Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.
Identifieur interne : 000751 ( PubMed/Checkpoint ); précédent : 000750; suivant : 000752Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.
Auteurs : Andrew Vo [Canada] ; Nole M. Hiebert [Canada] ; Ken N. Seergobin [Canada] ; Stephanie Solcz [Canada] ; Allison Partridge [Canada] ; Penny A. Macdonald [Canada]Source :
- Frontiers in human neuroscience ; 2014.
Abstract
Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.
DOI: 10.3389/fnhum.2014.00784
PubMed: 25324767
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:25324767Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.</title><author><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name><affiliation wicri:level="1"><nlm:affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25324767</idno><idno type="pmid">25324767</idno><idno type="doi">10.3389/fnhum.2014.00784</idno><idno type="wicri:Area/PubMed/Corpus">000664</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000664</idno><idno type="wicri:Area/PubMed/Curation">000664</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000664</idno><idno type="wicri:Area/PubMed/Checkpoint">000664</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.</title><author><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name><affiliation wicri:level="1"><nlm:affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name><affiliation wicri:level="1"><nlm:affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in human neuroscience</title><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">25324767</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>17</Day></DateCreated><DateCompleted><Year>2014</Year><Month>10</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><JournalIssue CitedMedium="Print"><Volume>8</Volume><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Frontiers in human neuroscience</Title><ISOAbbreviation>Front Hum Neurosci</ISOAbbreviation></Journal><ArticleTitle>Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>784</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fnhum.2014.00784</ELocationID><Abstract><AbstractText>Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vo</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiebert</LastName><ForeName>Nole M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seergobin</LastName><ForeName>Ken N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solcz</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Partridge</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacDonald</LastName><ForeName>Penny A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>The Brain and Mind Institute, University of Western Ontario London, ON, Canada ; Department of Psychology, University of Western Ontario London, ON, Canada ; Department of Physiology and Pharmacology, University of Western Ontario London, ON, Canada ; Schulich School of Medicine and Dentistry, University of Western Ontario London, ON, Canada ; Department of Clinical Neurological Sciences, University of Western Ontario London, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Hum Neurosci</MedlineTA><NlmUniqueID>101477954</NlmUniqueID><ISSNLinking>1662-5161</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parkinsons Dis. 2011 Mar 06;2011:572743</RefSource><PMID Version="1">21437185</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2007 Jan;32(1):180-9</RefSource><PMID Version="1">16841074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4</RefSource><PMID Version="1">1564476</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 2004 Aug;27(8):468-74</RefSource><PMID Version="1">15271494</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Neurosci. 2004 Aug;118(4):676-86</RefSource><PMID Version="1">15301595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 2001 Dec;159(1):10-20</RefSource><PMID Version="1">11797064</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Psychol Rev. 2007 Jul;114(3):632-56</RefSource><PMID Version="1">17638499</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2006 Oct;129(Pt 10):2667-78</RefSource><PMID Version="1">16844713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Feb;28(2):153-60</RefSource><PMID Version="1">23165957</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2012 Jun;135(Pt 6):1871-83</RefSource><PMID Version="1">22508958</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):308-12</RefSource><PMID Version="1">10945804</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2007 Apr;13(3):146-51</RefSource><PMID Version="1">17055764</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 2007 Jan;10(1):126-31</RefSource><PMID Version="1">17187065</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2012 Mar 1;228(1):82-6</RefSource><PMID Version="1">22155477</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2001 Dec 11;57(11):2083-8</RefSource><PMID Version="1">11739830</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2011 May;134(Pt 5):1447-63</RefSource><PMID Version="1">21596772</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Syst Neurosci. 