Surgery for levodopa-induced dyskinesias. Discussion
Identifieur interne : 000B54 ( PascalFrancis/Checkpoint ); précédent : 000B53; suivant : 000B55Surgery for levodopa-induced dyskinesias. Discussion
Auteurs : A. E. Lang [Canada] ; LANGSTON ; RASCOL ; BROTCHIE ; BENABID ; MELAMED ; BONUCELLI ; OLANOW ; OBESO ; GIMENEZ-ROLDAN ; RAJPUT ; FAHN ; NUTT ; BROOKS ; CHASESource :
- Annals of neurology [ 0364-5134 ] ; 2000.
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Abstract
The effects of surgical interventions for levodopa-induced dyskinesias (LIDs) in Parkinson's disease are reviewed. Since the introduction of levodopa, thalamotomy has been reported to have variable effects on LIDs. Striking benefit has been demonstrated, and efficacy is probably dependent on the size and location of the lesion. However, it remains unclear whether it is an effective treatment for all types of LIDs. Currently, pallidotomy is probably the most reliable and effective surgical treatment for LIDs, and will continue to play an important role in its management until other treatments become more widely available. Deep brain stimulation is an extremely exciting mode of therapy, particularly in the subthalamic nucleus and the globus pallidus, and early results of its use in the treatment of LIDs are promising. The effects of cerebral transplantation, still an experimental technique, on LIDs are inconsistent and controversial, and there is little reliable evidence that gamma knife radiosurgery can be safely applied to parkinsonian patients for the treatment of LIDs.
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Lang</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Morton & Gloria Shulman Movement Disorders Clinic; and the University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Langston" sort="Langston" uniqKey="Langston" last="Langston">LANGSTON</name></author><author><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">RASCOL</name></author><author><name sortKey="Brotchie" sort="Brotchie" uniqKey="Brotchie" last="Brotchie">BROTCHIE</name></author><author><name sortKey="Benabid" sort="Benabid" uniqKey="Benabid" last="Benabid">BENABID</name></author><author><name sortKey="Melamed" sort="Melamed" uniqKey="Melamed" last="Melamed">MELAMED</name></author><author><name sortKey="Bonucelli" sort="Bonucelli" uniqKey="Bonucelli" last="Bonucelli">BONUCELLI</name></author><author><name sortKey="Olanow" sort="Olanow" uniqKey="Olanow" last="Olanow">OLANOW</name></author><author><name sortKey="Obeso" sort="Obeso" uniqKey="Obeso" last="Obeso">OBESO</name></author><author><name sortKey="Gimenez Roldan" sort="Gimenez Roldan" uniqKey="Gimenez Roldan" last="Gimenez-Roldan">GIMENEZ-ROLDAN</name></author><author><name sortKey="Rajput" sort="Rajput" uniqKey="Rajput" last="Rajput">RAJPUT</name></author><author><name sortKey="Fahn" sort="Fahn" uniqKey="Fahn" last="Fahn">FAHN</name></author><author><name sortKey="Nutt" sort="Nutt" uniqKey="Nutt" last="Nutt">NUTT</name></author><author><name sortKey="Brooks" sort="Brooks" uniqKey="Brooks" last="Brooks">BROOKS</name></author><author><name sortKey="Chase" sort="Chase" uniqKey="Chase" last="Chase">CHASE</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0262068</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0262068 INIST</idno><idno type="RBID">Pascal:00-0262068</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D04</idno><idno type="wicri:Area/PascalFrancis/Curation">000020</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000B54</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Surgery for levodopa-induced dyskinesias. Discussion</title><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Toronto Western Hospital, Morton & Gloria Shulman Movement Disorders Clinic; and the University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Langston" sort="Langston" uniqKey="Langston" last="Langston">LANGSTON</name></author><author><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">RASCOL</name></author><author><name sortKey="Brotchie" sort="Brotchie" uniqKey="Brotchie" last="Brotchie">BROTCHIE</name></author><author><name sortKey="Benabid" sort="Benabid" uniqKey="Benabid" last="Benabid">BENABID</name></author><author><name sortKey="Melamed" sort="Melamed" uniqKey="Melamed" last="Melamed">MELAMED</name></author><author><name sortKey="Bonucelli" sort="Bonucelli" uniqKey="Bonucelli" last="Bonucelli">BONUCELLI</name></author><author><name sortKey="Olanow" sort="Olanow" uniqKey="Olanow" last="Olanow">OLANOW</name></author><author><name sortKey="Obeso" sort="Obeso" uniqKey="Obeso" last="Obeso">OBESO</name></author><author><name sortKey="Gimenez Roldan" sort="Gimenez Roldan" uniqKey="Gimenez Roldan" last="Gimenez-Roldan">GIMENEZ-ROLDAN</name></author><author><name sortKey="Rajput" sort="Rajput" uniqKey="Rajput" last="Rajput">RAJPUT</name></author><author><name sortKey="Fahn" sort="Fahn" uniqKey="Fahn" last="Fahn">FAHN</name></author><author><name sortKey="Nutt" sort="Nutt" uniqKey="Nutt" last="Nutt">NUTT</name></author><author><name sortKey="Brooks" sort="Brooks" uniqKey="Brooks" last="Brooks">BROOKS</name></author><author><name sortKey="Chase" sort="Chase" uniqKey="Chase" last="Chase">CHASE</name></author></analytic><series><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson agent</term><term>Dyskinesia</term><term>Human</term><term>Levodopa</term><term>Pallidum</term><term>Parkinson disease</term><term>Review</term><term>Surgery</term><term>Thalamotomy</term><term>Transplantation</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Dyskinésie</term><term>Lévodopa</term><term>Antiparkinsonien</term><term>Chirurgie</term><term>Article