Panorama of ancient metazoan macromolecular complexes.
Identifieur interne : 001D00 ( Ncbi/Merge ); précédent : 001C99; suivant : 001D01Panorama of ancient metazoan macromolecular complexes.
Auteurs : Cuihong Wan [Canada] ; Blake Borgeson [États-Unis] ; Sadhna Phanse [Canada] ; Fan Tu [États-Unis] ; Kevin Drew [États-Unis] ; Greg Clark [Canada] ; Xuejian Xiong [Canada] ; Olga Kagan [Canada] ; Julian Kwan [Canada] ; Alexandr Bezginov [Canada] ; Kyle Chessman [Canada] ; Swati Pal [Canada] ; Graham Cromar [Canada] ; Ophelia Papoulas [États-Unis] ; Zuyao Ni [Canada] ; Daniel R. Boutz [États-Unis] ; Snejana Stoilova [Canada] ; Pierre C. Havugimana [Canada] ; Xinghua Guo [Canada] ; Ramy H. Malty [Canada] ; Mihail Sarov [Allemagne] ; Jack Greenblatt [Canada] ; Mohan Babu [Canada] ; W Brent Derry [Canada] ; Elisabeth R. Tillier [Canada] ; John B. Wallingford [États-Unis] ; John Parkinson [Canada] ; Edward M. Marcotte [États-Unis] ; Andrew Emili [Canada]Source :
- Nature [ 1476-4687 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Multiprotein Complexes.
- chemical , metabolism : Multiprotein Complexes.
- Animals, Datasets as Topic, Evolution, Molecular, Humans, Protein Interaction Mapping, Protein Interaction Maps, Reproducibility of Results, Systems Biology, Tandem Mass Spectrometry.
Abstract
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species with fully sequenced genomes that encompasses functional modules present broadly across all extant animals. Clustering reveals a spectrum of conservation, ranging from ancient eukaryotic assemblies that have probably served cellular housekeeping roles for at least one billion years, ancestral complexes that have accrued contemporary components, and rarer metazoan innovations linked to multicellularity. We validated these projections by independent co-fractionation experiments in evolutionarily distant species, affinity purification and functional analyses. The comprehensiveness, centrality and modularity of these reconstructed interactomes reflect their fundamental mechanistic importance and adaptive value to animal cell systems.
DOI: 10.1038/nature14877
PubMed: 26344197
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type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ni, Zuyao" sort="Ni, Zuyao" uniqKey="Ni Z" first="Zuyao" last="Ni">Zuyao Ni</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Boutz, Daniel R" sort="Boutz, Daniel R" uniqKey="Boutz D" first="Daniel R" last="Boutz">Daniel R. Boutz</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Stoilova, Snejana" sort="Stoilova, Snejana" uniqKey="Stoilova S" first="Snejana" last="Stoilova">Snejana Stoilova</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Havugimana, Pierre C" sort="Havugimana, Pierre C" uniqKey="Havugimana P" first="Pierre C" last="Havugimana">Pierre C. Havugimana</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Malty, Ramy H" sort="Malty, Ramy H" uniqKey="Malty R" first="Ramy H" last="Malty">Ramy H. Malty</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2</wicri:regionArea><orgName type="university">Université de Regina</orgName><placeName><settlement type="city">Saskatchewan</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Sarov, Mihail" sort="Sarov, Mihail" uniqKey="Sarov M" first="Mihail" last="Sarov">Mihail Sarov</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Greenblatt, Jack" sort="Greenblatt, Jack" uniqKey="Greenblatt J" first="Jack" last="Greenblatt">Jack Greenblatt</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2</wicri:regionArea><orgName type="university">Université de Regina</orgName><placeName><settlement type="city">Saskatchewan</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Derry, W Brent" sort="Derry, W Brent" uniqKey="Derry W" first="W Brent" last="Derry">W Brent Derry</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tillier, Elisabeth R" sort="Tillier, Elisabeth R" uniqKey="Tillier E" first="Elisabeth R" last="Tillier">Elisabeth R. Tillier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, Toronto, Ontario M5G 1L7</wicri:regionArea><wicri:noRegion>Ontario M5G 1L7</wicri:noRegion></affiliation></author><author><name sortKey="Wallingford, John B" sort="Wallingford, John B" uniqKey="Wallingford J" first="John B" last="Wallingford">John B. Wallingford</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Marcotte, Edward M" sort="Marcotte, Edward M" uniqKey="Marcotte E" first="Edward M" last="Marcotte">Edward M. 