ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000068

Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease

Identifieur interne : 000068 ( PascalFrancis/Corpus ); précédent : 000067; suivant : 000069

Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease

Auteurs : Leigh Christopher ; Antonio P. Strafella

Source :

Journal of neuropsychology : (Print) [ 1748-6645 ] ; 2013.

RBID : Pascal:13-0320404

Descripteurs français

Pascal (Inist)
- Encéphale, Trouble cognitif, Maladie de Parkinson, Article synthèse, Déficit cognitif léger, Tomoscintigraphie, Homme, Imagerie par résonance magnétique fonctionnelle.

English descriptors

KwdEn :
- Cognitive disorder, Emission tomography, Encephalon, Functional magnetic resonance imaging, Human, Parkinson disease, Review, mild cognitive impairment.

Abstract

Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 13-0320404 INIST
ET :	Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease
AU :	CHRISTOPHER (Leigh); STRAFELLA (Antonio P.); EDELSTYN (Nicky); POLIAKOFF (Ellen)
AF :	Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto/Ontario/Canada (1 aut., 2 aut.); Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto/Ontario/Canada (1 aut., 2 aut.); Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto/Ontario/Canada (2 aut.); Keele University/Royaume-Uni (1 aut.); University of Manchester/Royaume-Uni (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of neuropsychology : (Print); ISSN 1748-6645; Royaume-Uni; Da. 2013; Vol. 7; No. 2; Pp. 225-240; Bibl. 4 p.1/2
LA :	Anglais
EA :	Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.
CC :	002B18C13; 002B17G; 002B17A01
FD :	Encéphale; Trouble cognitif; Maladie de Parkinson; Article synthèse; Déficit cognitif léger; Tomoscintigraphie; Homme; Imagerie par résonance magnétique fonctionnelle
FG :	Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux
ED :	Encephalon; Cognitive disorder; Parkinson disease; Review; mild cognitive impairment; Emission tomography; Human; Functional magnetic resonance imaging
EG :	Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases
SD :	Encéfalo; Trastorno cognitivo; Parkinson enfermedad; Artículo síntesis; Disturbio cognitivo ligero; Tomocentelleografía; Hombre; Imagen por resonancia magnética funcional
LO :	INIST-28032.354000501984320050
ID :	13-0320404

Links to Exploration step

Pascal:13-0320404

Le document en format XML

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<front><div type="abstract" xml:lang="en">Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.</div>
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<server><NO>PASCAL 13-0320404 INIST</NO>
<ET>Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease</ET>
<AU>CHRISTOPHER (Leigh); STRAFELLA (Antonio P.); EDELSTYN (Nicky); POLIAKOFF (Ellen)</AU>
<AF>Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto/Ontario/Canada (1 aut., 2 aut.); Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto/Ontario/Canada (1 aut., 2 aut.); Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto/Ontario/Canada (2 aut.); Keele University/Royaume-Uni (1 aut.); University of Manchester/Royaume-Uni (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of neuropsychology : (Print); ISSN 1748-6645; Royaume-Uni; Da. 2013; Vol. 7; No. 2; Pp. 225-240; Bibl. 4 p.1/2</SO>
<LA>Anglais</LA>
<EA>Cognitive impairment occurs frequently in Parkinson's disease (PD) and the concept of Mild Cognitive Impairment in PD (PD-MCI) has recently emerged. Patients with mild impairment are at risk of developing dementia, and thus it is a topic of growing interest. Many previous studies have investigated the neural correlates of cognitive impairment, in particular executive dysfunction, in PD patients without dementia using neuroimaging techniques including structural MRI, functional MRI and PET imaging. These studies, which have provided a foundation for understanding which brain regions and neurotransmitter systems may be involved in executive dysfunction in PD, will be reviewed. Recent neuroimaging studies that have used specific criteria to classify patients as PD-MCI, in the hopes of gaining further insight into the underlying neural mechanisms will also be discussed. In particular, this review will cover key findings involving structural MRI investigating grey and white matter changes, functional MRI to examine changes in neural activation and PET imaging to investigate metabolic and neurochemical changes that have led to an improved understanding of pathology associated with executive dysfunction in PD without dementia and PD-MCI.</EA>
<CC>002B18C13; 002B17G; 002B17A01</CC>
<FD>Encéphale; Trouble cognitif; Maladie de Parkinson; Article synthèse; Déficit cognitif léger; Tomoscintigraphie; Homme; Imagerie par résonance magnétique fonctionnelle</FD>
<FG>Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie du système nerveux</FG>
<ED>Encephalon; Cognitive disorder; Parkinson disease; Review; mild cognitive impairment; Emission tomography; Human; Functional magnetic resonance imaging</ED>
<EG>Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases</EG>
<SD>Encéfalo; Trastorno cognitivo; Parkinson enfermedad; Artículo síntesis; Disturbio cognitivo ligero; Tomocentelleografía; Hombre; Imagen por resonancia magnética funcional</SD>
<LO>INIST-28032.354000501984320050</LO>
<ID>13-0320404</ID>
</server>
</inist>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease

Neuroimaging of brain changes associated with cognitive impairment in Parkinson's disease

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