synthèse</term><term>Traitement</term><term>Homme</term><term>Thalamotomie</term><term>Pallidum</term><term>Transplantation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of surgical interventions for levodopa-induced dyskinesias (LIDs) in Parkinson's disease are reviewed. Since the introduction of levodopa, thalamotomy has been reported to have variable effects on LIDs. Striking benefit has been demonstrated, and efficacy is probably dependent on the size and location of the lesion. However, it remains unclear whether it is an effective treatment for all types of LIDs. Currently, pallidotomy is probably the most reliable and effective surgical treatment for LIDs, and will continue to play an important role in its management until other treatments become more widely available. Deep brain stimulation is an extremely exciting mode of therapy, particularly in the subthalamic nucleus and the globus pallidus, and early results of its use in the treatment of LIDs are promising. The effects of cerebral transplantation, still an experimental technique, on LIDs are inconsistent and controversial, and there is little reliable evidence that gamma knife radiosurgery can be safely applied to parkinsonian patients for the treatment of LIDs.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0364-5134</s0></fA01><fA02 i1="01"><s0>ANNED3</s0></fA02><fA03 i2="1"><s0>Ann. neurol.</s0></fA03><fA05><s2>47</s2></fA05><fA06><s2>4</s2><s3>SUP1</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Surgery for levodopa-induced dyskinesias. Discussion</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Levodopa-induced dyskinesias</s1></fA09><fA11 i1="01" i2="1"><s1>LANG (A. E.)</s1></fA11><fA11 i1="02" i2="1"><s1>LANGSTON</s1><s9>comment.</s9></fA11><fA11 i1="03" i2="1"><s1>RASCOL</s1><s9>comment.</s9></fA11><fA11 i1="04" i2="1"><s1>BROTCHIE</s1><s9>comment.</s9></fA11><fA11 i1="05" i2="1"><s1>BENABID</s1><s9>comment.</s9></fA11><fA11 i1="06" i2="1"><s1>MELAMED</s1><s9>comment.</s9></fA11><fA11 i1="07" i2="1"><s1>BONUCELLI</s1><s9>comment.</s9></fA11><fA11 i1="08" i2="1"><s1>OLANOW</s1><s9>comment.</s9></fA11><fA11 i1="09" i2="1"><s1>OBESO</s1><s9>comment.</s9></fA11><fA11 i1="10" i2="1"><s1>GIMENEZ-ROLDAN</s1><s9>comment.</s9></fA11><fA11 i1="11" i2="1"><s1>RAJPUT</s1><s9>comment.</s9></fA11><fA11 i1="12" i2="1"><s1>FAHN</s1><s9>comment.</s9></fA11><fA11 i1="13" i2="1"><s1>NUTT</s1><s9>comment.</s9></fA11><fA11 i1="14" i2="1"><s1>BROOKS</s1><s9>comment.</s9></fA11><fA11 i1="15" i2="1"><s1>CHASE</s1><s9>comment.</s9></fA11><fA12 i1="01" i2="1"><s1>OLANOW (C. Warren)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>Toronto Western Hospital, Morton & Gloria Shulman Movement Disorders Clinic; and the University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA14><fA15 i1="01"><s1>Department of Neurology, Mount Sinai School of Medicine, 1 Gustave Levy Place, Annenburg 14-94</s1><s2>New York, NY 10029</s2><s3>USA</s3><sZ>1 aut.</sZ></fA15><fA20><s2>S193-S202</s2></fA20><fA21><s1>2000</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>16555</s2><s5>354000082146950220</s5></fA43><fA44><s0>0000</s0><s1>© 2000 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>53 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>00-0262068</s0></fA47><fA60><s1>P</s1><s3>AR</s3><s3>CT</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Annals of neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The effects of surgical interventions for levodopa-induced dyskinesias (LIDs) in Parkinson's disease are reviewed. Since the introduction of levodopa, thalamotomy has been reported to have variable effects on LIDs. Striking benefit has been demonstrated, and efficacy is probably dependent on the size and location of the lesion. However, it remains unclear whether it is an effective treatment for all types of LIDs. Currently, pallidotomy is probably the most reliable and effective surgical treatment for LIDs, and will continue to play an important role in its management until other treatments become more widely available. Deep brain stimulation is an extremely exciting mode of therapy, particularly in the subthalamic nucleus and the globus pallidus, and early results of its use in the treatment of LIDs are promising. The effects of cerebral transplantation, still an experimental technique, on LIDs are inconsistent and controversial, and there is little reliable evidence that gamma knife radiosurgery can be safely applied to parkinsonian patients for the treatment of LIDs.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Dyskinésie</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Dyskinesia</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Disquinesia</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Lévodopa</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Levodopa</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Levodopa</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" 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sort="Fahn" uniqKey="Fahn" last="Fahn">FAHN</name><name sortKey="Gimenez Roldan" sort="Gimenez Roldan" uniqKey="Gimenez Roldan" last="Gimenez-Roldan">GIMENEZ-ROLDAN</name><name sortKey="Langston" sort="Langston" uniqKey="Langston" last="Langston">LANGSTON</name><name sortKey="Melamed" sort="Melamed" uniqKey="Melamed" last="Melamed">MELAMED</name><name sortKey="Nutt" sort="Nutt" uniqKey="Nutt" last="Nutt">NUTT</name><name sortKey="Obeso" sort="Obeso" uniqKey="Obeso" last="Obeso">OBESO</name><name sortKey="Olanow" sort="Olanow" uniqKey="Olanow" last="Olanow">OLANOW</name><name sortKey="Rajput" sort="Rajput" uniqKey="Rajput" last="Rajput">RAJPUT</name><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">RASCOL</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. 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