Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Identifieur interne : 000224 ( PubMed/Checkpoint ); précédent : 000223; suivant : 000225Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Auteurs : Zuzanna Kurowska [États-Unis] ; Jeffrey H. Kordower [États-Unis] ; A Jon Stoessl [Canada] ; Robert E. Burke [États-Unis] ; Patrik Brundin [États-Unis] ; Zhenyu Yue [États-Unis] ; Scott T. Brady [États-Unis] ; Jeffrey Milbrandt [États-Unis] ; Bruce D. Trapp [États-Unis] ; Todd B. Sherer [États-Unis] ; Satish Medicetty [États-Unis]Source :
- Journal of Parkinson's disease [ 1877-718X ] ; 2016.
Abstract
Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.
DOI: 10.3233/JPD-160881
PubMed: 27497486
Affiliations:
- Canada, États-Unis
- Illinois, Massachusetts, Michigan, Missouri (État), Ohio, État de New York
- Chicago
- Université de l'Illinois à Chicago
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Kordower</name><affiliation wicri:level="2"><nlm:affiliation>Research Center for Brain Repair, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Research Center for Brain Repair, Rush University Medical Center, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, Division of Neurology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia and Vancouver Coastal Health, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, Division of Neurology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia and Vancouver Coastal Health, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Burke, Robert E" sort="Burke, Robert E" uniqKey="Burke R" first="Robert E" last="Burke">Robert E. 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Brady</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA; Marine Biological Laboratory, Woods Hole, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA; Marine Biological Laboratory, Woods Hole, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Milbrandt, Jeffrey" sort="Milbrandt, Jeffrey" uniqKey="Milbrandt J" first="Jeffrey" last="Milbrandt">Jeffrey Milbrandt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, St. Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Trapp, Bruce D" sort="Trapp, Bruce D" uniqKey="Trapp B" first="Bruce D" last="Trapp">Bruce D. Trapp</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name><affiliation wicri:level="2"><nlm:affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Michael J. Fox Foundation for Parkinson's Research, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Medicetty, Satish" sort="Medicetty, Satish" uniqKey="Medicetty S" first="Satish" last="Medicetty">Satish Medicetty</name><affiliation wicri:level="2"><nlm:affiliation>Renovo Neural Inc., Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renovo Neural Inc., Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27497486</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>06</Day></DateCreated><DateRevised><Year>2016</Year><Month>10</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1877-718X</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>Oct</Month><Day>19</Day></PubDate></JournalIssue><Title>Journal of Parkinson's disease</Title><ISOAbbreviation>J Parkinsons Dis</ISOAbbreviation></Journal><ArticleTitle>Is Axonal Degeneration a Key Early Event in Parkinson's Disease?</ArticleTitle><Pagination><MedlinePgn>703-707</MedlinePgn></Pagination><Abstract><AbstractText>Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kurowska</LastName><ForeName>Zuzanna</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Renovo Neural Inc., Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kordower</LastName><ForeName>Jeffrey H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Research Center for Brain Repair, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stoessl</LastName><ForeName>A Jon</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Pacific Parkinson's Research Centre, Division of Neurology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia and Vancouver Coastal Health, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burke</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York City, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brundin</LastName><ForeName>Patrik</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yue</LastName><ForeName>Zhenyu</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brady</LastName><ForeName>Scott T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA; Marine Biological Laboratory, Woods Hole, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milbrandt</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trapp</LastName><ForeName>Bruce D</ForeName><Initials>BD</Initials><AffiliationInfo><Affiliation>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Renovo Neural Inc., Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sherer</LastName><ForeName>Todd B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medicetty</LastName><ForeName>Satish</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Renovo Neural Inc., Cleveland, OH, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Parkinsons Dis</MedlineTA><NlmUniqueID>101567362</NlmUniqueID><ISSNLinking>1877-7171</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson disease</Keyword><Keyword MajorTopicYN="N">animal disease models</Keyword><Keyword MajorTopicYN="N">autophagy</Keyword><Keyword MajorTopicYN="N">axonal transport</Keyword><Keyword MajorTopicYN="N">axons</Keyword><Keyword MajorTopicYN="N">dopaminergic neurons</Keyword><Keyword MajorTopicYN="N">retrograde degeneration</Keyword><Keyword MajorTopicYN="N">review</Keyword><Keyword MajorTopicYN="N">substantia nigra pars compacta</Keyword><Keyword MajorTopicYN="N">synapses</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27497486</ArticleId><ArticleId IdType="pii">JPD160881</ArticleId><ArticleId IdType="doi">10.3233/JPD-160881</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>Michigan</li><li>Missouri (État)</li><li>Ohio</li><li>État de New York</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Kurowska, Zuzanna" sort="Kurowska, Zuzanna" uniqKey="Kurowska Z" first="Zuzanna" last="Kurowska">Zuzanna Kurowska</name></region><name sortKey="Brady, Scott T" sort="Brady, Scott T" uniqKey="Brady S" first="Scott T" last="Brady">Scott T. 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