The effects of dopaminergic medication on dynamic decision making in Parkinson's disease.
Identifieur interne : 000632 ( PubMed/Checkpoint ); précédent : 000631; suivant : 000633The effects of dopaminergic medication on dynamic decision making in Parkinson's disease.
Auteurs : Magda Osman [Royaume-Uni] ; Agata Ryterska [Royaume-Uni] ; Kash Karimi [Royaume-Uni] ; Lingling Tu [République populaire de Chine] ; Ignacio Obeso [Canada] ; Maarten Speekenbrink [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Neuropsychologia [ 1873-3514 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Cues, Decision Making (drug effects), Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Female, Goals, Humans, Learning (drug effects), Levodopa (pharmacology), Levodopa (therapeutic use), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (drug therapy), Task Performance and Analysis.
- MESH :
- chemical , pharmacology : Dopamine Agents, Levodopa.
- drug effects : Decision Making, Learning.
- drug therapy : Parkinson Disease.
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- Aged, Cues, Female, Goals, Humans, Male, Middle Aged, Neuropsychological Tests, Task Performance and Analysis.
Abstract
In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.
DOI: 10.1016/j.neuropsychologia.2013.10.024
PubMed: 24269857
Affiliations:
- Canada, Royaume-Uni, République populaire de Chine
- Angleterre, Grand Londres, Ontario
- Londres, Toronto
- University College de Londres, Université de Londres, Université de Toronto
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pubmed:24269857Le document en format XML
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<front><div type="abstract" xml:lang="en">In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.</div>
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<Abstract><AbstractText>In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.</AbstractText>
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