Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.
Identifieur interne : 000529 ( PubMed/Checkpoint ); précédent : 000528; suivant : 000530Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.
Auteurs : Eric J. Lenze [États-Unis] ; Benoit H. Mulsant [Canada] ; Daniel M. Blumberger [Canada] ; Jordan F. Karp [États-Unis] ; John W. Newcomer [États-Unis] ; Stewart J. Anderson [États-Unis] ; Mary Amanda Dew [États-Unis] ; Meryl A. Butters [États-Unis] ; Jacqueline A. Stack [États-Unis] ; Amy E. Begley [États-Unis] ; Charles F. Reynolds [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2015.
English descriptors
- KwdEn :
- Aged, Akathisia, Drug-Induced (etiology), Antidepressive Agents (administration & dosage), Antidepressive Agents (adverse effects), Aripiprazole (administration & dosage), Aripiprazole (adverse effects), Depressive Disorder, Treatment-Resistant (drug therapy), Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Parkinson Disease, Secondary (chemically induced), Recurrence, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antidepressive Agents, Aripiprazole.
- chemical , adverse effects : Antidepressive Agents, Aripiprazole.
- chemically induced : Parkinson Disease, Secondary.
- drug therapy : Depressive Disorder, Treatment-Resistant.
- etiology : Akathisia, Drug-Induced.
- Aged, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Recurrence, Treatment Outcome.
Abstract
Treatment-resistant major depression is common and potentially life-threatening in elderly people, in whom little is known about the benefits and risks of augmentation pharmacotherapy. We aimed to assess whether aripiprazole is associated with a higher probability of remission than is placebo.
DOI: 10.1016/S0140-6736(15)00308-6
PubMed: 26423182
Affiliations:
- Canada, États-Unis
- Floride, Missouri (État), Ontario, Pennsylvanie
- Saint-Louis (Missouri), Toronto
- Université de Toronto, École de médecine (Université Washington de Saint-Louis)
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pubmed:26423182Le document en format XML
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Lenze</name><affiliation wicri:level="4"><nlm:affiliation>Washington University School of Medicine, St Louis, MO, USA. Electronic address: lenzee@psychiatry.wustl.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington University School of Medicine, St Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H" last="Mulsant">Benoit H. 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Karp</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Newcomer, John W" sort="Newcomer, John W" uniqKey="Newcomer J" first="John W" last="Newcomer">John W. Newcomer</name><affiliation wicri:level="2"><nlm:affiliation>Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J" last="Anderson">Stewart J. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dew, Mary Amanda" sort="Dew, Mary Amanda" uniqKey="Dew M" first="Mary Amanda" last="Dew">Mary Amanda Dew</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Butters, Meryl A" sort="Butters, Meryl A" uniqKey="Butters M" first="Meryl A" last="Butters">Meryl A. Butters</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Stack, Jacqueline A" sort="Stack, Jacqueline A" uniqKey="Stack J" first="Jacqueline A" last="Stack">Jacqueline A. Stack</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Begley, Amy E" sort="Begley, Amy E" uniqKey="Begley A" first="Amy E" last="Begley">Amy E. Begley</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Reynolds, Charles F" sort="Reynolds, Charles F" uniqKey="Reynolds C" first="Charles F" last="Reynolds">Charles F. Reynolds</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Akathisia, Drug-Induced (etiology)</term><term>Antidepressive Agents (administration & dosage)</term><term>Antidepressive Agents (adverse effects)</term><term>Aripiprazole (administration & dosage)</term><term>Aripiprazole (adverse effects)</term><term>Depressive Disorder, Treatment-Resistant (drug therapy)</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Recurrence</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antidepressive Agents</term><term>Aripiprazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antidepressive Agents</term><term>Aripiprazole</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depressive Disorder, Treatment-Resistant</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Akathisia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Recurrence</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment-resistant major depression is common and potentially life-threatening in elderly people, in whom little is known about the benefits and risks of augmentation pharmacotherapy. We aimed to assess whether aripiprazole is associated with a higher probability of remission than is placebo.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26423182</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>24</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>04</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>386</Volume><Issue>10011</Issue><PubDate><Year>2015</Year><Month>Dec</Month><Day>12</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial.</ArticleTitle><Pagination><MedlinePgn>2404-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(15)00308-6</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(15)00308-6</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Treatment-resistant major depression is common and potentially life-threatening in elderly people, in whom little is known about the benefits and risks of augmentation pharmacotherapy. We aimed to assess whether aripiprazole is associated with a higher probability of remission than is placebo.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We did a randomised, double-blind, placebo-controlled trial at three centres in the USA and Canada to test the efficacy and safety of aripiprazole augmentation for adults aged older than 60 years with treatment-resistant depression (Montgomery Asberg Depression Rating Scale [MADRS] score of ≥15). Patients who did not achieve remission during a pre-trial with venlafaxine extended-release (150-300 mg/day) were randomly assigned (1:1) to the addition of aripiprazole (target dose 10 mg [maximum 15 mg] daily) daily or placebo for 12 weeks. The computer-generated randomisation was done in blocks and stratified by site. Only the database administrator and research pharmacists had knowledge of treatment assignment. The primary endpoint was remission, defined as an MADRS score of 10 or less (and at least 2 points below the score at the start of the randomised phase) at both of the final two consecutive visits, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00892047.