La maladie de Parkinson au Canada (serveur d'exploration)

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Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.

Identifieur interne : 000F55 ( PubMed/Checkpoint ); précédent : 000F54; suivant : 000F56

Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.

Auteurs : A H Rajput [Canada] ; H H Sitte ; A. Rajput ; M E Fenton ; C. Pifl ; O. Hornykiewicz

Source :

RBID : pubmed:18172064

English descriptors

Abstract

Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.

DOI: 10.1212/01.wnl.0000285082.18969.3a
PubMed: 18172064


Affiliations:


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pubmed:18172064

Le document en format XML

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<name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A H" last="Rajput">A H Rajput</name>
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<nlm:affiliation>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Canada. ali.rajput@saskatoonhealthregion.ca</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Saskatchewan/Saskatoon Health Region</wicri:regionArea>
<wicri:noRegion>University of Saskatchewan/Saskatoon Health Region</wicri:noRegion>
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<name sortKey="Sitte, H H" sort="Sitte, H H" uniqKey="Sitte H" first="H H" last="Sitte">H H Sitte</name>
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<name sortKey="Rajput, A" sort="Rajput, A" uniqKey="Rajput A" first="A" last="Rajput">A. Rajput</name>
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<name sortKey="Fenton, M E" sort="Fenton, M E" uniqKey="Fenton M" first="M E" last="Fenton">M E Fenton</name>
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<name sortKey="Pifl, C" sort="Pifl, C" uniqKey="Pifl C" first="C" last="Pifl">C. Pifl</name>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain Chemistry (physiology)</term>
<term>Dopamine (metabolism)</term>
<term>Female</term>
<term>Globus Pallidus (chemistry)</term>
<term>Globus Pallidus (metabolism)</term>
<term>Globus Pallidus (pathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Skills Disorders (classification)</term>
<term>Motor Skills Disorders (metabolism)</term>
<term>Motor Skills Disorders (pathology)</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
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<term>Dopamine</term>
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<term>Globus Pallidus</term>
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<term>Motor Skills Disorders</term>
<term>Parkinson Disease</term>
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<term>Globus Pallidus</term>
<term>Motor Skills Disorders</term>
<term>Parkinson Disease</term>
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<term>Globus Pallidus</term>
<term>Motor Skills Disorders</term>
<term>Parkinson Disease</term>
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<div type="abstract" xml:lang="en">Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.</div>
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<Day>07</Day>
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<Month>11</Month>
<Day>21</Day>
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<Issue>16 Pt 2</Issue>
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<ArticleTitle>Globus pallidus dopamine and Parkinson motor subtypes: clinical and brain biochemical correlation.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The pathophysiologic basis of different PD phenotypes is unknown. This study assessed pallidal and striatal dopamine level patterns in different motor subgroups of PD and normal control brains.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Globus pallidus and striatum dopamine (DA) levels were measured with high performance liquid chromatography in eight autopsy confirmed PD and five control frozen brains.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">DA levels in the external globus pallidus (GPe) of normal brains were nearly six times greater than in the internal pallidum (GPi). In PD, the mean loss of DA was marked (-82%) in GPe and moderate (-51%) in GPi. DA loss of variable degree was seen in different subdivisions of GPe and GPi in PD; however, DA levels were near normal in the ventral (rostral and caudal) GPi of PD cases with prominent tremor. There was marked loss of DA (-89%) in the caudate and severe loss (-98.4%) in the putamen in PD. The pattern of pallidal DA loss did not match the putaminal DA loss.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There is sufficient loss of dopamine (DA) in external globus pallidus and the internal globus pallidum (GPi) as may contribute to the motor manifestations of Parkinson disease (PD). The possible functional disequilibrium between GABAergic and DAergic influences in favor of DA in the caudoventral parts of the GPi may contribute to resting tremor in tremor dominant and classic PD cases.</AbstractText>
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