Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial.
Identifieur interne : 000750 ( PubMed/Checkpoint ); précédent : 000749; suivant : 000751Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial.
Auteurs : Kit N. Simpson [États-Unis] ; Annie N. Simpson ; Patrick D. Mauldin ; Michael D. Hill ; Sharon D. Yeatts ; Judith A. Spilker ; Lydia D. Foster ; Pooja Khatri ; Renee Martin ; Edward C. Jauch ; Dawn Kleindorfer ; Yuko Y. Palesch ; Joseph P. BroderickSource :
- Stroke [ 1524-4628 ] ; 2014.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Acute Disease, Adolescent, Adult, Aged, Anesthesia, General (economics), Costs and Cost Analysis, Female, Humans, Male, Middle Aged, Stroke (economics), Stroke (therapy), Thrombolytic Therapy (economics), Tissue Plasminogen Activator (economics), Tissue Plasminogen Activator (therapeutic use), United States.
- MESH :
- chemical , economics : Tissue Plasminogen Activator.
- geographic : United States.
- economics : Anesthesia, General, Stroke, Thrombolytic Therapy.
- chemical , therapeutic use : Tissue Plasminogen Activator.
- therapy : Stroke.
- Acute Disease, Adolescent, Adult, Aged, Costs and Cost Analysis, Female, Humans, Male, Middle Aged.
Abstract
The Interventional Management of Stroke (IMS) III study tested the effect of intravenous tissue-type plasminogen activator (tPA) alone when compared with intravenous tPA followed by endovascular therapy and collected cost data to assess the economic implications of the 2 therapies. This report describes the factors affecting the costs of the initial hospitalization for acute stroke subjects from the United States.
DOI: 10.1161/STROKEAHA.113.003874
PubMed: 24876261
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial.</title><author><name sortKey="Simpson, Kit N" sort="Simpson, Kit N" uniqKey="Simpson K" first="Kit N" last="Simpson">Kit N. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston. simpsonk@musc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Simpson, Annie N" sort="Simpson, Annie N" uniqKey="Simpson A" first="Annie N" last="Simpson">Annie N. Simpson</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Mauldin, Patrick D" sort="Mauldin, Patrick D" uniqKey="Mauldin P" first="Patrick D" last="Mauldin">Patrick D. Mauldin</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Spilker, Judith A" sort="Spilker, Judith A" uniqKey="Spilker J" first="Judith A" last="Spilker">Judith A. Spilker</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D" last="Foster">Lydia D. Foster</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Renee" sort="Martin, Renee" uniqKey="Martin R" first="Renee" last="Martin">Renee Martin</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C" last="Jauch">Edward C. Jauch</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Kleindorfer, Dawn" sort="Kleindorfer, Dawn" uniqKey="Kleindorfer D" first="Dawn" last="Kleindorfer">Dawn Kleindorfer</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24876261</idno><idno type="pmid">24876261</idno><idno type="doi">10.1161/STROKEAHA.113.003874</idno><idno type="wicri:Area/PubMed/Corpus">000746</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000746</idno><idno type="wicri:Area/PubMed/Curation">000746</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000746</idno><idno type="wicri:Area/PubMed/Checkpoint">000746</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000746</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial.</title><author><name sortKey="Simpson, Kit N" sort="Simpson, Kit N" uniqKey="Simpson K" first="Kit N" last="Simpson">Kit N. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston. simpsonk@musc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Simpson, Annie N" sort="Simpson, Annie N" uniqKey="Simpson A" first="Annie N" last="Simpson">Annie N. Simpson</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Mauldin, Patrick D" sort="Mauldin, Patrick D" uniqKey="Mauldin P" first="Patrick D" last="Mauldin">Patrick D. Mauldin</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Spilker, Judith A" sort="Spilker, Judith A" uniqKey="Spilker J" first="Judith A" last="Spilker">Judith A. Spilker</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D" last="Foster">Lydia D. Foster</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Martin, Renee" sort="Martin, Renee" uniqKey="Martin R" first="Renee" last="Martin">Renee Martin</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C" last="Jauch">Edward C. Jauch</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Kleindorfer, Dawn" sort="Kleindorfer, Dawn" uniqKey="Kleindorfer D" first="Dawn" last="Kleindorfer">Dawn Kleindorfer</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation><nlm:affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author></analytic><series><title level="j">Stroke</title><idno type="eISSN">1524-4628</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Anesthesia, General (economics)</term><term>Costs and Cost Analysis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Stroke (economics)</term><term>Stroke (therapy)</term><term>Thrombolytic Therapy (economics)</term><term>Tissue Plasminogen Activator (economics)</term><term>Tissue Plasminogen Activator (therapeutic use)</term><term>United States</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Anesthesia, General</term><term>Stroke</term><term>Thrombolytic Therapy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Tissue Plasminogen Activator</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Costs and Cost Analysis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Interventional Management of Stroke (IMS) III study tested the effect of intravenous tissue-type plasminogen activator (tPA) alone when compared with intravenous tPA followed by endovascular therapy and collected cost data to assess the economic implications of the 2 therapies. This report describes the factors affecting the costs of the initial hospitalization for acute stroke subjects from the United States.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24876261</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>30</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1524-4628</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Stroke</Title><ISOAbbreviation>Stroke</ISOAbbreviation></Journal><ArticleTitle>Drivers of costs associated with reperfusion therapy in acute stroke: the Interventional Management of Stroke III Trial.</ArticleTitle><Pagination><MedlinePgn>1791-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1161/STROKEAHA.113.003874</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">The Interventional Management of Stroke (IMS) III study tested the effect of intravenous tissue-type plasminogen activator (tPA) alone when compared with intravenous tPA followed by endovascular therapy and collected cost data to assess the economic implications of the 2 therapies. This report describes the factors affecting the costs of the initial hospitalization for acute stroke subjects from the United States.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Prospective cost analysis of the US subjects was treated with intravenous tPA alone or with intravenous tPA followed by endovascular therapy in the IMS III trial. Results were compared with expected Medicare payments.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The adjusted cost of a stroke admission in the study was $35 130 for subjects treated with endovascular therapy after intravenous tPA treatment and $25 630 for subjects treated with intravenous tPA alone (P<0.0001). Significant factors related to costs included treatment group, baseline National Institutes of Health Stroke Scale, time from stroke onset to intravenous tPA, age, stroke location, and comorbid diabetes mellitus. The mean cost for subjects who had routine use of general anesthesia as part of endovascular therapy was $46 444 when compared with $30 350 for those who did not have general anesthesia. The costs of embolectomy for IMS III subjects and patients from the National Inpatient Sample cohort exceeded the Medicare diagnosis-related group payment in ≥75% of patients.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Minimizing the time to start of intravenous tPA and decreasing the use of routine general anesthesia may improve the cost-effectiveness of medical and endovascular therapy for acute stroke.</AbstractText><AbstractText Label="CLINICAL TRIAL REGISTRATION URL" NlmCategory="BACKGROUND">http://www.clinicaltrials.gov. Unique identifier: NCT00359424.</AbstractText><CopyrightInformation>© 2014 American Heart Association, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Kit N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston. simpsonk@musc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Annie N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mauldin</LastName><ForeName>Patrick D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeatts</LastName><ForeName>Sharon D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spilker</LastName><ForeName>Judith A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foster</LastName><ForeName>Lydia D</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khatri</LastName><ForeName>Pooja</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Renee</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jauch</LastName><ForeName>Edward C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kleindorfer</LastName><ForeName>Dawn</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palesch</LastName><ForeName>Yuko Y</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broderick</LastName><ForeName>Joseph P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>From the Department of Neurology and Rehabilitation Medicine, University of Cincinnati Academic Health Center, OH (J.P.B., D.K., P.K., J.A.S.); Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada (M.D.H.); and Department of Healthcare Leadership and Management (K.N.S., A.N.S.), Department of General Internal Medicine (P.D.M.), Department of Public Health Sciences (S.D.Y., L.D.F., R.M., Y.Y.P.), Department of Emergency Medicine (E.C.J.), Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>IMS III Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00359424</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>U01NS077304</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UC U01NS052220</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01NS054630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 NS054630</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 NS077304</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 NS052220</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D017428">Clinical Trial, Phase III</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Stroke</MedlineTA><NlmUniqueID>0235266</NlmUniqueID><ISSNLinking>0039-2499</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.4.21.68</RegistryNumber><NameOfSubstance UI="D010959">Tissue Plasminogen Activator</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Stroke. 2012 Apr;43(4):1131-3</RefSource><PMID Version="1">22198978</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stroke. 2012 Jun;43(6):1617-23</RefSource><PMID Version="1">22535277</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2012 Jul 18;308(3):257-64</RefSource><PMID Version="1">22797643</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2012 Jul 24;79(4):306-13</RefSource><PMID Version="1">22622858</PMID></CommentsCorrections><CommentsCorrections 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Version="1">22222475</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000208" MajorTopicYN="N">Acute Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000768" MajorTopicYN="N">Anesthesia, General</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003365" MajorTopicYN="N">Costs and Cost Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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Mauldin</name><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><name sortKey="Simpson, Annie N" sort="Simpson, Annie N" uniqKey="Simpson A" first="Annie N" last="Simpson">Annie N. Simpson</name><name sortKey="Spilker, Judith A" sort="Spilker, Judith A" uniqKey="Spilker J" first="Judith A" last="Spilker">Judith A. Spilker</name><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Simpson, Kit N" sort="Simpson, Kit N" uniqKey="Simpson K" first="Kit N" last="Simpson">Kit N. Simpson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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