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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease</title><author><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I. H." last="Richard">I. H. Richard</name></author><author><name sortKey="Mcdermott, M P" sort="Mcdermott, M P" uniqKey="Mcdermott M" first="M. P." last="Mcdermott">M. P. Mcdermott</name></author><author><name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name></author><author><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J. M." last="Lyness">J. M. Lyness</name></author><author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name></author><author><name sortKey="Pearson, N" sort="Pearson, N" uniqKey="Pearson N" first="N." last="Pearson">N. Pearson</name></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name></author><author><name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name></author><author><name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. Shulman</name></author><author><name sortKey="Fernandez, H H" sort="Fernandez, H H" uniqKey="Fernandez H" first="H. H." last="Fernandez">H. H. Fernandez</name></author><author><name sortKey="Black, K J" sort="Black, K J" uniqKey="Black K" first="K. J." last="Black">K. J. Black</name></author><author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M." last="Panisset">M. Panisset</name></author><author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C. W." last="Christine">C. W. Christine</name></author><author><name sortKey="Jiang, W" sort="Jiang, W" uniqKey="Jiang W" first="W." last="Jiang">W. Jiang</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Horn, S" sort="Horn, S" uniqKey="Horn S" first="S." last="Horn">S. Horn</name></author><author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R." last="Pfeiffer">R. Pfeiffer</name></author><author><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D." last="Rottenberg">D. Rottenberg</name></author><author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J." last="Slevin">J. Slevin</name></author><author><name sortKey="Elmer, L" sort="Elmer, L" uniqKey="Elmer L" first="L." last="Elmer">L. Elmer</name></author><author><name sortKey="Press, D" sort="Press, D" uniqKey="Press D" first="D." last="Press">D. Press</name></author><author><name sortKey="Hyson, H C" sort="Hyson, H C" uniqKey="Hyson H" first="H. C." last="Hyson">H. C. Hyson</name></author><author><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W." last="Mcdonald">W. Mcdonald</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22496199</idno><idno type="pmc">3324323</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324323</idno><idno type="RBID">PMC:3324323</idno><idno type="doi">10.1212/WNL.0b013e3182516244</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000630</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000630</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease</title><author><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I. H." last="Richard">I. H. Richard</name></author><author><name sortKey="Mcdermott, M P" sort="Mcdermott, M P" uniqKey="Mcdermott M" first="M. P." last="Mcdermott">M. P. Mcdermott</name></author><author><name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name></author><author><name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J. M." last="Lyness">J. M. Lyness</name></author><author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name></author><author><name sortKey="Pearson, N" sort="Pearson, N" uniqKey="Pearson N" first="N." last="Pearson">N. Pearson</name></author><author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name></author><author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name></author><author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name></author><author><name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name></author><author><name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name></author><author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name></author><author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. Shulman</name></author><author><name sortKey="Fernandez, H H" sort="Fernandez, H H" uniqKey="Fernandez H" first="H. H." last="Fernandez">H. H. Fernandez</name></author><author><name sortKey="Black, K J" sort="Black, K J" uniqKey="Black K" first="K. J." last="Black">K. J. Black</name></author><author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M." last="Panisset">M. Panisset</name></author><author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C. W." last="Christine">C. W. Christine</name></author><author><name sortKey="Jiang, W" sort="Jiang, W" uniqKey="Jiang W" first="W." last="Jiang">W. Jiang</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Horn, S" sort="Horn, S" uniqKey="Horn S" first="S." last="Horn">S. Horn</name></author><author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R." last="Pfeiffer">R. Pfeiffer</name></author><author><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D." last="Rottenberg">D. Rottenberg</name></author><author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J." last="Slevin">J. Slevin</name></author><author><name sortKey="Elmer, L" sort="Elmer, L" uniqKey="Elmer L" first="L." last="Elmer">L. Elmer</name></author><author><name sortKey="Press, D" sort="Press, D" uniqKey="Press D" first="D." last="Press">D. Press</name></author><author><name sortKey="Hyson, H C" sort="Hyson, H C" uniqKey="Hyson H" first="H. C." last="Hyson">H. C. Hyson</name></author><author><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W." last="Mcdonald">W. Mcdonald</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n = 34), or placebo (n = 39). Subjects met <italic>DSM-IV</italic> criteria for a depressive disorder, or operationally defined subsyndromal depression, and scored >12 on the first 17 items of the Hamilton Rating Scale for Depression (HAM-D). Subjects were followed for 12 weeks (6-week dosage adjustment, 6-week maintenance). Maximum daily dosages were 40 mg for paroxetine and 225 mg for venlafaxine XR. The primary outcome measure was change in the HAM-D score from baseline to week 12.