Medulloblastomics: The End of the Beginning
Identifieur interne : 000743 ( Pmc/Corpus ); précédent : 000742; suivant : 000744Medulloblastomics: The End of the Beginning
Auteurs : Paul A. Northcott ; David Tw Jones ; Marcel Kool ; Giles W. Robinson ; Richard J. Gilbertson ; Yoon-Jae Cho ; Scott L. Pomeroy ; Andrey Korshunov ; Peter Lichter ; Michael D. Taylor ; Stefan M. PfisterSource :
- Nature reviews. Cancer [ 1474-175X ] ; 2012.
Abstract
Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.
Url:
DOI: 10.1038/nrc3410
PubMed: 23175120
PubMed Central: 3889646
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Northcott</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Jones, David Tw" sort="Jones, David Tw" uniqKey="Jones D" first="David Tw" last="Jones">David Tw Jones</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Robinson, Giles W" sort="Robinson, Giles W" uniqKey="Robinson G" first="Giles W" last="Robinson">Giles W. Robinson</name><affiliation><nlm:aff id="A2">Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105</nlm:aff></affiliation></author><author><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. 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Pfister</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Pediatric Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany, 69120</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23175120</idno><idno type="pmc">3889646</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889646</idno><idno type="RBID">PMC:3889646</idno><idno type="doi">10.1038/nrc3410</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000743</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000743</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Medulloblastomics: The End of the Beginning</title><author><name sortKey="Northcott, Paul A" sort="Northcott, Paul A" uniqKey="Northcott P" first="Paul A" last="Northcott">Paul A. Northcott</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Jones, David Tw" sort="Jones, David Tw" uniqKey="Jones D" first="David Tw" last="Jones">David Tw Jones</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Kool, Marcel" sort="Kool, Marcel" uniqKey="Kool M" first="Marcel" last="Kool">Marcel Kool</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Robinson, Giles W" sort="Robinson, Giles W" uniqKey="Robinson G" first="Giles W" last="Robinson">Giles W. Robinson</name><affiliation><nlm:aff id="A2">Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105</nlm:aff></affiliation></author><author><name sortKey="Gilbertson, Richard J" sort="Gilbertson, Richard J" uniqKey="Gilbertson R" first="Richard J" last="Gilbertson">Richard J. Gilbertson</name><affiliation><nlm:aff id="A2">Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105</nlm:aff></affiliation></author><author><name sortKey="Cho, Yoon Jae" sort="Cho, Yoon Jae" uniqKey="Cho Y" first="Yoon-Jae" last="Cho">Yoon-Jae Cho</name><affiliation><nlm:aff id="A3">Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Building, Rm P213, Palo Alto, CA, United States, 94305</nlm:aff></affiliation></author><author><name sortKey="Pomeroy, Scott L" sort="Pomeroy, Scott L" uniqKey="Pomeroy S" first="Scott L" last="Pomeroy">Scott L. Pomeroy</name><affiliation><nlm:aff id="A4">Department of Neurology, Harvard Medical School, Boston Children’s Hospital, Fegan 1103, 300 Longwood Avenue, Boston, MA, United States, 02115</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA, 02142</nlm:aff></affiliation></author><author><name sortKey="Korshunov, Andrey" sort="Korshunov, Andrey" uniqKey="Korshunov A" first="Andrey" last="Korshunov">Andrey Korshunov</name><affiliation><nlm:aff id="A6">CCU Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name><affiliation><nlm:aff id="A7">Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D" last="Taylor">Michael D. Taylor</name><affiliation><nlm:aff id="A8">Department of Surgery, Division of Neurosurgery and Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Hill 1503, Toronto, Ontario, Canada, M5G 1X8</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Developmental & Stem Cell Biology Program, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, Ontario, Canada, M5G 1L7</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Buildings, 1 King’s College Circle, 6th Floor, Toronto, Ontario, Canada, M5S 1A8</nlm:aff></affiliation></author><author><name sortKey="Pfister, Stefan M" sort="Pfister, Stefan M" uniqKey="Pfister S" first="Stefan M" last="Pfister">Stefan M. Pfister</name><affiliation><nlm:aff id="A1">Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Department of Pediatric Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany, 69120</nlm:aff></affiliation></author></analytic><series><title level="j">Nature reviews. Cancer</title><idno type="ISSN">1474-175X</idno><idno type="eISSN">1474-1768</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101124168</journal-id><journal-id journal-id-type="pubmed-jr-id">27016</journal-id><journal-id journal-id-type="nlm-ta">Nat Rev Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Rev. Cancer</journal-id><journal-title-group><journal-title>Nature reviews. Cancer</journal-title></journal-title-group><issn pub-type="ppub">1474-175X</issn><issn pub-type="epub">1474-1768</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23175120</article-id><article-id pub-id-type="pmc">3889646</article-id><article-id pub-id-type="doi">10.1038/nrc3410</article-id><article-id pub-id-type="manuscript">NIHMS440649</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Medulloblastomics: The End of the Beginning</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Northcott</surname><given-names>Paul A</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>David TW</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kool</surname><given-names>Marcel</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Robinson</surname><given-names>Giles W</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Gilbertson</surname><given-names>Richard J</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Yoon-Jae</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pomeroy</surname><given-names>Scott L</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Korshunov</surname><given-names>Andrey</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lichter</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Michael D</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Pfister</surname><given-names>Stefan M</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A11">11</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff><aff id="A2"><label>2</label>Departments of Developmental Neurobiology and Oncology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis TN 38105</aff><aff id="A3"><label>3</label>Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Building, Rm P213, Palo Alto, CA, United States, 94305</aff><aff id="A4"><label>4</label>Department of Neurology, Harvard Medical School, Boston Children’s Hospital, Fegan 1103, 300 Longwood Avenue, Boston, MA, United States, 02115</aff><aff id="A5"><label>5</label>Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA, 02142</aff><aff id="A6"><label>6</label>CCU Neuropathology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff><aff id="A7"><label>7</label>Division of Molecular Genetics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany, 69120</aff><aff id="A8"><label>8</label>Department of Surgery, Division of Neurosurgery and Labatt Brain Tumour Research Centre, The Hospital for Sick Children, 555 University Avenue, Hill 1503, Toronto, Ontario, Canada, M5G 1X8</aff><aff id="A9"><label>9</label>Developmental & Stem Cell Biology Program, The Hospital for Sick Children, 101 College Street, TMDT-11-401M, Toronto, Ontario, Canada, M5G 1L7</aff><aff id="A10"><label>10</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Buildings, 1 King’s College Circle, 6th Floor, Toronto, Ontario, Canada, M5S 1A8</aff><aff id="A11"><label>11</label>Department of Pediatric Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 430, Heidelberg, Germany, 69120</aff><author-notes><corresp id="CR1">Correspondence to: <email>mdtaylor@sickkids.ca</email> or <email>s.pfister@dkfz-heidelberg.de</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>1</month><year>2014</year></pub-date><volume>12</volume><issue>12</issue><fpage>818</fpage><lpage>834</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nrc3410</pmc-comment>
<abstract><p id="P1">Subgrouping of medulloblastoma by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. Here, we summarize the ’explosion’ of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are making their way into contemporary clinical trials as we seek to integrate conventional and molecularly targeted therapies.</p></abstract><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA159859 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA148699 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA129541 || CA</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA109467 || CA</award-id></award-group><award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source><award-id>P30 HD018655 || HD</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA096832 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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