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xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26344197</idno><idno type="pmid">26344197</idno><idno type="doi">10.1038/nature14877</idno><idno type="wicri:Area/PubMed/Corpus">000415</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000415</idno><idno type="wicri:Area/PubMed/Curation">000415</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000415</idno><idno type="wicri:Area/PubMed/Checkpoint">000415</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000415</idno><idno type="wicri:Area/Ncbi/Merge">001D00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Panorama of ancient metazoan macromolecular complexes.</title><author><name sortKey="Wan, Cuihong" sort="Wan, Cuihong" uniqKey="Wan C" first="Cuihong" last="Wan">Cuihong Wan</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Borgeson, Blake" sort="Borgeson, Blake" uniqKey="Borgeson B" first="Blake" last="Borgeson">Blake Borgeson</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Phanse, Sadhna" sort="Phanse, Sadhna" uniqKey="Phanse S" first="Sadhna" last="Phanse">Sadhna Phanse</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tu, Fan" sort="Tu, Fan" uniqKey="Tu F" first="Fan" last="Tu">Fan Tu</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Drew, Kevin" sort="Drew, Kevin" uniqKey="Drew K" first="Kevin" last="Drew">Kevin Drew</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Clark, Greg" sort="Clark, Greg" uniqKey="Clark G" first="Greg" last="Clark">Greg Clark</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, Toronto, Ontario M5G 1L7</wicri:regionArea><wicri:noRegion>Ontario M5G 1L7</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Xuejian" sort="Xiong, Xuejian" uniqKey="Xiong X" first="Xuejian" last="Xiong">Xuejian Xiong</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kagan, Olga" sort="Kagan, Olga" uniqKey="Kagan O" first="Olga" last="Kagan">Olga Kagan</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kwan, Julian" sort="Kwan, Julian" uniqKey="Kwan J" first="Julian" last="Kwan">Julian Kwan</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Bezginov, Alexandr" sort="Bezginov, Alexandr" uniqKey="Bezginov A" first="Alexandr" last="Bezginov">Alexandr Bezginov</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, Toronto, Ontario M5G 1L7</wicri:regionArea><wicri:noRegion>Ontario M5G 1L7</wicri:noRegion></affiliation></author><author><name sortKey="Chessman, Kyle" sort="Chessman, Kyle" uniqKey="Chessman K" first="Kyle" last="Chessman">Kyle Chessman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Pal, Swati" sort="Pal, Swati" uniqKey="Pal S" first="Swati" last="Pal">Swati Pal</name><affiliation wicri:level="1"><nlm:affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Hospital for Sick Children, Toronto, Ontario M5G 1X8</wicri:regionArea><wicri:noRegion>Ontario M5G 1X8</wicri:noRegion></affiliation></author><author><name sortKey="Cromar, Graham" sort="Cromar, Graham" uniqKey="Cromar G" first="Graham" last="Cromar">Graham Cromar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Papoulas, Ophelia" sort="Papoulas, Ophelia" uniqKey="Papoulas O" first="Ophelia" last="Papoulas">Ophelia Papoulas</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ni, Zuyao" sort="Ni, Zuyao" uniqKey="Ni Z" first="Zuyao" last="Ni">Zuyao Ni</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Boutz, Daniel R" sort="Boutz, Daniel R" uniqKey="Boutz D" first="Daniel R" last="Boutz">Daniel R. Boutz</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Stoilova, Snejana" sort="Stoilova, Snejana" uniqKey="Stoilova S" first="Snejana" last="Stoilova">Snejana Stoilova</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Havugimana, Pierre C" sort="Havugimana, Pierre C" uniqKey="Havugimana P" first="Pierre C" last="Havugimana">Pierre C. Havugimana</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Malty, Ramy H" sort="Malty, Ramy H" uniqKey="Malty R" first="Ramy H" last="Malty">Ramy