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">From July 20, 2009, to Dec 30, 2013, we recruited 468 eligible participants, 181 (39%) of whom did not remit and were randomly assigned to aripiprazole (n=91) or placebo (n=90). A greater proportion of participants in the aripiprazole group achieved remission than did those in the placebo group (40 [44%] vs 26 [29%] participants; odds ratio [OR] 2·0 [95% CI 1·1-3·7], p=0·03; number needed to treat [NNT] 6·6 [95% CI 3·5-81·8]). Akathisia was the most common adverse effect of aripiprazole (reported in 24 [26%] of 91 participants on aripiprazole vs 11 [12%] of 90 on placebo). Compared with placebo, aripiprazole was also associated with more Parkinsonism (15 [17%] of 86 vs two [2%] of 81 participants), but not with treatment-emergent suicidal ideation (13 [21%] of 61 vs 19 [29%] of 65 participants) or other measured safety variables.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">In adults aged 60 years or older who do not achieve remission from depression with a first-line antidepressant, the addition of aripiprazole is effective in achieving and sustaining remission. Tolerability concerns include the potential for akathisia and Parkinsonism.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">National Institute of Mental Health, UPMC Endowment in Geriatric Psychiatry, Taylor Family Institute for Innovative Psychiatric Research, National Center for Advancing Translational Sciences, and the Campbell Family Mental Health Research Institute.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lenze</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Washington University School of Medicine, St Louis, MO, USA. Electronic address: lenzee@psychiatry.wustl.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulsant</LastName><ForeName>Benoit H</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blumberger</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karp</LastName><ForeName>Jordan F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newcomer</LastName><ForeName>John W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Charles E Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Stewart J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dew</LastName><ForeName>Mary Amanda</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butters</LastName><ForeName>Meryl A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stack</LastName><ForeName>Jacqueline A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Begley</LastName><ForeName>Amy E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reynolds</LastName><ForeName>Charles F</ForeName><Initials>CF</Initials><Suffix>3rd</Suffix><AffiliationInfo><Affiliation>University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00892047</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList 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HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000448</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>KL2 TR000146</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH090250</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH084921</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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Mar 3;291(9):1081-91</RefSource><PMID Version="1">14996777</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Psychopharmacol. 2004 Sep;18(3):375-83</RefSource><PMID Version="1">15358981</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2015 Dec 12;386(10011):2374-5</RefSource><PMID Version="1">26423179</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Ann Intern Med. 2016 Jan 19;164(2):JC10</RefSource><PMID Version="1">26784490</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet. 2015 Dec 12;386(10011):2394</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017109" MajorTopicYN="N">Akathisia, Drug-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000928" MajorTopicYN="N">Antidepressive Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000068180" MajorTopicYN="N">Aripiprazole</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061218" MajorTopicYN="N">Depressive Disorder, Treatment-Resistant</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004334" MajorTopicYN="N">Drug Administration Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS720946 [Available on 12/12/16]</OtherID><OtherID Source="NLM">PMC4690746 [Available on 12/12/16]</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>10</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26423182</ArticleId><ArticleId IdType="pii">S0140-6736(15)00308-6</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(15)00308-6</ArticleId><ArticleId IdType="pmc">PMC4690746</ArticleId><ArticleId IdType="mid">NIHMS720946</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li><li>Missouri (État)</li><li>Ontario</li><li>Pennsylvanie</li></region><settlement><li>Saint-Louis (Missouri)</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Lenze, Eric J" sort="Lenze, Eric J" uniqKey="Lenze E" first="Eric J" last="Lenze">Eric J. Lenze</name></region><name sortKey="Anderson, Stewart J" sort="Anderson, Stewart J" uniqKey="Anderson S" first="Stewart J" last="Anderson">Stewart J. Anderson</name><name sortKey="Begley, Amy E" sort="Begley, Amy E" uniqKey="Begley A" first="Amy E" last="Begley">Amy E. Begley</name><name sortKey="Butters, Meryl A" sort="Butters, Meryl A" uniqKey="Butters M" first="Meryl A" last="Butters">Meryl A. Butters</name><name sortKey="Dew, Mary Amanda" sort="Dew, Mary Amanda" uniqKey="Dew M" first="Mary Amanda" last="Dew">Mary Amanda Dew</name><name sortKey="Karp, Jordan F" sort="Karp, Jordan F" uniqKey="Karp J" first="Jordan F" last="Karp">Jordan F. Karp</name><name sortKey="Newcomer, John W" sort="Newcomer, John W" uniqKey="Newcomer J" first="John W" last="Newcomer">John W. Newcomer</name><name sortKey="Reynolds, Charles F" sort="Reynolds, Charles F" uniqKey="Reynolds C" first="Charles F" last="Reynolds">Charles F. Reynolds</name><name sortKey="Stack, Jacqueline A" sort="Stack, Jacqueline A" uniqKey="Stack J" first="Jacqueline A" last="Stack">Jacqueline A. Stack</name></country><country name="Canada"><region name="Ontario"><name sortKey="Mulsant, Benoit H" sort="Mulsant, Benoit H" uniqKey="Mulsant B" first="Benoit H" last="Mulsant">Benoit H. Mulsant</name></region><name sortKey="Blumberger, Daniel M" sort="Blumberger, Daniel M" uniqKey="Blumberger D" first="Daniel M" last="Blumberger">Daniel M. Blumberger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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