Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease
Identifieur interne : 000322 ( PascalFrancis/Checkpoint ); précédent : 000321; suivant : 000323Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease
Auteurs : Pierre-Luc Tremblay [Canada] ; Marc-Andre Bedard [Canada] ; Dominic Langlois [Canada] ; Pierre J. Blanchet [Canada] ; Martin Lemay [Canada] ; Maxime Parent [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2010.
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Abstract
Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.
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Box 8888</s1><s2>Montreal, QC H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC H3C 3P8</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, Marc Andre" sort="Bedard, Marc Andre" uniqKey="Bedard M" first="Marc-Andre" last="Bedard">Marc-Andre Bedard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888</s1><s2>Montreal, QC H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC H3C 3P8</wicri:noRegion></affiliation></author><author><name sortKey="Langlois, Dominic" sort="Langlois, Dominic" uniqKey="Langlois D" first="Dominic" last="Langlois">Dominic Langlois</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888</s1><s2>Montreal, QC H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC H3C 3P8</wicri:noRegion></affiliation></author><author><name sortKey="Blanchet, Pierre J" sort="Blanchet, Pierre J" uniqKey="Blanchet P" first="Pierre J." last="Blanchet">Pierre J. Blanchet</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>André-Barbeau Movement Disorder Centre, CHUM</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC</wicri:noRegion></affiliation></author><author><name sortKey="Lemay, Martin" sort="Lemay, Martin" uniqKey="Lemay M" first="Martin" last="Lemay">Martin Lemay</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Département de kinésiologie, UQAM</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)</wicri:noRegion></affiliation></author><author><name sortKey="Parent, Maxime" sort="Parent, Maxime" uniqKey="Parent M" first="Maxime" last="Parent">Maxime Parent</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888</s1><s2>Montreal, QC H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, QC H3C 3P8</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus striatum</term><term>Depletion</term><term>Encephalon</term><term>Human</term><term>Levodopa</term><term>Motor control</term><term>Motor learning</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Apprentissage moteur</term><term>Encéphale</term><term>Déplétion</term><term>Corps strié</term><term>Lévodopa</term><term>Contrôle moteur</term><term>Maladie de Parkinson</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0014-4819</s0></fA01><fA02 i1="01"><s0>EXBRAP</s0></fA02><fA03 i2="1"><s0>Exp. brain res.</s0></fA03><fA05><s2>205</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>TREMBLAY (Pierre-Luc)</s1></fA11><fA11 i1="02" i2="1"><s1>BEDARD (Marc-Andre)</s1></fA11><fA11 i1="03" i2="1"><s1>LANGLOIS (Dominic)</s1></fA11><fA11 i1="04" i2="1"><s1>BLANCHET (Pierre J.)</s1></fA11><fA11 i1="05" i2="1"><s1>LEMAY (Martin)</s1></fA11><fA11 i1="06" i2="1"><s1>PARENT (Maxime)</s1></fA11><fA14 i1="01"><s1>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888</s1><s2>Montreal, QC H3C 3P8</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>André-Barbeau Movement Disorder Centre, CHUM</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Département de kinésiologie, UQAM</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>375-385</s1></fA20><fA21><s1>2010</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>12535</s2><s5>354000192634910070</s5></fA43><fA44><s0>0000</s0><s1>© 2010 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>3/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>10-0428398</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Experimental brain research</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC02 i1="02" i2="X"><s0>002A25E</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Apprentissage moteur</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Motor learning</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Aprendizaje motor</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Encéphale</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Encephalon</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Encéfalo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Déplétion</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Depletion</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Depleción</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Corps strié</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Corpus striatum</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Cuerpo estriado</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Lévodopa</s0><s2>NK</s2><s2>FR</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Levodopa</s0><s2>NK</s2><s2>FR</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Contrôle moteur</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Motor control</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Control motor</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>54</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>54</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>54</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Motricité</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Motricity</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Motricidad</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Processus acquisition</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Acquisition process</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Proceso adquisición</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>24</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>25</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>25</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>25</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>26</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>26</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>26</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>27</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system</s0><s5>27</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>27</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Noyau gris central</s0><s5>28</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Basal ganglion</s0><s5>28</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Núcleo basal</s0><s5>28</s5></fC07><fN21><s1>277</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Tremblay, Pierre Luc" sort="Tremblay, Pierre Luc" uniqKey="Tremblay P" first="Pierre-Luc" last="Tremblay">Pierre-Luc Tremblay</name></noRegion><name sortKey="Bedard, Marc Andre" sort="Bedard, Marc Andre" uniqKey="Bedard M" first="Marc-Andre" last="Bedard">Marc-Andre Bedard</name><name sortKey="Blanchet, Pierre J" sort="Blanchet, Pierre J" uniqKey="Blanchet P" first="Pierre J." last="Blanchet">Pierre J. Blanchet</name><name sortKey="Blanchet, Pierre J" sort="Blanchet, Pierre J" uniqKey="Blanchet P" first="Pierre J." last="Blanchet">Pierre J. Blanchet</name><name sortKey="Langlois, Dominic" sort="Langlois, Dominic" uniqKey="Langlois D" first="Dominic" last="Langlois">Dominic Langlois</name><name sortKey="Lemay, Martin" sort="Lemay, Martin" uniqKey="Lemay M" first="Martin" last="Lemay">Martin Lemay</name><name sortKey="Lemay, Martin" sort="Lemay, Martin" uniqKey="Lemay M" first="Martin" last="Lemay">Martin Lemay</name><name sortKey="Parent, Maxime" sort="Parent, Maxime" uniqKey="Parent M" first="Maxime" last="Parent">Maxime Parent</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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