ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000405

CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION

Identifieur interne : 000405 ( PascalFrancis/Corpus ); précédent : 000404; suivant : 000406

CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION

Auteurs : B. Xu ; J. S. Goldman ; V. V. Rymar ; C. Forget ; P. S. Lo ; S. J. Bull ; E. Vereker ; P. A. Barker ; L. E. Trudeau ; A. F. Sadikot ; T. E. Kennedy

Source :

Neuroscience [ 0306-4522 ] ; 2010.

RBID : Pascal:10-0397347

Descripteurs français

Pascal (Inist)
- Récepteur biologique, Dopamine, Axone, Synaptogenèse, Maladie de Parkinson, Schizophrénie.

English descriptors

KwdEn :
- Axon, Biological receptor, Dopamine, Parkinson disease, Schizophrenia, Synaptogenesis.

Abstract

DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibility that DA axons could be attracted or repelled by netrins. Examining newborn dcc null mice, we report that loss of DCC function results in profound alterations of DA circuitry, including DA progenitor cell migration defects, reduced numbers of DA cells in midbrain nuclei, an anomalous DA ventral commissure, malformed DA innervation of the ventral striatum, and reduced DA innervation of the cerebral cortex. Caspase-3 activation was detected in inappropriately localized DA cells, consistent with apoptosis contributing to reduced cell numbers. Dcc heterozygous mice express reduced levels of DCC protein. Although less severely disrupted than dcc nulls, newborn and adult dcc heterozygotes also have fewer DA neurons in ventral mesenscephalic nuclei. Despite the reduced numbers of DA neurons, newborn dcc heterozygotes and nulls exhibit similar DA innervation density as wild-type littermates in the nucleus accumbens core, and adult dcc heterozygotes exhibit increased DA innervation in medial prefrontal cortex. A trend towards increased innervation of medial prefrontal cortex was detected in newborn dcc heterozygotes, but did not reach statistical significance, suggesting that the increase in adult heterozygotes results from enhanced DA arborization during postnatal development. Consistent with the hypothesis that DCC regulates DA axonal projections, disrupting DCC function in culture inhibits netrin-1 induced DA axon extension and axon branching. Furthermore, disrupting DCC function in isolated DA neurons grown as micro-island cultures reduces the number of autaptic synapses per cell. We conclude that DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C03	`02`	`X`	`FRE`	`@0 Dopamine @2 NK @2 FR @5 02`
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Format Inist (serveur)

NO :	PASCAL 10-0397347 INIST
ET :	CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION
AU :	XU (B.); GOLDMAN (J. S.); RYMAR (V. V.); FORGET (C.); LO (P. S.); BULL (S. J.); VEREKER (E.); BARKER (P. A.); TRUDEAU (L. E.); SADIKOT (A. F.); KENNEDY (T. E.)
AF :	Centre for Neuronal Survival, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, QC, H3A 2B4/Canada (1 aut., 2 aut., 5 aut., 6 aut., 7 aut., 8 aut., 11 aut.); Cone Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, QC, H3A 2B4/Canada (3 aut., 5 aut., 10 aut.); Département de Pharmacologie, Faculté de Médecine, Université de Montréal/Montréal, QC, H3C 3J7/Canada (4 aut., 9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2010; Vol. 169; No. 2; Pp. 932-949; Bibl. 1 p.
LA :	Anglais
EA :	DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibility that DA axons could be attracted or repelled by netrins. Examining newborn dcc null mice, we report that loss of DCC function results in profound alterations of DA circuitry, including DA progenitor cell migration defects, reduced numbers of DA cells in midbrain nuclei, an anomalous DA ventral commissure, malformed DA innervation of the ventral striatum, and reduced DA innervation of the cerebral cortex. Caspase-3 activation was detected in inappropriately localized DA cells, consistent with apoptosis contributing to reduced cell numbers. Dcc heterozygous mice express reduced levels of DCC protein. Although less severely disrupted than dcc nulls, newborn and adult dcc heterozygotes also have fewer DA neurons in ventral mesenscephalic nuclei. Despite the reduced numbers of DA neurons, newborn dcc heterozygotes and nulls exhibit similar DA innervation density as wild-type littermates in the nucleus accumbens core, and adult dcc heterozygotes exhibit increased DA innervation in medial prefrontal cortex. A trend towards increased innervation of medial prefrontal cortex was detected in newborn dcc heterozygotes, but did not reach statistical significance, suggesting that the increase in adult heterozygotes results from enhanced DA arborization during postnatal development. Consistent with the hypothesis that DCC regulates DA axonal projections, disrupting DCC function in culture inhibits netrin-1 induced DA axon extension and axon branching. Furthermore, disrupting DCC function in isolated DA neurons grown as micro-island cultures reduces the number of autaptic synapses per cell. We conclude that DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons.
CC :	002A25; 002B17G
FD :	Récepteur biologique; Dopamine; Axone; Synaptogenèse; Maladie de Parkinson; Schizophrénie
FG :	Catécholamine; Neurotransmetteur; Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central; Psychose
ED :	Biological receptor; Dopamine; Axon; Synaptogenesis; Parkinson disease; Schizophrenia
EG :	Catecholamine; Neurotransmitter; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Psychosis
SD :	Receptor biológico; Dopamina; Axón; Sinaptogénesis; Parkinson enfermedad; Esquizofrenia
LO :	INIST-17194.354000194123870350
ID :	10-0397347

