Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Identifieur interne : 000138 ( PubMed/Corpus ); précédent : 000137; suivant : 000139Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Auteurs : Zuzanna Kurowska ; Jeffrey H. Kordower ; A Jon Stoessl ; Robert E. Burke ; Patrik Brundin ; Zhenyu Yue ; Scott T. Brady ; Jeffrey Milbrandt ; Bruce D. Trapp ; Todd B. Sherer ; Satish MedicettySource :
- Journal of Parkinson's disease [ 1877-718X ] ; 2016.
Abstract
Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.
DOI: 10.3233/JPD-160881
PubMed: 27497486
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pubmed:27497486Le document en format XML
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<author><name sortKey="Kurowska, Zuzanna" sort="Kurowska, Zuzanna" uniqKey="Kurowska Z" first="Zuzanna" last="Kurowska">Zuzanna Kurowska</name>
<affiliation><nlm:affiliation>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation>
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<author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name>
<affiliation><nlm:affiliation>Pacific Parkinson's Research Centre, Division of Neurology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia and Vancouver Coastal Health, BC, Canada.</nlm:affiliation>
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<author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name>
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<author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name>
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<front><div type="abstract" xml:lang="en">Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.</div>
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<Abstract><AbstractText>Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.</AbstractText>
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