ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000036

Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study

Identifieur interne : 000036 ( PascalFrancis/Corpus ); précédent : 000035; suivant : 000037

Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study

Auteurs : Mauro Pettorruso ; Giovanni Martinotti ; Alfonso Fasano ; Giovanna Loria ; Marco Di Nicola ; Luisa De Risio ; Lucia Ricciardi ; Gianluigi Conte ; Luigi Janiri ; Anna Rita Bentivoglio

Source :

Psychiatry research : (Print) [ 0165-1781 ] ; 2014.

RBID : Pascal:14-0060802

Descripteurs français

Pascal (Inist)
- Anhédonie, Maladie de Parkinson, Etude comparative, Jeu pathologique, Etude cas témoin, Addiction, Comportement, Récompense, Plaisir déplaisir, Bien-être, Trouble du contrôle des impulsions, Impulsivité, Lobe frontal, Dopamine, Traitement substitutif, Homme.

English descriptors

KwdEn :
- Addiction, Anhedonia, Behavior, Case control study, Comparative study, Dopamine, Frontal lobe, Human, Impulse control disorder, Impulsivity, Parkinson disease, Pathological gambling, Pleasure unpleasure, Replacement therapy, Reward, Well being.

Abstract

Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0 ± 1.3 vs. 1.0 ± 1.1 vs. 1.0 + 1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0 ± 10.6 vs. 64.8 ± 11 vs. 60.9 ±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4 ±4.9 vs. 15.5 ± 1.6 vs. 14.4 ±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 14-0060802 INIST
ET :	Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study
AU :	PETTORRUSO (Mauro); MARTINOTTI (Giovanni); FASANO (Alfonso); LORIA (Giovanna); DI NICOLA (Marco); DE RISIO (Luisa); RICCIARDI (Lucia); CONTE (Gianluigi); JANIRI (Luigi); BENTIVOGLIO (Anna Rita)
AF :	Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart/Rome/Italie (1 aut., 5 aut., 6 aut., 8 aut., 9 aut.); Department of Neurosciences and Imaging, University "G. D'Annunzio"/Chieti/Italie (2 aut.); Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (3 aut.); Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart/Rome/Italie (4 aut., 7 aut., 10 aut.)
DT :	Publication en série; Niveau analytique
SO :	Psychiatry research : (Print); ISSN 0165-1781; Coden PSRSDR; Royaume-Uni; Da. 2014; Vol. 215; No. 2; Pp. 448-452; Bibl. 1 p.1/4
LA :	Anglais
EA :	Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0 ± 1.3 vs. 1.0 ± 1.1 vs. 1.0 + 1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0 ± 10.6 vs. 64.8 ± 11 vs. 60.9 ±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4 ±4.9 vs. 15.5 ± 1.6 vs. 14.4 ±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.
CC :	002B18C13; 002B17G; 002B18C14; 002B18C04
FD :	Anhédonie; Maladie de Parkinson; Etude comparative; Jeu pathologique; Etude cas témoin; Addiction; Comportement; Récompense; Plaisir déplaisir; Bien-être; Trouble du contrôle des impulsions; Impulsivité; Lobe frontal; Dopamine; Traitement substitutif; Homme
FG :	Affect affectivité; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux; Encéphale; Système nerveux central; Catécholamine; Neurotransmetteur
ED :	Anhedonia; Parkinson disease; Comparative study; Pathological gambling; Case control study; Addiction; Behavior; Reward; Pleasure unpleasure; Well being; Impulse control disorder; Impulsivity; Frontal lobe; Dopamine; Replacement therapy; Human
EG :	Affect affectivity; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Encephalon; Central nervous system; Catecholamine; Neurotransmitter
SD :	Anhedonia; Parkinson enfermedad; Estudio comparativo; Juego patológico; Estudio caso control; Adicción; Conducta; Recompensa; Placer disgusto; Bienestar; Trastorno control impulso; Impulsividad; Lóbulo frontal; Dopamina; Tratamiento sustitutivo; Hombre
LO :	INIST-18303.354000505754560300
ID :	14-0060802