</p></sec><sec><title>Results:</title><p>Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3, <italic>p</italic> = 0.0007) in the paroxetine group and 4.2 points (97.5% CI 0.1 to 8.4, <italic>p</italic> = 0.02) in the venlafaxine XR group. No treatment effects were seen on motor function.</p></sec><sec><title>Conclusions:</title><p>Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function.</p></sec><sec><title>Classification of Evidence:</title><p>This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-id journal-id-type="iso-abbrev">Neurology</journal-id><journal-id journal-id-type="hwp">neurology</journal-id><journal-id journal-id-type="publisher-id">neur</journal-id><journal-id journal-id-type="pmc">neurology</journal-id><journal-id journal-id-type="publisher-id">WNL</journal-id><journal-title-group><journal-title>Neurology</journal-title></journal-title-group><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name><publisher-loc>Hagerstown, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22496199</article-id><article-id pub-id-type="pmc">3324323</article-id><article-id pub-id-type="publisher-id">WNL203639</article-id><article-id pub-id-type="doi">10.1212/WNL.0b013e3182516244</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>20</subject><subject>321</subject><subject>165</subject><subject>239</subject></subj-group><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Richard</surname><given-names>I.H.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>McDermott</surname><given-names>M.P.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Kurlan</surname><given-names>R.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Lyness</surname><given-names>J.M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Como</surname><given-names>P.G.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Pearson</surname><given-names>N.</given-names></name><degrees>RN, MS</degrees></contrib><contrib contrib-type="author"><name><surname>Factor</surname><given-names>S.A.</given-names></name><degrees>DO</degrees></contrib><contrib contrib-type="author"><name><surname>Juncos</surname><given-names>J.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Serrano Ramos</surname><given-names>C.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Brodsky</surname><given-names>M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Manning</surname><given-names>C.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Marsh</surname><given-names>L.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Shulman</surname><given-names>L.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Fernandez</surname><given-names>H.H.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Black</surname><given-names>K.J.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Panisset</surname><given-names>M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Christine</surname><given-names>C.W.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>W.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Singer</surname><given-names>C.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Horn</surname><given-names>S.</given-names></name><degrees>DO</degrees></contrib><contrib contrib-type="author"><name><surname>Pfeiffer</surname><given-names>R.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Rottenberg</surname><given-names>D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Slevin</surname><given-names>J.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Elmer</surname><given-names>L.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Press</surname><given-names>D.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hyson</surname><given-names>H.C.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>McDonald</surname><given-names>W.</given-names></name><degrees>MD</degrees></contrib><on-behalf-of>For the SAD-PD Study Group</on-behalf-of><aff>From the University of Rochester (I.H.R., M.P.M., R.K., J.M.L., P.G.C., N.P.), Rochester, NY; Atlantic Neuroscience Institute (R.K.), Summit, NJ; Emory University (S.A.F., J.J., W.M.), Atlanta, GA; University of Puerto Rico (C.S.R.), San Juan; Oregon Health Sciences University (M.B.), Portland; University of Virginia (C.M.), Charlottesville; Johns Hopkins University (L.M.), Baltimore, MD; University of Maryland (L.S.), College Park; University of Florida (H.H.F.), Gainesville; Washington University (K.J.B.), St. Louis, MO; Hotel-Dieu Hospital-CHUM, Notre Dame (M.P.), Montreal, Canada; University of California San Francisco (C.W.C.), San Francisco; Duke University (W.J.), Durham, NC; University of Miami (C.S.), Miami, FL; University of Pennsylvania (S.H.), Philadelphia; University of Tennessee (R.P.), Knoxville; University of Minnesota (D.R.), Minneapolis; University of Kentucky (J.S.), Lexington; Medical University of Ohio (L.E.), Toledo; Beth Israel Deaconess (D.P.), Boston, MA; London Health Sciences Centre (H.C.H.), London, Canada.