MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE
Identifieur interne : 000406 ( PascalFrancis/Corpus ); précédent : 000405; suivant : 000407MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE
Auteurs : M. Barnett-Cowan ; R. T. Dyde ; S. H. Fox ; E. Moro ; W. D. Hutchison ; L. R. HarrisSource :
- Neuroscience [ 0306-4522 ] ; 2010.
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- Pascal (Inist)
English descriptors
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Abstract
Perception of the relative orientation of the self and objects in the environment requires integration of visual and vestibular sensory information, and an internal representation of the body's orientation. Parkinson's disease (PD) patients are more visually dependent than controls, implicating the basal ganglia in using visual orientation cues. We examined the relative roles of visual and non-visual cues to orientation in PD using two different measures: the subjective visual vertical (SW) and the perceptual upright (PU). We tested twelve PD patients (nine both on- and off-medication), and thirteen age-matched controls. Visual, vestibular and body cues were manipulated using a polarized visual room presented in various orientations while observers were upright or lying right-side-down. Relative to age-matched controls, patients with PD showed more influence of visual cues for the SW but were more influenced by the direction of gravity for the PU. Increased SW visual dependence corresponded with equal decreases of the contributions of body sense and gravity. Increased PU gravitational dependence corresponded mainly with a decreased contribution of body sense. Curiously however, both of these effects were significant only when patients were medicated. Increased SW visual dependence was highest for PD patients with left-side initial motor symptoms. PD patients when on and off medication were more variable than controls when making judgments. Our results suggest that (i) PD patients are not more visually dependent in general, rather increased visual dependence is task specific and varies with initial onset side, (ii) PD patients may rely more on vestibular information for some perceptual tasks which is reflected in relying less on the internal representation of the body, and (iii) these effects are only present when PD patients are taking dopaminergic medication.
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| NO : | PASCAL 10-0396929 INIST |
|---|---|
| ET : | MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE |
| AU : | BARNETT-COWAN (M.); DYDE (R. T.); FOX (S. H.); MORO (E.); HUTCHISON (W. D.); HARRIS (L. R.) |
| AF : | Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street/Toronto, ON, M3J 1P3/Canada (1 aut., 2 aut., 6 aut.); Department of Psychology, York University, 4700 Keele Street/Toronto, ON, M3J 1P3/Canada (1 aut., 6 aut.); Department of Medicine, Division of Neurology, University of Toronto, Toronto Western Hospital, Movement Disorders Unit, 399 Bathurst Street/Toronto, ON, M5T 2S8/Canada (3 aut., 4 aut.); Department of Surgery and Physiology, University of Toronto, Toronto Western Hospital, 399 Bathurst Street/Toronto, ON, M5T 2S8/Canada (5 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2010; Vol. 167; No. 4; Pp. 1138-1150; Bibl. 2 p. |
| LA : | Anglais |
| EA : | Perception of the relative orientation of the self and objects in the environment requires integration of visual and vestibular sensory information, and an internal representation of the body's orientation. Parkinson's disease (PD) patients are more visually dependent than controls, implicating the basal ganglia in using visual orientation cues. We examined the relative roles of visual and non-visual cues to orientation in PD using two different measures: the subjective visual vertical (SW) and the perceptual upright (PU). We tested twelve PD patients (nine both on- and off-medication), and thirteen age-matched controls. Visual, vestibular and body cues were manipulated using a polarized visual room presented in various orientations while observers were upright or lying right-side-down. Relative to age-matched controls, patients with PD showed more influence of visual cues for the SW but were more influenced by the direction of gravity for the PU. Increased SW visual dependence corresponded with equal decreases of the contributions of body sense and gravity. Increased PU gravitational dependence corresponded mainly with a decreased contribution of body sense. Curiously however, both of these effects were significant only when patients were medicated. Increased SW visual dependence was highest for PD patients with left-side initial motor symptoms. PD patients when on and off medication were more variable than controls when making judgments. Our results suggest that (i) PD patients are not more visually dependent in general, rather increased visual dependence is task specific and varies with initial onset side, (ii) PD patients may rely more on vestibular information for some perceptual tasks which is reflected in relying less on the internal representation of the body, and (iii) these effects are only present when PD patients are taking dopaminergic medication. |
| CC : | 002A25; 002B17G |
| FD : | Orientation; Perception; Dépendance; Maladie de Parkinson |
| FG : | Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central |
| ED : | Orientation; Perception; Dependence; Parkinson disease |
| EG : | Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease |
| SD : | Orientación; Percepción; Dependencia; Parkinson enfermedad |
| LO : | INIST-17194.354000191804710170 |
| ID : | 10-0396929 |
