Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-lnduced behavioral sensitization in dyskinetic rats
Identifieur interne : 000809 ( PascalFrancis/Checkpoint ); précédent : 000808; suivant : 000810Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-lnduced behavioral sensitization in dyskinetic rats
Auteurs : Véronique Sgambato-Faure [France] ; Virginie Buggia [France] ; Frangois Gilbert [Canada] ; Daniel Levesque [Canada] ; Alim-Louis Benabid [France] ; Francois Berger [France]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2005.
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- Pascal (Inist)
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Abstract
Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptations remain to be elucidated. In this study, using a rat model of L-Dopainduced dyskinesia, we report that activity regulated cytoskeletal (Arc)-associated protein is strongly upregulated in the lesioned striatum and that the extent of its induction further varies according to the occurrence or absence of locomotor sensitization. Moreover, Arc is preferentially induced, along with FosB, nur77, and homer-1a, in striatonigral neurons, which express mRNA encoding the precursor of dynorphin. Given the likely importance of Arc in the regulation of cytoskeleton during synaptic plasticity, its upregulation supports the hypothesis that a relationship exists between cytoskeletal modifications and the longlasting action of chronically administrated L-Dopa.
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wicri:step="Checkpoint">000809</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-lnduced behavioral sensitization in dyskinetic rats</title><author><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Véronique" last="Sgambato-Faure">Véronique Sgambato-Faure</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>From Inserm U318, Laboratoire de Neurosciences Précliniques, CHU Pavilion B</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Buggia, Virginie" sort="Buggia, Virginie" uniqKey="Buggia V" first="Virginie" last="Buggia">Virginie Buggia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>From Inserm U318, Laboratoire de Neurosciences Précliniques, CHU Pavilion B</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Gilbert, Frangois" sort="Gilbert, Frangois" uniqKey="Gilbert F" first="Frangois" last="Gilbert">Frangois Gilbert</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre de recherche en Neuroscience, CHUL</s1><s2>Sainte Foy, Québec</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sainte Foy, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Levesque, Daniel" sort="Levesque, Daniel" uniqKey="Levesque D" first="Daniel" last="Levesque">Daniel Levesque</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre de recherche en Neuroscience, CHUL</s1><s2>Sainte Foy, Québec</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sainte Foy, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>From Inserm U318, Laboratoire de Neurosciences Précliniques, CHU Pavilion B</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Berger, Francois" sort="Berger, Francois" uniqKey="Berger F" first="Francois" last="Berger">Francois Berger</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>From Inserm U318, Laboratoire de Neurosciences Précliniques, CHU Pavilion B</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Cytoskeleton</term><term>Dyskinesia</term><term>Levodopa</term><term>Pathogenesis</term><term>Plasticity</term><term>Rat</term><term>Synapse</term><term>Toxicity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dyskinésie</term><term>Lévodopa</term><term>Animal</term><term>Rat</term><term>Toxicité</term><term>Pathogénie</term><term>Plasticité</term><term>Synapse</term><term>Cytosquelette</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptations remain to be elucidated. In this study, using a rat model of L-Dopainduced dyskinesia, we report that activity regulated cytoskeletal (Arc)-associated protein is strongly upregulated in the lesioned striatum and that the extent of its induction further varies according to the occurrence or absence of locomotor sensitization. Moreover, Arc is preferentially induced, along with FosB, nur77, and homer-1a, in striatonigral neurons, which express mRNA encoding the precursor of dynorphin. Given the likely importance of Arc in the regulation of cytoskeleton during synaptic plasticity, its upregulation supports the hypothesis that a relationship exists between cytoskeletal modifications and the longlasting action of chronically administrated L-Dopa.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3069</s0></fA01><fA02 i1="01"><s0>JNENAD</s0></fA02><fA03 i2="1"><s0>J. neuropathol. exp. neurol.</s0></fA03><fA05><s2>64</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-lnduced behavioral sensitization in dyskinetic rats</s1></fA08><fA11 i1="01" i2="1"><s1>SGAMBATO-FAURE (Véronique)</s1></fA11><fA11 i1="02" i2="1"><s1>BUGGIA (Virginie)</s1></fA11><fA11 i1="03" i2="1"><s1>GILBERT (Frangois)</s1></fA11><fA11 i1="04" i2="1"><s1>LEVESQUE (Daniel)</s1></fA11><fA11 i1="05" i2="1"><s1>BENABID (Alim-Louis)</s1></fA11><fA11 i1="06" i2="1"><s1>BERGER (Francois)</s1></fA11><fA14 i1="01"><s1>From Inserm U318, Laboratoire de Neurosciences Précliniques, CHU Pavilion B</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Centre de recherche en Neuroscience, CHUL</s1><s2>Sainte Foy, Québec</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>936-947</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>3036</s2><s5>354000135132060020</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>88 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0179710</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of neuropathology and experimental neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptations remain to be elucidated. 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Buggia</name></country><country name="Canada"><noRegion><name sortKey="Gilbert, Frangois" sort="Gilbert, Frangois" uniqKey="Gilbert F" first="Frangois" last="Gilbert">Frangois Gilbert</name></noRegion><name sortKey="Levesque, Daniel" sort="Levesque, Daniel" uniqKey="Levesque D" first="Daniel" last="Levesque">Daniel Levesque</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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