ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000D11

Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum

Identifieur interne : 000D11 ( PascalFrancis/Corpus ); précédent : 000D10; suivant : 000D12

Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum

Auteurs : W. J. Lombardi ; R. E. Gross ; L. L. Trepanier ; A. E. Lang ; A. M. Lozano ; J. A. Saint-Cyr

Source :

Brain [ 0006-8950 ] ; 2000.

RBID : Pascal:00-0167366

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Exérèse, Pallidum, Microélectrode, Motricité, Cognition, Localisation, Réseau nerveux, Traitement, Evolution, Psychométrie, Homme, Pallidotomie.

English descriptors

KwdEn :
- Cognition, Evolution, Exeresis, Human, Localization, Microelectrode, Motricity, Nervous network, Pallidum, Parkinson disease, Psychometrics, Treatment.

Abstract

Current models of basal ganglia anatomy posit the existence of multiple parallel, anatomically segregated circuits. Anatomical data from non-human primates suggest that the circuits subserving motor functions are segregated from those subserving cognitive functions. Here we present data that demonstrate that, in humans, motor and cognitive frontosubcortical circuits are segregated. We studied a group of patients with Parkinson's disease undergoing surgical lesioning of the globus pallidus internus for relief of their symptoms. Lesion location along an anteromedial-to-posterolateral axis was found to be related to postsurgical outcome on both cognitive and motor measures. Performance on several neuropsychological measures, including the generation of category exemplars and continuous mental addition, was linearly related to distance along this axis, with anteromedial lesions leading to postsurgical impairment, intermediate lesions having little effect and posterolateral lesions leading to an improvement on several measures. The same relationship was found between memory performance under conditions of proactive interference and lesion location within the globus pallidus internus. In contrast, bradykinesia, assessed as the speed of finger-tapping, had a nonlinear relationship to lesion location, intermediate lesions leading to greater postsurgical improvement than lesions in more extreme anteromedial or posterolateral locations. These data demonstrate that the cognitive effects of pallidotomy can be dissociated from the motor effects. These effects depend upon the placement of the lesions within the globus pallidus internus, supporting the segregation of functionally distinct circuits in the human pallidum.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 00-0167366 INIST
ET :	Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum
AU :	LOMBARDI (W. J.); GROSS (R. E.); TREPANIER (L. L.); LANG (A. E.); LOZANO (A. M.); SAINT-CYR (J. A.)
AF :	Department of Neurosurgery, University of Utah/Salt Lake City, UT/Etats-Unis (1 aut., 2 aut.); Department of Psychology, The Toronto Hospital/Toronto, Ontario/Canada (1 aut., 3 aut., 6 aut.); Department of Surgery, University of Toronto, Division of Neurosurgery, The Toronto Hospital/Toronto, Ontario/Canada (2 aut., 5 aut.); Department of Psychology, York University/Toronto, Ontario/Canada (3 aut.); Movement Disorders Centre, The Toronto Hospital/Toronto, Ontario/Canada (4 aut.); Department of Medicine, University of Toronto, Division of Neurology, The Toronto Hospital/Toronto, Ontario/Canada (4 aut.); Departments of Anatomy and Cell Biology and of Psychology, University of Toronto/Toronto, Ontario/Canada (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Brain; ISSN 0006-8950; Royaume-Uni; Da. 2000; Vol. 123; No. p.4; Pp. 746-758; Bibl. 1 p.1/4
LA :	Anglais
EA :	Current models of basal ganglia anatomy posit the existence of multiple parallel, anatomically segregated circuits. Anatomical data from non-human primates suggest that the circuits subserving motor functions are segregated from those subserving cognitive functions. Here we present data that demonstrate that, in humans, motor and cognitive frontosubcortical circuits are segregated. We studied a group of patients with Parkinson's disease undergoing surgical lesioning of the globus pallidus internus for relief of their symptoms. Lesion location along an anteromedial-to-posterolateral axis was found to be related to postsurgical outcome on both cognitive and motor measures. Performance on several neuropsychological measures, including the generation of category exemplars and continuous mental addition, was linearly related to distance along this axis, with anteromedial lesions leading to postsurgical impairment, intermediate lesions having little effect and posterolateral lesions leading to an improvement on several measures. The same relationship was found between memory performance under conditions of proactive interference and lesion location within the globus pallidus internus. In contrast, bradykinesia, assessed as the speed of finger-tapping, had a nonlinear relationship to lesion location, intermediate lesions leading to greater postsurgical improvement than lesions in more extreme anteromedial or posterolateral locations. These data demonstrate that the cognitive effects of pallidotomy can be dissociated from the motor effects. These effects depend upon the placement of the lesions within the globus pallidus internus, supporting the segregation of functionally distinct circuits in the human pallidum.
CC :	002B25J01
FD :	Parkinson maladie; Exérèse; Pallidum; Microélectrode; Motricité; Cognition; Localisation; Réseau nerveux; Traitement; Evolution; Psychométrie; Homme; Pallidotomie
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Chirurgie
ED :	Parkinson disease; Exeresis; Pallidum; Microelectrode; Motricity; Cognition; Localization; Nervous network; Treatment; Evolution; Psychometrics; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Surgery
SD :	Parkinson enfermedad; Exéresis; Pallidum; Microeléctrodo; Motricidad; Cognición; Localización; Red nerviosa; Tratamiento; Evolución; Psicometría; Hombre
LO :	INIST-998.354000086976000100
ID :	00-0167366

