Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
Identifieur interne : 001A62 ( Ncbi/Merge ); précédent : 001A61; suivant : 001A63Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
Auteurs : Karl Kieburtz [États-Unis] ; Barbara C. Tilley ; Jordan J. Elm ; Debra Babcock [États-Unis] ; Robert Hauser [États-Unis] ; G Webster Ross [États-Unis] ; Alicia H. Augustine [États-Unis] ; Erika U. Augustine [États-Unis] ; Michael J. Aminoff [États-Unis] ; Ivan G. Bodis-Wollner ; James Boyd ; Franca Cambi ; Kelvin Chou ; Chadwick W. Christine [États-Unis] ; Michelle Cines [États-Unis] ; Nabila Dahodwala [États-Unis] ; Lorelei Derwent [Canada] ; Richard B. Dewey ; Katherine Hawthorne [États-Unis] ; David J. Houghton [États-Unis] ; Cornelia Kamp [États-Unis] ; Maureen Leehey ; Mark F. Lew [États-Unis] ; Grace S Lin Liang [États-Unis] ; Sheng T. Luo ; Zoltan Mari [États-Unis] ; John C. Morgan ; Sotirios Parashos [États-Unis] ; Adriana Pérez ; Helen Petrovitch [États-Unis] ; Suja Rajan ; Sue Reichwein [États-Unis] ; Jessie Tatsuno Roth [États-Unis] ; Jay S. Schneider [États-Unis] ; Kathleen M. Shannon [États-Unis] ; David K. Simon [États-Unis] ; Tanya Simuni [États-Unis] ; Carlos Singer [États-Unis] ; Lewis Sudarsky [États-Unis] ; Caroline M. Tanner [États-Unis] ; Chizoba C. Umeh [États-Unis] ; Karen Williams [États-Unis] ; Anne-Marie Wills [États-Unis]Source :
- JAMA [ 1538-3598 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Creatine (adverse effects), Creatine (blood), Creatine (therapeutic use), Disease Progression, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Medication Adherence, Middle Aged, Parkinson Disease (drug therapy), Treatment Outcome.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Creatine.
- chemical , blood : Creatine.
- chemical , therapeutic use : Antiparkinson Agents, Creatine.
- drug therapy : Parkinson Disease.
- Aged, Disease Progression, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Medication Adherence, Middle Aged, Treatment Outcome.
Abstract
There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.
DOI: 10.1001/jama.2015.120
PubMed: 25668262
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pubmed:25668262Le document en format XML
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Aminoff</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Bodis Wollner, Ivan G" sort="Bodis Wollner, Ivan G" uniqKey="Bodis Wollner I" first="Ivan G" last="Bodis-Wollner">Ivan G. Bodis-Wollner</name><affiliation><nlm:affiliation>State University of New York Downstate Medical Center, Brooklyn.</nlm:affiliation><wicri:noCountry code="subField">Brooklyn</wicri:noCountry></affiliation></author><author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name><affiliation><nlm:affiliation>University of Vermont, Burlington.</nlm:affiliation><wicri:noCountry code="subField">Burlington</wicri:noCountry></affiliation></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name><affiliation><nlm:affiliation>University of Kentucky, Lexington.</nlm:affiliation><wicri:noCountry code="subField">Lexington</wicri:noCountry></affiliation></author><author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><affiliation><nlm:affiliation>University of Michigan, Ann Arbor.</nlm:affiliation><wicri:noCountry code="subField">Ann Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name><affiliation wicri:level="3"><nlm:affiliation>University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name><affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name><affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas.</nlm:affiliation><wicri:noCountry code="subField">Dallas</wicri:noCountry></affiliation></author><author><name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name><affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name><affiliation wicri:level="2"><nlm:affiliation>Ochsner Medical Center, New Orleans, Louisiana.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Ochsner Medical Center, New Orleans</wicri:cityArea></affiliation></author><author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Leehey, Maureen" sort="Leehey, Maureen" uniqKey="Leehey M" first="Maureen" last="Leehey">Maureen Leehey</name><affiliation><nlm:affiliation>University of Colorado Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name><affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name><affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Luo, Sheng T" sort="Luo, Sheng T" uniqKey="Luo S" first="Sheng T" last="Luo">Sheng T. Luo</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Morgan, John C" sort="Morgan, John C" uniqKey="Morgan J" first="John C" last="Morgan">John C. Morgan</name><affiliation><nlm:affiliation>Georgia Regents University, Augusta.</nlm:affiliation><wicri:noCountry code="subField">Augusta</wicri:noCountry></affiliation></author><author><name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name><affiliation wicri:level="2"><nlm:affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Struthers Parkinson's Center, Golden Valley</wicri:cityArea></affiliation></author><author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><affiliation wicri:level="2"><nlm:affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Rajan, Suja" sort="Rajan, Suja" uniqKey="Rajan S" first="Suja" last="Rajan">Suja Rajan</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name><affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name><affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Thomas Jefferson University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><nlm:affiliation>Rush University Medical Center, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation wicri:level="2"><nlm:affiliation>University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25668262</idno><idno type="pmid">25668262</idno><idno type="doi">10.1001/jama.2015.120</idno><idno type="wicri:Area/PubMed/Corpus">000564</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000564</idno><idno type="wicri:Area/PubMed/Curation">000564</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000564</idno><idno type="wicri:Area/PubMed/Checkpoint">000564</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000564</idno><idno type="wicri:Area/Ncbi/Merge">001A62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.</title><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Tilley, Barbara C" sort="Tilley, Barbara C" uniqKey="Tilley B" first="Barbara C" last="Tilley">Barbara C. Tilley</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Elm, Jordan J" sort="Elm, Jordan J" uniqKey="Elm J" first="Jordan J" last="Elm">Jordan J. Elm</name><affiliation><nlm:affiliation>Medical University of South Carolina, Charleston.</nlm:affiliation><wicri:noCountry code="subField">Charleston</wicri:noCountry></affiliation></author><author><name sortKey="Babcock, Debra" sort="Babcock, Debra" uniqKey="Babcock D" first="Debra" last="Babcock">Debra Babcock</name><affiliation wicri:level="2"><nlm:affiliation>National Institutes of Health, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name><affiliation wicri:level="4"><nlm:affiliation>University of South Florida, Tampa.</nlm:affiliation><orgName type="university">Université de Floride du Sud</orgName><country>États-Unis</country><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name><affiliation wicri:level="2"><nlm:affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Augustine, Alicia H" sort="Augustine, Alicia H" uniqKey="Augustine A" first="Alicia H" last="Augustine">Alicia H. Augustine</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Augustine, Erika U" sort="Augustine, Erika U" uniqKey="Augustine E" first="Erika U" last="Augustine">Erika U. Augustine</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Aminoff, Michael J" sort="Aminoff, Michael J" uniqKey="Aminoff M" first="Michael J" last="Aminoff">Michael J. Aminoff</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Bodis Wollner, Ivan G" sort="Bodis Wollner, Ivan G" uniqKey="Bodis Wollner I" first="Ivan G" last="Bodis-Wollner">Ivan G. Bodis-Wollner</name><affiliation><nlm:affiliation>State University of New York Downstate Medical Center, Brooklyn.</nlm:affiliation><wicri:noCountry code="subField">Brooklyn</wicri:noCountry></affiliation></author><author><name sortKey="Boyd, James" sort="Boyd, James" uniqKey="Boyd J" first="James" last="Boyd">James Boyd</name><affiliation><nlm:affiliation>University of Vermont, Burlington.</nlm:affiliation><wicri:noCountry code="subField">Burlington</wicri:noCountry></affiliation></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name><affiliation><nlm:affiliation>University of Kentucky, Lexington.</nlm:affiliation><wicri:noCountry code="subField">Lexington</wicri:noCountry></affiliation></author><author><name sortKey="Chou, Kelvin" sort="Chou, Kelvin" uniqKey="Chou K" first="Kelvin" last="Chou">Kelvin Chou</name><affiliation><nlm:affiliation>University of Michigan, Ann Arbor.</nlm:affiliation><wicri:noCountry code="subField">Ann Arbor</wicri:noCountry></affiliation></author><author><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name><affiliation wicri:level="3"><nlm:affiliation>University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name><affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Dewey, Richard B" sort="Dewey, Richard B" uniqKey="Dewey R" first="Richard B" last="Dewey">Richard B. Dewey</name><affiliation><nlm:affiliation>University of Texas Southwestern Medical Center, Dallas.</nlm:affiliation><wicri:noCountry code="subField">Dallas</wicri:noCountry></affiliation></author><author><name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name><affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name><affiliation wicri:level="2"><nlm:affiliation>Ochsner Medical Center, New Orleans, Louisiana.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Ochsner Medical Center, New Orleans</wicri:cityArea></affiliation></author><author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name><affiliation wicri:level="2"><nlm:affiliation>University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Leehey, Maureen" sort="Leehey, Maureen" uniqKey="Leehey M" first="Maureen" last="Leehey">Maureen Leehey</name><affiliation><nlm:affiliation>University of Colorado Denver, Aurora.</nlm:affiliation><wicri:noCountry code="subField">Aurora</wicri:noCountry></affiliation></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name><affiliation wicri:level="3"><nlm:affiliation>University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name><affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Luo, Sheng T" sort="Luo, Sheng T" uniqKey="Luo S" first="Sheng T" last="Luo">Sheng T. Luo</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Morgan, John C" sort="Morgan, John C" uniqKey="Morgan J" first="John C" last="Morgan">John C. Morgan</name><affiliation><nlm:affiliation>Georgia Regents University, Augusta.</nlm:affiliation><wicri:noCountry code="subField">Augusta</wicri:noCountry></affiliation></author><author><name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name><affiliation wicri:level="2"><nlm:affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Struthers Parkinson's Center, Golden Valley</wicri:cityArea></affiliation></author><author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><affiliation wicri:level="2"><nlm:affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Pacific Health Research and Education Institute, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Rajan, Suja" sort="Rajan, Suja" uniqKey="Rajan S" first="Suja" last="Rajan">Suja Rajan</name><affiliation><nlm:affiliation>University of Texas Health Science Center at Houston.</nlm:affiliation><wicri:noCountry code="no comma">University of Texas Health Science Center at Houston.</wicri:noCountry></affiliation></author><author><name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name><affiliation wicri:level="3"><nlm:affiliation>University of Pennsylvania, Philadelphia.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pennsylvania</wicri:orgArea></affiliation></author><author><name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name><affiliation wicri:level="3"><nlm:affiliation>University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>University of California</wicri:orgArea></affiliation></author><author><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name><affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Thomas Jefferson University, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name><affiliation wicri:level="2"><nlm:affiliation>Rush University Medical Center, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name><affiliation wicri:level="2"><nlm:affiliation>Beth Israel Deaconess Medical Center, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation wicri:level="2"><nlm:affiliation>University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name><affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name><affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Creatine (adverse effects)</term><term>Creatine (blood)</term><term>Creatine (therapeutic use)</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Medication Adherence</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Creatine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Creatine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Creatine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Medication Adherence</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25668262</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>11</Day></DateCreated><DateCompleted><Year>2015</Year><Month>02</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>04</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3598</ISSN><JournalIssue CitedMedium="Internet"><Volume>313</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Feb</Month><Day>10</Day></PubDate></JournalIssue><Title>JAMA</Title><ISOAbbreviation>JAMA</ISOAbbreviation></Journal><ArticleTitle>Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.</ArticleTitle><Pagination><MedlinePgn>584-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jama.2015.120</ELocationID><Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease program was established to promote discovery of potential therapies.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether creatine monohydrate was more effective than placebo in slowing long-term clinical decline in participants with Parkinson disease.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PATIENTS" NlmCategory="METHODS">The Long-term Study 1, a multicenter, double-blind, parallel-group, placebo-controlled, 1:1 randomized efficacy trial. Participants were recruited from 45 investigative sites in the United States and Canada and included 1741 men and women with early (within 5 years of diagnosis) and treated (receiving dopaminergic therapy) Parkinson disease. Participants were enrolled from March 2007 to May 2010 and followed up until September 2013.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Participants were randomized to placebo or creatine (10 g/d) monohydrate for a minimum of 5 years (maximum follow-up, 8 years).</AbstractText><AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">The primary outcome measure was a difference in clinical decline from baseline to 5-year follow-up, compared between the 2 treatment groups using a global statistical test. Clinical status was defined by 5 outcome measures: Modified Rankin Scale, Symbol Digit Modalities Test, PDQ-39 Summary Index, Schwab and England Activities of Daily Living scale, and ambulatory capacity. All outcomes were coded such that higher scores indicated worse outcomes and were analyzed by a global statistical test. Higher summed ranks (range, 5-4775) indicate worse outcomes.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The trial was terminated early for futility based on results of a planned interim analysis of participants enrolled at least 5 years prior to the date of the analysis (n = 955). The median follow-up time was 4 years. Of the 955 participants, the mean of the summed ranks for placebo was 2360 (95% CI, 2249-2470) and for creatine was 2414 (95% CI, 2304-2524). The global statistical test yielded t1865.8 = -0.75 (2-sided P = .45). There were no detectable differences (P < .01 to partially adjust for multiple comparisons) in adverse and serious adverse events by body system.</AbstractText><AbstractText Label="CONCLUSIONS AND RELEVANCE" NlmCategory="CONCLUSIONS">Among patients with early and treated Parkinson disease, treatment with creatine monohydrate for at least 5 years, compared with placebo did not improve clinical outcomes. These findings do not support the use of creatine monohydrate in patients with Parkinson disease.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">clinicaltrials.gov Identifier: NCT00449865.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><CollectiveName>Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators</CollectiveName></Author><Author ValidYN="Y"><LastName>Kieburtz</LastName><ForeName>Karl</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tilley</LastName><ForeName>Barbara C</ForeName><Initials>BC</Initials><AffiliationInfo><Affiliation>University of Texas Health Science Center at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Elm</LastName><ForeName>Jordan J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Medical University of South Carolina, Charleston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Babcock</LastName><ForeName>Debra</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>National Institutes of Health, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of South Florida, Tampa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>G Webster</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>Pacific Health Research and Education Institute, Honolulu, Hawaii.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augustine</LastName><ForeName>Alicia H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augustine</LastName><ForeName>Erika U</ForeName><Initials>EU</Initials><AffiliationInfo><Affiliation>University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aminoff</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>University of California, San Francisco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodis-Wollner</LastName><ForeName>Ivan G</ForeName><Initials>IG</Initials><AffiliationInfo><Affiliation>State University of New York Downstate Medical Center, Brooklyn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boyd</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Vermont, Burlington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cambi</LastName><ForeName>Franca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Kentucky, Lexington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chou</LastName><ForeName>Kelvin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Michigan, Ann Arbor.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christine</LastName><ForeName>Chadwick W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>University of California, San Francisco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cines</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Maryland School of Medicine, Baltimore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dahodwala</LastName><ForeName>Nabila</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Pennsylvania, Philadelphia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Derwent</LastName><ForeName>Lorelei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dewey</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>University of Texas Southwestern Medical Center, Dallas.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hawthorne</LastName><ForeName>Katherine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houghton</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Ochsner Medical Center, New Orleans, Louisiana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamp</LastName><ForeName>Cornelia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leehey</LastName><ForeName>Maureen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Colorado Denver, Aurora.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lew</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Grace S Lin</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Sheng T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>University of Texas Health Science Center at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mari</LastName><ForeName>Zoltan</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Johns Hopkins University, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morgan</LastName><ForeName>John C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Georgia Regents University, Augusta.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parashos</LastName><ForeName>Sotirios</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pérez</LastName><ForeName>Adriana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Texas Health Science Center at Houston.</Affiliation></AffiliationInfo></Author><Author 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UI="D003401">Creatine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1992 Dec;32(6):782-8</RefSource><PMID Version="1">1471869</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2010 Nov 15;25(15):2649-53</RefSource><PMID Version="1">21069833</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 1990 Mar;54(3):823-7</RefSource><PMID Version="1">2154550</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1989 Dec;26(6):719-23</RefSource><PMID Version="1">2557792</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biometrics. 1988 Jun;44(2):579-85</RefSource><PMID Version="1">3390511</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stroke. 1988 May;19(5):604-7</RefSource><PMID Version="1">3363593</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Mol Neurosci. 2003;21(3):191-8</RefSource><PMID Version="1">14645986</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Methods Med Res. 2016 Apr;25(2):821-37</RefSource><PMID Version="1">23242384</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2014 Sep 27;384(9949):1196-205</RefSource><PMID Version="1">24928805</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2013 Mar;28(3):311-8</RefSource><PMID Version="1">23436720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2009 Sep 15;24(12):1732-9</RefSource><PMID Version="1">19514076</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Neuropharmacol. 2008 May-Jun;31(3):141-50</RefSource><PMID Version="1">18520981</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Jan 30;68(5):384-6</RefSource><PMID Version="1">17082464</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pers Assess. 1996 Dec;67(3):588-97</RefSource><PMID Version="1">8991972</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Nov 11;61(9):1222-8</RefSource><PMID Version="1">14610124</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Epidemiol. 2003 Sep;56(9):843-7</RefSource><PMID Version="1">14505768</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Apr 22;60(8):1234-40</RefSource><PMID Version="1">12707423</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Jan 2;68(1):20-8</RefSource><PMID Version="1">17200487</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Mar 14;66(5):628-33</RefSource><PMID Version="1">16534099</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Mar 14;66(5):664-71</RefSource><PMID Version="1">16481597</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biometrics. 2005 Jun;61(2):532-9</RefSource><PMID Version="1">16011701</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Qual Life Res. 1999 Jun;8(4):345-50</RefSource><PMID Version="1">10472167</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 1999 May;157(1):142-9</RefSource><PMID Version="1">10222117</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2012 Oct;27(12):1513-21</RefSource><PMID Version="1">23079770</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Health Policy. 1990 Dec;16(3):199-208</RefSource><PMID 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Augustine</name><name sortKey="Babcock, Debra" sort="Babcock, Debra" uniqKey="Babcock D" first="Debra" last="Babcock">Debra Babcock</name><name sortKey="Christine, Chadwick W" sort="Christine, Chadwick W" uniqKey="Christine C" first="Chadwick W" last="Christine">Chadwick W. Christine</name><name sortKey="Cines, Michelle" sort="Cines, Michelle" uniqKey="Cines M" first="Michelle" last="Cines">Michelle Cines</name><name sortKey="Dahodwala, Nabila" sort="Dahodwala, Nabila" uniqKey="Dahodwala N" first="Nabila" last="Dahodwala">Nabila Dahodwala</name><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name><name sortKey="Hawthorne, Katherine" sort="Hawthorne, Katherine" uniqKey="Hawthorne K" first="Katherine" last="Hawthorne">Katherine Hawthorne</name><name sortKey="Houghton, David J" sort="Houghton, David J" uniqKey="Houghton D" first="David J" last="Houghton">David J. Houghton</name><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F" last="Lew">Mark F. Lew</name><name sortKey="Liang, Grace S Lin" sort="Liang, Grace S Lin" uniqKey="Liang G" first="Grace S Lin" last="Liang">Grace S Lin Liang</name><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><name sortKey="Parashos, Sotirios" sort="Parashos, Sotirios" uniqKey="Parashos S" first="Sotirios" last="Parashos">Sotirios Parashos</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Reichwein, Sue" sort="Reichwein, Sue" uniqKey="Reichwein S" first="Sue" last="Reichwein">Sue Reichwein</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name><name sortKey="Roth, Jessie Tatsuno" sort="Roth, Jessie Tatsuno" uniqKey="Roth J" first="Jessie Tatsuno" last="Roth">Jessie Tatsuno Roth</name><name sortKey="Schneider, Jay S" sort="Schneider, Jay S" uniqKey="Schneider J" first="Jay S" last="Schneider">Jay S. Schneider</name><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name><name sortKey="Simon, David K" sort="Simon, David K" uniqKey="Simon D" first="David K" last="Simon">David K. Simon</name><name sortKey="Simuni, Tanya" sort="Simuni, Tanya" uniqKey="Simuni T" first="Tanya" last="Simuni">Tanya Simuni</name><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><name sortKey="Sudarsky, Lewis" sort="Sudarsky, Lewis" uniqKey="Sudarsky L" first="Lewis" last="Sudarsky">Lewis Sudarsky</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C" last="Umeh">Chizoba C. Umeh</name><name sortKey="Williams, Karen" sort="Williams, Karen" uniqKey="Williams K" first="Karen" last="Williams">Karen Williams</name><name sortKey="Wills, Anne Marie" sort="Wills, Anne Marie" uniqKey="Wills A" first="Anne-Marie" last="Wills">Anne-Marie Wills</name></country><country name="Canada"><region name="Alberta"><name sortKey="Derwent, Lorelei" sort="Derwent, Lorelei" uniqKey="Derwent L" first="Lorelei" last="Derwent">Lorelei Derwent</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= pubmed:25668262
|texte= Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
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