Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease
Identifieur interne : 000066 ( PascalFrancis/Checkpoint ); précédent : 000065; suivant : 000067Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease
Auteurs : Leigh Christopher [Canada] ; Antonio P. Strafella [Canada]Source :
- Journal of neuropsychology : (Print) [ 1748-6645 ] ; 2013.
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- Pascal (Inist)
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- topic : Homme.
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Abstract
Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.
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Strafella</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropsychology : (Print)</title><title level="j" type="abbreviated">J. neuropsychol. : (Print)</title><idno type="ISSN">1748-6645</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropsychology : (Print)</title><title level="j" type="abbreviated">J. neuropsychol. : (Print)</title><idno type="ISSN">1748-6645</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Emission tomography</term><term>Encephalon</term><term>Functional magnetic resonance imaging</term><term>Human</term><term>Parkinson disease</term><term>Review</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Trouble cognitif</term><term>Maladie de Parkinson</term><term>Article synthèse</term><term>Déficit cognitif léger</term><term>Tomoscintigraphie</term><term>Homme</term><term>Imagerie par résonance magnétique fonctionnelle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1748-6645</s0></fA01><fA03 i2="1"><s0>J. neuropsychol. : (Print)</s0></fA03><fA05><s2>7</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Parkinson's Disease and Cognition</s1></fA09><fA11 i1="01" i2="1"><s1>CHRISTOPHER (Leigh)</s1></fA11><fA11 i1="02" i2="1"><s1>STRAFELLA (Antonio P.)</s1></fA11><fA12 i1="01" i2="1"><s1>EDELSTYN (Nicky)</s1><s9>ed.</s9></fA12><fA12 i1="02" i2="1"><s1>POLIAKOFF (Ellen)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Morton and Gloria Shulman Movement Disorder Unit & E.J. 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Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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