greater than in the internal pallidum (GPi). In PD, the mean loss of DA was marked (-82%) in GPe and moderate (-51%) in GPi. DA loss of variable degree was seen in different subdivisions of GPe and GPi in PD; however, DA levels were near normal in the ventral (rostral and caudal) GPi of PD cases with prominent tremor. There was marked loss of DA (-89%) in the caudate and severe loss (-98.4%) in the putamen in PD. The pattern of pallidal DA loss did not match the putaminal DA loss.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There is sufficient loss of dopamine (DA) in external globus pallidus and the internal globus pallidum (GPi) as may contribute to the motor manifestations of Parkinson disease (PD). The possible functional disequilibrium between GABAergic and DAergic influences in favor of DA in the caudoventral parts of the GPi may contribute to resting tremor in tremor dominant and classic PD cases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>A H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Canada. ali.rajput@saskatoonhealthregion.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sitte</LastName><ForeName>H H</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Rajput</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fenton</LastName><ForeName>M E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Pifl</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hornykiewicz</LastName><ForeName>O</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>01</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001923" MajorTopicYN="N">Brain Chemistry</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005917" MajorTopicYN="N">Globus Pallidus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019957" MajorTopicYN="N">Motor Skills Disorders</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>1</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>5</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>1</Month><Day>4</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18172064</ArticleId><ArticleId IdType="pii">01.wnl.0000285082.18969.3a</ArticleId><ArticleId IdType="doi">10.1212/01.wnl.0000285082.18969.3a</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Fenton, M E" sort="Fenton, M E" uniqKey="Fenton M" first="M E" last="Fenton">M E Fenton</name><name sortKey="Hornykiewicz, O" sort="Hornykiewicz, O" uniqKey="Hornykiewicz O" first="O" last="Hornykiewicz">O. Hornykiewicz</name><name sortKey="Pifl, C" sort="Pifl, C" uniqKey="Pifl C" first="C" last="Pifl">C. Pifl</name><name sortKey="Rajput, A" sort="Rajput, A" uniqKey="Rajput A" first="A" last="Rajput">A. Rajput</name><name sortKey="Sitte, H H" sort="Sitte, H H" uniqKey="Sitte H" first="H H" last="Sitte">H H Sitte</name></noCountry><country name="Canada"><noRegion><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A H" last="Rajput">A H Rajput</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F55 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000F55 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:18172064
|texte= Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:18172064" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |