Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations
Identifieur interne : 000019 ( PascalFrancis/Curation ); précédent : 000018; suivant : 000020Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations
Auteurs : I. Mendez [Canada] ; A. Dagher ; M. Hong ; A. Hebb ; P. Gaudet ; A. Law ; S. Weerasinghe ; D. King ; J. Desrosiers ; S. Darvesh ; T. Acorn ; H. RobertsonSource :
- Journal of neurosurgery [ 0022-3085 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluoro-dopa uptake from baseline values was observed 12 months postgrafting.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor in patients with Parkinson's disease : Report of two cases and technical considerations</title>
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<author><name sortKey="King, D" sort="King, D" uniqKey="King D" first="D." last="King">D. King</name>
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<author><name sortKey="Desrosiers, J" sort="Desrosiers, J" uniqKey="Desrosiers J" first="J." last="Desrosiers">J. Desrosiers</name>
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<author><name sortKey="Acorn, T" sort="Acorn, T" uniqKey="Acorn T" first="T." last="Acorn">T. Acorn</name>
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<series><title level="j" type="main">Journal of neurosurgery</title>
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<term>Dopaminergic neuron</term>
<term>Glial cell line derived neurotrophic factor</term>
<term>Graft</term>
<term>Human</term>
<term>Midbrain</term>
<term>Parkinson disease</term>
<term>Survival</term>
<term>Technique</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Facteur GDNF</term>
<term>Neurone dopaminergique</term>
<term>Greffe</term>
<term>Mésencéphale</term>
<term>Antérieur</term>
<term>Etude cas</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluoro-dopa uptake from baseline values was observed 12 months postgrafting.</div>
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