ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000396

Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease

Identifieur interne : 000396 ( PascalFrancis/Corpus ); précédent : 000395; suivant : 000397

Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease

Auteurs : Pierre-Luc Tremblay ; Marc-Andre Bedard ; Dominic Langlois ; Pierre J. Blanchet ; Martin Lemay ; Maxime Parent

Source :

Experimental brain research [ 0014-4819 ] ; 2010.

RBID : Pascal:10-0428398

Descripteurs français

Pascal (Inist)
- Apprentissage moteur, Encéphale, Déplétion, Corps strié, Lévodopa, Contrôle moteur, Maladie de Parkinson, Homme.

English descriptors

KwdEn :
- Corpus striatum, Depletion, Encephalon, Human, Levodopa, Motor control, Motor learning, Parkinson disease.

Abstract

Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 10-0428398 INIST
ET :	Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease
AU :	TREMBLAY (Pierre-Luc); BEDARD (Marc-Andre); LANGLOIS (Dominic); BLANCHET (Pierre J.); LEMAY (Martin); PARENT (Maxime)
AF :	Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888/Montreal, QC H3C 3P8/Canada (1 aut., 2 aut., 3 aut., 6 aut.); André-Barbeau Movement Disorder Centre, CHUM/Montreal, QC/Canada (4 aut.); Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal/Montreal, QC/Canada (4 aut.); Département de kinésiologie, UQAM/Montreal, QC/Canada (5 aut.); Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)/Montreal, QC/Canada (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Experimental brain research; ISSN 0014-4819; Coden EXBRAP; Allemagne; Da. 2010; Vol. 205; No. 3; Pp. 375-385; Bibl. 3/4 p.
LA :	Anglais
EA :	Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.
CC :	002B17G; 002A25E
FD :	Apprentissage moteur; Encéphale; Déplétion; Corps strié; Lévodopa; Contrôle moteur; Maladie de Parkinson; Homme
FG :	Motricité; Processus acquisition; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux; Système nerveux central; Noyau gris central
ED :	Motor learning; Encephalon; Depletion; Corpus striatum; Levodopa; Motor control; Parkinson disease; Human
EG :	Motricity; Acquisition process; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system; Basal ganglion
SD :	Aprendizaje motor; Encéfalo; Depleción; Cuerpo estriado; Levodopa; Control motor; Parkinson enfermedad; Hombre
LO :	INIST-12535.354000192634910070
ID :	10-0428398

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Pascal:10-0428398

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<front><div type="abstract" xml:lang="en">Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease</s1>
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<fA11 i1="01" i2="1"><s1>TREMBLAY (Pierre-Luc)</s1>
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<fA11 i1="02" i2="1"><s1>BEDARD (Marc-Andre)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>LANGLOIS (Dominic)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BLANCHET (Pierre J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LEMAY (Martin)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>PARENT (Maxime)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888</s1>
<s2>Montreal, QC H3C 3P8</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>André-Barbeau Movement Disorder Centre, CHUM</s1>
<s2>Montreal, QC</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal</s1>
<s2>Montreal, QC</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Département de kinésiologie, UQAM</s1>
<s2>Montreal, QC</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)</s1>
<s2>Montreal, QC</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>375-385</s1>
</fA20>
<fA21><s1>2010</s1>
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<fA66 i1="01"><s0>DEU</s0>
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<fC01 i1="01" l="ENG"><s0>Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.</s0>
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<fC02 i1="01" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A25E</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Apprentissage moteur</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Motor learning</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Aprendizaje motor</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>02</s5>
</fC03>
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<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Déplétion</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Depletion</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Depleción</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Corps strié</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Corpus striatum</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cuerpo estriado</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Lévodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Contrôle moteur</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Motor control</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Control motor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Human</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Motricité</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Motricity</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Motricidad</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Processus acquisition</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Acquisition process</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Proceso adquisición</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>26</s5>
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<fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>27</s5>
</fC07>
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<s5>27</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>27</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>28</s5>
</fC07>
<fN21><s1>277</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
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<server><NO>PASCAL 10-0428398 INIST</NO>
<ET>Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease</ET>
<AU>TREMBLAY (Pierre-Luc); BEDARD (Marc-Andre); LANGLOIS (Dominic); BLANCHET (Pierre J.); LEMAY (Martin); PARENT (Maxime)</AU>
<AF>Department of Psychology, Cognitive Pharmacology Research Unit, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888/Montreal, QC H3C 3P8/Canada (1 aut., 2 aut., 3 aut., 6 aut.); André-Barbeau Movement Disorder Centre, CHUM/Montreal, QC/Canada (4 aut.); Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal/Montreal, QC/Canada (4 aut.); Département de kinésiologie, UQAM/Montreal, QC/Canada (5 aut.); Centre de Réadaptation Marie-Enfant (CHU Sainte-Justine)/Montreal, QC/Canada (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Experimental brain research; ISSN 0014-4819; Coden EXBRAP; Allemagne; Da. 2010; Vol. 205; No. 3; Pp. 375-385; Bibl. 3/4 p.</SO>
<LA>Anglais</LA>
<EA>Chunking of single movements into integrated sequences has been described during motor learning, and we have recently demonstrated that this process involves a dopamine-dependant mechanism in animal (Levesque et al. in Exp Brain Res 182:499-508, 2007; Tremblay et al. in Behav Brain Res 198:231-239, 2009). However, there is no such evidence in human. The aim of the present study was to assess this question in Parkinson's disease (PD), a neurological condition known for its dopamine depletion in the striatum. Eleven PD patients were tested under their usual levodopa medication (ON state), and following a 12-h levodopa withdrawal (OFF state). Patients were compared with 12 healthy participants on a motor learning sequencing task, requiring pressing fourteen buttons in the correct order, which was determined by visual stimuli presented on a computer screen. Learning was assessed from three blocks of 20 trials administered successively. Chunks of movements were intrinsically created by each participant during this learning period. Then, the sequence was shuffled according to the participant's own chunks, generating two new sequences, with either preserved or broken chunks. Those new motor sequences had to be performed separately in a fourth and fifth blocks of 20 trials. Results showed that execution time improved in every group during the learning period (from blocks 1 to 3). However, while motor chunking occurred in healthy controls and ON-PD patients, it did not in OFF-PD patients. In the shuffling conditions, a significant difference was seen between the preserved and the broken chunks conditions for both healthy participants and ON-PD patients, but not for OFF-PD patients. These results suggest that movement chunking during motor sequence learning is a dopamine-dependent process in human.</EA>
<CC>002B17G; 002A25E</CC>
<FD>Apprentissage moteur; Encéphale; Déplétion; Corps strié; Lévodopa; Contrôle moteur; Maladie de Parkinson; Homme</FD>
<FG>Motricité; Processus acquisition; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie du   système nerveux; Système nerveux central; Noyau gris central</FG>
<ED>Motor learning; Encephalon; Depletion; Corpus striatum; Levodopa; Motor control; Parkinson disease; Human</ED>
<EG>Motricity; Acquisition process; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Central nervous system; Basal ganglion</EG>
<SD>Aprendizaje motor; Encéfalo; Depleción; Cuerpo estriado; Levodopa; Control motor; Parkinson enfermedad; Hombre</SD>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease

Movement chunking during sequence learning is a dopamine-dependant process: a study conducted in Parkinson's disease

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