Medulloblastomics: The End of the Beginning
Identifieur interne : 000743 ( Pmc/Corpus ); précédent : 000742; suivant : 000744Medulloblastomics: The End of the Beginning
Auteurs : Paul A. Northcott ; David Tw Jones ; Marcel Kool ; Giles W. Robinson ; Richard J. Gilbertson ; Yoon-Jae Cho ; Scott L. Pomeroy ; Andrey Korshunov ; Peter Lichter ; Michael D. Taylor ; Stefan M. PfisterSource :
- Nature reviews. Cancer [ 1474-175X ] ; 2012.
Abstract
Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.
Url:
DOI: 10.1038/nrc3410
PubMed: 23175120
PubMed Central: 3889646
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PMC:3889646Le document en format XML
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<affiliation><nlm:aff id="A10">Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Buildings, 1 King’s College Circle, 6th Floor, Toronto, Ontario, Canada, M5S 1A8</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Medulloblastomics: The End of the Beginning</title>
<author><name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A" last="Northcott">Paul A. Northcott</name>
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<author><name sortKey="Robinson, Giles W" sort="Robinson, Giles W" uniqKey="Robinson G" first="Giles W" last="Robinson">Giles W. Robinson</name>
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<author><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. Gilbertson</name>
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<author><name sortKey="Cho, Yoon Jae" sort="Cho, Yoon Jae" uniqKey="Cho Y" first="Yoon-Jae" last="Cho">Yoon-Jae Cho</name>
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</affiliation>
<affiliation><nlm:aff id="A9">Developmental & Stem Cell Biology Program, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, Ontario, Canada, M5G 1L7</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A10">Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Buildings, 1 King’s College Circle, 6th Floor, Toronto, Ontario, Canada, M5S 1A8</nlm:aff>
</affiliation>
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<author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name>
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<affiliation><nlm:aff id="A11">Department of Pediatric Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany, 69120</nlm:aff>
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<series><title level="j">Nature reviews. Cancer</title>
<idno type="ISSN">1474-175X</idno>
<idno type="eISSN">1474-1768</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101124168</journal-id>
<journal-id journal-id-type="pubmed-jr-id">27016</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Rev Cancer</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat. Rev. Cancer</journal-id>
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<article-id pub-id-type="pmc">3889646</article-id>
<article-id pub-id-type="doi">10.1038/nrc3410</article-id>
<article-id pub-id-type="manuscript">NIHMS440649</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Medulloblastomics: The End of the Beginning</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Northcott</surname>
<given-names>Paul A</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>David TW</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kool</surname>
<given-names>Marcel</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Robinson</surname>
<given-names>Giles W</given-names>
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<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Gilbertson</surname>
<given-names>Richard J</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cho</surname>
<given-names>Yoon-Jae</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pomeroy</surname>
<given-names>Scott L</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
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<contrib contrib-type="author"><name><surname>Korshunov</surname>
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<contrib contrib-type="author"><name><surname>Lichter</surname>
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<contrib contrib-type="author"><name><surname>Taylor</surname>
<given-names>Michael D</given-names>
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<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A9">9</xref>
<xref ref-type="aff" rid="A10">10</xref>
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<contrib contrib-type="author"><name><surname>Pfister</surname>
<given-names>Stefan M</given-names>
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<xref ref-type="aff" rid="A11">11</xref>
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<aff id="A1"><label>1</label>
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff>
<aff id="A2"><label>2</label>
Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105</aff>
<aff id="A3"><label>3</label>
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Building, Rm P213, Palo Alto, CA, United States, 94305</aff>
<aff id="A4"><label>4</label>
Department of Neurology, Harvard Medical School, Boston Children’s Hospital, Fegan 1103, 300 Longwood Avenue, Boston, MA, United States, 02115</aff>
<aff id="A5"><label>5</label>
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA, 02142</aff>
<aff id="A6"><label>6</label>
CCU Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff>
<aff id="A7"><label>7</label>
Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff>
<aff id="A8"><label>8</label>
Department of Surgery, Division of Neurosurgery and Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Hill 1503, Toronto, Ontario, Canada, M5G 1X8</aff>
<aff id="A9"><label>9</label>
Developmental & Stem Cell Biology Program, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, Ontario, Canada, M5G 1L7</aff>
<aff id="A10"><label>10</label>
Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Buildings, 1 King’s College Circle, 6th Floor, Toronto, Ontario, Canada, M5S 1A8</aff>
<aff id="A11"><label>11</label>
Department of Pediatric Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany, 69120</aff>
<author-notes><corresp id="CR1">Correspondence to: <email>mdtaylor@sickkids.ca</email>
or <email>s.pfister@dkfz-heidelberg.de</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>23</day>
<month>5</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>13</day>
<month>1</month>
<year>2014</year>
</pub-date>
<volume>12</volume>
<issue>12</issue>
<fpage>818</fpage>
<lpage>834</lpage>
<pmc-comment>elocation-id from pubmed: 10.1038/nrc3410</pmc-comment>
<abstract><p id="P1">Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
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<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
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<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
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<award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source>
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