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Pascal:10-0397347

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION</title>
<author><name sortKey="Xu, B" sort="Xu, B" uniqKey="Xu B" first="B." last="Xu">B. Xu</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuronal Survival, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</s1>
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<author><name sortKey="Goldman, J S" sort="Goldman, J S" uniqKey="Goldman J" first="J. S." last="Goldman">J. S. Goldman</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuronal Survival, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</s1>
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<author><name sortKey="Sadikot, A F" sort="Sadikot, A F" uniqKey="Sadikot A" first="A. F." last="Sadikot">A. F. Sadikot</name>
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<series><title level="j" type="main">Neuroscience</title>
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<term>Schizophrenia</term>
<term>Synaptogenesis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Récepteur biologique</term>
<term>Dopamine</term>
<term>Axone</term>
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<front><div type="abstract" xml:lang="en">DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibility that DA axons could be attracted or repelled by netrins. Examining newborn dcc null mice, we report that loss of DCC function results in profound alterations of DA circuitry, including DA progenitor cell migration defects, reduced numbers of DA cells in midbrain nuclei, an anomalous DA ventral commissure, malformed DA innervation of the ventral striatum, and reduced DA innervation of the cerebral cortex. Caspase-3 activation was detected in inappropriately localized DA cells, consistent with apoptosis contributing to reduced cell numbers. Dcc heterozygous mice express reduced levels of DCC protein. Although less severely disrupted than dcc nulls, newborn and adult dcc heterozygotes also have fewer DA neurons in ventral mesenscephalic nuclei. Despite the reduced numbers of DA neurons, newborn dcc heterozygotes and nulls exhibit similar DA innervation density as wild-type littermates in the nucleus accumbens core, and adult dcc heterozygotes exhibit increased DA innervation in medial prefrontal cortex. A trend towards increased innervation of medial prefrontal cortex was detected in newborn dcc heterozygotes, but did not reach statistical significance, suggesting that the increase in adult heterozygotes results from enhanced DA arborization during postnatal development. Consistent with the hypothesis that DCC regulates DA axonal projections, disrupting DCC function in culture inhibits netrin-1 induced DA axon extension and axon branching. Furthermore, disrupting DCC function in isolated DA neurons grown as micro-island cultures reduces the number of autaptic synapses per cell. We conclude that DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION</s1>
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<fC01 i1="01" l="ENG"><s0>DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibility that DA axons could be attracted or repelled by netrins. Examining newborn dcc null mice, we report that loss of DCC function results in profound alterations of DA circuitry, including DA progenitor cell migration defects, reduced numbers of DA cells in midbrain nuclei, an anomalous DA ventral commissure, malformed DA innervation of the ventral striatum, and reduced DA innervation of the cerebral cortex. Caspase-3 activation was detected in inappropriately localized DA cells, consistent with apoptosis contributing to reduced cell numbers. Dcc heterozygous mice express reduced levels of DCC protein. Although less severely disrupted than dcc nulls, newborn and adult dcc heterozygotes also have fewer DA neurons in ventral mesenscephalic nuclei. Despite the reduced numbers of DA neurons, newborn dcc heterozygotes and nulls exhibit similar DA innervation density as wild-type littermates in the nucleus accumbens core, and adult dcc heterozygotes exhibit increased DA innervation in medial prefrontal cortex. A