ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000634

Early, untreated Parkinson's disease patients show reaction time variability

Identifieur interne : 000634 ( PascalFrancis/Corpus ); précédent : 000633; suivant : 000635

Early, untreated Parkinson's disease patients show reaction time variability

Auteurs : Richard M. Camicioli ; Marguerite Wieler ; Cindy M. De Frias ; W. R. Wayne Martin

Source :

Neuroscience letters [ 0304-3940 ] ; 2008.

RBID : Pascal:08-0374938

Descripteurs français

Pascal (Inist)
- Précoce, Sénescence, Maladie de Parkinson, Homme.

English descriptors

KwdEn :
- Early, Human, Parkinson disease, Senescence.

Abstract

While Parkinson's disease (PD) is associated with motor slowing, less attention has been paid to variability in performance on motor and cognitive tasks. To examine reaction time latencies and intraindividual variability in untreated patients with PD compared to healthy controls. Twenty-nine (19 men/10 women) patients with untreated PD and 16 controls (8 men/8 women) were examined using measures of simple reaction time (SRT) and choice reaction time (CRT) in addition to cognitive measures of executive function (Trail Making Test; adaptive digit ordering). Latencies and intraindividual variability were compared between groups. Partial correlation coefficients, adjusting for age, sex and education were used to examine the relationship between RT measures and motor or cognitive measures. Patients and controls did not differ with respect to age or sex distribution. Education and cognitive status differed between groups, but no subject was demented or clinically depressed. After adjusting for age, sex and education, significant group differences were found in latencies (2-choice RT and 8-choice RT) and intraindividual variability scores (all CRT conditions). Latencies did not differ significantly after adjusting for finger tapping rate. In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 08-0374938 INIST
ET :	Early, untreated Parkinson's disease patients show reaction time variability
AU :	CAMICIOLI (Richard M.); WIELER (Marguerite); DE FRIAS (Cindy M.); WAYNE MARTIN (W. R.)
AF :	Department of Medicine (Neurology), University of Alberta/Edmonton, Alberta/Canada (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2008; Vol. 441; No. 1; Pp. 77-80; Bibl. 23 ref.
LA :	Anglais
EA :	While Parkinson's disease (PD) is associated with motor slowing, less attention has been paid to variability in performance on motor and cognitive tasks. To examine reaction time latencies and intraindividual variability in untreated patients with PD compared to healthy controls. Twenty-nine (19 men/10 women) patients with untreated PD and 16 controls (8 men/8 women) were examined using measures of simple reaction time (SRT) and choice reaction time (CRT) in addition to cognitive measures of executive function (Trail Making Test; adaptive digit ordering). Latencies and intraindividual variability were compared between groups. Partial correlation coefficients, adjusting for age, sex and education were used to examine the relationship between RT measures and motor or cognitive measures. Patients and controls did not differ with respect to age or sex distribution. Education and cognitive status differed between groups, but no subject was demented or clinically depressed. After adjusting for age, sex and education, significant group differences were found in latencies (2-choice RT and 8-choice RT) and intraindividual variability scores (all CRT conditions). Latencies did not differ significantly after adjusting for finger tapping rate. In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD.
CC :	002A25; 002B17G
FD :	Précoce; Sénescence; Maladie de Parkinson; Homme
FG :	Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central
ED :	Early; Senescence; Parkinson disease; Human
EG :	Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease
SD :	Precoz; Senescencia; Parkinson enfermedad; Hombre
LO :	INIST-17240.354000197670950160
ID :	08-0374938

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Pascal:08-0374938

Le document en format XML

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<front><div type="abstract" xml:lang="en">While Parkinson's disease (PD) is associated with motor slowing, less attention has been paid to variability in performance on motor and cognitive tasks. To examine reaction time latencies and intraindividual variability in untreated patients with PD compared to healthy controls. Twenty-nine (19 men/10 women) patients with untreated PD and 16 controls (8 men/8 women) were examined using measures of simple reaction time (SRT) and choice reaction time (CRT) in addition to cognitive measures of executive function (Trail Making Test; adaptive digit ordering). Latencies and intraindividual variability were compared between groups. Partial correlation coefficients, adjusting for age, sex and education were used to examine the relationship between RT measures and motor or cognitive measures. Patients and controls did not differ with respect to age or sex distribution. Education and cognitive status differed between groups, but no subject was demented or clinically depressed. After adjusting for age, sex and education, significant group differences were found in latencies (2-choice RT and 8-choice RT) and intraindividual variability scores (all CRT conditions). Latencies did not differ significantly after adjusting for finger tapping rate. In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD.</div>
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<SO>Neuroscience letters; ISSN 0304-3940; Coden NELED5; Irlande; Da. 2008; Vol. 441; No. 1; Pp. 77-80; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>While Parkinson's disease (PD) is associated with motor slowing, less attention has been paid to variability in performance on motor and cognitive tasks. To examine reaction time latencies and intraindividual variability in untreated patients with PD compared to healthy controls. Twenty-nine (19 men/10 women) patients with untreated PD and 16 controls (8 men/8 women) were examined using measures of simple reaction time (SRT) and choice reaction time (CRT) in addition to cognitive measures of executive function (Trail Making Test; adaptive digit ordering). Latencies and intraindividual variability were compared between groups. Partial correlation coefficients, adjusting for age, sex and education were used to examine the relationship between RT measures and motor or cognitive measures. Patients and controls did not differ with respect to age or sex distribution. Education and cognitive status differed between groups, but no subject was demented or clinically depressed. After adjusting for age, sex and education, significant group differences were found in latencies (2-choice RT and 8-choice RT) and intraindividual variability scores (all CRT conditions). Latencies did not differ significantly after adjusting for finger tapping rate. In the PD group neither the motor nor the executive measures correlated significantly with any of the reaction time measures. We conclude that CRT intraindividual variability and latencies are increased in untreated PD.</EA>
<CC>002A25; 002B17G</CC>
<FD>Précoce; Sénescence; Maladie de Parkinson; Homme</FD>
<FG>Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du   système nerveux central</FG>
<ED>Early; Senescence; Parkinson disease; Human</ED>
<EG>Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease</EG>
<SD>Precoz; Senescencia; Parkinson enfermedad; Hombre</SD>
<LO>INIST-17240.354000197670950160</LO>
<ID>08-0374938</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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Early, untreated Parkinson's disease patients show reaction time variability

Early, untreated Parkinson's disease patients show reaction time variability

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