Ventricular Dilatation and Brain Atrophy in Patients with Parkinson's Disease with Incipient Dementia
Identifieur interne : 000204 ( PascalFrancis/Checkpoint ); précédent : 000203; suivant : 000205Ventricular Dilatation and Brain Atrophy in Patients with Parkinson's Disease with Incipient Dementia
Auteurs : Richard Camicioli [Canada] ; Jennifer Sabino [Canada] ; Myrlene Gee [Canada] ; Thomas Bouchard [Canada] ; Nancy Fisher [Canada] ; Chris Hanstock [Canada] ; Derek Emery [Canada] ; W. R. Wayne Martin [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
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Abstract
Age-related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline in Parkinson's disease is less clear, even though dementia is common in Parkinson's disease. Our goals were to determine if greater enlargement of the ventricles and gray or white matter atrophy occurred in Parkinson's disease patients developing cognitive decline. Older nondemented patients with Parkinson's disease (33) and age- and sex-matched controls (39) were recruited and prospectively assessed for the development of significant cognitive decline over 36 months. Magnetic resonance imaging was obtained every 18 months, and ventricular volume and total brain gray and white matter volumes were measured using reliable segmentation of T1-weighted volumetric scans. Subjects with incidental intracranial abnormalities, an atypical course, and stroke as well as dropouts were excluded from a cohort of 52 patients and 50 controls. Among 33 patients and 39 controls, 10 patients and 3 controls developed significant cognitive impairment or dementia. Ventricular change and Parkinson's disease status were significantly associated with dementia. Ventricular change was significantly correlated with change in Mini-Mental Status Examination in the Parkinson's disease with dementia group (r = 0.87, P = .001). Gray matter atrophy was greater in Parkinson's disease with dementia, with similar change over time in both Parkinson's disease and Parkinson's disease with dementia. White matter volumes were not significantly different between Parkinson's disease and Parkinson's disease with dementia; however, the decrease over time might be greater in Parkinson's disease with dementia. Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss.
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Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine (Neurology), University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0353361</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0353361 INIST</idno><idno type="RBID">Pascal:11-0353361</idno><idno type="wicri:Area/PascalFrancis/Corpus">000297</idno><idno type="wicri:Area/PascalFrancis/Curation">000966</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000204</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ventricular Dilatation and Brain Atrophy in Patients with Parkinson's Disease with Incipient Dementia</title><author><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine (Neurology), University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Sabino, Jennifer" sort="Sabino, Jennifer" uniqKey="Sabino J" first="Jennifer" last="Sabino">Jennifer Sabino</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine (Neurology), University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Medicine, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Fisher, Nancy" sort="Fisher, Nancy" uniqKey="Fisher N" first="Nancy" last="Fisher">Nancy Fisher</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Division of Neurosciences, Alberta Health Services</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Hanstock, Chris" sort="Hanstock, Chris" uniqKey="Hanstock C" first="Chris" last="Hanstock">Chris Hanstock</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Radiology and Diagnostic Imaging, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Wayne Martin, W R" sort="Wayne Martin, W R" uniqKey="Wayne Martin W" first="W. R." last="Wayne Martin">W. R. Wayne Martin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine (Neurology), University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Edmonton, Alberta</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrophy</term><term>Dementia</term><term>Dilatation</term><term>Encephalon</term><term>Human</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie</term><term>Maladie de Parkinson</term><term>Démence</term><term>Pathologie du système nerveux</term><term>Dilatation</term><term>Encéphale</term><term>Homme</term><term>Imagerie RMN</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Age-related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline in Parkinson's disease is less clear, even though dementia is common in Parkinson's disease. Our goals were to determine if greater enlargement of the ventricles and gray or white matter atrophy occurred in Parkinson's disease patients developing cognitive decline. Older nondemented patients with Parkinson's disease (33) and age- and sex-matched controls (39) were recruited and prospectively assessed for the development of significant cognitive decline over 36 months. Magnetic resonance imaging was obtained every 18 months, and ventricular volume and total brain gray and white matter volumes were measured using reliable segmentation of T1-weighted volumetric scans. Subjects with incidental intracranial abnormalities, an atypical course, and stroke as well as dropouts were excluded from a cohort of 52 patients and 50 controls. Among 33 patients and 39 controls, 10 patients and 3 controls developed significant cognitive impairment or dementia. Ventricular change and Parkinson's disease status were significantly associated with dementia. Ventricular change was significantly correlated with change in Mini-Mental Status Examination in the Parkinson's disease with dementia group (r = 0.87, P = .001). Gray matter atrophy was greater in Parkinson's disease with dementia, with similar change over time in both Parkinson's disease and Parkinson's disease with dementia. White matter volumes were not significantly different between Parkinson's disease and Parkinson's disease with dementia; however, the decrease over time might be greater in Parkinson's disease with dementia. Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Ventricular Dilatation and Brain Atrophy in Patients with Parkinson's Disease with Incipient Dementia</s1></fA08><fA11 i1="01" i2="1"><s1>CAMICIOLI (Richard)</s1></fA11><fA11 i1="02" i2="1"><s1>SABINO (Jennifer)</s1></fA11><fA11 i1="03" i2="1"><s1>GEE (Myrlene)</s1></fA11><fA11 i1="04" i2="1"><s1>BOUCHARD (Thomas)</s1></fA11><fA11 i1="05" i2="1"><s1>FISHER (Nancy)</s1></fA11><fA11 i1="06" i2="1"><s1>HANSTOCK (Chris)</s1></fA11><fA11 i1="07" i2="1"><s1>EMERY (Derek)</s1></fA11><fA11 i1="08" i2="1"><s1>WAYNE MARTIN (W. R.)</s1></fA11><fA14 i1="01"><s1>Department of Medicine (Neurology), University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Biomedical Engineering, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Division of Neurosciences, Alberta Health Services</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Radiology and Diagnostic Imaging, University of Alberta</s1><s2>Edmonton, Alberta</s2><s3>CAN</s3><sZ>7 aut.</sZ></fA14><fA20><s1>1443-1450</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000508552620110</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>37 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0353361</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Age-related ventricular enlargement is accelerated in Alzheimer's disease, but its relationship to cognitive decline in Parkinson's disease is less clear, even though dementia is common in Parkinson's disease. Our goals were to determine if greater enlargement of the ventricles and gray or white matter atrophy occurred in Parkinson's disease patients developing cognitive decline. Older nondemented patients with Parkinson's disease (33) and age- and sex-matched controls (39) were recruited and prospectively assessed for the development of significant cognitive decline over 36 months. Magnetic resonance imaging was obtained every 18 months, and ventricular volume and total brain gray and white matter volumes were measured using reliable segmentation of T1-weighted volumetric scans. Subjects with incidental intracranial abnormalities, an atypical course, and stroke as well as dropouts were excluded from a cohort of 52 patients and 50 controls. Among 33 patients and 39 controls, 10 patients and 3 controls developed significant cognitive impairment or dementia. Ventricular change and Parkinson's disease status were significantly associated with dementia. Ventricular change was significantly correlated with change in Mini-Mental Status Examination in the Parkinson's disease with dementia group (r = 0.87, P = .001). Gray matter atrophy was greater in Parkinson's disease with dementia, with similar change over time in both Parkinson's disease and Parkinson's disease with dementia. White matter volumes were not significantly different between Parkinson's disease and Parkinson's disease with dementia; however, the decrease over time might be greater in Parkinson's disease with dementia. Ventricular dilatation occurs early in the course of significant cognitive decline in patients with Parkinson's disease, possibly reflecting both cortical gray and white matter loss.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Atrophie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Atrophy</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Atrofia</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Démence</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Dementia</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Demencia</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Dilatation</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Dilatation</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Dilatación</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Encéphale</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Encephalon</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>241</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Camicioli, Richard" sort="Camicioli, Richard" uniqKey="Camicioli R" first="Richard" last="Camicioli">Richard Camicioli</name></noRegion><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name><name sortKey="Bouchard, Thomas" sort="Bouchard, Thomas" uniqKey="Bouchard T" first="Thomas" last="Bouchard">Thomas Bouchard</name><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name><name sortKey="Emery, Derek" sort="Emery, Derek" uniqKey="Emery D" first="Derek" last="Emery">Derek Emery</name><name sortKey="Fisher, Nancy" sort="Fisher, Nancy" uniqKey="Fisher N" first="Nancy" last="Fisher">Nancy Fisher</name><name sortKey="Gee, Myrlene" sort="Gee, Myrlene" uniqKey="Gee M" first="Myrlene" last="Gee">Myrlene Gee</name><name sortKey="Hanstock, Chris" sort="Hanstock, Chris" uniqKey="Hanstock C" first="Chris" last="Hanstock">Chris Hanstock</name><name sortKey="Sabino, Jennifer" sort="Sabino, Jennifer" uniqKey="Sabino J" first="Jennifer" last="Sabino">Jennifer Sabino</name><name sortKey="Wayne Martin, W R" sort="Wayne Martin, W R" uniqKey="Wayne Martin W" first="W. R." last="Wayne Martin">W. R. Wayne Martin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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