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Barnett-Cowan</name><affiliation><inist:fA14 i1="01"><s1>Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Psychology, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dyde, R T" sort="Dyde, R T" uniqKey="Dyde R" first="R. T." last="Dyde">R. T. Dyde</name><affiliation><inist:fA14 i1="01"><s1>Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fox, S H" sort="Fox, S H" uniqKey="Fox S" first="S. H." last="Fox">S. H. Fox</name><affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Division of Neurology, University of Toronto, Toronto Western Hospital, Movement Disorders Unit, 399 Bathurst Street</s1><s2>Toronto, ON, M5T 2S8</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Moro, E" sort="Moro, E" uniqKey="Moro E" first="E." last="Moro">E. Moro</name><affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Division of Neurology, University of Toronto, Toronto Western Hospital, Movement Disorders Unit, 399 Bathurst Street</s1><s2>Toronto, ON, M5T 2S8</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hutchison, W D" sort="Hutchison, W D" uniqKey="Hutchison W" first="W. D." last="Hutchison">W. D. Hutchison</name><affiliation><inist:fA14 i1="04"><s1>Department of Surgery and Physiology, University of Toronto, Toronto Western Hospital, 399 Bathurst Street</s1><s2>Toronto, ON, M5T 2S8</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Harris, L R" sort="Harris, L R" uniqKey="Harris L" first="L. R." last="Harris">L. R. Harris</name><affiliation><inist:fA14 i1="01"><s1>Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Psychology, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dependence</term><term>Orientation</term><term>Parkinson disease</term><term>Perception</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Orientation</term><term>Perception</term><term>Dépendance</term><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Perception of the relative orientation of the self and objects in the environment requires integration of visual and vestibular sensory information, and an internal representation of the body's orientation. Parkinson's disease (PD) patients are more visually dependent than controls, implicating the basal ganglia in using visual orientation cues. We examined the relative roles of visual and non-visual cues to orientation in PD using two different measures: the subjective visual vertical (SW) and the perceptual upright (PU). We tested twelve PD patients (nine both on- and off-medication), and thirteen age-matched controls. Visual, vestibular and body cues were manipulated using a polarized visual room presented in various orientations while observers were upright or lying right-side-down. Relative to age-matched controls, patients with PD showed more influence of visual cues for the SW but were more influenced by the direction of gravity for the PU. Increased SW visual dependence corresponded with equal decreases of the contributions of body sense and gravity. Increased PU gravitational dependence corresponded mainly with a decreased contribution of body sense. Curiously however, both of these effects were significant only when patients were medicated. Increased SW visual dependence was highest for PD patients with left-side initial motor symptoms. PD patients when on and off medication were more variable than controls when making judgments. Our results suggest that (i) PD patients are not more visually dependent in general, rather increased visual dependence is task specific and varies with initial onset side, (ii) PD patients may rely more on vestibular information for some perceptual tasks which is reflected in relying less on the internal representation of the body, and (iii) these effects are only present when PD patients are taking dopaminergic medication.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0306-4522</s0></fA01><fA02 i1="01"><s0>NRSCDN</s0></fA02><fA03 i2="1"><s0>Neuroscience</s0></fA03><fA05><s2>167</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE</s1></fA08><fA11 i1="01" i2="1"><s1>BARNETT-COWAN (M.)</s1></fA11><fA11 i1="02" i2="1"><s1>DYDE (R. T.)</s1></fA11><fA11 i1="03" i2="1"><s1>FOX (S. 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R.)</s1></fA11><fA14 i1="01"><s1>Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Psychology, York University, 4700 Keele Street</s1><s2>Toronto, ON, M3J 1P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, Division of Neurology, University of Toronto, Toronto Western Hospital, Movement Disorders Unit, 399 Bathurst Street</s1><s2>Toronto, ON, M5T 2S8</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Surgery and Physiology, University of Toronto, Toronto Western Hospital, 399 Bathurst Street</s1><s2>Toronto, ON, M5T 2S8</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>1138-1150</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>17194</s2><s5>354000191804710170</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0396929</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neuroscience</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>Perception of the relative orientation of the self and objects in the environment requires integration of visual and vestibular sensory information, and an internal representation of the body's orientation. Parkinson's disease (PD) patients are more visually dependent than controls, implicating the basal ganglia in using visual orientation cues. We examined the relative roles of visual and non-visual cues to orientation in PD using two different measures: the subjective visual vertical (SW) and the perceptual upright (PU). We tested