Gout and the risk of Parkinson's disease: a cohort study.
Identifieur interne : 000F54 ( PubMed/Checkpoint ); précédent : 000F53; suivant : 000F55Gout and the risk of Parkinson's disease: a cohort study.
Auteurs : Mary De Vera [Canada] ; M Mushfiqur Rahman ; James Rankin ; Jacek Kopec ; Xiang Gao ; Hyon ChoiSource :
- Arthritis and rheumatism [ 0004-3591 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antioxidants (physiology), British Columbia (epidemiology), Case-Control Studies, Cohort Studies, Diuretics (therapeutic use), Female, Follow-Up Studies, Gout (blood), Gout (complications), Humans, Incidence, Male, Multivariate Analysis, Parkinson Disease (epidemiology), Parkinson Disease (prevention & control), Proportional Hazards Models, Risk Factors, Uric Acid (blood).
- MESH :
- chemical , blood : Uric Acid.
- chemical , physiology : Antioxidants.
- geographic , epidemiology : British Columbia.
- chemical , therapeutic use : Diuretics.
- blood : Gout.
- complications : Gout.
- epidemiology : Parkinson Disease.
- prevention & control : Parkinson Disease.
- Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Female, Follow-Up Studies, Humans, Incidence, Male, Multivariate Analysis, Proportional Hazards Models, Risk Factors.
Abstract
Several studies have suggested that higher serum uric acid levels lead to a lower risk of Parkinson's disease (PD) because uric acid exerts antioxidant effects on neurons. Our objective was to examine the relationship between gout and the risk of PD in persons age > or = 65 years.
DOI: 10.1002/art.24193
PubMed: 18975349
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gout and the risk of Parkinson's disease: a cohort study.</title><author><name sortKey="De Vera, Mary" sort="De Vera, Mary" uniqKey="De Vera M" first="Mary" last="De Vera">Mary De Vera</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis Research Centre of Canada and University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Arthritis Research Centre of Canada and University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, M Mushfiqur" sort="Rahman, M Mushfiqur" uniqKey="Rahman M" first="M Mushfiqur" last="Rahman">M Mushfiqur Rahman</name></author><author><name sortKey="Rankin, James" sort="Rankin, James" uniqKey="Rankin J" first="James" last="Rankin">James Rankin</name></author><author><name sortKey="Kopec, Jacek" sort="Kopec, Jacek" uniqKey="Kopec J" first="Jacek" last="Kopec">Jacek Kopec</name></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Choi, Hyon" sort="Choi, Hyon" uniqKey="Choi H" first="Hyon" last="Choi">Hyon Choi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18975349</idno><idno type="pmid">18975349</idno><idno type="doi">10.1002/art.24193</idno><idno type="wicri:Area/PubMed/Corpus">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F32</idno><idno type="wicri:Area/PubMed/Curation">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F32</idno><idno type="wicri:Area/PubMed/Checkpoint">000F32</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F32</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gout and the risk of Parkinson's disease: a cohort study.</title><author><name sortKey="De Vera, Mary" sort="De Vera, Mary" uniqKey="De Vera M" first="Mary" last="De Vera">Mary De Vera</name><affiliation wicri:level="1"><nlm:affiliation>Arthritis Research Centre of Canada and University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Arthritis Research Centre of Canada and University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, M Mushfiqur" sort="Rahman, M Mushfiqur" uniqKey="Rahman M" first="M Mushfiqur" last="Rahman">M Mushfiqur Rahman</name></author><author><name sortKey="Rankin, James" sort="Rankin, James" uniqKey="Rankin J" first="James" last="Rankin">James Rankin</name></author><author><name sortKey="Kopec, Jacek" sort="Kopec, Jacek" uniqKey="Kopec J" first="Jacek" last="Kopec">Jacek Kopec</name></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Choi, Hyon" sort="Choi, Hyon" uniqKey="Choi H" first="Hyon" last="Choi">Hyon Choi</name></author></analytic><series><title level="j">Arthritis and rheumatism</title><idno type="ISSN">0004-3591</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antioxidants (physiology)</term><term>British Columbia (epidemiology)</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Diuretics (therapeutic use)</term><term>Female</term><term>Follow-Up Studies</term><term>Gout (blood)</term><term>Gout (complications)</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Multivariate Analysis</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (prevention & control)</term><term>Proportional Hazards Models</term><term>Risk Factors</term><term>Uric Acid (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Uric Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Antioxidants</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>British Columbia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diuretics</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Gout</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Gout</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Multivariate