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Pascal:00-0167366

Le document en format XML

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<front><div type="abstract" xml:lang="en">Current models of basal ganglia anatomy posit the existence of multiple parallel, anatomically segregated circuits. Anatomical data from non-human primates suggest that the circuits subserving motor functions are segregated from those subserving cognitive functions. Here we present data that demonstrate that, in humans, motor and cognitive frontosubcortical circuits are segregated. We studied a group of patients with Parkinson's disease undergoing surgical lesioning of the globus pallidus internus for relief of their symptoms. Lesion location along an anteromedial-to-posterolateral axis was found to be related to postsurgical outcome on both cognitive and motor measures. Performance on several neuropsychological measures, including the generation of category exemplars and continuous mental addition, was linearly related to distance along this axis, with anteromedial lesions leading to postsurgical impairment, intermediate lesions having little effect and posterolateral lesions leading to an improvement on several measures. The same relationship was found between memory performance under conditions of proactive interference and lesion location within the globus pallidus internus. In contrast, bradykinesia, assessed as the speed of finger-tapping, had a nonlinear relationship to lesion location, intermediate lesions leading to greater postsurgical improvement than lesions in more extreme anteromedial or posterolateral locations. These data demonstrate that the cognitive effects of pallidotomy can be dissociated from the motor effects. These effects depend upon the placement of the lesions within the globus pallidus internus, supporting the segregation of functionally distinct circuits in the human pallidum.</div>
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<ET>Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum</ET>
<AU>LOMBARDI (W. J.); GROSS (R. E.); TREPANIER (L. L.); LANG (A. E.); LOZANO (A. M.); SAINT-CYR (J. A.)</AU>
<AF>Department of Neurosurgery, University of Utah/Salt Lake City, UT/Etats-Unis (1 aut., 2 aut.); Department of Psychology, The Toronto Hospital/Toronto, Ontario/Canada (1 aut., 3 aut., 6 aut.); Department of Surgery, University of Toronto, Division of Neurosurgery, The Toronto Hospital/Toronto, Ontario/Canada (2 aut., 5 aut.); Department of Psychology, York University/Toronto, Ontario/Canada (3 aut.); Movement Disorders Centre, The Toronto Hospital/Toronto, Ontario/Canada (4 aut.); Department of Medicine, University of Toronto, Division of Neurology, The Toronto Hospital/Toronto, Ontario/Canada (4 aut.); Departments of Anatomy and Cell Biology and of Psychology, University of Toronto/Toronto, Ontario/Canada (6 aut.)</AF>
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<EA>Current models of basal ganglia anatomy posit the existence of multiple parallel, anatomically segregated circuits. Anatomical data from non-human primates suggest that the circuits subserving motor functions are segregated from those subserving cognitive functions. Here we present data that demonstrate that, in humans, motor and cognitive frontosubcortical circuits are segregated. We studied a group of patients with Parkinson's disease undergoing surgical lesioning of the globus pallidus internus for relief of their symptoms. Lesion location along an anteromedial-to-posterolateral axis was found to be related to postsurgical outcome on both cognitive and motor measures. Performance on several neuropsychological measures, including the generation of category exemplars and continuous mental addition, was linearly related to distance along this axis, with anteromedial lesions leading to postsurgical impairment, intermediate lesions having little effect and posterolateral lesions leading to an improvement on several measures. The same relationship was found between memory performance under conditions of proactive interference and lesion location within the globus pallidus internus. In contrast, bradykinesia, assessed as the speed of finger-tapping, had a nonlinear relationship to lesion location, intermediate lesions leading to greater postsurgical improvement than lesions in more extreme anteromedial or posterolateral locations. These data demonstrate that the cognitive effects of pallidotomy can be dissociated from the motor effects. These effects depend upon the placement of the lesions within the globus pallidus internus, supporting the segregation of functionally distinct circuits in the human pallidum.</EA>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum

Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum

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