H. Malty</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2</wicri:regionArea><orgName type="university">Université de Regina</orgName><placeName><settlement type="city">Saskatchewan</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Sarov, Mihail" sort="Sarov, Mihail" uniqKey="Sarov M" first="Mihail" last="Sarov">Mihail Sarov</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Greenblatt, Jack" sort="Greenblatt, Jack" uniqKey="Greenblatt J" first="Jack" last="Greenblatt">Jack Greenblatt</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2</wicri:regionArea><orgName type="university">Université de Regina</orgName><placeName><settlement type="city">Saskatchewan</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Derry, W Brent" sort="Derry, W Brent" uniqKey="Derry W" first="W Brent" last="Derry">W Brent Derry</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tillier, Elisabeth R" sort="Tillier, Elisabeth R" uniqKey="Tillier E" first="Elisabeth R" last="Tillier">Elisabeth R. Tillier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, Toronto, Ontario M5G 1L7</wicri:regionArea><wicri:noRegion>Ontario M5G 1L7</wicri:noRegion></affiliation></author><author><name sortKey="Wallingford, John B" sort="Wallingford, John B" uniqKey="Wallingford J" first="John B" last="Wallingford">John B. Wallingford</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Marcotte, Edward M" sort="Marcotte, Edward M" uniqKey="Marcotte E" first="Edward M" last="Marcotte">Edward M. Marcotte</name><affiliation wicri:level="4"><nlm:affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712</wicri:regionArea><orgName type="university">Université du Texas à Austin</orgName><placeName><settlement type="city">Austin (Texas)</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name><affiliation wicri:level="4"><nlm:affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Datasets as Topic</term><term>Evolution, Molecular</term><term>Humans</term><term>Multiprotein Complexes (chemistry)</term><term>Multiprotein Complexes (metabolism)</term><term>Protein Interaction Mapping</term><term>Protein Interaction Maps</term><term>Reproducibility of Results</term><term>Systems Biology</term><term>Tandem Mass Spectrometry</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Multiprotein Complexes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Multiprotein Complexes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Datasets as Topic</term><term>Evolution, Molecular</term><term>Humans</term><term>Protein Interaction Mapping</term><term>Protein Interaction Maps</term><term>Reproducibility of Results</term><term>Systems Biology</term><term>Tandem Mass Spectrometry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species with fully sequenced genomes that encompasses functional modules present broadly across all extant animals. Clustering reveals a spectrum of conservation, ranging from ancient eukaryotic assemblies that have probably served cellular housekeeping roles for at least one billion years, ancestral complexes that have accrued contemporary components, and rarer metazoan innovations linked to multicellularity. We validated these projections by independent co-fractionation experiments in evolutionarily distant species, affinity purification and functional analyses. The comprehensiveness, centrality and modularity of these reconstructed interactomes reflect their fundamental mechanistic importance and adaptive value to animal cell systems.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26344197</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>19</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN><JournalIssue CitedMedium="Internet"><Volume>525</Volume><Issue>7569</Issue><PubDate><Year>2015</Year><Month>Sep</Month><Day>17</Day></PubDate></JournalIssue><Title>Nature</Title><ISOAbbreviation>Nature</ISOAbbreviation></Journal><ArticleTitle>Panorama of ancient metazoan macromolecular complexes.