Treatment of Alzheimer Disease With CT Scans
Identifieur interne : 000135 ( Pmc/Curation ); précédent : 000134; suivant : 000136Treatment of Alzheimer Disease With CT Scans
Auteurs : Jerry M. Cuttler [Canada] ; Eugene R. Moore [États-Unis] ; Victor D. Hosfeld [États-Unis] ; David L. Nadolski [États-Unis]Source :
- Dose-Response [ 1559-3258 ] ; 2016.
Abstract
Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patient’s adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite.
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DOI: 10.1177/1559325816640073
PubMed: 27103883
PubMed Central: 4826954
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Hosfeld</name><affiliation wicri:level="1"><nlm:aff id="aff3-1559325816640073">MidMichigan Health, Midland, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>MidMichigan Health, Midland, MI</wicri:regionArea></affiliation></author><author><name sortKey="Nadolski, David L" sort="Nadolski, David L" uniqKey="Nadolski D" first="David L." last="Nadolski">David L. Nadolski</name><affiliation wicri:level="1"><nlm:aff id="aff4-1559325816640073">Midland Internal Medicine Associates PC, Midland, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Midland Internal Medicine Associates PC, Midland, MI</wicri:regionArea></affiliation></author></analytic><series><title level="j">Dose-Response</title><idno type="eISSN">1559-3258</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patient’s adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wolk, Da" uniqKey="Wolk D">DA Wolk</name></author><author><name sortKey="Dickerson, Bc" uniqKey="Dickerson B">BC Dickerson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherva, R" uniqKey="Sherva R">R Sherva</name></author><author><name sortKey="Kowall, Nw" uniqKey="Kowall N">NW Kowall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keene, Cd" uniqKey="Keene C">CD Keene</name></author><author><name sortKey="Montine, Tj" uniqKey="Montine T">TJ Montine</name></author><author><name sortKey="Kuller, Lh" uniqKey="Kuller L">LH Kuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Relkin, N" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Dose Response</journal-id><journal-id journal-id-type="iso-abbrev">Dose Response</journal-id><journal-id journal-id-type="publisher-id">DOS</journal-id><journal-id journal-id-type="hwp">spdos</journal-id><journal-title-group><journal-title>Dose-Response</journal-title></journal-title-group><issn pub-type="epub">1559-3258</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage CA: Los Angeles, CA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27103883</article-id><article-id pub-id-type="pmc">4826954</article-id><article-id pub-id-type="doi">10.1177/1559325816640073</article-id><article-id pub-id-type="publisher-id">10.1177_1559325816640073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Treatment of Alzheimer Disease With CT Scans</article-title><subtitle>A Case Report</subtitle></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Cuttler</surname><given-names>Jerry M.</given-names></name><xref ref-type="aff" rid="aff1-1559325816640073">1</xref><xref ref-type="corresp" rid="corresp1-1559325816640073"></xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Eugene R.</given-names></name><xref ref-type="aff" rid="aff2-1559325816640073">2</xref></contrib><contrib contrib-type="author"><name><surname>Hosfeld</surname><given-names>Victor D.</given-names></name><xref ref-type="aff" rid="aff3-1559325816640073">3</xref></contrib><contrib contrib-type="author"><name><surname>Nadolski</surname><given-names>David L.</given-names></name><xref ref-type="aff" rid="aff4-1559325816640073">4</xref></contrib></contrib-group><aff id="aff1-1559325816640073"><label>1</label>Cuttler & Associates Inc, Ontario, Canada</aff><aff id="aff2-1559325816640073"><label>2</label>Dow Chemical Company, Midland, MI, USA</aff><aff id="aff3-1559325816640073"><label>3</label>MidMichigan Health, Midland, MI, USA</aff><aff id="aff4-1559325816640073"><label>4</label>Midland Internal Medicine Associates PC, Midland, MI, USA</aff><author-notes><corresp id="corresp1-1559325816640073">Jerry M. Cuttler, Cuttler & Associates Inc, 1104 - 11 Townsgate Drive, Vaughan, Ontario, Canada L4J8G4. Email: <email>jerrycuttler@rogers.com</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="collection"><season>Apr-Jun</season><year>2016</year></pub-date><volume>14</volume><issue>2</issue><elocation-id>1559325816640073</elocation-id><permissions><copyright-statement>© The Author(s) 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder content-type="sage">SAGE Publications</copyright-holder><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/3.0/">http://www.creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>).</license-p></license></permissions><abstract><p>Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patient’s adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite.</p></abstract><kwd-group><kwd>Alzheimer disease</kwd><kwd>CT scan</kwd><kwd>adaptive protection systems</kwd><kwd>ionizing radiation</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>April-June 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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