</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Richard</surname><given-names>Irene</given-names></name><role>PI</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>McDonald</surname><given-names>William</given-names></name><role>Co-PI</role><aff>Emory University</aff></contrib><contrib contrib-type="author"><name><surname>McDermott</surname><given-names>Michael</given-names></name><role>Chief Biostatistician</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Como</surname><given-names>Peter G.</given-names></name><role>Neuropsychologist</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Kurlan</surname><given-names>Roger</given-names></name><role>Investigator Representative</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Lyness</surname><given-names>Jeffrey M.</given-names></name><role>Geriatric Psychiatry Consultant</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Pearson</surname><given-names>Nancy</given-names></name><role>Project Manager</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Sommerfeld</surname><given-names>Barbara</given-names></name><degrees>MSN, RN</degrees><role>Coordinator</role><aff>Emory University</aff></contrib><contrib contrib-type="author"><name><surname>Deeley</surname><given-names>Cheryl</given-names></name><degrees>MS RNc</degrees><role>Coordinator</role><aff>University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>de la Torre</surname><given-names>Tania</given-names></name><degrees>MD</degrees><role>Coordinator</role><aff>University of Puerto Rico</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Barnard</surname><given-names>Michele</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>April</given-names></name><role>Coordinator</role></contrib><aff>Oregon Health and Sciences University</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Lincoln</surname><given-names>Maryann</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Damgaard</surname><given-names>Paula</given-names></name><degrees>RN, CCRC</degrees><role>Coordinator</role></contrib><aff>University of Virginia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Gerstenhaber</surname><given-names>Melissa</given-names></name><degrees>RNC MSN</degrees><role>Coordinator</role></contrib><aff>Johns Hopkins University</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Dustin</surname><given-names>Kelly</given-names></name><degrees>RN, MS, CCRC</degrees><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Zappala</surname><given-names>Nancy</given-names></name><degrees>RN</degrees><role>Coordinator</role></contrib><aff>University of Maryland</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Swartz</surname><given-names>Camille</given-names></name><role>Coordinator</role></contrib><aff>University of Florida</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Creech</surname><given-names>Mary</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Shipley</surname><given-names>Elda</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Blankenship</surname><given-names>Samantha</given-names></name><degrees>MSW</degrees><role>Coordinator</role></contrib><aff>Washington University</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Beland</surname><given-names>Monica</given-names></name><role>Coordinator</role><aff>Hotel-Dieu Hospital-CHUM, Notre Dame</aff></contrib><contrib contrib-type="author"><name><surname>Roth</surname><given-names>Jessie</given-names></name><degrees>RN</degrees><role>Coordinator</role><aff>University of California San Francisco</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Burnette</surname><given-names>Heather</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Foxworth</surname><given-names>Tamara</given-names></name><role>Coordinator</role></contrib><aff>Duke University</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Quesada</surname><given-names>Monica</given-names></name><degrees>MA</degrees><role>Coordinator</role><aff>University of Miami</aff></contrib><contrib contrib-type="author"><name><surname>Lloyd</surname><given-names>Mary</given-names></name><degrees>RN, PhD</degrees><role>Coordinator</role><aff>University of Pennsylvania</aff></contrib><contrib contrib-type="author"><name><surname>Pfeiffer</surname><given-names>Brenda</given-names></name><degrees>RN, BSN</degrees><role>Coordinator</role><aff>University of Tennessee</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Hansen</surname><given-names>Joy</given-names></name><degrees>MSN, RN</degrees><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Folie</surname><given-names>Joy</given-names></name><role>Coordinator</role></contrib><aff>University of Minnesota</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Wagner</surname><given-names>Renee</given-names></name><degrees>RN CCRC</degrees><role>Coordinator</role></contrib><aff>University of Kentucky</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Spears</surname><given-names>Julia</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Colleen</given-names></name><role>Coordinator</role></contrib><aff>Medical University of Ohio</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Rachel</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Iguchi</surname><given-names>Lisa</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Lim</surname><given-names>Chen</given-names></name><role>Coordinator</role></contrib><aff>Beth Israel Deaconess</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>LaDonna</surname><given-names>Kori</given-names></name><role>Coordinator</role></contrib><contrib