</ArticleTitle><Pagination><MedlinePgn>339-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nature14877</ELocationID><Abstract><AbstractText>Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species with fully sequenced genomes that encompasses functional modules present broadly across all extant animals. Clustering reveals a spectrum of conservation, ranging from ancient eukaryotic assemblies that have probably served cellular housekeeping roles for at least one billion years, ancestral complexes that have accrued contemporary components, and rarer metazoan innovations linked to multicellularity. We validated these projections by independent co-fractionation experiments in evolutionarily distant species, affinity purification and functional analyses. The comprehensiveness, centrality and modularity of these reconstructed interactomes reflect their fundamental mechanistic importance and adaptive value to animal cell systems.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Cuihong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borgeson</LastName><ForeName>Blake</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phanse</LastName><ForeName>Sadhna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Fan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drew</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Greg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Xuejian</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kagan</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwan</LastName><ForeName>Julian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bezginov</LastName><ForeName>Alexandr</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chessman</LastName><ForeName>Kyle</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pal</LastName><ForeName>Swati</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cromar</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papoulas</LastName><ForeName>Ophelia</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ni</LastName><ForeName>Zuyao</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutz</LastName><ForeName>Daniel R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stoilova</LastName><ForeName>Snejana</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Havugimana</LastName><ForeName>Pierre C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xinghua</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malty</LastName><ForeName>Ramy H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarov</LastName><ForeName>Mihail</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greenblatt</LastName><ForeName>Jack</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Babu</LastName><ForeName>Mohan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Derry</LastName><ForeName>W Brent</ForeName><Initials>WB</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tillier</LastName><ForeName>Elisabeth R</ForeName><Initials>ER</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, Toronto, Ontario M5G 1L7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallingford</LastName><ForeName>John B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.</Affiliation></AffiliationInfo></Author><Author 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and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>F32GM112495</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM076536</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DP1 GM106408</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 GM067779</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>F32 GM112495</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nature</MedlineTA><NlmUniqueID>0410462</NlmUniqueID><ISSNLinking>0028-0836</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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MajorTopicYN="N">Datasets as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="Y">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025941" MajorTopicYN="N">Protein Interaction Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060066" MajorTopicYN="Y">Protein Interaction Maps</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049490" MajorTopicYN="N">Systems Biology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053719" MajorTopicYN="N">Tandem Mass Spectrometry</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS704400</OtherID><OtherID Source="NLM">PMC5036527</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26344197</ArticleId><ArticleId IdType="pii">nature14877</ArticleId><ArticleId