Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring
Identifieur interne : 001A52 ( Ncbi/Merge ); précédent : 001A51; suivant : 001A53Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring
Auteurs : Dafna Sussman [Canada] ; Jurgen Germann [Canada] ; Mark Henkelman [Canada]Source :
- Brain and Behavior [ 2162-3279 ] ; 2014.
Abstract
The ketogenic diet (KD) has seen an increase in popularity for clinical and non-clinical purposes, leading to rise in concern about the diet's impact on following generations. The KD is known to have a neurological effect, suggesting that exposure to it during prenatal brain development may alter neuro-anatomy. Studies have also indicated that the KD has an anti-depressant effect on the consumer. However, it is unclear whether any neuro-anatomical and/or behavioral changes would occur in the offspring and persist into adulthood.
To fill this knowledge gap we assessed the brain morphology and behavior of 8-week-old young-adult CD-1 mice, who were exposed to the KD in utero, and were fed only a standard-diet (SD) in postnatal life. Standardized neuro-behavior tests included the Open-Field, Forced-Swim, and Exercise Wheel tests, and were followed by post-mortem Magnetic Resonance Imaging (MRI) to assess brain anatomy.
The adult KD offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the SD both in utero and postnatally. Many neuro-anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement by 4.8%, a hypothalamic reduction by 1.39%, and a corpus callosum reduction by 4.77%, as computed relative to total brain volume.
These results suggest that prenatal exposure to the KD programs the offspring neuro-anatomy and influences their behavior in adulthood.
Url:
DOI: 10.1002/brb3.300
PubMed: 25642385
PubMed Central: 4309881
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring</title><author><name sortKey="Sussman, Dafna" sort="Sussman, Dafna" uniqKey="Sussman D" first="Dafna" last="Sussman">Dafna Sussman</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Physiology and Experimental Medicine, The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Germann, Jurgen" sort="Germann, Jurgen" uniqKey="Germann J" first="Jurgen" last="Germann">Jurgen Germann</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Mouse Imaging Center (MICe), The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Henkelman, Mark" sort="Henkelman, Mark" uniqKey="Henkelman M" first="Mark" last="Henkelman">Mark Henkelman</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Mouse Imaging Center (MICe), The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25642385</idno><idno type="pmc">4309881</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309881</idno><idno type="RBID">PMC:4309881</idno><idno type="doi">10.1002/brb3.300</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000934</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000934</idno><idno type="wicri:Area/Pmc/Curation">000934</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000934</idno><idno type="wicri:Area/Pmc/Checkpoint">000479</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000479</idno><idno type="wicri:Area/Ncbi/Merge">001A52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring</title><author><name sortKey="Sussman, Dafna" sort="Sussman, Dafna" uniqKey="Sussman D" first="Dafna" last="Sussman">Dafna Sussman</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Physiology and Experimental Medicine, The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Germann, Jurgen" sort="Germann, Jurgen" uniqKey="Germann J" first="Jurgen" last="Germann">Jurgen Germann</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Mouse Imaging Center (MICe), The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Henkelman, Mark" sort="Henkelman, Mark" uniqKey="Henkelman M" first="Mark" last="Henkelman">Mark Henkelman</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Mouse Imaging Center (MICe), The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain and Behavior</title><idno type="ISSN">2162-3279</idno><idno type="eISSN">2162-3279</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The ketogenic diet (KD) has seen an increase in popularity for clinical and non-clinical purposes, leading to rise in concern about the diet's impact on following generations. The KD is known to have a neurological effect, suggesting that exposure to it during prenatal brain development may alter neuro-anatomy. Studies have also indicated that the KD has an anti-depressant effect on the consumer. However, it is unclear whether any neuro-anatomical and/or behavioral changes would occur in the offspring and persist into adulthood.</p></sec><sec><title>Methods</title><p>To fill this knowledge gap we assessed the brain morphology and behavior of 8-week-old young-adult CD-1 mice, who were exposed to the KD in utero, and were fed only a standard-diet (SD) in postnatal life. Standardized neuro-behavior tests included the Open-Field, Forced-Swim, and Exercise Wheel tests, and were followed by post-mortem Magnetic Resonance Imaging (MRI) to assess brain anatomy.</p></sec><sec><title>Results</title><p>The adult KD offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the SD both in utero and postnatally. Many neuro-anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement by 4.8%, a hypothalamic reduction by 1.39%, and a corpus callosum reduction by 4.77%, as computed relative to total brain volume.</p></sec><sec><title>Conclusions</title><p>These results suggest that prenatal exposure to the KD programs the offspring neuro-anatomy and influences their behavior in adulthood.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ahren, B" uniqKey="Ahren B">B Ahren</name></author><author><name sortKey="Mansson, S" uniqKey="Mansson S">S Mansson</name></author><author><name sortKey="Gingerich, Rl" uniqKey="Gingerich R">RL Gingerich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alamy, M" uniqKey="Alamy M">M Alamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Veech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veech, Rl" uniqKey="Veech R">RL Veech</name></author><author><name sortKey="Chance, B" uniqKey="Chance B">B Chance</name></author><author><name sortKey="Kashiwaya, Y" uniqKey="Kashiwaya Y">Y Kashiwaya</name></author><author><name sortKey="Lardy, Ha" uniqKey="Lardy H">HA Lardy</name></author><author><name sortKey="Cahill, Gf" uniqKey="Cahill G">GF Cahill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, Re" uniqKey="Watson R">RE Watson</name></author><author><name sortKey="Desesso, Jm" uniqKey="Desesso J">JM Desesso</name></author><author><name sortKey="Hurtt, Me" uniqKey="Hurtt M">ME Hurtt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name></author><author><name sortKey="Mukherjee, P" uniqKey="Mukherjee P">P Mukherjee</name></author><author><name sortKey="Kiebish, Ma" uniqKey="Kiebish M">MA Kiebish</name></author><author><name sortKey="Markis, Wt" uniqKey="Markis W">WT Markis</name></author><author><name sortKey="Mantis, Jg" uniqKey="Mantis J">JG Mantis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain Behav</journal-id><journal-id journal-id-type="iso-abbrev">Brain Behav</journal-id><journal-id journal-id-type="publisher-id">brb3</journal-id><journal-title-group><journal-title>Brain and Behavior</journal-title></journal-title-group><issn pub-type="ppub">2162-3279</issn><issn pub-type="epub">2162-3279</issn><publisher><publisher-name>BlackWell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25642385</article-id><article-id pub-id-type="pmc">4309881</article-id><article-id pub-id-type="doi">10.1002/brb3.300</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sussman</surname><given-names>Dafna</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Germann</surname><given-names>Jurgen</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Henkelman</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><aff id="au1"><label>1</label><institution>Physiology and Experimental Medicine, The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></aff><aff id="au2"><label>2</label><institution>Mouse Imaging Center (MICe), The Hospital for Sick Children</institution><addr-line>Toronto, Ontario, Canada</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence</bold>, Dafna Sussman, Physiology and Experimental Medicine, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario. M5G 1A4. Canada., Tel: 416-813-7654 ext. 309118, Fax: 416-813-7362, E-mail: <email>dafna.sussman@utoronto.ca</email></corresp><fn><p><bold>Funding Information</bold> The study was supported by The Hospital for Sick Children in Toronto, Canada. D. Sussman holds an Alexander Graham Bell Canada Graduate Scholarship (CGS) from the Natural Sciences and Engineering Research Council of Canada (NSERC). R.M. Henkelman holds a Canada Research Chair in Imaging Technologies in Human Disease and Preclinical Models.</p></fn></author-notes><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>29</day><month>12</month><year>2014</year></pub-date><volume>5</volume><issue>2</issue><elocation-id>e00300</elocation-id><history><date date-type="received"><day>22</day><month>7</month><year>2014</year></date><date date-type="rev-recd"><day>12</day><month>10</month><year>2014</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Authors. <italic>Brain and Behavior</italic> published by Wiley Periodicals, Inc.</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Introduction</title><p>The ketogenic diet (KD) has seen an increase in popularity for clinical and non-clinical purposes, leading to rise in concern about the diet's impact on following generations. The KD is known to have a neurological effect, suggesting that exposure to it during prenatal brain development may alter neuro-anatomy. Studies have also indicated that the KD has an anti-depressant effect on the consumer. However, it is unclear whether any neuro-anatomical and/or behavioral changes would occur in the offspring and persist into adulthood.</p></sec><sec><title>Methods</title><p>To fill this knowledge gap we assessed the brain morphology and behavior of 8-week-old young-adult CD-1 mice, who were exposed to the KD in utero, and were fed only a standard-diet (SD) in postnatal life. Standardized neuro-behavior tests included the Open-Field, Forced-Swim, and Exercise Wheel tests, and were followed by post-mortem Magnetic Resonance Imaging (MRI) to assess brain anatomy.</p></sec><sec><title>Results</title><p>The adult KD offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the SD both in utero and postnatally. Many neuro-anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement by 4.8%, a hypothalamic reduction by 1.39%, and a corpus callosum reduction by 4.77%, as computed relative to total brain volume.</p></sec><sec><title>Conclusions</title><p>These results suggest that prenatal exposure to the KD programs the offspring neuro-anatomy and influences their behavior in adulthood.</p></sec></abstract><kwd-group><kwd>Behavior</kwd><kwd>development</kwd><kwd>ketogenic diet</kwd><kwd>magnetic resonance imaging</kwd><kwd>neuroimaging</kwd><kwd>prenatal programming</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Sussman, Dafna" sort="Sussman, Dafna" uniqKey="Sussman D" first="Dafna" last="Sussman">Dafna Sussman</name></noRegion><name sortKey="Germann, Jurgen" sort="Germann, Jurgen" uniqKey="Germann J" first="Jurgen" last="Germann">Jurgen Germann</name><name sortKey="Henkelman, Mark" sort="Henkelman, Mark" uniqKey="Henkelman M" first="Mark" last="Henkelman">Mark Henkelman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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