trend towards increased innervation of medial prefrontal cortex was detected in newborn dcc heterozygotes, but did not reach statistical significance, suggesting that the increase in adult heterozygotes results from enhanced DA arborization during postnatal development. Consistent with the hypothesis that DCC regulates DA axonal projections, disrupting DCC function in culture inhibits netrin-1 induced DA axon extension and axon branching. Furthermore, disrupting DCC function in isolated DA neurons grown as micro-island cultures reduces the number of autaptic synapses per cell. We conclude that DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons.</s0>
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<server><NO>PASCAL 10-0397347 INIST</NO>
<ET>CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION</ET>
<AU>XU (B.); GOLDMAN (J. S.); RYMAR (V. V.); FORGET (C.); LO (P. S.); BULL (S. J.); VEREKER (E.); BARKER (P. A.); TRUDEAU (L. E.); SADIKOT (A. F.); KENNEDY (T. E.)</AU>
<AF>Centre for Neuronal Survival, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, QC, H3A 2B4/Canada (1 aut., 2 aut., 5 aut., 6 aut., 7 aut., 8 aut., 11 aut.); Cone Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, QC, H3A 2B4/Canada (3 aut., 5 aut., 10 aut.); Département de Pharmacologie, Faculté de Médecine, Université de Montréal/Montréal, QC, H3C 3J7/Canada (4 aut., 9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2010; Vol. 169; No. 2; Pp. 932-949; Bibl. 1 p.</SO>
<LA>Anglais</LA>
<EA>DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibility that DA axons could be attracted or repelled by netrins. Examining newborn dcc null mice, we report that loss of DCC function results in profound alterations of DA circuitry, including DA progenitor cell migration defects, reduced numbers of DA cells in midbrain nuclei, an anomalous DA ventral commissure, malformed DA innervation of the ventral striatum, and reduced DA innervation of the cerebral cortex. Caspase-3 activation was detected in inappropriately localized DA cells, consistent with apoptosis contributing to reduced cell numbers. Dcc heterozygous mice express reduced levels of DCC protein. Although less severely disrupted than dcc nulls, newborn and adult dcc heterozygotes also have fewer DA neurons in ventral mesenscephalic nuclei. Despite the reduced numbers of DA neurons, newborn dcc heterozygotes and nulls exhibit similar DA innervation density as wild-type littermates in the nucleus accumbens core, and adult dcc heterozygotes exhibit increased DA innervation in medial prefrontal cortex. A trend towards increased innervation of medial prefrontal cortex was detected in newborn dcc heterozygotes, but did not reach statistical significance, suggesting that the increase in adult heterozygotes results from enhanced DA arborization during postnatal development. Consistent with the hypothesis that DCC regulates DA axonal projections, disrupting DCC function in culture inhibits netrin-1 induced DA axon extension and axon branching. Furthermore, disrupting DCC function in isolated DA neurons grown as micro-island cultures reduces the number of autaptic synapses per cell. We conclude that DCC regulates appropriate precursor cell migration, axon guidance, and terminal arborization by DA neurons.</EA>
<CC>002A25; 002B17G</CC>
<FD>Récepteur biologique; Dopamine; Axone; Synaptogenèse; Maladie de Parkinson; Schizophrénie</FD>
<FG>Catécholamine; Neurotransmetteur; Maladie dégénérative; Pathologie du   système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du   système nerveux central; Psychose</FG>
<ED>Biological receptor; Dopamine; Axon; Synaptogenesis; Parkinson disease; Schizophrenia</ED>
<EG>Catecholamine; Neurotransmitter; Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Psychosis</EG>
<SD>Receptor biológico; Dopamina; Axón; Sinaptogénesis; Parkinson enfermedad; Esquizofrenia</SD>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION

CRITICAL ROLES FOR THE NETRIN RECEPTOR DELETED IN COLORECTAL CANCER IN DOPAMINERGIC NEURONAL PRECURSOR MIGRATION, AXON GUIDANCE, AND AXON ARBORIZATION

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