SLC Transporters as Therapeutic Targets: Emerging Opportunities
Identifieur interne : 000744 ( Pmc/Corpus ); précédent : 000743; suivant : 000745SLC Transporters as Therapeutic Targets: Emerging Opportunities
Auteurs : Lawrence Lin ; Sook Wah Yee ; Richard B. Kim ; Kathleen M. GiacominiSource :
- Nature reviews. Drug discovery [ 1474-1776 ] ; 2015.
Abstract
Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.
Url:
DOI: 10.1038/nrd4626
PubMed: 26111766
PubMed Central: 4698371
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Kim</name><affiliation><nlm:aff id="A2">Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London Health Science Centre, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Giacomini, Kathleen M" sort="Giacomini, Kathleen M" uniqKey="Giacomini K" first="Kathleen M." last="Giacomini">Kathleen M. Giacomini</name><affiliation><nlm:aff id="A1">Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institute for Human Genetics, University of California San Francisco, San Francisco, CA USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26111766</idno><idno type="pmc">4698371</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698371</idno><idno type="RBID">PMC:4698371</idno><idno type="doi">10.1038/nrd4626</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000744</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000744</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SLC Transporters as Therapeutic Targets: Emerging Opportunities</title><author><name sortKey="Lin, Lawrence" sort="Lin, Lawrence" uniqKey="Lin L" first="Lawrence" last="Lin">Lawrence Lin</name><affiliation><nlm:aff id="A1">Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Yee, Sook Wah" sort="Yee, Sook Wah" uniqKey="Yee S" first="Sook Wah" last="Yee">Sook Wah Yee</name><affiliation><nlm:aff id="A1">Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, USA</nlm:aff></affiliation></author><author><name sortKey="Kim, Richard B" sort="Kim, Richard B" uniqKey="Kim R" first="Richard B." last="Kim">Richard B. Kim</name><affiliation><nlm:aff id="A2">Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London Health Science Centre, London, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Giacomini, Kathleen M" sort="Giacomini, Kathleen M" uniqKey="Giacomini K" first="Kathleen M." last="Giacomini">Kathleen M. Giacomini</name><affiliation><nlm:aff id="A1">Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Institute for Human Genetics, University of California San Francisco, San Francisco, CA USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature reviews. Drug discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101124171</journal-id><journal-id journal-id-type="pubmed-jr-id">29776</journal-id><journal-id journal-id-type="nlm-ta">Nat Rev Drug Discov</journal-id><journal-id journal-id-type="iso-abbrev">Nat Rev Drug Discov</journal-id><journal-title-group><journal-title>Nature reviews. Drug discovery</journal-title></journal-title-group><issn pub-type="ppub">1474-1776</issn><issn pub-type="epub">1474-1784</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26111766</article-id><article-id pub-id-type="pmc">4698371</article-id><article-id pub-id-type="doi">10.1038/nrd4626</article-id><article-id pub-id-type="manuscript">NIHMS738780</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>SLC Transporters as Therapeutic Targets: Emerging Opportunities</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Lawrence</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yee</surname><given-names>Sook Wah</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Richard B.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Giacomini</surname><given-names>Kathleen M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California, USA</aff><aff id="A2"><label>2</label>Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London Health Science Centre, London, Ontario, Canada</aff><aff id="A3"><label>3</label>Institute for Human Genetics, University of California San Francisco, San Francisco, CA USA</aff><author-notes><corresp id="FN1">Corresponding Author: Kathleen M. Giacomini, <email>kathy.giacomini@ucsf.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>26</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>04</day><month>1</month><year>2016</year></pub-date><volume>14</volume><issue>8</issue><fpage>543</fpage><lpage>560</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nrd4626</pmc-comment>
<abstract><p id="P1">Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that facilitate the transport of a wide array of substrates across biological membranes — have important roles in physiological processes ranging from the cellular uptake of nutrients to the absorption of drugs and other xenobiotics. Several classes of marketed drugs target well-known SLC transporters, such as neurotransmitter transporters, and human genetic studies have provided powerful insight into the roles of more-recently characterized SLC transporters in both rare and common diseases, indicating a wealth of new therapeutic opportunities. This Review summarizes knowledge on the roles of SLC transporters in human disease, describes strategies to target such transporters, and highlights current and investigational drugs that modulate SLC transporters, as well as promising drug targets.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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