IdType="doi">10.1038/nature14877</ArticleId><ArticleId IdType="pmc">PMC5036527</ArticleId><ArticleId IdType="mid">NIHMS704400</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country><region><li>District de Dresde</li><li>Manitoba</li><li>Ontario</li><li>Saxe (Land)</li><li>Texas</li></region><settlement><li>Austin (Texas)</li><li>Dresde</li><li>Saskatchewan</li><li>Toronto</li></settlement><orgName><li>Université de Regina</li><li>Université de Toronto</li><li>Université du Texas à Austin</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Wan, Cuihong" sort="Wan, Cuihong" uniqKey="Wan C" first="Cuihong" last="Wan">Cuihong Wan</name></region><name sortKey="Babu, Mohan" sort="Babu, Mohan" uniqKey="Babu M" first="Mohan" last="Babu">Mohan Babu</name><name sortKey="Bezginov, Alexandr" sort="Bezginov, Alexandr" uniqKey="Bezginov A" first="Alexandr" last="Bezginov">Alexandr Bezginov</name><name sortKey="Chessman, Kyle" sort="Chessman, Kyle" uniqKey="Chessman K" first="Kyle" last="Chessman">Kyle Chessman</name><name sortKey="Clark, Greg" sort="Clark, Greg" uniqKey="Clark G" first="Greg" last="Clark">Greg Clark</name><name sortKey="Cromar, Graham" sort="Cromar, Graham" uniqKey="Cromar G" first="Graham" last="Cromar">Graham Cromar</name><name sortKey="Derry, W Brent" sort="Derry, W Brent" uniqKey="Derry W" first="W Brent" last="Derry">W Brent Derry</name><name sortKey="Emili, Andrew" sort="Emili, Andrew" uniqKey="Emili A" first="Andrew" last="Emili">Andrew Emili</name><name sortKey="Greenblatt, Jack" sort="Greenblatt, Jack" uniqKey="Greenblatt J" first="Jack" last="Greenblatt">Jack Greenblatt</name><name sortKey="Guo, Xinghua" sort="Guo, Xinghua" uniqKey="Guo X" first="Xinghua" last="Guo">Xinghua Guo</name><name sortKey="Havugimana, Pierre C" sort="Havugimana, Pierre C" uniqKey="Havugimana P" first="Pierre C" last="Havugimana">Pierre C. Havugimana</name><name sortKey="Kagan, Olga" sort="Kagan, Olga" uniqKey="Kagan O" first="Olga" last="Kagan">Olga Kagan</name><name sortKey="Kwan, Julian" sort="Kwan, Julian" uniqKey="Kwan J" first="Julian" last="Kwan">Julian Kwan</name><name sortKey="Malty, Ramy H" sort="Malty, Ramy H" uniqKey="Malty R" first="Ramy H" last="Malty">Ramy H. Malty</name><name sortKey="Ni, Zuyao" sort="Ni, Zuyao" uniqKey="Ni Z" first="Zuyao" last="Ni">Zuyao Ni</name><name sortKey="Pal, Swati" sort="Pal, Swati" uniqKey="Pal S" first="Swati" last="Pal">Swati Pal</name><name sortKey="Parkinson, John" sort="Parkinson, John" uniqKey="Parkinson J" first="John" last="Parkinson">John Parkinson</name><name sortKey="Phanse, Sadhna" sort="Phanse, Sadhna" uniqKey="Phanse S" first="Sadhna" last="Phanse">Sadhna Phanse</name><name sortKey="Stoilova, Snejana" sort="Stoilova, Snejana" uniqKey="Stoilova S" first="Snejana" last="Stoilova">Snejana Stoilova</name><name sortKey="Tillier, Elisabeth R" sort="Tillier, Elisabeth R" uniqKey="Tillier E" first="Elisabeth R" last="Tillier">Elisabeth R. Tillier</name><name sortKey="Xiong, Xuejian" sort="Xiong, Xuejian" uniqKey="Xiong X" first="Xuejian" last="Xiong">Xuejian Xiong</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Borgeson, Blake" sort="Borgeson, Blake" uniqKey="Borgeson B" first="Blake" last="Borgeson">Blake Borgeson</name></region><name sortKey="Boutz, Daniel R" sort="Boutz, Daniel R" uniqKey="Boutz D" first="Daniel R" last="Boutz">Daniel R. Boutz</name><name sortKey="Drew, Kevin" sort="Drew, Kevin" uniqKey="Drew K" first="Kevin" last="Drew">Kevin Drew</name><name sortKey="Marcotte, Edward M" sort="Marcotte, Edward M" uniqKey="Marcotte E" first="Edward M" last="Marcotte">Edward M. Marcotte</name><name sortKey="Papoulas, Ophelia" sort="Papoulas, Ophelia" uniqKey="Papoulas O" first="Ophelia" last="Papoulas">Ophelia Papoulas</name><name sortKey="Tu, Fan" sort="Tu, Fan" uniqKey="Tu F" first="Fan" last="Tu">Fan Tu</name><name sortKey="Wallingford, John B" sort="Wallingford, John B" uniqKey="Wallingford J" first="John B" last="Wallingford">John B. Wallingford</name></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Sarov, Mihail" sort="Sarov, Mihail" uniqKey="Sarov M" first="Mihail" last="Sarov">Mihail Sarov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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