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Pascal:14-0060802

Le document en format XML

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<author><name sortKey="Di Nicola, Marco" sort="Di Nicola, Marco" uniqKey="Di Nicola M" first="Marco" last="Di Nicola">Marco Di Nicola</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
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<author><name sortKey="De Risio, Luisa" sort="De Risio, Luisa" uniqKey="De Risio L" first="Luisa" last="De Risio">Luisa De Risio</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<author><name sortKey="Ricciardi, Lucia" sort="Ricciardi, Lucia" uniqKey="Ricciardi L" first="Lucia" last="Ricciardi">Lucia Ricciardi</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Conte, Gianluigi" sort="Conte, Gianluigi" uniqKey="Conte G" first="Gianluigi" last="Conte">Gianluigi Conte</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
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</author>
<author><name sortKey="Janiri, Luigi" sort="Janiri, Luigi" uniqKey="Janiri L" first="Luigi" last="Janiri">Luigi Janiri</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name>
<affiliation><inist:fA14 i1="04"><s1>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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</author>
</analytic>
<series><title level="j" type="main">Psychiatry research : (Print)</title>
<title level="j" type="abbreviated">Psychiatry res. : (Print)</title>
<idno type="ISSN">0165-1781</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Psychiatry research : (Print)</title>
<title level="j" type="abbreviated">Psychiatry res. : (Print)</title>
<idno type="ISSN">0165-1781</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Addiction</term>
<term>Anhedonia</term>
<term>Behavior</term>
<term>Case control study</term>
<term>Comparative study</term>
<term>Dopamine</term>
<term>Frontal lobe</term>
<term>Human</term>
<term>Impulse control disorder</term>
<term>Impulsivity</term>
<term>Parkinson disease</term>
<term>Pathological gambling</term>
<term>Pleasure unpleasure</term>
<term>Replacement therapy</term>
<term>Reward</term>
<term>Well being</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Anhédonie</term>
<term>Maladie de Parkinson</term>
<term>Etude comparative</term>
<term>Jeu pathologique</term>
<term>Etude cas témoin</term>
<term>Addiction</term>
<term>Comportement</term>
<term>Récompense</term>
<term>Plaisir déplaisir</term>
<term>Bien-être</term>
<term>Trouble du contrôle des impulsions</term>
<term>Impulsivité</term>
<term>Lobe frontal</term>
<term>Dopamine</term>
<term>Traitement substitutif</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0 ± 1.3 vs. 1.0 ± 1.1 vs. 1.0 + 1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0 ± 10.6 vs. 64.8 ± 11 vs. 60.9 ±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4 ±4.9 vs. 15.5 ± 1.6 vs. 14.4 ±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.</div>
</front>
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<fA06><s2>2</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PETTORRUSO (Mauro)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>MARTINOTTI (Giovanni)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>FASANO (Alfonso)</s1>
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<fA11 i1="04" i2="1"><s1>LORIA (Giovanna)</s1>
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<fA11 i1="05" i2="1"><s1>DI NICOLA (Marco)</s1>
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<fA11 i1="06" i2="1"><s1>DE RISIO (Luisa)</s1>
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<fA11 i1="07" i2="1"><s1>RICCIARDI (Lucia)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>CONTE (Gianluigi)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>JANIRI (Luigi)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>BENTIVOGLIO (Anna Rita)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neurosciences and Imaging, University "G. D'Annunzio"</s1>
<s2>Chieti</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA20><s1>448-452</s1>
</fA20>
<fA21><s1>2014</s1>
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<fA47 i1="01" i2="1"><s0>14-0060802</s0>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>Psychiatry research : (Print)</s0>
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<fC01 i1="01" l="ENG"><s0>Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0 ± 1.3 vs. 1.0 ± 1.1 vs. 1.0 + 1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0 ± 10.6 vs. 64.8 ± 11 vs. 60.9 ±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4 ±4.9 vs. 15.5 ± 1.6 vs. 14.4 ±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B18C13</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B18C14</s0>
</fC02>
<fC02 i1="04" i2="X"><s0>002B18C04</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Anhédonie</s0>
<s5>01</s5>
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<s5>01</s5>
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<s5>01</s5>
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<fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
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<s5>02</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>03</s5>
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<fC03 i1="03" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE"><s0>Jeu pathologique</s0>
<s5>04</s5>
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<fC03 i1="04" i2="X" l="ENG"><s0>Pathological gambling</s0>
<s5>04</s5>
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<fC03 i1="04" i2="X" l="SPA"><s0>Juego patológico</s0>
<s5>04</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Etude cas témoin</s0>
<s5>05</s5>
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<s5>05</s5>
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<fC03 i1="06" i2="X" l="ENG"><s0>Addiction</s0>
<s2>NM</s2>
<s5>06</s5>
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<fC03 i1="06" i2="X" l="SPA"><s0>Adicción</s0>
<s2>NM</s2>
<s5>06</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Comportement</s0>
<s5>07</s5>
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<s5>07</s5>
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<s5>07</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Récompense</s0>
<s5>08</s5>
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<s5>08</s5>
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<fC03 i1="08" i2="X" l="SPA"><s0>Recompensa</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Plaisir déplaisir</s0>
<s5>09</s5>
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<s5>09</s5>
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<s5>09</s5>