2010 Aug 12;4:null</RefSource><PMID Version="1">20740077</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 1988 Apr 7;318(14):876-80</RefSource><PMID Version="1">3352672</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2012 Apr;35(7):1144-51</RefSource><PMID Version="1">22487043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Jun 10;60(11):1744-9</RefSource><PMID Version="1">12796524</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2006 Jun;7(6):464-76</RefSource><PMID Version="1">16715055</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2010 Sep;205(3):375-85</RefSource><PMID Version="1">20680249</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2000;38(5):596-612</RefSource><PMID Version="1">10689037</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2009 Aug 21;460(1):6-10</RefSource><PMID Version="1">19463891</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2002 Jun 1;22(11):4563-7</RefSource><PMID Version="1">12040063</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Apr;19(4):397-405</RefSource><PMID Version="1">15077237</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Hum Neurosci. 2010 Oct 14;4:169</RefSource><PMID Version="1">21048900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2009 Aug 15;24(11):1641-9</RefSource><PMID Version="1">19514014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2006;44(5):774-84</RefSource><PMID Version="1">16150469</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Rev Neurobiol. 1997;11(4):323-42</RefSource><PMID Version="1">9336716</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1988 Apr;111 ( Pt 2):299-321</RefSource><PMID Version="1">3378138</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2003;41(11):1431-41</RefSource><PMID Version="1">12849761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2007 Jan 28;45(2):357-67</RefSource><PMID Version="1">16876208</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2013 Nov 27;310(20):2191-4</RefSource><PMID Version="1">24141714</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Learn Mem. 2009 Apr 29;16(5):324-31</RefSource><PMID Version="1">19403795</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2004 Dec 10;306(5703):1940-3</RefSource><PMID Version="1">15528409</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2006 Aug;129(Pt 8):2189-201</RefSource><PMID Version="1">16815876</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Cogn. 2009 Nov;71(2):84-91</RefSource><PMID Version="1">19442427</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroimage. 2014 Nov 1;101:448-57</RefSource><PMID Version="1">25038436</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2011 Apr 27;31(17):6296-304</RefSource><PMID Version="1">21525269</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroreport. 2005 Aug 22;16(12):1291-5</RefSource><PMID Version="1">16056127</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2007 Aug 1;27(31):8181-3</RefSource><PMID Version="1">17670964</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Neurobiol. 2004 Dec;14(6):769-76</RefSource><PMID Version="1">15582382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychopharmacology. 2006 Nov;31(11):2552-64</RefSource><PMID Version="1">16880771</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Behav Neurosci. 1993 Feb;107(1):3-22</RefSource><PMID Version="1">8447956</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychologia. 2010 Mar;48(4):1096-103</RefSource><PMID Version="1">20006629</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Biobehav Rev. 2006;30(1):1-23</RefSource><PMID Version="1">15935475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013 Sep 26;8(9):e74044</RefSource><PMID Version="1">24086309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cereb Cortex. 2001 Dec;11(12):1136-43</RefSource><PMID Version="1">11709484</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4183099</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">cognitive impairment</Keyword><Keyword MajorTopicYN="N">dopamine</Keyword><Keyword MajorTopicYN="N">learning</Keyword><Keyword MajorTopicYN="N">stimulus-response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25324767</ArticleId><ArticleId IdType="doi">10.3389/fnhum.2014.00784</ArticleId><ArticleId IdType="pmc">PMC4183099</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Vo, Andrew" sort="Vo, Andrew" uniqKey="Vo A" first="Andrew" last="Vo">Andrew Vo</name></noRegion><name sortKey="Hiebert, Nole M" sort="Hiebert, Nole M" uniqKey="Hiebert N" first="Nole M" last="Hiebert">Nole M. Hiebert</name><name sortKey="Macdonald, Penny A" sort="Macdonald, Penny A" uniqKey="Macdonald P" first="Penny A" last="Macdonald">Penny A. Macdonald</name><name sortKey="Partridge, Allison" sort="Partridge, Allison" uniqKey="Partridge A" first="Allison" last="Partridge">Allison Partridge</name><name sortKey="Seergobin, Ken N" sort="Seergobin, Ken N" uniqKey="Seergobin K" first="Ken N" last="Seergobin">Ken N. Seergobin</name><name sortKey="Solcz, Stephanie" sort="Solcz, Stephanie" uniqKey="Solcz S" first="Stephanie" last="Solcz">Stephanie Solcz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000751 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000751 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:25324767
|texte= Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:25324767" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |