Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study
Identifieur interne : 000845 ( Pmc/Curation ); précédent : 000844; suivant : 000846Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study
Auteurs : Tanya Simuni [États-Unis] ; Chelsea Caspell-Garcia [États-Unis] ; Christopher Coffey [États-Unis] ; Lama M. Chahine [États-Unis] ; Shirley Lasch [États-Unis] ; Wolfgang H. Oertel [Allemagne] ; Geert Mayer ; Birgit Högl [Autriche] ; Ron Postuma [Canada] ; Aleksandar Videnovic [États-Unis] ; Amy Willis Amara [États-Unis] ; Ken Marek [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2015.
Abstract
This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls.
Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10.
Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (
This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.
Url:
DOI: 10.1002/mds.26248
PubMed: 26095202
PubMed Central: 4822999
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000845
Links to Exploration step
PMC:4822999Curation
No country items
Geert Mayer<affiliation><nlm:aff id="A6">Hephata-Klinik, Hephata Hessisches Diakoniezentrum e. V</nlm:aff>
<wicri:noCountry code="subfield">Hephata Hessisches Diakoniezentrum e. V</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study</title>
<author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caspell Garcia, Chelsea" sort="Caspell Garcia, Chelsea" uniqKey="Caspell Garcia C" first="Chelsea" last="Caspell-Garcia">Chelsea Caspell-Garcia</name>
<affiliation wicri:level="1"><nlm:aff id="A2">The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Iowa, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coffey, Christopher" sort="Coffey, Christopher" uniqKey="Coffey C" first="Christopher" last="Coffey">Christopher Coffey</name>
<affiliation wicri:level="1"><nlm:aff id="A2">The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Iowa, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chahine, Lama M" sort="Chahine, Lama M" uniqKey="Chahine L" first="Lama M." last="Chahine">Lama M. Chahine</name>
<affiliation wicri:level="1"><nlm:aff id="A3">The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasch, Shirley" sort="Lasch, Shirley" uniqKey="Lasch S" first="Shirley" last="Lasch">Shirley Lasch</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Institute for Neurodegenerative Disorders, New Haven, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Charitable Hertie Foundation, Frankfurt/Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Charitable Hertie Foundation, Frankfurt/Main</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name>
<affiliation><nlm:aff id="A6">Hephata-Klinik, Hephata Hessisches Diakoniezentrum e. V</nlm:aff>
<wicri:noCountry code="subfield">Hephata Hessisches Diakoniezentrum e. V</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name>
<affiliation wicri:level="1"><nlm:aff id="A8">McGill University, Montréal, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University, Montréal, Québec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Videnovic, Aleksandar" sort="Videnovic, Aleksandar" uniqKey="Videnovic A" first="Aleksandar" last="Videnovic">Aleksandar Videnovic</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amara, Amy Willis" sort="Amara, Amy Willis" uniqKey="Amara A" first="Amy Willis" last="Amara">Amy Willis Amara</name>
<affiliation wicri:level="1"><nlm:aff id="A10">UAB School of Medicine, Birmingham, AL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UAB School of Medicine, Birmingham, AL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Institute for Neurodegenerative Disorders, New Haven, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26095202</idno>
<idno type="pmc">4822999</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822999</idno>
<idno type="RBID">PMC:4822999</idno>
<idno type="doi">10.1002/mds.26248</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000845</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000845</idno>
<idno type="wicri:Area/Pmc/Curation">000845</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000845</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study</title>
<author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Northwestern University Feinberg School of Medicine, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Northwestern University Feinberg School of Medicine, Chicago, IL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Caspell Garcia, Chelsea" sort="Caspell Garcia, Chelsea" uniqKey="Caspell Garcia C" first="Chelsea" last="Caspell-Garcia">Chelsea Caspell-Garcia</name>
<affiliation wicri:level="1"><nlm:aff id="A2">The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Iowa, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coffey, Christopher" sort="Coffey, Christopher" uniqKey="Coffey C" first="Christopher" last="Coffey">Christopher Coffey</name>
<affiliation wicri:level="1"><nlm:aff id="A2">The University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Iowa, Iowa City, IA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chahine, Lama M" sort="Chahine, Lama M" uniqKey="Chahine L" first="Lama M." last="Chahine">Lama M. Chahine</name>
<affiliation wicri:level="1"><nlm:aff id="A3">The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lasch, Shirley" sort="Lasch, Shirley" uniqKey="Lasch S" first="Shirley" last="Lasch">Shirley Lasch</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Institute for Neurodegenerative Disorders, New Haven, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Charitable Hertie Foundation, Frankfurt/Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Charitable Hertie Foundation, Frankfurt/Main</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name>
<affiliation><nlm:aff id="A6">Hephata-Klinik, Hephata Hessisches Diakoniezentrum e. V</nlm:aff>
<wicri:noCountry code="subfield">Hephata Hessisches Diakoniezentrum e. V</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Innsbruck Medical University, Innsbruck, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Innsbruck Medical University, Innsbruck</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Postuma, Ron" sort="Postuma, Ron" uniqKey="Postuma R" first="Ron" last="Postuma">Ron Postuma</name>
<affiliation wicri:level="1"><nlm:aff id="A8">McGill University, Montréal, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University, Montréal, Québec</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Videnovic, Aleksandar" sort="Videnovic, Aleksandar" uniqKey="Videnovic A" first="Aleksandar" last="Videnovic">Aleksandar Videnovic</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital, Boston, MA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Amara, Amy Willis" sort="Amara, Amy Willis" uniqKey="Amara A" first="Amy Willis" last="Amara">Amy Willis Amara</name>
<affiliation wicri:level="1"><nlm:aff id="A10">UAB School of Medicine, Birmingham, AL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>UAB School of Medicine, Birmingham, AL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Institute for Neurodegenerative Disorders, New Haven, CT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (<italic>P</italic>
= 0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (<italic>P</italic>
= 0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (<italic>P</italic>
= 0.05) but not alpha-synuclein spinal fluid levels in PD.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id>
<journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
</journal-title-group>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26095202</article-id>
<article-id pub-id-type="pmc">4822999</article-id>
<article-id pub-id-type="doi">10.1002/mds.26248</article-id>
<article-id pub-id-type="manuscript">NIHMS772007</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Simuni</surname>
<given-names>Tanya</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Caspell-Garcia</surname>
<given-names>Chelsea</given-names>
</name>
<degrees>MS</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coffey</surname>
<given-names>Christopher</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chahine</surname>
<given-names>Lama M.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lasch</surname>
<given-names>Shirley</given-names>
</name>
<degrees>MBA</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oertel</surname>
<given-names>Wolfgang H.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mayer</surname>
<given-names>Geert</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Högl</surname>
<given-names>Birgit</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Postuma</surname>
<given-names>Ron</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Videnovic</surname>
<given-names>Aleksandar</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Amara</surname>
<given-names>Amy Willis</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marek</surname>
<given-names>Ken</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<on-behalf-of>for the PPMI Sleep Working group on behalf of the PPMI Investigators</on-behalf-of>
</contrib-group>
<aff id="A1"><label>1</label>
Northwestern University Feinberg School of Medicine, Chicago, IL, USA</aff>
<aff id="A2"><label>2</label>
The University of Iowa, Iowa City, IA, USA</aff>
<aff id="A3"><label>3</label>
The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</aff>
<aff id="A4"><label>4</label>
Institute for Neurodegenerative Disorders, New Haven, CT, USA</aff>
<aff id="A5"><label>5</label>
Charitable Hertie Foundation, Frankfurt/Main, Germany</aff>
<aff id="A6"><label>6</label>
Hephata-Klinik, Hephata Hessisches Diakoniezentrum e. V</aff>
<aff id="A7"><label>7</label>
Innsbruck Medical University, Innsbruck, Austria</aff>
<aff id="A8"><label>8</label>
McGill University, Montréal, Québec, Canada</aff>
<aff id="A9"><label>9</label>
Massachusetts General Hospital, Boston, MA, USA</aff>
<aff id="A10"><label>10</label>
UAB School of Medicine, Birmingham, AL, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Correspondence to: Dr. Tanya Simuni, MD, Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, 1126, Chicago, IL 60611, <email>tsimuni@nmff.org</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>1</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>9</month>
<year>2016</year>
</pub-date>
<volume>30</volume>
<issue>10</issue>
<fpage>1371</fpage>
<lpage>1381</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/mds.26248</pmc-comment>
<abstract><sec id="S1"><title>Objective</title>
<p id="P1">This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Four hundred twenty-three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (<italic>P</italic>
= 0.54). Sixty-six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (<italic>P</italic>
= 0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness-positive versus the negative group. The sleepiness-positive group had higher MDS-UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A-beta (<italic>P</italic>
= 0.05) but not alpha-synuclein spinal fluid levels in PD.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy.</p>
</sec>
</abstract>
<kwd-group><kwd>Parkinson's disease</kwd>
<kwd>daytime somnolence</kwd>
<kwd>biomarkers</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000845 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000845 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:4822999 |texte= Correlates of Excessive Daytime Sleepiness in De Novo Parkinson's Disease: A Case Control Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26095202" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |