Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Identifieur interne : 001B67 ( Ncbi/Merge ); précédent : 001B66; suivant : 001B68Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Auteurs : Brice Laurens [France] ; Radu Constantinescu [Suède] ; Roy Freeman [États-Unis] ; Alexander Gerhard [Royaume-Uni] ; Kurt Jellinger [Autriche] ; Andreas Jeromin [États-Unis] ; Florian Krismer [Autriche] ; Brit Mollenhauer [Allemagne] ; Michael G. Schlossmacher [Canada] ; Leslie M. Shaw ; Marcel M. Verbeek [Pays-Bas] ; Gregor K. Wenning [Autriche] ; Kristian Winge [Danemark] ; Jing Zhang [États-Unis] ; Wassilios G. Meissner [France]Source :
- Neurobiology of disease [ 1095-953X ] ; 2015.
English descriptors
- KwdEn :
- Animals, Biomarkers (blood), Biomarkers (cerebrospinal fluid), Brain (metabolism), Catecholamines (analysis), Humans, Intermediate Filaments (metabolism), Multiple System Atrophy (blood), Multiple System Atrophy (cerebrospinal fluid), Multiple System Atrophy (diagnosis), Nerve Degeneration (metabolism), alpha-Synuclein (analysis).
- MESH :
- chemical , analysis : Catecholamines, alpha-Synuclein.
- chemical , blood : Biomarkers.
- chemical , cerebrospinal fluid : Biomarkers.
- blood : Multiple System Atrophy.
- cerebrospinal fluid : Multiple System Atrophy.
- diagnosis : Multiple System Atrophy.
- metabolism : Brain, Intermediate Filaments, Nerve Degeneration.
- Animals, Humans.
Abstract
Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results suggest that combining several CSF fluid biomarkers may be more successful than using single markers, at least for the diagnosis. Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau. Beyond future efforts in biomarker discovery, the harmonization of standard operating procedures will be crucial for future success.
DOI: 10.1016/j.nbd.2015.05.004
PubMed: 25982836
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pubmed:25982836Le document en format XML
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<author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name>
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<author><name sortKey="Krismer, Florian" sort="Krismer, Florian" uniqKey="Krismer F" first="Florian" last="Krismer">Florian Krismer</name>
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<author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name>
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<author><name sortKey="Shaw, Leslie M" sort="Shaw, Leslie M" uniqKey="Shaw L" first="Leslie M" last="Shaw">Leslie M. Shaw</name>
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<wicri:regionArea>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen</wicri:regionArea>
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<author><name sortKey="Winge, Kristian" sort="Winge, Kristian" uniqKey="Winge K" first="Kristian" last="Winge">Kristian Winge</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux</wicri:regionArea>
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<series><title level="j">Neurobiology of disease</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biomarkers (blood)</term>
<term>Biomarkers (cerebrospinal fluid)</term>
<term>Brain (metabolism)</term>
<term>Catecholamines (analysis)</term>
<term>Humans</term>
<term>Intermediate Filaments (metabolism)</term>
<term>Multiple System Atrophy (blood)</term>
<term>Multiple System Atrophy (cerebrospinal fluid)</term>
<term>Multiple System Atrophy (diagnosis)</term>
<term>Nerve Degeneration (metabolism)</term>
<term>alpha-Synuclein (analysis)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Catecholamines</term>
<term>alpha-Synuclein</term>
</keywords>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Intermediate Filaments</term>
<term>Nerve Degeneration</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results suggest that combining several CSF fluid biomarkers may be more successful than using single markers, at least for the diagnosis. Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau. Beyond future efforts in biomarker discovery, the harmonization of standard operating procedures will be crucial for future success.</div>
</front>
</TEI>
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<DateCreated><Year>2015</Year>
<Month>06</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>02</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>06</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-953X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>80</Volume>
<PubDate><Year>2015</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Neurobiology of disease</Title>
<ISOAbbreviation>Neurobiol. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.</ArticleTitle>
<Pagination><MedlinePgn>29-41</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nbd.2015.05.004</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0969-9961(15)00166-7</ELocationID>
<Abstract><AbstractText>Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results suggest that combining several CSF fluid biomarkers may be more successful than using single markers, at least for the diagnosis. Currently, the clinically most useful markers may comprise a combination of the light chain of neurofilament (which is consistently elevated in MSA compared to controls and Parkinson's disease), metabolites of the catecholamine pathway and proteins such as α-synuclein, DJ-1 and total-tau. Beyond future efforts in biomarker discovery, the harmonization of standard operating procedures will be crucial for future success.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laurens</LastName>
<ForeName>Brice</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Constantinescu</LastName>
<ForeName>Radu</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Freeman</LastName>
<ForeName>Roy</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gerhard</LastName>
<ForeName>Alexander</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Brain Behaviour and Mental Heath, University of Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jellinger</LastName>
<ForeName>Kurt</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Neurobiology, Kenyongasse 18, A-1070 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jeromin</LastName>
<ForeName>Andreas</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Quanterix, Inc., Lexington, MA 021421, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krismer</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mollenhauer</LastName>
<ForeName>Brit</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Paracelsus-Elena-Klinik, Kassel, Germany and Department of Neuropathology, University Medical Center Goettingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schlossmacher</LastName>
<ForeName>Michael G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Program in Neuroscience, The Ottawa Hospital, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shaw</LastName>
<ForeName>Leslie M</ForeName>
<Initials>LM</Initials>
<AffiliationInfo><Affiliation>Perelman School of Medicine, University of Pennsylvania.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Verbeek</LastName>
<ForeName>Marcel M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wenning</LastName>
<ForeName>Gregor K</ForeName>
<Initials>GK</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Winge</LastName>
<ForeName>Kristian</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of WA, Seattle, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meissner</LastName>
<ForeName>Wassilios G</ForeName>
<Initials>WG</Initials>
<AffiliationInfo><Affiliation>Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address: wassilios.meissner@chu-bordeaux.fr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>05</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Neurobiol Dis</MedlineTA>
<NlmUniqueID>9500169</NlmUniqueID>
<ISSNLinking>0969-9961</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<NameOfSubstance UI="D002395">Catecholamines</NameOfSubstance>
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<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000134" MajorTopicYN="Y">cerebrospinal fluid</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D007382" MajorTopicYN="N">Intermediate Filaments</DescriptorName>
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<QualifierName UI="Q000134" MajorTopicYN="N">cerebrospinal fluid</QualifierName>
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<MeshHeading><DescriptorName UI="D051844" MajorTopicYN="N">alpha-Synuclein</DescriptorName>
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</MeshHeading>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Blood</Keyword>
<Keyword MajorTopicYN="N">Cerebrospinal fluid</Keyword>
<Keyword MajorTopicYN="N">Glia</Keyword>
<Keyword MajorTopicYN="N">Multiple system atrophy</Keyword>
<Keyword MajorTopicYN="N">Tau</Keyword>
<Keyword MajorTopicYN="N">α-synuclein</Keyword>
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<Month>04</Month>
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