twelve PD patients (nine both on- and off-medication), and thirteen age-matched controls. Visual, vestibular and body cues were manipulated using a polarized visual room presented in various orientations while observers were upright or lying right-side-down. Relative to age-matched controls, patients with PD showed more influence of visual cues for the SW but were more influenced by the direction of gravity for the PU. Increased SW visual dependence corresponded with equal decreases of the contributions of body sense and gravity. Increased PU gravitational dependence corresponded mainly with a decreased contribution of body sense. Curiously however, both of these effects were significant only when patients were medicated. Increased SW visual dependence was highest for PD patients with left-side initial motor symptoms. PD patients when on and off medication were more variable than controls when making judgments. Our results suggest that (i) PD patients are not more visually dependent in general, rather increased visual dependence is task specific and varies with initial onset side, (ii) PD patients may rely more on vestibular information for some perceptual tasks which is reflected in relying less on the internal representation of the body, and (iii) these effects are only present when PD patients are taking dopaminergic medication.</s0></fC01><fC02 i1="01" i2="X"><s0>002A25</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Orientation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Orientation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Orientación</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Perception</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Perception</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Percepción</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Dépendance</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dependence</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Dependencia</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>09</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>24</s5></fC07><fN21><s1>256</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 10-0396929 INIST</NO><ET>MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE</ET><AU>BARNETT-COWAN (M.); DYDE (R. T.); FOX (S. H.); MORO (E.); HUTCHISON (W. D.); HARRIS (L. R.)</AU><AF>Multisensory Integration Laboratory, Centre for Vision Research, York University, 4700 Keele Street/Toronto, ON, M3J 1P3/Canada (1 aut., 2 aut., 6 aut.); Department of Psychology, York University, 4700 Keele Street/Toronto, ON, M3J 1P3/Canada (1 aut., 6 aut.); Department of Medicine, Division of Neurology, University of Toronto, Toronto Western Hospital, Movement Disorders Unit, 399 Bathurst Street/Toronto, ON, M5T 2S8/Canada (3 aut., 4 aut.); Department of Surgery and Physiology, University of Toronto, Toronto Western Hospital, 399 Bathurst Street/Toronto, ON, M5T 2S8/Canada (5 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2010; Vol. 167; No. 4; Pp. 1138-1150; Bibl. 2 p.</SO><LA>Anglais</LA><EA>Perception of the relative orientation of the self and objects in the environment requires integration of visual and vestibular sensory information, and an internal representation of the body's orientation. Parkinson's disease (PD) patients are more visually dependent than controls, implicating the basal ganglia in using visual orientation cues. We examined the relative roles of visual and non-visual cues to orientation in PD using two different measures: the subjective visual vertical (SW) and the perceptual upright (PU). We tested twelve PD patients (nine both on- and off-medication), and thirteen age-matched controls. Visual, vestibular and body cues were manipulated using a polarized visual room presented in various orientations while observers were upright or lying right-side-down. Relative to age-matched controls, patients with PD showed more influence of visual cues for the SW but were more influenced by the direction of gravity for the PU. Increased SW visual dependence corresponded with equal decreases of the contributions of body sense and gravity. Increased PU gravitational dependence corresponded mainly with a decreased contribution of body sense. Curiously however, both of these effects were significant only when patients were medicated. Increased SW visual dependence was highest for PD patients with left-side initial motor symptoms. PD patients when on and off medication were more variable than controls when making judgments. Our results suggest that (i) PD patients are not more visually dependent in general, rather increased visual dependence is task specific and varies with initial onset side, (ii) PD patients may rely more on vestibular information for some perceptual tasks which is reflected in relying less on the internal representation of the body, and (iii) these effects are only present when PD patients are taking dopaminergic medication.</EA><CC>002A25; 002B17G</CC><FD>Orientation; Perception; Dépendance; Maladie de Parkinson</FD><FG>Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central</FG><ED>Orientation; Perception; Dependence; Parkinson disease</ED><EG>Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease</EG><SD>Orientación; Percepción; Dependencia; Parkinson enfermedad</SD><LO>INIST-17194.354000191804710170</LO><ID>10-0396929</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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|type= RBID
|clé= Pascal:10-0396929
|texte= MULTISENSORY DETERMINANTS OF ORIENTATION PERCEPTION IN PARKINSON'S DISEASE
}}
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