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<s5>10</s5>
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<fC03 i1="10" i2="X" l="ENG"><s0>Well being</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Bienestar</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Trouble du contrôle des impulsions</s0>
<s2>NM</s2>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Impulse control disorder</s0>
<s2>NM</s2>
<s5>11</s5>
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<fC03 i1="11" i2="X" l="SPA"><s0>Trastorno control impulso</s0>
<s2>NM</s2>
<s5>11</s5>
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<fC03 i1="12" i2="X" l="FRE"><s0>Impulsivité</s0>
<s5>12</s5>
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<fC03 i1="12" i2="X" l="ENG"><s0>Impulsivity</s0>
<s5>12</s5>
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<s5>13</s5>
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<s5>13</s5>
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<fC03 i1="13" i2="X" l="SPA"><s0>Lóbulo frontal</s0>
<s5>13</s5>
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<fC03 i1="14" i2="X" l="FRE"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
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<fC03 i1="14" i2="X" l="ENG"><s0>Dopamine</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
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<fC03 i1="14" i2="X" l="SPA"><s0>Dopamina</s0>
<s2>NK</s2>
<s2>FR</s2>
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<s5>15</s5>
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<s5>15</s5>
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<s5>18</s5>
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<s5>18</s5>
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<s5>18</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
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<s5>40</s5>
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<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
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<s5>42</s5>
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<s5>42</s5>
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<s5>43</s5>
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<s5>43</s5>
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<s5>43</s5>
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<s5>45</s5>
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<s5>45</s5>
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<s5>45</s5>
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<s5>46</s5>
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<s5>46</s5>
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<s5>46</s5>
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<fN21><s1>083</s1>
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<server><NO>PASCAL 14-0060802 INIST</NO>
<ET>Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study</ET>
<AU>PETTORRUSO (Mauro); MARTINOTTI (Giovanni); FASANO (Alfonso); LORIA (Giovanna); DI NICOLA (Marco); DE RISIO (Luisa); RICCIARDI (Lucia); CONTE (Gianluigi); JANIRI (Luigi); BENTIVOGLIO (Anna Rita)</AU>
<AF>Department of Psychiatry, Drug Addiction Unit, Catholic University of The Sacred Heart/Rome/Italie (1 aut., 5 aut., 6 aut., 8 aut., 9 aut.); Department of Neurosciences and Imaging, University "G. D'Annunzio"/Chieti/Italie (2 aut.); Movement Disorders Center, TWH, UHN, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (3 aut.); Department of Neurology, Movement Disorder Unit, Catholic University of The Sacred Heart/Rome/Italie (4 aut., 7 aut., 10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Psychiatry research : (Print); ISSN 0165-1781; Coden PSRSDR; Royaume-Uni; Da. 2014; Vol. 215; No. 2; Pp. 448-452; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Anhedonia is present in Parkinson's Disease (PD) as well as in addictive behaviors. Pathological Gambling (PG) and other Impulse Control Disorders (ICDs) have emerged as iatrogenic complications associated with dopamine replacement therapy. We studied 154 PD patients, divided into three groups: 11 with PG, 23 with other ICDs (compulsive buying, hypersexuality, binge eating), 120 without ICDs. All patients underwent a thorough clinical, neuropsychological and psychiatric evaluation. The PG-group, compared to the ICDs-group and PD-controls, reported a significantly higher incidence of anhedonia (45% vs. 9% vs. 14% respectively), higher Snaith-Hamilton Pleasure Scale (SHAPS) scores (2.0 ± 1.3 vs. 1.0 ± 1.1 vs. 1.0 + 1.2), higher levels of impulsivity traits as measured by the Barratt Impulsiveness Scale (70.0 ± 10.6 vs. 64.8 ± 11 vs. 60.9 ±9.3) and more severe frontal dysfunctions (Frontal Assessment Battery, FAB: 12.4 ±4.9 vs. 15.5 ± 1.6 vs. 14.4 ±3). A model for PG (incorporating anhedonia, impulsivity levels and frontal impairment) is discussed in the context of the pathophysiology of addictive behaviors. The impairment of hedonic capacity, possibly resulting from an underlying neuropsychological dysfunction, might facilitate loss of control over reward-related behavior, thus favoring the shift towards predominantly habit-based compulsive behaviors.</EA>
<CC>002B18C13; 002B17G; 002B18C14; 002B18C04</CC>
<FD>Anhédonie; Maladie de Parkinson; Etude comparative; Jeu pathologique; Etude cas témoin; Addiction; Comportement; Récompense; Plaisir déplaisir; Bien-être; Trouble du contrôle des impulsions; Impulsivité; Lobe frontal; Dopamine; Traitement substitutif; Homme</FD>
<FG>Affect affectivité; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie du   système nerveux; Encéphale; Système nerveux central; Catécholamine; Neurotransmetteur</FG>
<ED>Anhedonia; Parkinson disease; Comparative study; Pathological gambling; Case control study; Addiction; Behavior; Reward; Pleasure unpleasure; Well being; Impulse control disorder; Impulsivity; Frontal lobe; Dopamine; Replacement therapy; Human</ED>
<EG>Affect affectivity; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Encephalon; Central nervous system; Catecholamine; Neurotransmitter</EG>
<SD>Anhedonia; Parkinson enfermedad; Estudio comparativo; Juego patológico; Estudio caso control; Adicción; Conducta; Recompensa; Placer disgusto; Bienestar; Trastorno control impulso; Impulsividad; Lóbulo frontal; Dopamina; Tratamiento sustitutivo; Hombre</SD>
<LO>INIST-18303.354000505754560300</LO>
<ID>14-0060802</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study

Anhedonia in Parkinson's disease patients with and without pathological gambling: A case-control study

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