Analysis</term><term>Proportional Hazards Models</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have suggested that higher serum uric acid levels lead to a lower risk of Parkinson's disease (PD) because uric acid exerts antioxidant effects on neurons. Our objective was to examine the relationship between gout and the risk of PD in persons age > or = 65 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18975349</PMID><DateCreated><Year>2008</Year><Month>11</Month><Day>10</Day></DateCreated><DateCompleted><Year>2009</Year><Month>01</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0004-3591</ISSN><JournalIssue CitedMedium="Print"><Volume>59</Volume><Issue>11</Issue><PubDate><Year>2008</Year><Month>Nov</Month><Day>15</Day></PubDate></JournalIssue><Title>Arthritis and rheumatism</Title><ISOAbbreviation>Arthritis Rheum.</ISOAbbreviation></Journal><ArticleTitle>Gout and the risk of Parkinson's disease: a cohort study.</ArticleTitle><Pagination><MedlinePgn>1549-54</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/art.24193</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Several studies have suggested that higher serum uric acid levels lead to a lower risk of Parkinson's disease (PD) because uric acid exerts antioxidant effects on neurons. Our objective was to examine the relationship between gout and the risk of PD in persons age > or = 65 years.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a population-based cohort study using the British Columbia Linked Health Database and PharmaCare data (i.e., prescription drug data for those age > or = 65 years). We compared incidence rates of PD between 11,258 gout patients and 56,199 controls matched on age, sex, date of gout diagnosis, and length of medical record. Cox proportional hazards models were used to estimate the relative risk (RR) of PD, adjusting for age, sex, prior comorbid conditions, and use of diuretics and nonsteroidal antiinflammatory drugs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Over an 8-year median followup, we identified 1,182 new cases of PD. Compared with individuals without gout, the multivariate RR of PD among those with gout was 0.70 (95% confidence interval [95% CI] 0.59-0.83). In subgroup analyses, the inverse association was similarly present in both sexes and was evident among those who did not use diuretics (RR 0.66, 95% CI 0.54-0.81), but not among diuretic users (RR 0.80, 95% CI 0.58-1.10, P for interaction 0.35).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our population-based data provide evidence for a protective effect of gout on the risk of PD and support the purported protective role of uric acid.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>De Vera</LastName><ForeName>Mary</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Arthritis Research Centre of Canada and University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>M Mushfiqur</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Rankin</LastName><ForeName>James</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kopec</LastName><ForeName>Jacek</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Xiang</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Hyon</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arthritis Rheum</MedlineTA><NlmUniqueID>0370605</NlmUniqueID><ISSNLinking>0004-3591</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004232">Diuretics</NameOfSubstance></Chemical><Chemical><RegistryNumber>268B43MJ25</RegistryNumber><NameOfSubstance UI="D014527">Uric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001955" MajorTopicYN="N" Type="Geographic">British Columbia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004232" MajorTopicYN="N">Diuretics</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006073" MajorTopicYN="N">Gout</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014527" MajorTopicYN="N">Uric Acid</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>11</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>1</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>11</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18975349</ArticleId><ArticleId IdType="doi">10.1002/art.24193</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Choi, Hyon" sort="Choi, Hyon" uniqKey="Choi H" first="Hyon" last="Choi">Hyon Choi</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Kopec, Jacek" sort="Kopec, Jacek" uniqKey="Kopec J" first="Jacek" last="Kopec">Jacek Kopec</name><name sortKey="Rahman, M Mushfiqur" sort="Rahman, M Mushfiqur" uniqKey="Rahman M" first="M Mushfiqur" last="Rahman">M Mushfiqur Rahman</name><name sortKey="Rankin, James" sort="Rankin, James" uniqKey="Rankin J" first="James" last="Rankin">James Rankin</name></noCountry><country name="Canada"><noRegion><name sortKey="De Vera, Mary" sort="De Vera, Mary" uniqKey="De Vera M" first="Mary" last="De Vera">Mary De Vera</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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