contrib-type="author"><name><surname>Megens</surname><given-names>Julie</given-names></name><degrees>RN</degrees><role>Coordinator</role></contrib><aff>London Health Sciences Centre</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Menza</surname><given-names>Matthew</given-names></name><role>DSMB Members</role><aff>Chair, Robert Wood Johnson</aff></contrib><contrib contrib-type="author"><name><surname>Cummings</surname><given-names>Jeffrey</given-names></name><role>DSMB Members</role><aff>UCLA</aff></contrib><contrib contrib-type="author"><name><surname>Hamer</surname><given-names>Robert</given-names></name><role>DSMB Members</role><aff>UNC</aff></contrib><contrib contrib-type="author"><name><surname>Shannon</surname><given-names>Kathleen</given-names></name><role>DSMB Members</role><aff>RushUniversity</aff></contrib><contrib contrib-type="author"><name><surname>Odenkirchen</surname><given-names>Joanne</given-names></name><role>NINDS Staff</role><aff>DSMB</aff></contrib><contrib contrib-type="author"><name><surname>Conwit</surname><given-names>Robin</given-names></name><role>NINDS Staff</role><aff>Program Officer</aff></contrib><contrib contrib-type="author"><name><surname>Beck</surname><given-names>Christopher</given-names></name><role>Additional SAD-PD Personnel</role><aff>Statistician, University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>LaDonna</surname><given-names>Donna</given-names></name><role>Additional SAD-PD Personnel</role><aff>Administrator, University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Bausch</surname><given-names>Jan</given-names></name><role>Additional SAD-PD Personnel</role><aff>Biostatistics Programmer, University of Rochester</aff></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Scott</given-names></name><role>Additional SAD-PD Personnel</role><aff>MaCAT Consultant, University of Michigan</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Chismar</surname><given-names>Ron</given-names></name><degrees>RN</degrees><role>Additional SAD-PD Personnel</role></contrib><contrib contrib-type="author"><name><surname>Quinn</surname><given-names>Sinead</given-names></name><role>Additional SAD-PD Personnel</role></contrib><aff>Rating Scale Evaluators, Emory University</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Bean</surname><given-names>Steve</given-names></name><role>Additional SAD-PD Personnel</role></contrib><aff>Pharmacist, University of Rochester</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Daigneault</surname><given-names>Susan</given-names></name><role>Additional SAD-PD Personnel</role></contrib><contrib contrib-type="author"><name><surname>Lindsay</surname><given-names>Patricia</given-names></name><role>Additional SAD-PD Personnel</role></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>Tori</given-names></name><role>Additional SAD-PD Personnel</role></contrib><aff>CTCC Staff, University of Rochester</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Kompoliti</surname><given-names>Katie</given-names></name><role>Medical Monitor</role></contrib><aff>Rush University</aff></contrib-group><author-notes><fn fn-type="other"><p><italic>Study funding:</italic> Supported by NIH/NINDS R01 NS046487 and the General Clinical Research Center at Johns Hopkins University School of Medicine (National Center for Research Resources/NIH M01-RR00052). Wyeth Pharmaceuticals provided venlafaxine XR and matching placebo. Glaxo-Smith Kline provided paroxetine.</p></fn><corresp>Correspondence & reprint requests to Dr. Richard: <email>Irene_Richard@urmc.rochester.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>17</day><month>4</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>17</day><month>4</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>78</volume><issue>16</issue><fpage>1229</fpage><lpage>1236</lpage><history><date date-type="received"><day>8</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>18</day><month>10</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012 by AAN Enterprises, Inc.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>AAN Enterprises, Inc.</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="znl01612001229.pdf"></self-uri><abstract><sec><title>Objective:</title><p>To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD).</p></sec><sec><title>Methods:</title><p>A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n = 34), or placebo (n = 39). Subjects met <italic>DSM-IV</italic> criteria for a depressive disorder, or operationally defined subsyndromal depression, and scored >12 on the first 17 items of the Hamilton Rating Scale for Depression (HAM-D). Subjects were followed for 12 weeks (6-week dosage adjustment, 6-week maintenance). Maximum daily dosages were 40 mg for paroxetine and 225 mg for venlafaxine XR. The primary outcome measure was change in the HAM-D score from baseline to week 12.</p></sec><sec><title>Results:</title><p>Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3, <italic>p</italic> = 0.0007) in the paroxetine group and 4.2 points (97.5% CI 0.1 to 8.4, <italic>p</italic> = 0.02) in the venlafaxine XR group. No treatment effects were seen on motor function.</p></sec><sec><title>Conclusions:</title><p>Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function.</p></sec><sec><title>Classification of Evidence:</title><p>This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>special-property</meta-name><meta-value>podcast</meta-value></custom-meta><custom-meta><meta-name>special-property</meta-name><meta-value>triangle</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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